A recombinase diversified: new functions of the RAG proteins (Q34547234)

2 August 2017

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title

A recombinase diversified: new functions of the RAG proteins (English)

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2 August 2017

Vicky L Brandt

1

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2 August 2017

David B Roth

series ordinal

2

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2 August 2017

publication date

1 April 2002

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Current Opinion in Immunology

2 August 2017

published in

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2 August 2017

volume

14

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2 August 2017

issue

2

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2 August 2017

page(s)

224-229

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DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

2 August 2017

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The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo

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The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

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Initiation of V(D)J recombination in vitro obeying the 12/23 rule

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Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

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The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination

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Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

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Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex

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Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

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Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase

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Conditional RAG-1 mutants block the hairpin formation step of V(D)J recombination

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Rag-1 mutations associated with B-cell-negative scid dissociate the nicking and transesterification steps of V(D)J recombination

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Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking

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A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1.

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Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences

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V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.

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A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.

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Identification of two topologically independent domains in RAG1 and their role in macromolecular interactions relevant to V(D)J recombination

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RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

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Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

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7 January 2021

Identification of basic residues in RAG2 critical for DNA binding by the RAG1-RAG2 complex

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7 January 2021

RAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro

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A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

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A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2.

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A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination

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Functional organization of single and paired V(D)J cleavage complexes

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7 January 2021

The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination

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How to make ends meet in V(D)J recombination

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DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

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Analysis of ku80-mutant mice and cells with deficient levels of p53

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Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

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DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

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7 January 2021

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

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7 January 2021

V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

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7 January 2021

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

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The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

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Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

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Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro

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Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome

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Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

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DNA hairpin opening mediated by the RAG1 and RAG2 proteins

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Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

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Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks

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Association of terminal deoxynucleotidyl transferase with Ku

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Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase

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7 January 2021

Ku recruits the XRCC4-ligase IV complex to DNA ends

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7 January 2021

Crystal structure of the Xrcc4 DNA repair protein and implications for end joining

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7 January 2021

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

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7 January 2021

Cell-free V(D)J recombination

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7 January 2021

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

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7 January 2021

Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

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7 January 2021

Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.

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7 January 2021

Postcleavage sequence specificity in V(D)J recombination

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7 January 2021

Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination

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7 January 2021

Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents

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7 January 2021

Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors

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7 January 2021

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

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7 January 2021

RAG transposase can capture and commit to target DNA before or after donor cleavage

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7 January 2021

New insights into V(D)J recombination and its role in the evolution of the immune system

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RAG1/2-mediated resolution of transposition intermediates: two pathways and possible consequences

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Targeted transposition by the V(D)J recombinase

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RAG mutations in human B cell-negative SCID.

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7 January 2021

V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

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7 January 2021

Identical mutations in RAG1 or RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B-severe combined immune deficiency or Omenn syndrome

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7 January 2021

A severe combined immunodeficiency mutation in the mouse

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7 January 2021

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

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7 January 2021

Partial V(D)J recombination activity leads to Omenn syndrome

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7 January 2021

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

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7 January 2021

The RAG proteins in V(D)J recombination: more than just a nuclease

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7 January 2021

Unequal access: regulating V(D)J recombination through chromatin remodeling

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7 January 2021

10.1016/S0952-7915(02)00325-4

Identifiers

DOI

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2 August 2017

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