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    PhysioEx Exercise 4 Activity 3

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    PabloAndresPalaciosAgila
    This lab report summarizes an experiment examining the effects of hormone replacement therapy on bone density in ovariectomized rats. Rats were injected with either saline (control), estrogen, or calcitonin over 7 days. Bone density was measured via X-ray scans and reported as T-scores. As predicted, the estrogen and calcitonin injections increased bone density compared to the saline injections, evidenced by less negative T-scores. The results support the use of estrogen and calcitonin therapies to prevent osteoporosis in postmenopausal women.

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    © All Rights Reserved
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    PhysioEx Exercise 4 Activity 3

    Uploaded by

    PabloAndresPalaciosAgila
    147 views3 pages
    This lab report summarizes an experiment examining the effects of hormone replacement therapy on bone density in ovariectomized rats. Rats were injected with either saline (control), estrogen, or calcitonin over 7 days. Bone density was measured via X-ray scans and reported as T-scores. As predicted, the estrogen and calcitonin injections increased bone density compared to the saline injections, evidenced by less negative T-scores. The results support the use of estrogen and calcitonin therapies to prevent osteoporosis in postmenopausal women.

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    This lab report summarizes an experiment examining the effects of hormone replacement therapy on bone density in ovariectomized rats. Rats were injected with either saline (control), estrogen, or calcitonin over 7 days. Bone density was measured via X-ray scans and reported as T-scores. As predicted, the estrogen and calcitonin injections increased bone density compared to the saline injections, evidenced by less negative T-scores. The results support the use of estrogen and calcitonin therapies to prevent osteoporosis in postmenopausal women.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    147 views3 pages

    PhysioEx Exercise 4 Activity 3

    Uploaded by

    PabloAndresPalaciosAgila
    This lab report summarizes an experiment examining the effects of hormone replacement therapy on bone density in ovariectomized rats. Rats were injected with either saline (control), estrogen, or calcitonin over 7 days. Bone density was measured via X-ray scans and reported as T-scores. As predicted, the estrogen and calcitonin injections increased bone density compared to the saline injections, evidenced by less negative T-scores. The results support the use of estrogen and calcitonin therapies to prevent osteoporosis in postmenopausal women.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 3

    PhysioEx Exercise 4 Activity 3 10/7/23 09:22

    PhysioEx Lab Report


    Exercise 4: Endocrine System Physiology
    Activity 3: Hormone Replacement Therapy
    Name: Pablo Palacios
    Date: 10 July 2023
    Session ID: session-7a8b5c53-4ca0-6bf4-a5a6-2275dcc40614

    Pre-lab Quiz Results


    You scored 100% by answering 4 out of 4 questions correctly.

    1 Follicle-stimulating hormone (FSH)

    You correctly answered: stimulates ovarian follicle development.

    2 Estrogen

    You correctly answered: is produced by developing ovarian follicles.

    3 Calcitonin

    You correctly answered: works against the development of osteoporosis.

    4 Which of the following statements is true?

    You correctly answered: The ovaries stop secreting estrogen after menopause.

    Experiment Results
    Predict Questions
    1 Predict Question 1: What effect will the saline injections have on the control rat's
    vertebral bone density?

    Your answer: The saline injections will not change the rat's vertebral bone density
    (indicated by an unchanging T score).

    2 Predict Question 2: What effect will the estrogen injections have on the estrogen-
    treated rat's vertebral bone density?

    Your answer: The estrogen injections will increase the rat's vertebral bone density
    (indicated by a less-negative T score).

    https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act3/ Página 1 de 3
    PhysioEx Exercise 4 Activity 3 10/7/23 09:22

    3 Predict Question 3: What effect will the calcitonin injections have on the calcitonin-
    treated rat's vertebral bone density?

    Your answer: The calcitonin injections will increase the rat's vertebral bone density
    (indicated by a less-negative T score).

    Stop & Think Questions


    Experiment Data
    Rat Elapsed Saline Estrogen Calcitonin T score
    Days injections injections injections
    Control 7 7 0 0 -2.84
    Estrogen 7 0 7 0 -1.54
    Calcitonin 7 0 0 7 -2.06

    Post-lab Quiz Results


    You scored 100% by answering 4 out of 4 questions correctly.

    1 Saline injections were used in this experiment to measure the effect of

    You correctly answered: a placebo on bone density.

    2 In the ovariectomized rats used in this experiment

    You correctly answered: osteoporosis was evident prior to the injections of estrogen.

    3 Injection of calcitonin into an ovariectomized rat will

    You correctly answered: inhibit osteoclast activity and stimulate calcium uptake and
    deposition in long bones.

    4 As the rat's bone density increases

    You correctly answered: the X-ray scanning assay reports a less-negative T-score.

    Review Sheet Results


    1 Why were ovariectomized rats used in this experiment? How does the fact that the rats
    are ovariectomized explain their baseline T scores?

    Your answer:

    Se usaron a ratas ovariectomizadas para evaluar la función de diferentes tratamientos

    https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act3/ Página 2 de 3
    PhysioEx Exercise 4 Activity 3 10/7/23 09:22

    hormonales como la administración de estrógenos y de calcitonina.

    2 What effect did the administration of saline injections have on the control rat? How
    well did the results compare with your prediction?

    Your answer:

    No tuvo ningún efecto ya que la solución salina no fue más que un placebo.

    3 What effect did the administration of estrogen injections have on the estrogen-treated
    rat? How well did the results compare with your prediction?

    Your answer:

    En efecto aumentó la densidad ósea de la rata.

    4 What effect did the administration of calcitonin injections have on the calcitonin-
    treated rat? How well did the results compare with your prediction?

    Your answer:

    De igual forma, aumentó la densidad ósea de la rata.

    5 What are some health risks that postmenopausal women must consider when
    contemplating estrogen hormone-replacement therapy?

    Your answer:

    Deberían considerar el hecho que tras la menopausia la densidad ósea disminuye, lo


    que produce osteoporosis, y una mayor probabilidad de fracturas.

    https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act3/ Página 3 de 3

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