ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection (Q36382754)

13 August 2017

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title

ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection (English)

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13 August 2017

0 references

3

Jayne S Danska

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13 August 2017

Irina R Matei

1

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13 August 2017

Cynthia J Guidos

series ordinal

2

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13 August 2017

publication date

1 February 2006

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13 August 2017

published in

Immunological Reviews

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13 August 2017

volume

209

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13 August 2017

page(s)

142-158

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The role of the non-homologous end-joining pathway in lymphocyte development

13 August 2017

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How to keep V(D)J recombination under control

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Increased cancer risk of heterozygotes with NBS1 germline mutations in Poland

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V(D)J rearrangement in Nijmegen breakage syndrome

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Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome

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Abnormalities in the T and NK lymphocyte phenotype in patients with Nijmegen breakage syndrome.

21 January 2018

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Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.

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The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

21 January 2018

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Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

21 January 2018

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Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

21 January 2018

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Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

21 January 2018

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Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

21 January 2018

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A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

21 January 2018

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Omenn syndrome due to ARTEMIS mutations

21 January 2018

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Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

21 January 2018

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Germ-line ATM gene alterations are associated with susceptibility to sporadic T-cell acute lymphoblastic leukemia in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Atm-deficient mice: a paradigm of ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Checkpoint signaling: epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Skewed T-cell receptor repertoire, decreased thymic output, and predominance of terminally differentiated T cells in ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Homeostatic T cell proliferation as a barrier to T cell tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Bone marrow transplantation restores immune system function and prevents lymphoma in Atm-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Immunoglobulin class switch recombination is impaired in Atm-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

ATM is required for efficient recombination between immunoglobulin switch regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

The many substrates and functions of ATM

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

The Mre11 complex is required for ATM activation and the G2/M checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Activation of DNA-dependent protein kinase by single-stranded DNA ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

The spreading influence of chromatin modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Radiation and the cell cycle, revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Radiosensitivity in ataxia-telangiectasia: a new explanation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Regulation of the G2/M transition by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Genomic integrity and the repair of double-strand DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Mechanism and regulation of human non-homologous DNA end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Homologous recombination-mediated double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

The controlling role of ATM in homologous recombinational repair of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Does the reservoir for self-renewal stem from the ends?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Association of immune abnormalities with telomere shortening in autosomal-dominant dyskeratosis congenita

21 January 2018

1 reference

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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Accelerated telomere shortening in ataxia telangiectasia

21 January 2018

1 reference

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Human cell senescence as a DNA damage response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Protection of mammalian telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Atm inactivation results in aberrant telomere clustering during meiotic prophase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Hybrid T cell receptor genes formed by interlocus recombination in normal and ataxia-telangiectasis lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Rescue of defective T cell development and function in Atm-/- mice by a functional TCR alpha beta transgene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Transient restoration of gene rearrangement at multiple T cell receptor loci in gamma-irradiated scid mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Sensing of intermediates in V(D)J recombination by ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

21 January 2018

1 reference

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Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Chk1 is haploinsufficient for multiple functions critical to tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Requirement for RORgamma in thymocyte survival and lymphoid organ development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Role of cystatin C and cysteine proteinases in the development of mouse LS-lymphosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

The ATM/p53 pathway is commonly targeted for inactivation in squamous cell carcinoma of the head and neck (SCCHN) by multiple molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Aberrant splicing of the ATM gene associated with shortening of the intronic mononucleotide tract in human colon tumor cell lines: a novel mutation target of microsatellite instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Disruption of the ATM gene in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

ATM gene and lymphoid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Ataxia telangiectasia gene mutations in leukaemia and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Biallelic mutations in the ATM gene in T-prolymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

ATM mutations in sporadic lymphoid tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Clustering of missense mutations in the ataxia-telanglectasia gene in a sporadic T-cell leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Control of Atm-/- thymic lymphoma cell proliferation in vitro and in vivo by dexamethasone

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

ATM heterozygosity and cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00361.X

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.7792600

Identifiers

DOI

10.1111/J.0105-2896.2006.00361.X

1 reference

13 August 2017

1 reference