Hepatocellular carcinoma pathogenesis: from genes to environment (Q29615767)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16929323%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

review article

1 reference

title

Hepatocellular carcinoma pathogenesis: from genes to environment (English)

2 references

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30 April 2017

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29 December 2019

1 reference

hepatocellular carcinoma

1 reference

1

1 reference

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29 December 2019

author name string

Ronald A DePinho

series ordinal

2

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language of work or name

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30 April 2017

publication date

1 September 2006

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29 December 2019

published in

Nature Reviews Cancer

2 references

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29 December 2019

volume

6

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29 December 2019

issue

9

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29 December 2019

page(s)

674-687

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Liver transplantation for malignancy

29 December 2019

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Understanding the hypercarcinogenic state in chronic hepatitis: a clue to the prevention of human hepatocellular carcinoma

31 March 2020

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The hepatitis C virus non-structural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling

31 March 2020

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Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent manner

31 March 2020

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Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis

31 March 2020

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Monocyte activation in alcoholic liver disease

31 March 2020

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Ethanol, oxidative stress, and cytokine-induced liver cell injury

31 March 2020

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Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma

31 March 2020

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F2-isoprostanes stimulate collagen synthesis in activated hepatic stellate cells: a link with liver fibrosis?

31 March 2020

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Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells

31 March 2020

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Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma.

31 March 2020

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Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells.

31 March 2020

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Geographic variation of p53 mutational profile in nonmalignant human liver

31 March 2020

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Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

31 March 2020

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Mutational hot spot in the p53 gene in human hepatocellular carcinomas

31 March 2020

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p53 mutation in hepatocellular carcinoma after aflatoxin exposure

31 March 2020

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In vitro activation of the human Harvey-ras proto-oncogene by aflatoxin B1.

31 March 2020

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Synergistic interaction between aflatoxin B1 and hepatitis B virus in hepatocarcinogenesis

31 March 2020

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31 March 2020

Hepatocellular carcinoma

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Mutation of p53 gene in regenerative nodules in cirrhotic liver

31 March 2020

1 reference

p53 gene mutations and 17p allelic deletions in hepatocellular carcinoma from Japan

31 March 2020

1 reference

Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression

31 March 2020

1 reference

Hepatitis B injury, male gender, aflatoxin, and p53 expression each contribute to hepatocarcinogenesis in transgenic mice†

31 March 2020

1 reference

The mouse equivalent of the human p53ser249 mutation p53ser246 enhances aflatoxin hepatocarcinogenesis in hepatitis B surface antigen transgenic and p53 heterozygous null mice

31 March 2020

1 reference

Wnt signaling in the intestinal epithelium: from endoderm to cancer

31 March 2020

1 reference

Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis

31 March 2020

1 reference

Molecular pathogenesis of human hepatocellular carcinoma

31 March 2020

1 reference

High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: significance of hepatitis virus infection, age, p53 and beta-catenin mutations.

31 March 2020

1 reference

Tumor heterogeneity in small hepatocellular carcinoma: analysis of tumor cell proliferation, expression and mutation of p53 AND beta-catenin

31 March 2020

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Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis

31 March 2020

1 reference

Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection

31 March 2020

1 reference

Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells.

31 March 2020

1 reference

Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes.

31 March 2020

1 reference

Analysis of chromosomal instability in pulmonary or liver metastases and matched primary hepatocellular carcinoma after orthotopic liver transplantation

31 March 2020

1 reference

Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice

31 March 2020

1 reference

Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma

31 March 2020

1 reference

Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma.

31 March 2020

1 reference

Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis

31 March 2020

1 reference

Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer

31 March 2020

1 reference

TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

31 March 2020

1 reference

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

31 March 2020

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Liver regeneration and hepatocarcinogenesis in transforming growth factor-alpha-targeted mice.

31 March 2020

1 reference

Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver

31 March 2020

1 reference

Nonrandom cytogenetic alterations in hepatocellular carcinoma from transgenic mice overexpressing c-Myc and transforming growth factor-alpha in the liver

31 March 2020

1 reference

Hepatocyte growth factor, transforming growth factor alpha, and their receptors as combined markers of prognosis in hepatocellular carcinoma

31 March 2020

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Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice

31 March 2020

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Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis

31 March 2020

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DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis.

31 March 2020

1 reference

Aberrant DNA methylation on chromosome 16 is an early event in hepatocarcinogenesis.

31 March 2020

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Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis

31 March 2020

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Aberrant CpG Island Hypermethylation Along Multistep Hepatocarcinogenesis

31 March 2020

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p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma

31 March 2020

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High frequency of p16INK4A gene alterations in hepatocellular carcinoma

31 March 2020

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Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells

31 March 2020

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Apoptotic speck protein-like, a highly homologous protein to apoptotic speck protein in the pyrin domain, is silenced by DNA methylation and induces apoptosis in human hepatocellular carcinoma

31 March 2020

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Effect of promoter methylation of the p16 gene on phosphorylation of retinoblastoma gene product and growth of hepatocellular carcinoma cells

31 March 2020

1 reference

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31 March 2020

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Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis

31 March 2020

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Telomere shortening in chronic liver diseases

31 March 2020

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Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis

31 March 2020

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Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma

31 March 2020

1 reference

Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma

31 March 2020

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Telomerase reverse transcriptase mRNA expression and telomerase activity in hepatocellular carcinoma

31 March 2020

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Detection of telomerase activity, telomerase RNA component, and telomerase reverse transcriptase in human hepatocellular carcinoma

31 March 2020

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Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT) gene in liver and cervical cancers

31 March 2020

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Examination of oncogene amplification by genomic DNA microarray in hepatocellular carcinomas: comparison with comparative genomic hybridization analysis.

