Velasof Pillsbag

Buy Velasof [Velpatasvir / Sofosbuvir] Hetero Tab Uses,
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VELASOF
Drug profile:
Trade name: Velasof

Composition: Sofosbuvir & Velpatasvir
Strength of the components: 400mg & 100mg respectively
Manufacturer name: Hetero healthcare
Package: 28 tablets in a container
Classification: Anti-hepaciviral drug.
Drug Prescribing Information of Velasof tablets:
velasof tablet is used in following conditions like;

Patients suffered from compensated cirrhosis or without cirrhosis.
Patients with decompensated with long-lasting condition used in combination with
ribavirin.
velasof tablets are used in the conditions like hepatitis C viral infection in
adolescents; HCV infection is caused by various genotypes like I, II, III, IV, V or VI.
Mechanism of Action of Velasof:
• A Velasof tablet containing directly acting anti-viral agents such

as sofosbuvir & Velpatasvir which expels their actions by undergoing some
mechanism includes;
• Sofosbuvir (Velasof ) is an inhibitor of HCV NS5B RNA dependent RNA
polymerase, an enzyme essential for viral production. Hence this inhibition
causes depletion in viral proliferation.
• Velpatasvir(Velasof tablet) is an inhibitor of HCV NS5A is a pan genotype,
NS5A is a protein required for HCV viral replication thus the inhibition leads
to reduce the production of HCV virus in the human body.
Absorption:
Velasof tablet If gastric pH level increases lead to cause depletes insolubility

of Velpatasvir.
The peak concentration time of both sofosbuvir and Velpatasvir occurs within 0.5 to
1 hour and 3 hours respectively.
The peak plasma concentration of sofosbuvir and Velpatasvir exist in 567ng/ml &
259ng/ml respectively.
Distribution:
The human plasma protein bound to sofosbuvir(Velasof tablet) and Velpatasvir

(Velasof ) with the range of 61 to 65% and >99.5% respectively.
Metabolism:
Sofosbuvir Velasof tablet is metabolized hepatically, with the help of cathepsin A,

CES1 & HINT1.
Sofosbuvir is a substrate of P-gp transporter and breast cancer resistance protein.
Velpatasvir Velasof is partially metabolized and it is excreted as an unchanged
form.
Elimination:
The Velasof tablet mean terminal half-life period of
both sofosbuvir and Velpatasvir and the circulating metabolite called GS-331007 are
reaching at 0.5 hours, 15 hours, & 27 hours respectively
The main routes of excretion of all the components like;
Sofosbuvir by metabolism; Velpatasvir through bile in unchanged form & GS-
331007 through glomerular filtration and active tubular secretion.
Urine:
Sofosbuvir: 80%; Velpatasvir: 14%
Feces:
Sofosbuvir: 0.4%; Velpatasvir: 94%
When to take the Tablet Velasof:
Velasof tablet should be taken with or without food.

To administer the Velasof frequently at the same time every day, as a single dose.
If concomitant with ribavirin, Velasof tablet must be taken with food.
Gastric pH increasing drugs causes depletion in effect of serum concentration
of Velpatasvir, to avoid these complications consume the antacids, H2 antagonist and
proton pump inhibitors before the dose of Velasof .
Dosage Regimens of Velasof tablets:
Before initiating the therapy, patients should be examined by counting the hepatitis B
surface antigen and hepatitis B core antibody (HBsAg & Anti-HBc) to prevent the
problem like reactivation of HBV infection.
The prescribed dosage of Velasof tablet includes as;
Velasof tablet containing fixed-dose combination drugs like 400mg of sofosbuvir and
100mg of Velpatasvir.
Recommended Velasof tablet in patients with chronic HCV infection related to
genotypes like I, II, III, IV, V or VI.
Patients with child Pugh A: one tablet of Velasof should be administered as a single
dose.
Patients with chronic cirrhosis or decompensated (child B or C): Velasof tablet should
be combined with ribavirin.
The ribavirin dosage should be administered on the basis of the weight of the patients.
Less than 75kg: 1000mg per day; at least75kg: 1200mg per day.
No dosage adjustment is required for renal impaired patients.
Drug Called side effects:
Some effects may occur during the therapy of Velasof tablet;

