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    Gabriel Ilasaca
    This document summarizes the results of a lab experiment on hormone replacement therapy. Rats were ovariectomized to simulate menopause and then received saline injections as a control, or estrogen or calcitonin injections. As predicted, estrogen injections increased bone density in treated rats, shown by a less negative T-score, while saline did not affect the control rat. Calcitonin also increased bone density, though not as much as estrogen. The document includes pre-lab and post-lab quiz results showing the learner understood hormone functions and the purpose and results of the experiment.

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    Untitled

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    Gabriel Ilasaca
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    This document summarizes the results of a lab experiment on hormone replacement therapy. Rats were ovariectomized to simulate menopause and then received saline injections as a control, or estrogen or calcitonin injections. As predicted, estrogen injections increased bone density in treated rats, shown by a less negative T-score, while saline did not affect the control rat. Calcitonin also increased bone density, though not as much as estrogen. The document includes pre-lab and post-lab quiz results showing the learner understood hormone functions and the purpose and results of the experiment.

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    This document summarizes the results of a lab experiment on hormone replacement therapy. Rats were ovariectomized to simulate menopause and then received saline injections as a control, or estrogen or calcitonin injections. As predicted, estrogen injections increased bone density in treated rats, shown by a less negative T-score, while saline did not affect the control rat. Calcitonin also increased bone density, though not as much as estrogen. The document includes pre-lab and post-lab quiz results showing the learner understood hormone functions and the purpose and results of the experiment.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    10 views4 pages

    Untitled

    Uploaded by

    Gabriel Ilasaca
    This document summarizes the results of a lab experiment on hormone replacement therapy. Rats were ovariectomized to simulate menopause and then received saline injections as a control, or estrogen or calcitonin injections. As predicted, estrogen injections increased bone density in treated rats, shown by a less negative T-score, while saline did not affect the control rat. Calcitonin also increased bone density, though not as much as estrogen. The document includes pre-lab and post-lab quiz results showing the learner understood hormone functions and the purpose and results of the experiment.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 4

    Exercise 4: Endocrine System Physiology: Activity 3: Hormone Replacement Therapy Lab Report

    Pre-lab Quiz Results


    You scored 100% by answering 4 out of 4 questions correctly.

    1. Follicle-stimulating hormone (FSH)


    You correctly answered: d. stimulates ovarian follicle development.

    2. Estrogen
    You correctly answered: d. is produced by developing ovarian follicles.

    3. Calcitonin
    You correctly answered: b. works against the development of osteoporosis.

    4. Which of the following statements is true?


    You correctly answered: c. The ovaries stop secreting estrogen after menopause.

    03/24/23 page 1
    Experiment Results
    Predict Question:
    Predict Question 1: What effect will the saline injections have on the control rat's vertebral bone density?
    Your answer : c. The saline injections will not change the rat's vertebral bone density (indicated by an unchanging T score).

    Predict Question 2: What effect will the estrogen injections have on the estrogen-treated rat's vertebral bone density?
    Your answer : a. The estrogen injections will increase the rat's vertebral bone density (indicated by a less-negative T score).

    Predict Question 3: What effect will the calcitonin injections have on the calcitonin-treated rat's vertebral bone density?
    Your answer : a. The calcitonin injections will increase the rat's vertebral bone density (indicated by a less-negative T
    score).

    Experiment Data:

    Rat Elapsed Days Saline injections Estrogen injections Calcitonin T score


    injections
    Control 7 7 0 0 -2.82
    Estrogen 7 0 7 0 -1.60
    Calcitonin 7 0 0 7 -2.17

    03/24/23 page 2
    Post-lab Quiz Results
    You scored 100% by answering 4 out of 4 questions correctly.

    1. Saline injections were used in this experiment to measure the effect of


    You correctly answered: c. a placebo on bone density.

    2. In the ovariectomized rats used in this experiment


    You correctly answered: d. osteoporosis was evident prior to the injections of estrogen.

    3. Injection of calcitonin into an ovariectomized rat will


    You correctly answered: b. inhibit osteoclast activity and stimulate calcium uptake and deposition in long bones.

    4. As the rat's bone density increases


    You correctly answered: a. the X-ray scanning assay reports a less-negative T-score.

    03/24/23 page 3
    Review Sheet Results
    1. Why were ovariectomized rats used in this experiment? How does the fact that the rats are ovariectomized explain their
    baseline T scores?
    Your answer:
    Se utiliza para ver la acción de la suplementación hormonal tuviera efectos sobre un organismo sin ningún tipo de
    influencia de hormonas endogenas por lo tanto, demostrar la cción de hormonas exogenas.

    Las puntuaciones T eran mas negativas por el deficit de las hormonas de estrogeno por ello, genero osteoporosis.

    2. What effect did the administration of saline injections have on the control rat? How well did the results compare with
    your prediction?
    Your answer:
    Ni cambia la densidad, puesto que, la solución salina se utiliza como placebo para tener un control y compración de los
    resultados de las otras hormonas en disminuir la negatividad.

    3. What effect did the administration of estrogen injections have on the estrogen-treated rat? How well did the results
    compare with your prediction?
    Your answer:
    El estrogeno actua aumentando la densidad, porque promueve la mineralización al estimular al osteoblasto generando
    aumento de la matriz osteoidea.
    Por lo tanto, la PUNTUACION T SE HARA MÁS NEGATIVA. porque aumenta la densidad y será más positivo.

    4. What effect did the administration of calcitonin injections have on the calcitonin-treated rat? How well did the results
    compare with your prediction?
    Your answer:
    aumento la mineralización por lo tanto aumenta la densidasd, aunque en menor medida que el estrógeno, segun los
    resultados observados el estrogeno tuvo mayor eumento de densidad.

    5. What are some health risks that postmenopausal women must consider when contemplating estrogen
    hormone-replacement therapy?
    Your answer:
    Náuseas, hiperpigmentación de la areola, menstruación y ganancia de peso.

    03/24/23 page 4

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