Sex-Linked 7E Lesson Plan
Sex-Linked 7E Lesson Plan
Sex-Linked 7E Lesson Plan
ENGAGE (5 minutes)
Show a poster of Anastasia the animated movie and ask the students if they are familiar with the
movie. The animated Anastasia character is based on a true princess from the house of Romanov. Tell a
short historical background of the Romanovs and their youngest son Alexie Romanov who happens to have
hemophilia. Relate the condition of Alexie to the present lesson which is sex-linked inheritance traits.
Include the condition of hemophilia in the Philippines in terms of occurrence.
EXPLORE (15 minutes)
The Royal Blight Activity
Royal Hemophilia Inheritance: Each lab group will be given one of four members of the Victorian
Royal Family, and will arrange marriages between their royal and one of twelve royals from other countries.
The hemophilia genotypes will be given for the royals, and the students will produce Punnett squares
predicting the possible offspring from their marriage. They will then roll a four-sided die to select one
outcome, and the resultant prince or princess (F1 generation) will be “married” to another group’s prince
or princess. Punnett squares will be produced based on these marriages, then the students will answer
questions about the nature of Mendelian genetics, and sex-linked traits.
Cross #1:
Cross #1 Parents:
Mother’s name: Mother’s genotype: Mother’s country:
Father’s name: Father’s genotype: Father’s country:
134 123
124 234
Cross #2
Cross #2 Parents:
Mother’s name: Mother’s genotype: Mother’s country: Father’s
name: Father’s genotype: Father’s country:
134 123
124 234
Cross #3:
134 123
124 234
Class data:
Questions:
1) How did the percentages of hemophiliacs, carriers, and non-carriers change from Cross #1 to
Cross #3?
2) Is it possible to have a male carrier of hemophilia? Why or why not?
3) Is it possible for a male hemophiliac to have a normal, non-carrier daughter? Why or why not?
4) When is it possible for a female carrier to have a female hemophiliac child? When is it not
possible?
5) Why is hemophilia more common in men than in women?
EXPLAIN (5 minutes)
Class discussion. Explain the nature of sex-linked inheritance traits by discussing the answers with
the students.
Sample problems:
1. If a normal female wants to have children with a color-blind male, what is the probability of
having a son who is color blind? A daughter who is color blind? A daughter who is a carrier?
In addition, determine the genotypes of the two parents.
2. If a female carrier wants to have children with a color-blind male, what is the probability of
one of their sons could be color blind? One of their daughters color blind? One of their
daughters a carrier? In addition, determine the genotypes of the two parents.
6. -10. A woman who is carrier of hemophilia marries a man who has hemophilia. Determine the
probability of having hemophiliac male, hemophiliac female and female who are carrier of the
condition.
EXTEND
Let the students access this website: https://www.sciencemusicvideos.com/ap-biology/genetics-
mendelian-blood-type-sex-linkage/solving-genetics-problems-involving-sex-linked-alleles/. Students
answer the interactive activities related to sex-linked traits.