The first mention of Divine Beast Vah Medoh is when Zelda and Link go to the Hebra region to ask Revali to pilot it. Revali first controls Vah Medoh in the Scenario "Freeing Korok Forest," when he is required to use it to destroy the Outposts surrounding Korok Forest. Unlike Breath of the Wild, Revali manages to survive an encounter with Windblight Ganon in the Scenario "Air and Lighting", which takes place in Vah Medoh. This is due to Terrako's ability to create time portals to bring Teba to defend him from a fatal shot by its laser cannons, and with Teba's help, Revali uses Vah Medoh to take out vast numbers of monsters and defeat Windblight Ganon. Because of these events, Vah Medoh as well as the other Divine Beasts have never fallen under Calamity Ganon's control.
Vah Medoh must also be used to complete the Challenges "Protector of the Forest", "Like the Wind", and "Through the Storm".