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    Skin & Nano Cosmetics - Skin Aging & Nanotechnology-Project

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    engineer bilal
    Skin & Nano Cosmetics -Skin aging & Nanotechnology Bilal Masood this is the presentation and this research is taken from the books, research articles and journals

    Copyright:

    © All Rights Reserved

    Skin & Nano Cosmetics - Skin Aging & Nanotechnology-Project

    Uploaded by

    engineer bilal
    67 views26 pages
    Skin & Nano Cosmetics -Skin aging & Nanotechnology Bilal Masood this is the presentation and this research is taken from the books, research articles and journals

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    Skin & Nano Cosmetics -Skin aging & Nanotechnology-project

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    © © All Rights Reserved

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    Skin & Nano Cosmetics -Skin aging & Nanotechnology Bilal Masood this is the presentation and this research is taken from the books, research articles and journals

    Copyright:

    © All Rights Reserved
    67 views26 pages

    Skin & Nano Cosmetics - Skin Aging & Nanotechnology-Project

    Uploaded by

    engineer bilal
    Skin & Nano Cosmetics -Skin aging & Nanotechnology Bilal Masood this is the presentation and this research is taken from the books, research articles and journals

    Copyright:

    © All Rights Reserved
    of 26

    NANOTECHNOLOGY

    &
    HUMAN SKIN AGING

    BILAL MASOOD

    12/8/2023 BILAL MASOOD 1


    ANATOMY OF SKIN

    12/8/2023 BILAL MASOOD 2


    THE SKIN

    EXTERNAL LAYER
    EXPOSED TO EXTERNAL STIMULI
    Injuries & wounds
    External Environment
    Aging & wrinkles
    Diseases
    REMIDIES
    Tissue regeneration & rejuvenation
    Scaffolds, Nanomaterials and Bioactive molecule

    12/8/2023 BILAL MASOOD 3


    AGING OF SKIN

    12/8/2023 BILAL MASOOD 4


    TYPES OF AGING
    Extrinsic aging

    Intrinsic aging-Photo aging


    • UV
    • Life Styles
    • Nutrition
    • Stress Response Mechanism
    • Sugar intakes
    • Smoking

    loss of tone and hyperpigmentation, deeply changing residents cell behavior


    12/8/2023 BILAL MASOOD 5
    AGING OF SKIN

    keratinocyte turnover

    12/8/2023 BILAL MASOOD 6


    AGING OF SKIN

    HUMAN SKIN
    Collagen
    Elastin fibers
    Glycosaminoglycan

    YOUNG SKIN
    • High collagen
    • High elastin fibers

    AGING OF SKIN
    • Loss of collagen
    • Loss of elastin fibers

    Collagen fibrils and hyaluronic acid


    organization and production change
    during aging

    12/8/2023 BILAL MASOOD 7


    HUMAN SKIN
    Collagen
    Elastin fibers
    Glycosaminoglycan

    12/8/2023 BILAL MASOOD 8


    12/8/2023 BILAL MASOOD 9
    EXTRACELLULAR MATRIX- ECM

    fibroblast-ECM

    Schematic representation of dermis evolution during human development and ageing (Haydont et al., 2019)
    12/8/2023 BILAL MASOOD 10
    HUMAN SKIN AGING REASON

    Reserving stem cell plasticity and differentiation capability represents an important goal in tissue regeneration.

    Downregulate related genes

    lose the capability to replace damaged elements triggering tissue aging

    HUMAN SKIN REGENERATION & REJUVENATION GOAL

    REJUNVENATION collagen, skin can lose structure, become


    Nanomaterials
    dry, have less fat, and begin to appear wrinkled, loose, and
    • Stimulate SSCs proliferation
    saggy. Skin rejuvenation encourages collagen growth to help
    • Maintenance of a young phenotype
    • Modulation of fibroblast gene expression skin become fuller and more youthful.