31 March 2020

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Functional evidence for a telomerase repressor gene on human chromosome 10p15.1.

31 March 2020

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Relationship between microvessel density and telomerase activity in hepatocellular carcinoma

31 March 2020

1 reference

Telomerase activity as a predictive marker for recurrence of hepatocellular carcinoma after hepatectomy

31 March 2020

1 reference

In situdetection of telomerase enzymatic activity in human hepatocellular carcinogenesis

31 March 2020

1 reference

Telomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesis

31 March 2020

1 reference

Constitutive telomerase expression promotes mammary carcinomas in aging mice

31 March 2020

1 reference

Mechanisms leading to chromosomal instability.

31 March 2020

1 reference

Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A

31 March 2020

1 reference

Aurora kinases: shining lights on the therapeutic horizon?

31 March 2020

1 reference

Frequent impairment of the spindle assembly checkpoint in hepatocellular carcinoma.

31 March 2020

1 reference

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

31 March 2020

1 reference

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

31 March 2020

1 reference

Evidence for the presence of two tumour-suppressor genes for hepatocellular carcinoma on chromosome 13q

31 March 2020

1 reference

A comprehensive karyotypic study on human hepatocellular carcinoma by spectral karyotyping.

31 March 2020

1 reference

A comprehensive karyotypic analysis on Korean hepatocellular carcinoma cell lines by cross-species color banding and comparative genomic hybridization

31 March 2020

1 reference

Comprehensive allelotype study of hepatocellular carcinoma: potential differences in pathways to hepatocellular carcinoma between hepatitis B virus-positive and -negative tumors

31 March 2020

1 reference

Chromosomal imbalances detected by comparative genomic hybridization are associated with outcome of patients with hepatocellular carcinoma

31 March 2020

1 reference

Analysis of chromosomal aberrations in large hepatocellular carcinomas by comparative genomic hybridization

31 March 2020

1 reference

Genetic alterations in hepatocellular carcinoma and intrahepatic cholangiocarcinoma

31 March 2020

1 reference

Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization

31 March 2020

1 reference

Analysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH.

31 March 2020

1 reference

Chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridization

31 March 2020

1 reference

Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: their relationship to clinicopathological features

31 March 2020

1 reference

Molecular cytogenetic evaluation of virus-associated and non-viral hepatocellular carcinoma: analysis of 26 carcinomas and 12 concurrent dysplasias

31 March 2020

1 reference

Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients.

31 March 2020

1 reference

Human hepatocellular carcinoma is characterized by a highly consistent pattern of genomic imbalances, including frequent loss of 16q23.1-24.1.

31 March 2020

1 reference

Quantitative evaluation of genomic instability as a possible predictor for development of hepatocellular carcinoma: comparison of loss of heterozygosity and replication error

31 March 2020

1 reference

Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization

31 March 2020

1 reference

Induction of aneuploidy by increasing chromosomal instability during dedifferentiation of hepatocellular carcinoma

31 March 2020

1 reference

Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis: relationship to disease stage, tumor size, and cirrhosis

31 March 2020

1 reference

Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection.

31 March 2020

1 reference

Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling.

31 March 2020

1 reference

Application of comparative functional genomics to identify best-fit mouse models to study human cancer

31 March 2020

1 reference

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

31 March 2020

1 reference

Genetic profiling of human hepatocellular carcinoma

31 March 2020

1 reference

Comparative functional genomics for identifying models of human cancer.

31 March 2020

1 reference

Telomere dysfunction provokes regional amplification and deletion in cancer genomes.

31 March 2020

1 reference

The role of hepatocytes and oval cells in liver regeneration and repopulation

31 March 2020

1 reference

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

31 March 2020

1 reference

Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma

31 March 2020

1 reference

A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

31 March 2020

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Cellular origin of hepatocellular carcinomas

31 March 2020

1 reference

Progenitor cell activation in chronic viralhepatitis

31 March 2020

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Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

31 March 2020

1 reference

Tissue repair and stem cell renewal in carcinogenesis

31 March 2020

1 reference

Hepatocellular carcinoma expressing both hepatocellular and biliary markers also expresses cytokeratin 14, a marker of bipotential progenitor cells

31 March 2020

1 reference

Expression of the Hoxa-13 gene correlates to hepatitis B and C virus associated HCC.

31 March 2020

1 reference

Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma

31 March 2020

1 reference

Epidemiology of hepatitis C virus (HCV) infection

31 March 2020

1 reference

Hereditary haemochromatosis

31 March 2020

1 reference

The management of porphyria cutanea tarda

31 March 2020

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Alpha(1)-antitrypsin deficiency, liver disease and emphysema

31 March 2020

1 reference

Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma

31 March 2020

1 reference

Nonalcoholic fatty liver disease: from steatosis to cirrhosis

31 March 2020

1 reference

Recent concepts in non-alcoholic fatty liver disease

31 March 2020

1 reference

Allelic imbalance regions on chromosomes 8p, 17p and 19p related to metastasis of hepatocellular carcinoma: comparison between matched primary and metastatic lesions in 22 patients by genome-wide microsatellite analysis.

31 March 2020

1 reference

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Identifiers

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

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29 December 2019

1023006618

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16929323

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30 April 2017

Consolidated OpenCitations Corpus – April 2017