Pharmaceutical Formulation: Principles and Dosage Forms

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PHARMACEUTICS 531P COURSE SYLLABUS 2014

Pharmaceutical Formulation: Principles and Dosage Forms


4 credits
3 hours lecture/week (MWF 10:30 AM -11:20 AM)
One 2-hour lab/week (T)
One 1-hour conference/week (M 11:30 AM – 12:20 PM)

Instructors

Course Coordinator:
Qingcheng Mao, Ph.D
H272P Health Sciences
(206) 685-0355
[email protected]

Suzanne H. Lee, Pharm. D. Danny Shen, Ph.D.


UW Medicine, Northwest Hospital & Medical Center Room 305B, 4225 Roosevelt Way NE
(206) 368-1696 (206) 685-2920
[email protected] [email protected]

Course Description

This course provides the knowledge base to be used in subsequent pharmacy courses
and professional practice. The student will study the theory and problems involved in
incorporating chemicals into stable dosage forms suitable for human medication as
well as the routes of drug administration. The basics of the appropriate handling and
use of various dosage forms will also be presented. The laboratory will expose the
student to common dosage forms, will illustrate important physical principles, and will
develop basic manipulative skills.

Examinations and Grading

Three written examinations will be given during the quarter. Two 1-hour midterm
exams (50 pts.) covering lecture and laboratory material will be given in class. A 2-
hour cumulative final exam over lecture and laboratory material (100 pts.) will be
given during the scheduled final exam period.

*Make-up of missed exams will be allowed only under exceptional circumstances.

The laboratory score (100 pts.) will be based on the quality of preparations and
graded questions from each laboratory.

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Thus, the total course score will be obtained as follows:

Midterm 1 50 pts.

Midterm 2 50 pts.

Final 100 pts.

Lab 100 pts.

Total 300 pts.

95% → 4
85% → 3
76% → 2
65% → 0.7
4

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Grade

0
60 70 80 90 100
Percentage (%)

Grade = 0.1102 x percentage - 6.418

Final grades will be calculated using the above equation. The passing grade is 0.7.

Objectives

This course will enable the successful student to:

1. Accurately and rapidly weigh quantities of material on a prescription balance.

2. Make visual approximations of weight of a solid or the volume of a liquid.

3. Choose an appropriate dosage form on the basis of the properties of the raw
drug.

4. Choose an appropriate dosage form for a given route of drug administration.

5. Accurately and rapidly weigh, measure, combine, and formulate raw materials
into acceptable dosage forms.

6. Identify common dosage forms by appearance and physical properties.


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7. Understand and explain the importance of solubility principles, acid-base theory,
colligative properties, and interfacial phenomena in the preparation and stability
of dosage forms.

8. Explain the purpose of ingredients found in various prescription and non-


prescription products.

9. Explain the proper use, as well as the practical, economic, and therapeutic
advantages and disadvantages of common dosage forms.

10. Synthesize dosage form theory and information into impromptu patient advice on
use and storage of a dispensed medication.

11. Describe methods for stabilizing and preserving medications.

12. Detect drug or vehicle incompatibilities in prescriptions.

13. Understand the basic principle of various routes of drug administration.

Textbooks

Recommended (in reverse in the health science library):

Pharmaceutical Dosage Forms and Drug Delivery Systems, Howard


C. Ansel, Nicholas G. Popovich and Lloyd V. Allen, Jr. 9th Edition,
2009.

For extra help and information (available in the health science library):

A Practical Guide to Contemporary Pharmacy Practice,


Thompson J.E., 1998.

Physical Pharmacy, A. Martin, 4th Edition, 1993.

USP31-NF26, 2008.

Remington's Pharmaceutical Sciences, 20th Edition, 2000.

Physicochemical Principles of Pharmacy, A.T. Florence and D.


Attwood, 2nd Edition, 1988.

Applied Pharmaceutics in Contemporary compounding, R.


Shrewsbury, Morton Publishing, 2001.

Syllabus/Pceut531P/2013

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