Targeting JNK for therapeutic benefit: from junk to gold? (Q35158010)

6 August 2017

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title

Targeting JNK for therapeutic benefit: from junk to gold? (English)

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6 August 2017

Anthony M Manning

1

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6 August 2017

Roger J Davis

series ordinal

2

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6 August 2017

language of work or name

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1 July 2003

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Nature Reviews Drug Discovery

6 August 2017

published in

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6 August 2017

volume

2

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6 August 2017

issue

7

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6 August 2017

page(s)

554-565

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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

6 August 2017

cites work

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

31 March 2020

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The stress-activated protein kinase subfamily of c-Jun kinases

31 March 2020

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Signal transduction by the JNK group of MAP kinases

31 March 2020

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Selective interaction of JNK protein kinase isoforms with transcription factors

31 March 2020

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c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor.

31 March 2020

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

31 March 2020

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Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro

31 March 2020

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MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

31 March 2020

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Regulation of MAP kinases by docking domains

31 March 2020

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Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

31 March 2020

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Transcription inhibitors in inflammation

31 March 2020

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Jun N-Terminal Kinase/Stress-Activated Protein Kinase (JNK/SAPK) Is Required for Lipopolysaccharide Stimulation of Tumor Necrosis Factor Alpha (TNF-α) Translation: Glucocorticoids Inhibit TNF-α Translation by Blocking JNK/SAPK

31 March 2020

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Mast cell tumor necrosis factor alpha production is regulated by MEK kinases

31 March 2020

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Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades

31 March 2020

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c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

31 March 2020

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Activation of stress-activated protein kinase in osteoarthritic cartilage: evidence for nitric oxide dependence

31 March 2020

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

31 March 2020

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Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis

31 March 2020

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JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.

31 March 2020

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The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

31 March 2020

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JNK is required for effector T-cell function but not for T-cell activation

31 March 2020

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Defective T Cell Differentiation in the Absence of Jnk1

31 March 2020

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Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

31 March 2020

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c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity.

31 March 2020

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c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation

31 March 2020

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JNK is involved in signal integration during costimulation of T lymphocytes.

31 March 2020

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Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

31 March 2020

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Signal transduction by MAP kinases in T lymphocytes

31 March 2020

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The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development

31 March 2020

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Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

31 March 2020

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

31 March 2020

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Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death

31 March 2020

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JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons

31 March 2020

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

31 March 2020

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Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

31 March 2020

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Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

31 March 2020

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Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.

31 March 2020

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JNK activation is associated with intracellular beta-amyloid accumulation

31 March 2020

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Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry

31 March 2020

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Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

31 March 2020

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Apoptosis in neurodegenerative disorders

31 March 2020

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Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury.

31 March 2020

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The disease burden associated with overweight and obesity

31 March 2020

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Hyperinsulinemia: the missing link among oxidative stress and age-related diseases?

31 March 2020

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Protection from obesity-induced insulin resistance in mice lacking TNF-α function

31 March 2020

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Disruption of IRS-2 causes type 2 diabetes in mice

31 March 2020

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c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

31 March 2020

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Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis

31 March 2020

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A central role for JNK in obesity and insulin resistance

31 March 2020

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Blocking oncogenic Ras signaling for cancer therapy

31 March 2020

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Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

31 March 2020

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Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms rat-1a cells as a single gene

31 March 2020

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Cellular transformation and malignancy induced by ras require c-jun

31 March 2020

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Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53

31 March 2020

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Control of cell cycle progression by c-Jun is p53 dependent

31 March 2020

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Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

31 March 2020

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The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin

31 March 2020

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c-Jun N-terminal kinase is essential for growth of human T98G glioblastoma cells.

31 March 2020

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Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation

31 March 2020

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Suppression of Ras-stimulated transformation by the JNK signal transduction pathway

31 March 2020

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The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase

31 March 2020

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The c-Jun NH2-terminal kinase3 (JNK3) gene: genomic structure, chromosomal assignment, and loss of expression in brain tumors

31 March 2020

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Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

31 March 2020

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Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.

31 March 2020

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Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

31 March 2020

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Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

31 March 2020

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Crystal structure of p38 mitogen-activated protein kinase

31 March 2020

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Crystal structure of JNK3: a kinase implicated in neuronal apoptosis

31 March 2020

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The specificities of protein kinase inhibitors: an update

31 March 2020

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The JNK signal transduction pathway

31 March 2020

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Stress-activated protein kinase/c-jun N-terminal kinase phosphorylates tau protein

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1132

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Dimensions Publication ID

6 August 2017

1022703165

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