DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis (Q37063328)

18 August 2017

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title

DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis (English)

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18 August 2017

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Nahum Puebla-Osorio

1

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18 August 2017

Chengming Zhu

series ordinal

2

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18 August 2017

publication date

1 January 2008

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18 August 2017

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18 August 2017

volume

41

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18 August 2017

issue

2

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18 August 2017

page(s)

103-122

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The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region

18 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS12026-008-8015-3

ATM activation and DNA damage response

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12026-008-8015-3

ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8015-3

Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8015-3

RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination

21 January 2018

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12 December 2020

53BP1 is required for class switch recombination

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12 December 2020

Discovery of activation-induced cytidine deaminase, the engraver of antibody memory

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12 December 2020

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

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12 December 2020

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

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12 December 2020

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

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12 December 2020

The generation of antibody diversity through somatic hypermutation and class switch recombination

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12 December 2020

The V(D)J recombination activating gene, RAG-1.

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12 December 2020

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

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12 December 2020

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

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12 December 2020

Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

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12 December 2020

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

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12 December 2020

Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro

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12 December 2020

V(D)J recombination and the cell cycle.

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12 December 2020

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

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12 December 2020

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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12 December 2020

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

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12 December 2020

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

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12 December 2020

Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

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12 December 2020

DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine

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12 December 2020

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

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12 December 2020

Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation

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12 December 2020

Somatic hypermutation of the AID transgene in B and non-B cells

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12 December 2020

Characterization of broken DNA molecules associated with V(D)J recombination

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12 December 2020

Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis

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12 December 2020

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

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12 December 2020

ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes

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12 December 2020

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells.

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12 December 2020

AID-initiated purposeful mutations in immunoglobulin genes

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12 December 2020

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

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12 December 2020

B cell differentiation and isotype switching is related to division cycle number

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12 December 2020

Ku80 is required for immunoglobulin isotype switching

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12 December 2020

The role of the non-homologous end-joining pathway in lymphocyte development

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12 December 2020

Megabase chromatin domains involved in DNA double-strand breaks in vivo

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12 December 2020

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

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12 December 2020

Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes.

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12 December 2020

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

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12 December 2020

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice

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12 December 2020

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

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12 December 2020

Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation

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12 December 2020

The mechanism and regulation of chromosomal V(D)J recombination

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12 December 2020

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

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12 December 2020

Ig Sgamma3 DNA-specifc double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination

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12 December 2020

MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes

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12 December 2020

V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals

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12 December 2020

S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase

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12 December 2020

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

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12 December 2020

MDC1 is required for the intra-S-phase DNA damage checkpoint

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12 December 2020

ATM in lymphoid development and tumorigenesis

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12 December 2020

Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

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12 December 2020

Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

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12 December 2020

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

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12 December 2020

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

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12 December 2020

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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12 December 2020

Initiation of V(D)J recombination in vitro obeying the 12/23 rule

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12 December 2020

Evolution of the immunoglobulin heavy chain class switch recombination mechanism

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12 December 2020

DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model

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12 December 2020

Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

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12 December 2020

Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro

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12 December 2020

A recombinase diversified: new functions of the RAG proteins

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12 December 2020

Inducible DNA breaks in Ig S regions are dependent on AID and UNG

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12 December 2020

Mechanism and control of class-switch recombination

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12 December 2020

RAG mutations in human B cell-negative SCID.

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12 December 2020

V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder

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12 December 2020

DNA ligase III as a candidate component of backup pathways of nonhomologous end joining

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12 December 2020

Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences

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12 December 2020

Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation

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12 December 2020

Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.

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12 December 2020

Role of non-homologous end joining (NHEJ) in maintaining genomic integrity

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12 December 2020

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

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12 December 2020

Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells

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12 December 2020

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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12 December 2020

Antigen receptor diversification and chromosome translocations

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12 December 2020

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

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12 December 2020

The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination

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12 December 2020

ATM is required for efficient recombination between immunoglobulin switch regions

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12 December 2020

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

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12 December 2020

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

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12 December 2020

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

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12 December 2020

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

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12 December 2020

Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability

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12 December 2020

Somatic generation of antibody diversity

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12 December 2020

Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.

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12 December 2020

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

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12 December 2020

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

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12 December 2020

DNA double strand break repair and chromosomal translocation: lessons from animal models

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12 December 2020

Rag mutations reveal robust alternative end joining

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12 December 2020

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

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12 December 2020

Immunoglobulin class switch recombination is impaired in Atm-deficient mice

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12 December 2020

H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity

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12 December 2020

Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control

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12 December 2020

Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination

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12 December 2020

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

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12 December 2020

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12 December 2020

H2AX: the histone guardian of the genome

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12 December 2020

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

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12 December 2020

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

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12 December 2020

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

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12 December 2020

Mechanisms of chromosomal translocations in B cell lymphomas

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12 December 2020

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

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12 December 2020

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

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12 December 2020

A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex

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12 December 2020

53BP1, an activator of ATM in response to DNA damage

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12 December 2020

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

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12 December 2020

Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells

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12 December 2020

Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

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12 December 2020

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

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12 December 2020

A murine model of Nijmegen breakage syndrome

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12 December 2020

Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase

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12 December 2020

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells

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12 December 2020

A human severe combined immunodeficiency (SCID) condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency

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12 December 2020

Pathways of DNA double-strand break repair during the mammalian cell cycle

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12 December 2020

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

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12 December 2020

Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis

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12 December 2020

ATM prevents the persistence and propagation of chromosome breaks in lymphocytes

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12 December 2020

ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection

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12 December 2020

Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

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12 December 2020

A severe combined immunodeficiency mutation in the mouse

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12 December 2020

IgH class switching and translocations use a robust non-classical end-joining pathway

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12 December 2020

Internal IgH class switch region deletions are position-independent and enhanced by AID expression

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12 December 2020

Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.

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12 December 2020

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

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12 December 2020

DNA double-strand break repair: a relentless hunt uncovers new prey.

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12 December 2020

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

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12 December 2020

Sensing of intermediates in V(D)J recombination by ATM.

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12 December 2020

Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification

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12 December 2020

AID is required for c-myc/IgH chromosome translocations in vivo

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12 December 2020

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

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12 December 2020

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

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12 December 2020

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

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12 December 2020

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

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12 December 2020

The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination

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12 December 2020

The role of DNA breaks in genomic instability and tumorigenesis

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12 December 2020

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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12 December 2020

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

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12 December 2020

Genomic instability in mice lacking histone H2AX

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12 December 2020

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

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12 December 2020

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

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12 December 2020

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

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12 December 2020

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

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12 December 2020

The role of activation-induced deaminase in antibody diversification and chromosome translocations

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12 December 2020

Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas

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12 December 2020

Delineation of the role of the Mre11 complex in class switch recombination

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12 December 2020

Abnormal rearrangement within the alpha/delta T-cell receptor locus in lymphomas from Atm-deficient mice

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12 December 2020

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

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12 December 2020

Atm-deficient mice: a paradigm of ataxia telangiectasia

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12 December 2020

RAG-1-deficient mice have no mature B and T lymphocytes

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12 December 2020

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

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12 December 2020

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations

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12 December 2020

Antibody class switching

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12 December 2020

Nibrin functions in Ig class-switch recombination

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12 December 2020

MDC1 is a mediator of the mammalian DNA damage checkpoint

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12 December 2020

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle

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12 December 2020

Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination.

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12 December 2020

Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development

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12 December 2020

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

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12 December 2020

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

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12 December 2020

Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.

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12 December 2020

10.1007/S12026-008-8015-3

Identifiers

DOI

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18 August 2017

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