The Multi-faceted role of Urai Mathirai – The Immune pill of Siddha

The Journal of Phytopharmacology

Standardization of Siddha formulations is a major step for establishment of biological activity, consistent chemical profile, or quality control for production and manufacturing of herbal drugs. Urai Mathirai (UM) is a Siddha polyherbal preparation comprising of Chukku (Zingiber officinale Roscoe), Adimathuram (Glycyrrhiza glabra L.), Akkirakaram (Anacyclus pyrethrum (L.) Lag.), Vashambu (Acorus calamus L.), Catikkai (Myristica fragrans Houtt.), Katukkai (Terminalia chebula Retz.), Masikkai (Quercus infectoria G.Olivier), Acanam (Allium sativum L.), Tippili (Piper longum L.) and Perunkayam (Ferula aasa-foetida L.). UM reduces accumulated Aiyam with ingredients having hot potency which increases Azhal. As UM is an important medicine in Siddha pediatrics the current study is aimed to standardize UM employing standard testing protocol for AYUSH drugs. Macroscopic authentication, powder microscopy and physico‐chemical studies like loss on drying, water soluble ash, acid insoluble ash, e...

Siddha Papers ISSN 0974-2522, 2019

Siddha medicine is a traditional system of medicine originated in India.According to this system, when the normal equilibrium of the three humors- Vatham, Pitham, and Kabam is disturbed, the disease is caused. They may be disturbed by environment, climatic conditions, diet, physical activities, and stress. Avuri mathirai (AV) is a siddha formulation indicated mainly for the disease Narambu Silanthi (Dracunculiasis ). Avuri is mainly used as an antidote in Siddha system. It is also used for curing Jaundice. Its root is used to cure Acid Peptic disease, leucoderma, and poisonous bites. In this work, we have mentioned about the antimicrobial property of Avuri mathirai against Staphylococcus aureus, Streptococcus mutans, Bacillus subtilis, Klebsiella pneumoniae, Proteus vulgaris and E.coli by Agar disk diffusion method.

Journal of Global Trends in Pharmaceutical Sciences, 2019

Key Words Uraimathirai; acute toxicity; sub acute toxicity; herbal formulation; histopathology; immunomodulatory activity.. The present study is to evaluate the acute, sub-acute toxicity and its immunomodulatory activity of the Uraimathirai in wistar albino rats. Methods: The acute and sub-acute toxicity study was carried out as per (OECD) test guideline 423 and 407 and Central Council for Research in Ayurvedic Sciences (CCRAS) respectively. In acute toxicity study, the dose (10, 50 and100 mg/kg b.wt) of Uraimathirai was orally administered to three rat groups in single dose and general behavior, adverse effects and mortality compared to normal group were recorded for 24 hours and once daily further for a period of 14 days. In sub-acute study, the Uraimathirai was administered at doses of (10, 50 and 100mg/kg b.wt) for every 24 hours orally for 28 days to three rat groups. At the end of each study, hematological analysis and biochemical parameters were evaluated. Histopathological examination of vital organs of the rats was taken for gross findings, compared to controls. In-vivo immunomodulatory activity of Uraimatirai was evaluated by hypersensitivity reactions using sheep red blood cells (SRBC) as the antigen. Distilled water aided as a control in all the tests. There was no significant difference (p > 0.05) observed in the relative organs weight, body weights, hematological, biochemical parameters, and gross abnormalities, compared to the control. No mortality was recorded. Administration of Uraimathirai for seven days has shown a dose related increase in early (4 h) and delayed (24 h) hypersensitivity reaction in rats at a dose of 100 mg/kg, b.wt. and the 4 hour-reaction was found to be of higher magnitude than the 24 hour-reaction. The results may lead that the oral administration of the Uraimathirai at doses of 10, 50 and100 mg/kg.b.wt for 28 days does not showed any toxicity effect in wistar rats and at a dose level of 100mg/kg.b.wt has a pronounced immunomodulatory effect.

