Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis (Q33996549)

30 July 2017

title

Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis (English)

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30 July 2017

M A Webster

1

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30 July 2017

J N Hutchinson

2

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30 July 2017

M J Rauh

3

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30 July 2017

S K Muthuswamy

4

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30 July 2017

M Anton

5

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30 July 2017

C G Tortorice

6

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30 July 2017

R D Cardiff

7

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30 July 2017

F L Graham

8

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30 July 2017

J A Hassell

9

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30 July 2017

W J Muller

10

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30 July 2017

language of work or name

English

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publication date

1 April 1998

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Molecular and Cellular Biology

30 July 2017

published in

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30 July 2017

volume

18

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30 July 2017

issue

4

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30 July 2017

page(s)

2344-2359

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Transformation and tumorigenic properties of a mutant polyomavirus containing a middle T antigen defective in Shc binding

30 July 2017

cites work

1 reference

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28 July 2018

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Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

28 July 2018

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

28 July 2018

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

28 July 2018

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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

28 July 2018

1 reference

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A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3

28 July 2018

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The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions

28 July 2018

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Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinase

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera

28 July 2018

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Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.

28 July 2018

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28 July 2018

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

28 July 2018

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Association of Polyomavirus middle tumor antigen with phospholipase C-gamma 1.

28 July 2018

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Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model

28 July 2018

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Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression

28 July 2018

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28 July 2018

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Protein modules and signalling networks

28 July 2018

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ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

28 July 2018

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Polyoma virus transforming protein associates with the product of the c-src cellular gene

28 July 2018

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Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

28 July 2018

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Mutants of polyomavirus middle-T antigen

28 July 2018

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Identification and characterization of p59fyn (a src-like protein tyrosine kinase) in normal and polyoma virus transformed cells

28 July 2018

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Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

28 July 2018

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Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

28 July 2018

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Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

28 July 2018

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Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus

28 July 2018

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Association of protein phosphatase 2A with polyoma virus medium tumor antigen

28 July 2018

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Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.

28 July 2018

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Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

28 July 2018

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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

28 July 2018

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Reversion of middle T antigen-transformed Rat-2 cells by Krev-1: implications for the role of p21c-ras in polyomavirus-mediated transformation

28 July 2018

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Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

28 July 2018

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Changes in frequency, morphology, and behavior of tumors induced in mice by a polyoma virus mutant with a specifically altered oncogene

28 July 2018

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Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

28 July 2018

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Detection of specific sequences among DNA fragments separated by gel electrophoresis

28 July 2018

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Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

28 July 2018

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Lobulo-Alveolar Development of Mouse Mammary Glands Is Regulated by Thyroid Hormones

28 July 2018

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

28 July 2018

1 reference

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Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro

29 October 2018

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The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

29 October 2018

1 reference

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Endothelial cell transformation by polyomavirus middle T antigen in mice lacking Src-related kinases.

29 October 2018

1 reference

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Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc.

29 October 2018

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Phosphorylation of middle T by pp60c-src: a switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis

29 October 2018

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Microcirculation and metastasis in a new mouse mammary tumor model system

29 October 2018

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12 December 2020

Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice

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12 December 2020

An 81 kd protein complexed with middle T antigen and pp60c-src: a possible phosphatidylinositol kinase

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12 December 2020

Pillars Article: T-Cell Apoptosis Detected In Situ during Positive and Negative Selection in the Thymus. Nature. 1994. 372: 100-103

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Association of the polyomavirus middle-T antigen with c-yes protein

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12 December 2020

Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice

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12 December 2020

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

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12 December 2020

The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors

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12 December 2020

Identifiers

DOI

10.1128/MCB.18.4.2344

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30 July 2017

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30 July 2017

1 reference