Renal Blood Flow (RBF) and Control of GFR and RBF: By: Prof./ Ibrahim Mohamady Ibrahim

Renal Blood Flow (RBF)
and Control of GFR and RBF
By:
Prof./ Ibrahim Mohamady Ibrahim
ILOs
• By the end of this lecture the student should be able to:
• State the normal renal blood flow (RBF), renal plasma flow
(RPF) and define the filtration fraction (FF).
• Describe the regional blood flow and O2 consumption in the
kidney.
• Define autoregulation of RBF and GFR and the blood pressure
range at which this is effective.
• Describe the different intrinsic mechanisms that regulate
RBF and GFR:
• Myogenic mechanism.
• Tubuloglomerular feedback.
• Describe the nervous (sympathetic) control of RBF and GFR.
• Describe the hormonal and paracrine control of RBF and
GFR.
Renal blood flow
In a resting adult, the kidneys receive 1.2-

1.3 liter of blood per minute, i.e. 21% of
the cardiac output.
Renal Vascular Arrangement:
•The renal arteries are

direct branches of the
aorta.
•Each renal artery on

entering hilum of the
kidney divides to form
the interlobar arteries,
arcuate arteries and
intratobular arteries.
•The afferent arterioles arise from the interlobular
arteries.
•Each arteriole divides into glomerular capillaries .
•The capillaries reunite to form the efferent arteriole,

which in turn breaks up into the peritubular capillaries
that supply the tubule.
•The capillaries draining the tubules of the cortical
nephrons form a peritubular network, whereas the
efferent arterioles from the juxtamedullary nephrons
drain not only into peritubular network, but also into
the vasa recta which are hairpin capillary loops that
lie side by side with the loops of Henle.
•The peritubular capillaries reunite to form

interlobular veins  arcuate veins  interlobar
veins renal veins.
Therefore, there are two capillary beds associated with each
nephron:
1) The glomerular capillary bed: "High pressure bed"
• It receives its blood from the afferent arteriole.

• The hydrostatic pressure in the glomerular capillaries is about 60 mmHg
which cause rapid filtration of fluid.
• The pressure in the glomerular capillaries is higher than in other capillary
beds due to:
a) The renal arteries are direct branches of the abdominal aorta.
b) The afferent arterioles are short, straight branches of the interlobular
arteries.
c) The efferent arterioles have high resistance than the afferent arteriole.
2) The peritubular capillary bed "Low pressure bed"
• The hydrostatic pressure is about 13 mmHg. The peritubular

capillaries behave like the venous ends of other capillaries. The low
pressure in these capillaries permits fluid reabsorption from the
interstitium into the blood.
Regional Blood Flow:
• The renal cortex receives most of the renal
blood flow (98%).
• This helps filtration of large volumes of

plasma through the glomeruli that lie in the
cortex.
• The renal medullary blood flow accounts

for 2 % of the total renal blood flow.
• This sluggish blood flow in the renal

medulla allows the kidney to form
concentrated urine.
Auto-regulation of the renal
blood flow:
 The renal blood flow is relatively kept constant
by change of blood pressure between 90 – 220
mmHg .
 Renal auto-regulation does not depend on

nerves or hormones as it is present in denervated
and isolated kidney.
Aim of auto-regulation
The major function of

auto-regulation of RBF
is to keep constant
glomerular filtration
rate and to allow
precise control of
renal excretion of
water waste products
and salts
Mechanisms of autoregulation of renal
blood flow:
1-Myogenic Mechanism:
A -With rise of pressure VC of afferent arterioles.

B- With drop of pressure VD of afferent arteriole.
2- Tubulo-glomerulr balance
feed- :
(Discussed with GFR)
Innervation of the renal vessels and
the renal tubule:
Sympathetic
fibers supply:
1) Renal vessels
Sympathetic stimulation produces vasoconstriction with

decrease in renal blood flow and glomerular filtration rate
(mediated by  – adrenergic receptor). This occurs during
exercise and rising from the supine to the standing position
and when the systemic blood pressure fall.
2) Juxtaglomerular
apparatus:
Sympathetic stimulation increases renin secretion by
juxtaglomerular cells (mediated by 1 adrenergic receptors).
3) Renal Tubule:
Sympathetic stimulation increases Sodium reabsorption by

the tubular cells . It is mediated via  - or  – adrenergic
receptors and it may be mediated by both.

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Renal Blood Flow (RBF)

and Control of GFR and RBF

In a resting adult, the kidneys receive 1.2-

•The renal arteries are

•Each renal artery on

•The capillaries reunite to form the efferent arteriole,

•The peritubular capillaries reunite to form

1) The glomerular capillary bed: "High pressure bed"

• It receives its blood from the afferent arteriole.

2) The peritubular capillary bed "Low pressure bed"

• The hydrostatic pressure is about 13 mmHg. The peritubular

• This helps filtration of large volumes of

• The renal medullary blood flow accounts

• This sluggish blood flow in the renal

 Renal auto-regulation does not depend on

The major function of

A -With rise of pressure VC of afferent arterioles.

Sympathetic stimulation produces vasoconstriction with

Sympathetic stimulation increases Sodium reabsorption by

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