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    Clinicopharmacological Conference

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    Nestley Tiongson
    This document discusses the systemic effects of chronic liver disease. It shows how liver dysfunction can impact protein synthesis and albumin levels, leading to fluid shifts and ascites. This causes renal and cardiac issues from decreased perfusion. Further impacts are intestinal ischemia, bacterial overgrowth, and sepsis. Ultimately, multiple organ failure can result in total organ failure and death.

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd

    Clinicopharmacological Conference

    Uploaded by

    Nestley Tiongson
    34 views7 pages
    This document discusses the systemic effects of chronic liver disease. It shows how liver dysfunction can impact protein synthesis and albumin levels, leading to fluid shifts and ascites. This causes renal and cardiac issues from decreased perfusion. Further impacts are intestinal ischemia, bacterial overgrowth, and sepsis. Ultimately, multiple organ failure can result in total organ failure and death.

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    clinicopharmacological conference case copy presentation last april 2018

    Original Title

    clinicopharmacological conference

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    This document discusses the systemic effects of chronic liver disease. It shows how liver dysfunction can impact protein synthesis and albumin levels, leading to fluid shifts and ascites. This causes renal and cardiac issues from decreased perfusion. Further impacts are intestinal ischemia, bacterial overgrowth, and sepsis. Ultimately, multiple organ failure can result in total organ failure and death.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    34 views7 pages

    Clinicopharmacological Conference

    Uploaded by

    Nestley Tiongson
    This document discusses the systemic effects of chronic liver disease. It shows how liver dysfunction can impact protein synthesis and albumin levels, leading to fluid shifts and ascites. This causes renal and cardiac issues from decreased perfusion. Further impacts are intestinal ischemia, bacterial overgrowth, and sepsis. Ultimately, multiple organ failure can result in total organ failure and death.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 7

    C

    B
    SALIENT
    FEATURES
    sage

    eated
    A

    d early
    l

    y,
    t
    n

    s,
    of

    est
    stric
    rugs
    CHRONIC
    PANCREATITIS
    METASTATIC ALCOHOL INDUCED
    HEPATOCELLULAR HEPATITIS
    ABDOMINAL TB
    CARCINOMA

    DIAGNOSIS
    DIFFERENTIAL
    DIAGNOSTIC
    IMPRESSION
    Upper Epigastrium pain
    + 50% weight loss

    Possible
    Diagnosis

    Gastric
    Cancer

    Early
    Satiety

    Possible metastasis
    to the liver Mass Effect

    Mural Bleeding

    Cirrhosis
    Liver
    parenchymal
    disease

    Portal Circulation
    Chronic Bleeding
    Blockage

    Portal
    Liver Dysfunction Anemia
    Hypertension

    Tarry stool,
    coffee
    ground
    emesis

    Backflow of blood
    Protein Synthesis Hyperammonemia to gastrointestinal
    Generalized
    circulation
    Body
    Weakness
    Protein Synthesis Hyperammonemia Backflow of blood to Generali
    gastrointestinal zed Body
    circulation Weakne
    ss

    Albumin Neurotoxicity
    EPO Synthesis Gastrointesti
    Synthesis nal vascular
    disease

    RBC
    Plasma Production Esophageal
    Albumin varices

    Anemia Chronic
    Oncotic Bleeding
    Pressure

    Fatigue

    Fluid Shift to
    EV spave
    Pleur
    Cardio
    al respirat
    effusi ory
    on distress

    Ascites
    Hypovolemia

    Systemic
    Perfusion
    Metabolic
    Function SYSTEMIC EFFECTS

    Na eabsorption

    Renal perfusion Intestinal ischemia Myocardial


    and infarction ischemia Cerebral Hypoxia
    Activate RAAS

    Ischemia Glutamate Activity

    Proliferation of
    Aldosterone intestinal
    release pathogenic bacteria
    Neurotoxicity
    Acute Kidney Injury

    Vascular Invasion
    Liquefactive
    Necrosis

    ↑BUN
    Bacteremia NEUTROPHILIA
    Cerebral Edema

    Uremia Sepsis (SIRS like)

    THROMBOCYTOPENIA ICP

    DIC
    Systemic Organ
    Toxicigy
    Altered Sensorium
    Infarction involving
    all perfused areas

    Multiple Organ
    Failure
    Coma

    Total Organ
    Failure
    DEATH
    CAUSE OF
    DEATH

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