The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer. (Q34005738)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20610622%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer (English)

1 reference

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7 February 2020

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20610622%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Katherine G Finegan

1

1 reference

ORCID Public Data File 2021

language of work or name

English

0 references

publication date

7 July 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20610622%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20610622%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

volume

70

1 reference

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7 February 2020

issue

14

1 reference

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7 February 2020

page(s)

5797-5806

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20610622%20AND%20SRC:MED&resulttype=core&format=json

JNK signalling modulates intestinal homeostasis and tumourigenesis in mice

7 February 2020

cites work

1 reference

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Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death

5 July 2018

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Role of mitogen-activated protein kinase kinase 4 in cancer

5 July 2018

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Physiological roles of MKK4 and MKK7: insights from animal models

5 July 2018

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A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes

5 July 2018

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Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss

5 July 2018

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Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumors

5 July 2018

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Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation

5 July 2018

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Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors

5 July 2018

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Transcriptional regulation by the MAP kinase signaling cascades

5 July 2018

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Mechanism of p38 MAP kinase activation in vivo.

5 July 2018

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c-Jun regulates eyelid closure and skin tumor development through EGFR signaling

5 July 2018

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Role of JNK in tumor development

5 July 2018

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Suppression of Ras-stimulated transformation by the JNK signal transduction pathway

5 July 2018

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Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma.

5 July 2018

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Differential gene expression profiles of Jnk1- and Jnk2-deficient murine fibroblast cells.

5 July 2018

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Targeted somatic mutagenesis in mouse epidermis

5 July 2018

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5 July 2018

Jun, the oncoprotein.

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Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.

5 July 2018

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Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers

5 July 2018

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Human gastric cancer kinase profile and prognostic significance of MKK4 kinase

5 July 2018

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Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation

5 July 2018

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

5 July 2018

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Integration of positive and negative growth signals during ras pathway activation in vivo

5 July 2018

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Control of cell cycle progression by c-Jun is p53 dependent

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906708

JNK targets p53 ubiquitination and degradation in nonstressed cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906708

Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906708

Inducible Gene Targeting in Mice Using the Cre/loxSystem

5 July 2018

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Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor

5 July 2018

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Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: the role of apurinic sites

5 July 2018

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The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

5 July 2018

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Selective regulation of c-jun gene expression by mitogen-activated protein kinases via the 12-o-tetradecanoylphorbol-13-acetate- responsive element and myocyte enhancer factor 2 binding sites.

5 July 2018

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MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course.

29 October 2018

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Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts

29 October 2018

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Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906708

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906708

JNK2 is a positive regulator of the cJun transcription factor

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20610622

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Overexpression of mitogen-activated protein kinase kinase 4 and nuclear factor-kappaB in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20610622

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20610622

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-09-3669

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20610622%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20610622%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

20610622

1 reference