    REGENERATION the complete replacement of damaged


    tissue with new tissue. Skin repair refers to the continued
    healing process of existing tissue. Skin regeneration isn't usually
    associated with scar tissue

    12/8/2023 BILAL MASOOD 11


    HUMAN SKIN DAMAGE & WOUNDS REGERATION

    Disorders of skin due to trauma or therapeutic conditions


    Due to Mechanical or physical damages occurring after heat, electricity or chemicals exposition as well as after
    surgery
    skin regeneration, undergoing proliferation and differentiation toward fibroblasts before the final re-epithelization

    HUMAN SKIN TREATMENT REGERATION


    Skin Permeation by Topical Treatments

    Cosmetic products as
    • Sunscreens,
    • Hair products,
    • Skin cream
    Nanomaterials

    Hydrogels

    12/8/2023 BILAL MASOOD 12


    Skin Permeation by Topical Treatments
    The flux of molecules through the skin occurs by passive diffusion, following a gradient concentration, both via
    intracellular and extracellular pathways. This delivery is still far from satisfying the clinic and cosmetic requests

    Nanomaterials in Skin Regeneration and Rejuvenation Emanuela Bellu ,Serenella Medici

    12/8/2023 BILAL MASOOD 13


    12/8/2023 BILAL MASOOD 14
    NANOMATERIALS FOR SKIN TREATMENT

    High surface-to volume ratio compared to bulky matter

    At least one dimension in the range 1–100nm

    There are two main routes of entry into the cell: direct fusion with the plasma membrane

    Cell targeting and drug delivery

    NANOMATERIALS & TISSUE REGERATION STRATEGIES

    Regenerative actions of nanomaterials

    (i) Direct stimulation of cell regrowth


    (ii) Antibacterial activity;
    (iii) Drug delivery.

    Metal & metal oxides regenerative actions of Gold, silver nanoparticles


    Hydrogels

    12/8/2023 BILAL MASOOD 15


    12/8/2023 BILAL MASOOD 16
    HYDROGELS
    they are composed of a 3D crosslinked polymeric network able to withhold large amounts of water while retaining
    its structure after swelling

    12/8/2023 BILAL MASOOD 17


    HYDROGELS
    Extracellular matrix ECM and provide a moist environment for tissue regrowth

    Elasticity close to that of the surrounding tissues, and a permeability to oxygen that prevents the growth of
    anaerobic bacteria
    Nanoparticle–hydrogel superstructures, on the other hand, are new materials prepared by embedding
    nanoparticles in hydrogels to produce nanoplatforms with highly tunable properties and a wide range of
    applications
    Typical components of hydrogels for wound dressings are polyvinyl alcohol (PVA), sodium alginate (SA),
    cyclodextrin (CD), hyaluronic acid (HA), polyacrylic acid (PAAc), polyacrylamide (PAAm), polycaprolactone (PCL),
    polyethylene glycol (PEG), polylactic acid (PLA), polyvinyl pyrrolidone (PVP), polyvinyl acetate (PVAc), collagen,
    pectin, chitin, and many others

    12/8/2023 BILAL MASOOD 18


    ANTIBACTERIAL ACTIONS
    metal or metal-based nanoparticles (such as gold, silver, copper, zinc oxide, copper oxide or sulphide.
    Metal nanoparticles (e.g., AuNPs and AgNPs) exert their antimicrobial activity by a series of mechanisms
    involving direct interaction with the negatively charged bacterial cell membrane, its disruption, and subsequent
    leakage of the inner cellular material
    Once the NPs get inside the cell, they can further damage it by impairing DNA or other cellular components
    CuS NPs, which are well established non-toxic nanomaterials, carry out their antibiotic action by damaging the
    cellular membrane
    Zinc ferrite (ZnFe2O4) NPs antimicrobial activity
    Antimicrobial peptides (AMPs) are also employed in the formulation of hydrogel for charge disruption
    of membrane of bacterias & cell death

    12/8/2023 BILAL MASOOD 19


    ANTIOXIDENT PROPERTIES
    Hydrogels can be formulated to host an antioxidant species to decrease damages

