Herbal medicines have been broadly used in developed countries hence they are natural and compara... more Herbal medicines have been broadly used in developed countries hence they are natural and comparatively safe. They contain plant materials as their pharmacologically active components. Infertility is one of the most extremely tragic all over the world. Despite recent advances in the treatment of male infertility, the problem has not been satisfactorily tackled. The male infertility is mainly due to an inadequate number of spermatozoa in the semen, the failure of the spermatozoa to move with sufficient vigor towards their goal. Aim of the study is to evaluate the acute and sub-acute toxicity of the spermatogenic siddha drug Isappukol Chooranam (IC) (siddha drug).For acute studies, different doses of IC were administered orally to rats once daily for one week. Forsub-acute studies, different doses of IC were administered orally to rats once daily for 28 days in various doses at 50,100,200 mg/kg of body weight. Detailed hematological, biochemical, necropsy and Histopathological evaluation of organs was performed for all animals. Histopathological analysis revealed that Spleen, Testes, Pancreas, Lung, Liver, Brain, Heart, Stomach, Intestine, Bone, Ovary, and Kidney tissues of treated groups did not show any signs of toxicity. No impairment in hepatic, renal, haemopoietic functions were observed throughout the study. No mortality was observed up to 200 mg/kg of body weight in acute and sub-acute toxicity studies.
Background: Pavala Parpam (PP) is a traditional Siddha medicinal preparation. This marine sourced... more Background: Pavala Parpam (PP) is a traditional Siddha medicinal preparation. This marine sourced medicine is synthesized through calcination of Corals as narrated in the classical Siddha literature -Anuboga Vaidhya avaneetham. This literature evident shows that Pavala Parpam has astringent action and becomes evident in arresting bleeding. The primary objective of this work was to validate the safety and haemostatic efficacy of PP. Methods: The raw Pavalam were procured from country drug store at Marthandam, Tamilnadu and purified by the traditional procedure by soaking in lemon juice for 24 h and the test drug PP was prepared by the process of Pudam (Calcination) described in Anuboga Vaidhya Navaneetham 3 rd part, page no: 132-133. Adrenochrome and other analytical grade chemicals were procured from Sigma chemicals, U.S.A and S.D fine chemicals Ltd, Mumbai. The experiments include preliminary biochemical studies by standard methods, quantitative analysis of Calcium by AAS, antibacterial studies by paper disc diffusion method, acute oral toxicity study under OECD 423 guidelines, and the haemostatic effects of PP in Albino mice including shortened bleeding and clotting time efficacy on by the method described in Ogle et al.,1977. Results: The qualitative and quantitative analyses of PP show that it has the contents of 37.48% of calcium, ferrous iron, tannin, and tannic acid. These compounds have the property of Haemostatic action. In vitro studies, Pavala Parpam has good anti microbial activity at the dilution of 25 microlitre/disc against the bacterial strains such as S.mutans, S.aureus, E.coli, K.pneumoniae and P.aeruginosa. Animals were found to be safe up to a maximum dose of 2000mg/kg body weight in acute toxicity studies. The experimental studies done on animal model, Pavala Parpam shows potent Haemostatic action by exhibiting significant reduction (P<0.001) in bleeding time and clotting time of blood compared with control group. Conclusion: Pavala Parpam is the safest and efficacious haemostatic drug comparable to Adrenochrome -a standard drug.
Patikaraparpam, a Siddha formulation in prepared by trituration of potash alum with egg albumin f... more Patikaraparpam, a Siddha formulation in prepared by trituration of potash alum with egg albumin followed by calcinatin. The three authentic laboratories made parpams as well as six commercial samples have been examined for their chemical composition. The analytical data that emerged from the analysis of the above samples showed that seven parpams contained only aluminium sulphate and they did respond to tests for potassium. An inspection of the crude drugs patikaram' available in the market established that potash alum and ammonia alum are indiscriminateldy taken for use, according to literature, only potash alum should be used in Indian system of medicine. Patikarapparapam is indicated in urinary inflammations and obstructions and is a reputed diuretic. Potassium salts are established diuretic. These studies show that the raw drugs sellers, the pharamaceutists or manufacturers of medicine and the physician as well should make sure that only potash alum is used in Indian medicine.
