JNK signalling in cancer: in need of new, smarter therapeutic targets (Q27023869)

full work available at URL

http://eprints.whiterose.ac.uk/101273/

content deliverer

White Rose Research Online

object of statement has role

postprint

0 references

published in

British Journal of Pharmacology

1 reference

volume

171

1 reference

issue

1

1 reference

page(s)

24-37

1 reference

Myeloid malignancies: mutations, models and management

cites work

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JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma

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Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer

20 March 2017

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Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

20 March 2017

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c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL

20 March 2017

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20 March 2017

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

20 March 2017

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Discovery of Potent and Selective Covalent Inhibitors of JNK

20 March 2017

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Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

20 March 2017

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Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

20 March 2017

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Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma

20 March 2017

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A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates

20 March 2017

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Signal transduction by the JNK group of MAP kinases

20 March 2017

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Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation

20 March 2017

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A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches

20 March 2017

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Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage

20 March 2017

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

20 March 2017

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Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene

20 March 2017

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The JNK inhibitor XG-102 protects against TNBS-induced colitis

20 March 2017

2 references

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Requirement of the JIP1 scaffold protein for stress-induced JNK activation

20 March 2017

2 references

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Targeting cancer with small molecule kinase inhibitors

20 March 2017

1 reference

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Hepatocellular carcinoma pathogenesis: from genes to environment

7 April 2017

1 reference

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7 April 2017

Hepatocellular carcinoma

1 reference

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Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

7 April 2017

1 reference

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A central role for JNK in obesity and insulin resistance

7 April 2017

1 reference

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

7 April 2017

1 reference

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AP-1: a double-edged sword in tumorigenesis

7 April 2017

1 reference

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The specificities of protein kinase inhibitors: an update

9 May 2017

1 reference

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The impact of JNK inhibitor D-JNKI-1 in a murine model of chronic colitis induced by dextran sulfate sodium

9 May 2017

1 reference

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Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds.

28 September 2017

1 reference

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The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer

28 September 2017

1 reference

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Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma.

28 September 2017

1 reference

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c-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells.

28 September 2017

1 reference

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Molecular pathways: BCR-ABL.

28 September 2017

1 reference

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Role of JNK in mammary gland development and breast cancer

28 September 2017

1 reference

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Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family

28 September 2017

1 reference

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PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.

28 September 2017

1 reference

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Development of JNK2-selective peptide inhibitors that inhibit breast cancer cell migration

28 September 2017

1 reference

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The role of JNK in the development of hepatocellular carcinoma

28 September 2017

1 reference

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Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors

28 September 2017

1 reference

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Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation

28 September 2017

1 reference

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Role of JNK in a Trp53-dependent mouse model of breast cancer

28 September 2017

1 reference

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The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer.

28 September 2017

1 reference

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JNK1, JNK2, and JNK3 are involved in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells.

28 September 2017

1 reference

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Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model

28 September 2017

1 reference

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The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia.

28 September 2017

1 reference

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Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation

28 September 2017

1 reference

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Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells.

28 September 2017

1 reference

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c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges.

28 September 2017

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Basal cancer cell survival involves JNK2 suppression of a novel JNK1/c-Jun/Bcl-3 apoptotic network

28 September 2017

1 reference

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Mechanisms of liver disease: cross-talk between the NF-kappaB and JNK pathways

28 September 2017

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JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis

28 September 2017

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Signal integration by JNK and p38 MAPK pathways in cancer development

28 September 2017

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Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model

28 September 2017

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c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D

28 September 2017

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Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications

28 September 2017

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c-Jun N-terminal kinase 1 phosphorylates Myt1 to prevent UVA-induced skin cancer.

28 September 2017

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JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand

28 September 2017

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Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

28 September 2017

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Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

28 September 2017

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Inhibitors of c-jun-N-terminal kinase (JNK).

28 September 2017

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Targeting the eukaryotic translation initiation factor 4E for cancer therapy

28 September 2017

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Role of the JNK signal transduction pathway in inflammatory bowel disease

28 September 2017

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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

28 September 2017

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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

28 September 2017

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Multiple myeloma: lusting for NF-kappaB.