    Polyphenols and their derivatives both natural and synthetic sources

    Ceria, curcumin, hydroxycinnamic acid derivatives, such as p-coumaric and ferulic acids, tannic acid,
    propolis,natural plant extracts, anthocyanins and many other phytochemicals within nanocomposites

    DRUG RELEASE

    The hydrogels are used for the controlled drug release for the proper wound healing

    To treat diabetic foot ulcers

    hydrogel with antibacterial properties applied in the treatment of chronic infected diabetic wounds

    12/8/2023 BILAL MASOOD


    NANO-FIBRE

    Electrospun Nano-Fibers for Biomedical and Tissue Engineering Applications: A Comprehensive Review
    12/8/2023 BILAL MASOOD 21
    NANO FIBRES
    Nowadays, nanofibers are used for skin regeneration and rejuvenation as scaffolds, and for drug delivery.
    Natural polymers are highly biocompatible, non-toxic, biodegradable
    synthetic polymers can be modulated and modified during their preparation to meet specific requirements for each
    case of application.
    This leads to a control in their composition, molecular weight, crystalline structure, chemical properties and
    mechanical features that allow high reproducibility for these materials
    Nanoporosity, together with other prominent features in nanofibers, can be controlled during the process of
    preparation . The most common way is through a technique called electrospinning
    Currently, nanofibers of electrospun poly-"-caprolactone (PCL) and polyvinyl alcohol (PVA) have been described
    as safe, well tolerated and effective
    Drug-loaded nanofibers, a cerium-doped bioactive glass in a chitosan/polyethylene oxide nanofiber showed
    remarkably high antibacterial
    Nanofibers are able to combine the controlled release of the drug to the skin regeneration properties
    SILVER SULFADIAZINE NANOMATERIALS-SSD
    Silver sulfadiazine (SSD) is a drug based on a silver complex with an antibiotic of the sulphonamide

    Polyvinyl alcohol/carboxymethylcellulose/silver sulfadiazine composite nanofibers (PVA/CMC/SSD) were prepared


    and found to be active in the treatment of excision wounds, leading to rapid healing in rabbits. The nanocomposite
    also displayed good antibacterial activity
    12/8/2023 BILAL MASOOD 22
    NANO FIBRES DRESSINGS

    High surface area


    Small pore size
    High strength
    Minimum aspect ratio of 1000:1

    ANTI SCAR ACTION


    Wound healing is associated to scar formation
    Hydrogel nanocomposites natural or synthetic (PCL, PLGA, PVA, collagen, chitosan, silk fibroin, alginate/PVA,
    etc--can help reduce the scarring process.

    Functionalization can enhance the binding of nanofibers to collagen or gelatine

    PVA nanofibers are able to induce scar-free wound healing retain humidity to maintain a moist wound
    12/8/2023 BILAL MASOOD 23
    NANOFORMULATIONS FOR SKIN CARE
    AND
    ANTI-AGAING
    PRODUCTS

    12/8/2023 BILAL MASOOD 24


    Nano-formulation is working of the development of skin care products for past 40 years
    TiO2 and ZnO NPs have been employed for decades as UV inorganic filters in sunscreens

    Antiaging useful NPs in cosmetics are dendrimers, nanocrystals, carbon nanotubes, niosomes, nanopolymers,

    Target drug delivery with the active release of nano-particles

    The cosmetic industry took advantage of the progresses in nanotechnology to expand its boundaries in personal
    care and antiaging areas of sales

    Metal-based NPs (Au, Ag, CuO, ZnO, etc.)


    Antibacterial activity and promotion of wound healing
    Facial masks and treatments based on AuNPs for skin rejuvenation

    It has been demonstrated that gold nanoparticles are able to reduce wrinkles, improve skin brightening, promote
    skin healing, have a cleansing effect

    Au nanosheets induce a low level of apoptosis


    AuNPs may have higher biocompatibility and less side effects

    12/8/2023 BILAL MASOOD 25


    THANK
    YOU
    BILAL MASOOD

    12/8/2023 BILAL MASOOD 26

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