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    Vitamin b12 & Asam Folat

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    Radya Agna
    Vitamin B12 and folate are important water-soluble vitamins that act as coenzymes in critical biochemical reactions in the body. Vitamin B12 is required for the methylation of homocysteine to methionine and the conversion of methylmalonyl-CoA to succinyl-CoA. Folate is essential for the transfer of one-carbon units in the synthesis of nucleotides and amino acids. Both vitamins are obtained primarily from animal products and plant sources can be reduced through cooking and processing. Deficiencies can impair DNA synthesis and the production of red blood cells.

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    Vitamin b12 & Asam Folat

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    Radya Agna
    79 views8 pages
    Vitamin B12 and folate are important water-soluble vitamins that act as coenzymes in critical biochemical reactions in the body. Vitamin B12 is required for the methylation of homocysteine to methionine and the conversion of methylmalonyl-CoA to succinyl-CoA. Folate is essential for the transfer of one-carbon units in the synthesis of nucleotides and amino acids. Both vitamins are obtained primarily from animal products and plant sources can be reduced through cooking and processing. Deficiencies can impair DNA synthesis and the production of red blood cells.

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    Vitamin B12 and folate are important water-soluble vitamins that act as coenzymes in critical biochemical reactions in the body. Vitamin B12 is required for the methylation of homocysteine to methionine and the conversion of methylmalonyl-CoA to succinyl-CoA. Folate is essential for the transfer of one-carbon units in the synthesis of nucleotides and amino acids. Both vitamins are obtained primarily from animal products and plant sources can be reduced through cooking and processing. Deficiencies can impair DNA synthesis and the production of red blood cells.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    79 views8 pages

    Vitamin b12 & Asam Folat

    Uploaded by

    Radya Agna
    Vitamin B12 and folate are important water-soluble vitamins that act as coenzymes in critical biochemical reactions in the body. Vitamin B12 is required for the methylation of homocysteine to methionine and the conversion of methylmalonyl-CoA to succinyl-CoA. Folate is essential for the transfer of one-carbon units in the synthesis of nucleotides and amino acids. Both vitamins are obtained primarily from animal products and plant sources can be reduced through cooking and processing. Deficiencies can impair DNA synthesis and the production of red blood cells.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 8

    VITAMIN B12 & ASAM FOLAT

    AHDA FAZA HUNAFA - 1610211070


    VITAMIN B12
    Water soluble vitamin.
    The term vitamin B12 refers to a family of cobalamin. This family includes analogs containing
    cobalt-bound methyl groups (methylcobalamin), 5'-deoryadenosyl groups (adenosylcobalamin),
    hydroxyl (OH -) groups (hydroxocobalamin), nitrito groups (nitritocobalamin), or water
    (aquacobalamin).
    Structure : cobalt-centered corrin nucleus.
    Sources : vit b12 is synthesized by bacteria, but the vitamin produced from the microflora in the
    colon is not absorbed. The richest sources of the vitamin are liver and kidney, milk,
    eggs, fish, cheese, and muscle meats.
    Function : coenzyme forms (adenosylcobalamin and methylcobalamin).
    BIOCHEMICAL FUNCTION

    Vitamin B12 is a coenzyme for two biochemical


    reactions:
    - as methyl B12 it is a cofactor for methionine
    synthase, the enzyme responsible for
    methylation of homocysteine to methionine
    using methyl tetrahydrofolate (methyl THF) as
    methyl donor
    - second, as deoxy adenosyl B12 (ado B12) it
    assists in conversion of methyl malonyl
    coenzyme A to succinyl CoA

    vitamin B12 is excreted intact by renal and biliary


    routes. only the free cobalamins (not the
    adenosylated or methylated forms) in plasma are
    available for excretion.
    FOLATE
    Folate refers generally to pteroyl monoglutamic acid.
    Sources: Folates exist as reduced folyl polyglutamates (of mostly
    5-methyl-FH4 and 10-formyl-FH4) in various foods of plant and
    animal origin. Liver, mushrooms, and green leafy vegetables
    (especially spinach, asparagus, and broccoli) are rich sources.
    Potatoes, whole-wheat bread, orange juice, and dried beans are
    good sources.
    The reduced forms in foods are easily oxidized, and losses of 50%
    - 90% typically occur during storage, cooking, or processing at
    high temperatures
    FOLATE
    Tetrahydrofolate produced from the vitamin folate, is the primary
    one-carbon carrier in the body.
    This vitamin obtains one-carbon units from serine, glycine,
    histidine, formaldehyde, and formate. While these carbons are
    attached to FH4 they can be either oxidized or reduced.
    one-carbon units are transferred to the pyrimidine base of
    deoxyuridine monophosphate (dUMP) to form deoxythymidine
    monophosphate (dTMP), to the amino acid glycine to form
    serine, to precursors of the purine bases to produce carbons C2
    and C8 of the purine ring.
    Krauses Food and Nutrition Theraphy 12th ed

    Marks Basic Medical Biochemistry: A Clinical Approach, 2nd Edition

    Hoffbrands Essential Haematology 7th ed

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