Pathophysio 2

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Good day mam, we are ms. baclay, wong, tejano and yap from bsn3A.

Our group has been assigned to be under your advisory for nursing research. For now, we would just like to introduce
ourselves, but we look forward to having consultations with you at your most convenient time. We are also open to comply with any guidelines for consultation or scheduling that you may have.
Genetic factors Defective regulation of tight Sigmoidoscopy/Colonoscopy
Sloughing including
Infection junction in the mucinous layer /Barium enema:
the smooth muscle
of the rectal epithelial barrier more than 6 cm dilation of
layer
transverse colon

↑ epithelial barrier Dilation of colon Treatment:


permeability (Toxic Megacolon)/ Proctocolectomy
Perforation w/ileostomy
(peritonitis)
Paracetamol
↑ uptake of luminal Erythropoietin
antigens

Fever (>38’C),
tachycardia,
(>120bps)
Dendritic cell Hypotension
mediates the (<60mmhg diastolic)
production of T cells
Corticotropin/
Erythrocyte Sedimentation corticosteroids
rate:
↑ ESR (>20mm/hr)
Inflammatory
response

Sulfasalazine
Sigmoidoscopy/Colonoscopy
/Barium enema: Erosion of epithelial
Findings of erythema, lining and formation
erosions, edema, mucosal of ulcers
friability, and ulcerations

Biopsy: to rule out Abscess and


complications sloughing = less
absorption
Anti-diarrheal
(Imodium)

Bloody diarrhea,
abdominal cramping,
less weight
Complete blood count: IV hydration therapy
↓ Hemoglobin
↓ Hct Iron supplement:
↓ Serum iron Ferrous sulfate
Anemia
Genetic factors Release of DNA (HLA-Cw6, B13, & Genetic testing
Environment Bw57) from keratinocytes findings:
Infection Increased HLA-Cw6,
High alcohol intake B13 & Bw57 DNA
Smoking alleles
Dendritic cells
release interferons

Dendritic cells migrate


to lymph node and
release interleukin

Interleukin
activates T-
cells

Cyclosporine
T-cell production of (Neoral)
cytokines to the
keratinocyte

Proliferation of
keratinocytes in the
epidermis and Proliferation
Skin Biopsy: Steroid cream
increased spreads to nail
Non-malignancy/ Anthralin ointment (AnthraDerm)
keratinocyte turnover matrix
Determine type of Psoralens + UV exposure
psoriasis Calcipotriene ointment (Dovonex)
Steroid cream
Methotrexate (Mexate)
Anthralin ointment (AnthraDerm)
Acitretin (Soriatane)
Psoralens + UV exposure
Calcipotriene ointment (Dovonex) Thickening of skin under
Methotrexate (Mexate) the nail (subungual
Acitretin (Soriatane) Erythematous and well- hyperkeratosis) and
Tar shampoo defined lesions, Plaques with onycholysis
Antihistamine - for itching silver scales, Itching and pain

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