Microorganisms include bacteria, fungi, virus, protozoa are present everywhere in the soil, water, atmosphere and on the body surfaces are solely responsible for large number of infectious diseases in mankind. Commonly infectious organisms attacks, respiratory tract, Gastro intestinal tract, Urogenital tract, Skin etc. The use of antibiotics against these infections cause many adverse effects. This leads to the use of medicinal plants to treat the infections. Many of the herbs possess anti microbial activity against the dreadful microorganisms. Siddha medicine is one of the ancient systems of medicines, treats the infections with herbs (mooligai), Inorganic substances (thathu) and animal products (Jeevam). Many of the Siddha formulations possess the herbs which has antimicrobial activity helps to treat acute and chronic infections. This article reviews on antimicrobial property possessing herbs in siddha medicine. This review has offered herbs in siddha medicines as an antimicrobial agent for further research to treat the acute and chronic infections.

The Siddha system of medicine is one among the great heritage of India. In Siddha system of medicine most of the chronic diseases are cured by the medicines prepared from the metal and mineral products namely Parpam, Chendooram, Chunnam etc. In the present study some clinically used herbo -mineral siddha drugs such as Linga chendooram-1, Linga chendooram -2, Vajerakandi, Kantharasa villai, Sandamarutham and Rasa chunnam were investigated for antibacterial potential against Escherichia coli, Salmonella typhi, Vibrio cholerae, Klebsiella pneumoniae, and Staphylococcus aureus. Study suggested that these herbo -mineral siddha preparations may be useful as an alternative medicine in the treatment of enteric bacterial pathogen.

International Journal of Pharmacy and Biological Sciences, 2014

Globally interest in traditional medicine is increasing day by day. At the same time safety and efficacy of traditional medicine have become important concerns for health authorities and the public. In siddha system of medicine Iya eraippu Noi may be correlated with the bronchial asthma in modern medicine. Airway inflammation in the bronchial wall causes bronical asthma. Since "swasakudori chooranam" has anti-inflammatory properties, the drug was taken for study to evaluate the effect on reducing acute and chronic inflammation. On pharmacological evaluation the drug showed moderate acute and chronic anti inflammatory effect. The study methods, observation and the data of the results will be presented and discussed.

Siddha papers ISSN 0974-2522, 2019

Siddha Medicine is the traditional medicine originating in ancient Thamilagam in south India. Eighteen siddhars laid the foundation for this system of medicine. The siddha system is largely therapeutic and prophylactic in nature. The aim of the work is to prove the anti-microbial activity of the Kottikkizhangu chooranam which is mainly indicated for Thaemal (Leucoderma) and Vellai (Leucorrhoea) mentioned in Materia Medica-Siddha. Kottikkizhangu chooranam (Aponogeton monostachyon) is a Siddha formulation. It has Kulirchiundakki (Refrigerant),Uramakki (Tonic) actions. Antibiotic susceptibility tests were determined by Agar disc diffusion (Kirby-Bauer) method. This drug was tested for antimicrobial property against Proteus vulgaris, Staphylococcus aureus, Streptococcus mutans, Bacillus subtilis, Klebsiella pneumoniae, Escherichia coli by Agar disc diffusion methods. Streptomycin is used as a positive control for this study. The results obtained from the study showed that Kottikkizhangu chooranam has antimicrobial property against Streptococcus mutans are more effective.

2016

Pharmaceutics in Siddha system of medicine is an important component with scientific background; the different aspects of this well developed discipline have been named as Gunapadam. As per the mode of application and medicinal forms, the pharmaceutical products in Siddha system have been classified into 32 internal and 32 external formulations. Basically the formulations are designed as per the concept of five elements and six tastes; employed the principles of synergism, antagonism and transformation into atomic or ionic form for the production of effective molecules. This manuscript highlights the GMP and guidelines exemplified in Siddha literature and address the scientific background of certain guidelines. One part of this article is devoted to discussion on influence of different factors in the expression of pharmacological activity of drug. Moreover this paper discusses the noteworthy endeavours in the standardization and commercialisation of Siddha formulations and contempla...