Scribd Logo
Upload

Welcome to Scribd!

  • 7 views

    Liver 1

    Uploaded by

    Ankit singh
    liver as organnnnnnnnn

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Liver 1

    Uploaded by

    Ankit singh
    7 views39 pages
    liver as organnnnnnnnn

    Original Title

    Liver 1-converted (2)

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    liver as organnnnnnnnn

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    7 views39 pages

    Liver 1

    Uploaded by

    Ankit singh
    liver as organnnnnnnnn

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 39

    LIVER

    * Liver plays a central role in metabolic


    homeostasis,
    *It is involved in the
    synthesis as well as detoxification of a wide
    range of compounds.
    • It is the largest solid organ in the
    body. Weight in the adult ranges
    from1200–1700 grams,
    • comprising 2%–5% of the total
    body weight
    HISTOLOGY OF LIVER
    • The basic functional unit of the liver
    is the liver lobule,
    • Lobule: a histological and functional unit

    • In the centre of the lobule is the central vein

    • Hepatocytes form single cell plates radiating from the


    central veins to the portal triad
    There are interlobular portal triads (portal vein, hepatic
    artery and bile duct branches) at the angles of the hexagon
    • .
    • The plates are located between the sinusoids
    that carry blood from the portal triad vessels
    to the central vein.
    • The plates are located between the sinusoids
    that carry blood from the portal triad vessels
    to the central vein.
    Bile is a production of secretion as well as excretion o
    liver
    FUNCTIONS OF LIVER
    In connection with blood
    • RBC formation in foetal life

    • RBC destruction in adult life

    • Store house of blood

    • Manufactures Prothrombin( with the help of vitamin K)


    & Fibrinogen & helps in blood coagulation

    • Produces Heparin & prevents intra vascular clotting


    • stores iron & Castles haematinic principle &
    thus helps in formation of RBC s &
    Hemoglobin

    • Liver produces Bile


    In connection with carbohydrate
    metabolism
    • Non glucose monosaccharides are converted
    to glucose & glycogen
    • Glycogenesis

    • Glycogenolysis

    • Neoglucogenesis
    In connection with Protein metabolism
    • It is the seat of specific dynamic action of
    proteins
    • Chief seat of deamination
    • Proteins are broken down and toxic ammonia
    is formed. This toxic ammonia is converted to
    nontoxic urea in liver & then it is excreted
    through urine.
    In connection with Fat metabolism
    • Stores fats and fat soluble vitamins A D E & K

    • Helps in---- oxidation of fats & releasing


    energy in the form of ATP.

    • Synthesizes fats from carbohydrates and


    proteins
    IN RELATION TO VITAMINES
    • Manufactures Prothrombin with the help of
    vitamin K

    • Stores Vitamin A & D


    • Liver is the site for detoxification of different
    toxic substances

    • It produces large amount of heat & takes part


    in heat regulation
    BILE
    • Bile is a production of secretion as well as
    excretion of liver
    • Formation of bile is a continuous
    process

    • But it is poured in duodenum


    intermittently only after meal.

    • Mean while it is stored in Gall bladder


    Bile
    • 500 to 1000 ml daily
    • Colour ----Yellowish green
    • Taste--- bitter
    • Constistency ----viscid mucoid liquid
    • Reaction ----Liver bile is alkaline
    • Composition
    Composition
    of Bile
    1) Inorganic salts
    • Chlorides carbonates & phosphates of Na ,k
    &Ca
    2) Bile salts
    • Sodium taurocholate & Sodium glychocholate

    3) Bile pigments
    • Bilirubin & Biliverdin
    Functions of Bile
    • Essential for complete digestion
    • Bile salts reduce surface tension
    • Fats are converted in to an emulation ,and
    provide large surface area for enzyme action
    • Activating action ---- Activates three lipases
    • Solvent action –good medium for enzyme
    action
    • Absorption
    • Essential for absorption of fats, iron, calcium &
    fat soluble vitamins A ,D ,E , &K .
    • Laxative action –Bile salts stimulate peristalsis
    • Bile acts as its own stimulant
    • Bile maintains a suitable pH & helps in action
    of all enzymes
    • Mucin of bile acts as a lubricant

    You might also like