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    214-8 Final Liver Transport&Function-1

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    Ingrid Yu
    This document discusses the transport and metabolic functions of the liver. It describes how the liver secretes bile which contains bile salts, cholesterol, and bilirubin. Bile salts help to emulsify and absorb fats. Most bile salts are reabsorbed through the enterohepatic circulation. The liver also processes nutrients, detoxifies compounds, synthesizes proteins, stores certain vitamins and minerals, and removes old red blood cells and bacteria from the bloodstream. It discusses the anatomy and flow of bile as well as the roles of bile salts and their reabsorption through enterohepatic circulation.

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    214-8 Final Liver Transport&Function-1

    Uploaded by

    Ingrid Yu
    12 views25 pages
    This document discusses the transport and metabolic functions of the liver. It describes how the liver secretes bile which contains bile salts, cholesterol, and bilirubin. Bile salts help to emulsify and absorb fats. Most bile salts are reabsorbed through the enterohepatic circulation. The liver also processes nutrients, detoxifies compounds, synthesizes proteins, stores certain vitamins and minerals, and removes old red blood cells and bacteria from the bloodstream. It discusses the anatomy and flow of bile as well as the roles of bile salts and their reabsorption through enterohepatic circulation.

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    This document discusses the transport and metabolic functions of the liver. It describes how the liver secretes bile which contains bile salts, cholesterol, and bilirubin. Bile salts help to emulsify and absorb fats. Most bile salts are reabsorbed through the enterohepatic circulation. The liver also processes nutrients, detoxifies compounds, synthesizes proteins, stores certain vitamins and minerals, and removes old red blood cells and bacteria from the bloodstream. It discusses the anatomy and flow of bile as well as the roles of bile salts and their reabsorption through enterohepatic circulation.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    12 views25 pages

    214-8 Final Liver Transport&Function-1

    Uploaded by

    Ingrid Yu
    This document discusses the transport and metabolic functions of the liver. It describes how the liver secretes bile which contains bile salts, cholesterol, and bilirubin. Bile salts help to emulsify and absorb fats. Most bile salts are reabsorbed through the enterohepatic circulation. The liver also processes nutrients, detoxifies compounds, synthesizes proteins, stores certain vitamins and minerals, and removes old red blood cells and bacteria from the bloodstream. It discusses the anatomy and flow of bile as well as the roles of bile salts and their reabsorption through enterohepatic circulation.

    Copyright:

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    Download as PPT, PDF, TXT or read online from Scribd
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    Liver: Transport and Metabolic

    functions
    Objectives
    • Functional anatomy of liver and bile
    system

    • Bile formation and secretion

    • Enterhepatic circulation of bile acids

    • Ammonia handling by liver


    Liver
    • Largest and most important metabolic
    organ in the body
    • Body’s major biochemical factory
    • Importance to digestive system – secretion
    of bile salts
    Liver
    • Functions not related to digestion
    – Metabolic processing of the major categories of
    nutrients
    – Detoxifying or degrading body wastes and hormones,
    drugs, and other foreign compounds
    – Synthesizes plasma proteins
    – Stores glycogen, fats, iron, copper, and many vitamins
    – Activates vitamin D
    – Removes bacteria and worn-out red blood cells
    – Excretes cholesterol and bilirubin
    Blood flow through splanchnic
    circulation in fasting human
    Hepatic lobule
    Interrelationships of major cell
    types in the liver
    Functional anatomy of biliary
    system
    Primary and secondary bile acids of
    bile
    Daily cholesterol balance in healthy
    human
    Liver
    • Bile
    – Actively secreted by liver and actively diverted to gallbladder
    between meals
    – Stored and concentrated in gallbladder
    – Consists of
    • Bile salts
    • Cholesterol
    • Lecithin
    • Bilirubin
    – After meal, bile enters duodenum
    • Bile salts
    – Derivatives of cholesterol
    – Convert large fat globules into a liquid emulsion
    – After participation in fat digestion and absorption, most are
    reabsorbed into the blood
    Schematic
    Structure and
    Function
    of Bile Salts
    Schematic Representation of a
    Micelle
    Pathways of entery of solutes into
    bile
    Transport in cholangicytes that
    secrete alkaline-rich fluid
    Concentration of bile in gallbladder
    Ducts and Gallbladder
    Neurohumoral control of
    gallbladder contraction and bile
    secretion
    Enterohepatic Circulation of Bile
    Salt
    Urea cycle
    Ammonium homeostasis in health

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