Mudu-Vanil Kaalam and Azhal Noigal In Kaar Kaalam, and the lyys Noigal In f inpanikkalam were obs... more Mudu-Vanil Kaalam and Azhal Noigal In Kaar Kaalam, and the lyys Noigal In f inpanikkalam were observed. Introduction: • In Slddha literature, the effects of Perum Pozhuthu (Six,seasons of the year) on Mukkutram (three humors) and the consequent occurrence of diseases is discussed. The six seasons are: Kaar Kaalam: Early rainy season from 15 August to 15 October; i.e.
Thundalam village in Chingelput districj, Tamilnadu by M.C.R.U. Madras. The Incidence of this dis... more Thundalam village in Chingelput districj, Tamilnadu by M.C.R.U. Madras. The Incidence of this disease was found to be more in younger age group (below 12 years). Among the affected people 54% were males and 28'/, females. The mild type (Vali neerkovai) of common cold was observed more (80%) among old age group, i.e. 35 years and above. The moderate type (Azhal 1. Assistant Research Officer 2. Statistical Assistant 3. Project Officer Mobile Clinical Research Unit, Madras-600106. neerkovai) was observed more (52%) among middle age group between 18 and 35 years. The severe type (Ayya neerkovai) was observed more (80%) among younger age group below 12 years. The drug was responded well In the mild type 80%, In the moderate type 56% and In the severe type 50% within three days. * d.
The Siddha system of medicine as practised by our aacients has been associated with religioa and ... more The Siddha system of medicine as practised by our aacients has been associated with religioa and philosophy aad thus evidently based on truth. This system of medicine recogriises the fact toat the human orcans are only, the material and the bodily representatives of invisible energies or activities that pervade and circulate the whole cosmic system.
One among ihc systems of medicinc is SidJlia, an indigenous system, in particular, the native sys... more One among ihc systems of medicinc is SidJlia, an indigenous system, in particular, the native system cf Tamilnadu. This rich heritage of Tamilnadu, ihouph remained eclipsed for centuries by the impact of modern medicine, is bring revived and brought to limeliyht through the unccasing and untiring efort of the Govt, of Tamilradu and as well as Govt, of India. This ancient system of mcdicine whose "age is more than 5000 years was jystematicaPv developed by siddhars who by their bard penance and incessant wanderings in jungles attained bliss and recorded their experiences in the form of poems. These siddhars were about eighteen in number like Agasthiar, Theraiyar, Nlachamuni, Idaikadar etc.
Herbal medicines have been broadly used in developed countries hence they are natural and compara... more Herbal medicines have been broadly used in developed countries hence they are natural and comparatively safe. They contain plant materials as their pharmacologically active components. Infertility is one of the most extremely tragic all over the world. Despite recent advances in the treatment of male infertility, the problem has not been satisfactorily tackled. The male infertility is mainly due to an inadequate number of spermatozoa in the semen, the failure of the spermatozoa to move with sufficient vigor towards their goal. Aim of the study is to evaluate the acute and sub-acute toxicity of the spermatogenic siddha drug Isappukol Chooranam (IC) (siddha drug).For acute studies, different doses of IC were administered orally to rats once daily for one week. Forsub-acute studies, different doses of IC were administered orally to rats once daily for 28 days in various doses at 50,100,200 mg/kg of body weight. Detailed hematological, biochemical, necropsy and Histopathological evaluation of organs was performed for all animals. Histopathological analysis revealed that Spleen, Testes, Pancreas, Lung, Liver, Brain, Heart, Stomach, Intestine, Bone, Ovary, and Kidney tissues of treated groups did not show any signs of toxicity. No impairment in hepatic, renal, haemopoietic functions were observed throughout the study. No mortality was observed up to 200 mg/kg of body weight in acute and sub-acute toxicity studies.
