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    DEngue Flowchart

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    Jelly Cruz
    Predisposing factors for dengue virus infection include living in tropical areas where the Aedes aegypti mosquito is present. The virus replicates in the mosquito and is transmitted to humans via mosquito bites. Following infection, the virus disseminates rapidly in the bloodstream and can cause a range of clinical manifestations from mild dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome. Diagnosis is based on hematological and biochemical abnormalities and imaging findings may include pleural effusions, ascites, and hepatosplenomegaly.

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    DEngue Flowchart

    Uploaded by

    Jelly Cruz
    4K views2 pages
    Predisposing factors for dengue virus infection include living in tropical areas where the Aedes aegypti mosquito is present. The virus replicates in the mosquito and is transmitted to humans via mosquito bites. Following infection, the virus disseminates rapidly in the bloodstream and can cause a range of clinical manifestations from mild dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome. Diagnosis is based on hematological and biochemical abnormalities and imaging findings may include pleural effusions, ascites, and hepatosplenomegaly.

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    Predisposing factors for dengue virus infection include living in tropical areas where the Aedes aegypti mosquito is present. The virus replicates in the mosquito and is transmitted to humans via mosquito bites. Following infection, the virus disseminates rapidly in the bloodstream and can cause a range of clinical manifestations from mild dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome. Diagnosis is based on hematological and biochemical abnormalities and imaging findings may include pleural effusions, ascites, and hepatosplenomegaly.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    4K views2 pages

    DEngue Flowchart

    Uploaded by

    Jelly Cruz
    Predisposing factors for dengue virus infection include living in tropical areas where the Aedes aegypti mosquito is present. The virus replicates in the mosquito and is transmitted to humans via mosquito bites. Following infection, the virus disseminates rapidly in the bloodstream and can cause a range of clinical manifestations from mild dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome. Diagnosis is based on hematological and biochemical abnormalities and imaging findings may include pleural effusions, ascites, and hepatosplenomegaly.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
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    of 2

    Precipitating

    Environmental conditions (open spaces with


    Predisposing water pots, and plants)
    Geographical area – tropical islands Immunocompromise
    in the Pacific (Philippines) and Asia Mosquito carrying dengue virus
    Soldier
    Sweaty skin

    Aedes aegypti (dengue virus carrier): 8-12 days of viral


    replication on mosquitos’ salivary glands

    Bite from mosquito (Portal of Entry in the Skin) Redness & itchiness in the area

    Allowing dengue virus to be inoculated


    towards the circulation/blood (Incubation
    Period: 3-14 days)

    Virus disseminated rapidly into the blood and stimulates Diagnostic:


    WBCs including B lymphocytes that produces and secretes Hematology :
    immunoglobulins (antibodies), and monocytes/macrophges, Increased WBC: 12,900/cumm
    neutrophils (5,000- 10,000/cumm)
    Increased Lymphocytes: 49%
    (20-40%)
    Diagnostic:
    Hematology :
    Decreased Antibodies attach to the viral antigens, and then
    Monocytes: 4%(8- monocytes/macrophages will perform
    phagocytosis through Fc receptor (FcR) within the
    14%)
    cells and dengue virus replicates in the cells of
    Decreased monocytes/macrophages
    Neutrophils:
    49%(50-70%) Entry to the spleen, Entry to the bone
    and liver marrow

    Recognition of dengue viral antigen on infected


    monocyte by cytotoxic T cells

    Release of cytokines which consist of vasoactive


    agents such as interleukins, tumor necrosis factor,
    urokinase and platelet activating factors which
    stimulates WBCs and pyrogen release

    Signs/ symptoms:
    Febrile: 38.6C
    Diaphoresis, warm skin, Dengue Fever
    flushed; headache of 3/10 pain
    scale; whitish spots; body
    weakness
    Virus ultimately targets liver and Cellular direct destruction and infection of
    spleen parenchymal cells where red bone marrow precursor cells as well as
    infection produces apoptosis/cell immunological shortened platelet survival
    death causing platelet lyses

    Diagnostic: Diagnostic:
    Ultrasound: Hematology :
    minimal hepatospleno Decreased Platelet:
    megaly Hepatosplenomegaly Thrombocytopenia 68,000/cumm (150,000-
    400,000)
    Blood Chemistry:
    SGOT: 558.0 U/L(Up to
    46) Signs/ symptoms:
    SGPT:433.3 U/L(Up to Signs/ symptoms: Dengue Hemorrhagic Fever Red sclera in both
    40) >Abdominal pain eyes
    Protein: 5.2g/dL (6.6-8.7) with 5/10 pain Petechiae
    Albumin:2.3g/dL (3.5- scale as
    5.5)
    verbalized. Increase number and size of the
    pores in the capillaries which leads Signs/ symptoms:
    to a leakage of fluid from the blood +1 Bipedal
    to the interstitial fluid (capillary edema; weak
    leakage) of the different organs bounding pulse of
    Signs/ symptoms: 79bpm
    and skin
    Profuse non-productive cough
    with white sputum with blood
    spots noted; shallow & rapid Signs/ symptoms:
    respirations of 35cpm; Abdominal distention with
    crackles/rales
    Pleural effusion Ascites abdominal girth of 93cm
    (36.6 inches); hypoactive
    bowel sounds of 2/min

    Diagnostic:
    Ultrasound:
    Conclusion:
    Minimal bilateral pleural Diagnostic:
    effusion. Recovery Complications: Ultrasound:
    Intense bleeding Conclusion:
    Pulmonary Edema
    Shock
    Moderate ascites
    Very low blood pressure
    Liver cirrhosis
    Death

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