28 September 2017

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c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression

28 September 2017

1 reference

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Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway

28 September 2017

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Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.

28 September 2017

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Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia

28 September 2017

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Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases

28 September 2017

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28 September 2017

Acute myeloid leukaemia

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The JIP family of MAPK scaffold proteins.

28 September 2017

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c-Jun NH(2)-terminal kinase 2alpha2 promotes the tumorigenicity of human glioblastoma cells

28 September 2017

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Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

28 September 2017

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Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity

28 September 2017

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Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor

28 September 2017

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The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease

28 September 2017

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JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance.

28 September 2017

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c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells

28 September 2017

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Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors

28 September 2017

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Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy

28 September 2017

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Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

28 September 2017

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JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

28 September 2017

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Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines

28 September 2017

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Targeting JNK for therapeutic benefit: from junk to gold?

28 September 2017

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JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells

28 September 2017

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C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma.

28 September 2017

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Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation

28 September 2017

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Mutation rate of MAP2K4/MKK4 in breast carcinoma

28 September 2017

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BH3-Only proteins-essential initiators of apoptotic cell death

28 September 2017

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Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome

28 September 2017

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28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

MEKK1/JNK signaling stabilizes and activates p53.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

Requirement for Both Shc and Phosphatidylinositol 3′ Kinase Signaling Pathways in Polyomavirus Middle T-Mediated Mammary Tumorigenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

Activation of the JNK pathway is essential for transformation by the Met oncogene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

Cooperation between antioxidants and 1,25-dihydroxyvitamin D3 in induction of leukemia HL60 cell differentiation through the JNK/AP-1/Egr-1 pathway.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

Elevated JNK activation contributes to the pathogenesis of human brain tumors

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

Identification of the critical features of a small peptide inhibitor of JNK activity

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

Transformation suppressor activity of a Jun transcription factor lacking its activation domain

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

31 May 2018

2 references

21 January 2018

12 December 2020

JNK1 and JNK2 play redundant functions in Myc-induced B cell lymphoma formation.

1 reference

Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis

21 January 2018

1 reference

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

21 January 2018

1 reference

AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties

21 January 2018

1 reference

Identification of small-molecule inhibitors of the JIP-JNK interaction

21 January 2018

1 reference

Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats

21 January 2018

1 reference

Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.

21 January 2018

1 reference

Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.

21 January 2018

1 reference

Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.

21 January 2018

1 reference

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

21 January 2018

1 reference

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

21 January 2018

1 reference

An inhibitory function for JNK in the regulation of IGF-I signaling in breast cancer

21 January 2018

1 reference

Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.

21 January 2018

1 reference

Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma.

21 January 2018

1 reference

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

21 January 2018

1 reference

Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways

21 January 2018

1 reference

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression

21 January 2018

1 reference

Small molecule JNK (c-Jun N-terminal kinase) inhibitors.

21 January 2018

1 reference

SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease

21 January 2018

1 reference

The c-Jun NH2-terminal kinase3 (JNK3) gene: genomic structure, chromosomal assignment, and loss of expression in brain tumors

21 January 2018

1 reference

Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma

21 January 2018

1 reference

Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874694

JNK2 is a positive regulator of the cJun transcription factor

28 November 2018

1 reference

12 December 2020

Constitutive activation of c-Jun N-terminal kinase correlates with histologic grade and EGFR expression in diffuse gliomas

1 reference

12 December 2020

Genetic deletion of JNK1 and JNK2 aggravates the DSS-induced colitis in mice

1 reference

12 December 2020

Primary brain tumours in adults

1 reference

12 December 2020

Identifiers

DOI

10.1111/BPH.12432

1 reference

Dimensions Publication ID

Altmetric DOI

10.1111/BPH.12432

0 references

1003774569

0 references

Fatcat ID

release_7eaigtpo35dvxi6ojgov4xrh3e

0 references

1 reference

1 reference

PubMed publication ID

24117156

1 reference