Background: Pavala Parpam (PP) is a traditional Siddha medicinal preparation. This marine sourced... more Background: Pavala Parpam (PP) is a traditional Siddha medicinal preparation. This marine sourced medicine is synthesized through calcination of Corals as narrated in the classical Siddha literature -Anuboga Vaidhya avaneetham. This literature evident shows that Pavala Parpam has astringent action and becomes evident in arresting bleeding. The primary objective of this work was to validate the safety and haemostatic efficacy of PP. Methods: The raw Pavalam were procured from country drug store at Marthandam, Tamilnadu and purified by the traditional procedure by soaking in lemon juice for 24 h and the test drug PP was prepared by the process of Pudam (Calcination) described in Anuboga Vaidhya Navaneetham 3 rd part, page no: 132-133. Adrenochrome and other analytical grade chemicals were procured from Sigma chemicals, U.S.A and S.D fine chemicals Ltd, Mumbai. The experiments include preliminary biochemical studies by standard methods, quantitative analysis of Calcium by AAS, antibacterial studies by paper disc diffusion method, acute oral toxicity study under OECD 423 guidelines, and the haemostatic effects of PP in Albino mice including shortened bleeding and clotting time efficacy on by the method described in Ogle et al.,1977. Results: The qualitative and quantitative analyses of PP show that it has the contents of 37.48% of calcium, ferrous iron, tannin, and tannic acid. These compounds have the property of Haemostatic action. In vitro studies, Pavala Parpam has good anti microbial activity at the dilution of 25 microlitre/disc against the bacterial strains such as S.mutans, S.aureus, E.coli, K.pneumoniae and P.aeruginosa. Animals were found to be safe up to a maximum dose of 2000mg/kg body weight in acute toxicity studies. The experimental studies done on animal model, Pavala Parpam shows potent Haemostatic action by exhibiting significant reduction (P<0.001) in bleeding time and clotting time of blood compared with control group. Conclusion: Pavala Parpam is the safest and efficacious haemostatic drug comparable to Adrenochrome -a standard drug.
Patikaraparpam, a Siddha formulation in prepared by trituration of potash alum with egg albumin f... more Patikaraparpam, a Siddha formulation in prepared by trituration of potash alum with egg albumin followed by calcinatin. The three authentic laboratories made parpams as well as six commercial samples have been examined for their chemical composition. The analytical data that emerged from the analysis of the above samples showed that seven parpams contained only aluminium sulphate and they did respond to tests for potassium. An inspection of the crude drugs patikaram' available in the market established that potash alum and ammonia alum are indiscriminateldy taken for use, according to literature, only potash alum should be used in Indian system of medicine. Patikarapparapam is indicated in urinary inflammations and obstructions and is a reputed diuretic. Potassium salts are established diuretic. These studies show that the raw drugs sellers, the pharamaceutists or manufacturers of medicine and the physician as well should make sure that only potash alum is used in Indian medicine.
Mudu-Vanil Kaalam and Azhal Noigal In Kaar Kaalam, and the lyys Noigal In f inpanikkalam were obs... more Mudu-Vanil Kaalam and Azhal Noigal In Kaar Kaalam, and the lyys Noigal In f inpanikkalam were observed. Introduction: • In Slddha literature, the effects of Perum Pozhuthu (Six,seasons of the year) on Mukkutram (three humors) and the consequent occurrence of diseases is discussed. The six seasons are: Kaar Kaalam: Early rainy season from 15 August to 15 October; i.e.
Thundalam village in Chingelput districj, Tamilnadu by M.C.R.U. Madras. The Incidence of this dis... more Thundalam village in Chingelput districj, Tamilnadu by M.C.R.U. Madras. The Incidence of this disease was found to be more in younger age group (below 12 years). Among the affected people 54% were males and 28'/, females. The mild type (Vali neerkovai) of common cold was observed more (80%) among old age group, i.e. 35 years and above. The moderate type (Azhal 1. Assistant Research Officer 2. Statistical Assistant 3. Project Officer Mobile Clinical Research Unit, Madras-600106. neerkovai) was observed more (52%) among middle age group between 18 and 35 years. The severe type (Ayya neerkovai) was observed more (80%) among younger age group below 12 years. The drug was responded well In the mild type 80%, In the moderate type 56% and In the severe type 50% within three days. * d.
The Siddha system of medicine as practised by our aacients has been associated with religioa and ... more The Siddha system of medicine as practised by our aacients has been associated with religioa and philosophy aad thus evidently based on truth. This system of medicine recogriises the fact toat the human orcans are only, the material and the bodily representatives of invisible energies or activities that pervade and circulate the whole cosmic system.
One among ihc systems of medicinc is SidJlia, an indigenous system, in particular, the native sys... more One among ihc systems of medicinc is SidJlia, an indigenous system, in particular, the native system cf Tamilnadu. This rich heritage of Tamilnadu, ihouph remained eclipsed for centuries by the impact of modern medicine, is bring revived and brought to limeliyht through the unccasing and untiring efort of the Govt, of Tamilradu and as well as Govt, of India. This ancient system of mcdicine whose "age is more than 5000 years was jystematicaPv developed by siddhars who by their bard penance and incessant wanderings in jungles attained bliss and recorded their experiences in the form of poems. These siddhars were about eighteen in number like Agasthiar, Theraiyar, Nlachamuni, Idaikadar etc.
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