Nausea
Insomnia
Asthenia
Elevate lipase level
Depression
Headache
Fatigue
Anemia
Rash
Elevation of creatinine kinase
Life-threatening condition like severe symptomatic bradycardia occurs while co-
administration with amiodarone.
Drug Interaction of Velasof:
Velasof tablet combining with HMG CoA reductase agents leads to increase the
concentration of these agents.
Velasof tablet concomitant with acid-reducing agents causes the decrease in the effect
of concentration of Velpatasvir.
Velasof are P-gp & BCRP drug transporters substrate while combining Velasof with
P-gp inducers causes depletion in plasma concentration of Velasof tablet leads to
reduce the curative effect.
Velasof concurrently used with anti-mycobacterials causes depletion
of Velasof tablet.
Velasof with amiodarone causes serious bradycardia.
Velasof tablet combined with digoxin causes increasing the serum concentration of
digoxin.
Velasof with anticonvulsants causes depletion of the effect of concentration
of Velasof tablet.
Velasof combined with HIV anti-retroviral agents leads to cause decrease the serum
concentration of Velpatasvir.
Food -Drug Interactions:
No food-drug interaction occurs, an herbal product like st. Johns wort combining
with Velasof causes decreasing the therapeutic effect of Velasof.
Possible Contraindications:
The anaphylactic reaction occurs while patients are contraindicated to the components
present in Velasof tablet.
Velasof while using alone it is safe if it is combined with ribavirin which is
contraindicated in pregnant women.
Safety Measures:
Ribavirin with Velasof tablet in chronic condition causes ill to pregnant women cause
fetal harm.
Serious bradycardia occurs while combining with amiodarone.
While taking Velasof some adverse effects occur, to avoid these conditions some
precautions should be taken.
Care should be taken in renal and hepatic impaired patients:
After completion of therapy, reactivation of HBV infection occurs in the patients who
are co-infected with HCV/HBV infections, to avoid these conditions investigate the
patient by measuring HBsAg and anti-HBc.
Reduction in the therapeutic effect of Velasof tablet, while the concomitant use
of Velasof with P-gp inducers.
Pregnancy and Lactation:
Velasof used alone then its pregnancy category comes under B1; safe to use.
If Velasof tablet combined with ribavirin, pregnancy category is X; causes fetal death.
Breastfeeding should not be recommended during therapy.
Storage and Handling:
Velasof tablet container should be stored at room temperature below 30oC.

Keep the container away from moisture, heat, and light.
Missed dose:
Velasof is not a normal drug, it is prescription medicine used only by the patients
who are all having a valid prescription.
If the patient fails to take the dose of Velasof tablet, must get advice from the
physician and take the medicine within the time because it is single dose therapy.
Otherwise, the missed dose should be skipped and follow the regular dosing schedule.
Overdosage:
No distinct antidote is applicable for overdosing of Velasof tablet; once the overdose
occurs to confirm the presence of toxicity.
Treatment:
Check the crucial manifestations and give adjuvant measures.
The Hemodialysis is another method used in an overdose of Velasof tablet, can
efficiently dispose of the dominant circulating metabolite of sofosbuvir, GS-331007
with eradicating ration of 53%.
Hence Velpatasvir is highly bound to the human plasma protein; it is not cleared by
hemodialysis and gives incredible results.
CONTACT US
EMAIL ID : [email protected]
PHONE NO : +91-9940472902
WEBSITE URL : https://pillsbag.com/products/velasof
KEYWORDS : velasof, velasof tablet, velasof price in India

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Buy Velasof [Velpatasvir / Sofosbuvir] Hetero Tab Uses,

Trade name: Velasof

Drug Prescribing Information of Velasof tablets:

velasof tablet is used in following conditions like;

• A Velasof tablet containing directly acting anti-viral agents such

Velasof tablet If gastric pH level increases lead to cause depletes insolubility

The human plasma protein bound to sofosbuvir(Velasof tablet) and Velpatasvir

Sofosbuvir Velasof tablet is metabolized hepatically, with the help of cathepsin A,

When to take the Tablet Velasof:

Velasof tablet should be taken with or without food.

Dosage Regimens of Velasof tablets:

Some effects may occur during the therapy of Velasof tablet;

Drug Interaction of Velasof:

Food -Drug Interactions:

Care should be taken in renal and hepatic impaired patients:

Pregnancy and Lactation:

Storage and Handling:

Velasof tablet container should be stored at room temperature below 30oC.

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