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2014, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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multidisciplinary treatment were done. The patient underwent plastic surgery and is still being followed up. Odontogenic neoplasms composed of predominantly clear cells are quite unusual and represent a diagnostic challenge.
Head and Neck Pathology, 2011
Elastofibromas of the oral cavity are rare, with only 5 cases reported. In this paper, we present a series of five new cases of oral elastofibromatous lesions, occurring in 4 males and 1 female, with ages ranging from 33 to 76 years. The clinical differential diagnosis includes fibroepithelial polyp or fibroma, among other connective tissue tumours. Elastofibromas probably develop as reactive lesions, for which surgical treatment is definitive.
Medical Principles and Practice, 2012
Journal of Oral Science, 2009
Myofibroma is a rare benign nodular tumor of the soft tissues, bones, or internal organs, and may affect both children and adults. It is mostly found in the head and neck region, although uncommon in the jaw bones, where only a few lesions have been described. Radiographically, it may appear as a welldefined unilocular radiolucent entity simulating a cystic or odontogenic lesion. Histopathologic findings alone may be insufficient for a final diagnosis, and immunostaining for markers such as vimentin, alphasmooth muscle actin, desmin and S-100 may be required. Intraosseous myofibroma is a diagnostic challenge and requires careful histopathologic, immunohistochemical and radiographic correlation. The present article describes a conservatively treated intraosseous myofibroma that occurred in a 7-year-old girl. The clinical, radiographic, histopathologic and immunohistochemical features are discussed.
Journal of Hard Tissue Biology, 2013
Odontogenic fibroma (OF) is a relatively rare benign tumor derived from odontogenic ectodermal mesenchymal tissue. It is divided into central (COF) or peripheral OF (POF) based on the affected area. Regarding its pathological features, OF can also be classified as epithelium-rich (WHO type) or epithelium-poor (simple type), depending on the amount of odontogenic epithelium in the tumor. There is limited information available about the latter type because of its low incidence. We report case of simple type COF apparently like POF. A 52year-old Japanese male was suffering from tenderness at the right posterior maxilla during occlusion with his removable partial denture. The lesion was diagnosed as a simple type OF arising at the edentulous region around the right molar site of the maxilla. A tumor resection was performed, and there was no evidence of recurrence at his 18-month follow-up examination. In addition, we provide a review of the literature with the most up-to-date information about this lesion so that it can be diagnosed correctly.
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2021
T a g g e d P Objective. The aim of this study was to report the clinicopathologic features of 62 cases of central odontogenic fibroma (COdF). Study Design. Clinical and radiographic data were collected from the records of 13 oral pathology laboratories. All cases were microscopically reviewed, considering the current World Health Organization classification of tumors and were classified according to histopathologic features. Results. There were 43 females and 19 males (average age 33.9 years; range 8À63 years). Clinically, COdF lesions appeared as asymptomatic swellings, occurring similarly in the maxilla (n = 33) and the mandible (n = 29); 9 cases exhibited palatal depression. Imaging revealed well-defined, interradicular unilocular (n = 27), and multilocular (n = 12) radiolucencies, with displacement of contiguous teeth (55%) and root resorption (46.4%). Microscopically, classic features of epithelial-rich (n = 33), amyloid (n = 10), associated giant cell lesion (n = 7), ossifying (n = 6), epithelial-poor (n = 3), and granular cell (n = 3) variants were seen. Langerhans cells were highlighted by CD1a staining in 17 cases. Most patients underwent conservative surgical treatments, with 1 patient experiencing recurrence. Conclusions. To the best of our knowledge, this study represents the largest clinicopathologic study of COdF. Most cases appeared as locally aggressive lesions located in tooth-bearing areas in middle-aged women. Inactive-appearing odontogenic epithelium is usually observed within a fibrous/fibromyxoid stroma, occasionally exhibiting amyloid deposits, multinucleated giant cells, or granular cells.
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2011
The aim of this study was to describe the clinicopathologic and immunohistochemical characteristics of 14 cases of central odontogenic fibroma (COF), and the ultrastructural features of 2 of them. Study design. Collaborative retrospective study based on the records of 4 oral pathology diagnostic services in Latin America based on the current World Health Organization classification. Results. There were 7 male and 7 female patients (mean age 31.8 years). Eight tumors occurred in the maxilla and 6 in the mandible. Thirteen cases were epithelium-rich and 1 epithelium-poor COF. Three were classified as hybrid COF with giant cell lesion. Mean size of the hybrid lesions were larger than pure COF (3.8 vs. 2.4 cm). Odontogenic epithelial islands were immunoreactive for cytokeratin (CK) AE1/AE3, CK5, CK14, CK19, and 34BE12 and negative for CK1 and CK18. Langerhans cells positive for S-100 and CD1a were found within the epithelial islands in 6/6 tested cases. CD68 was expressed in the giant cells of the hybrid lesions and in a few mononuclear cells of 2 cases of COF. Ki-67 index was Ͻ1% in all cases. In 6 tumors (42.8%), there were small globular eosinophilic droplets within the epithelial islands, which were positive for collagen type IV, and 9/13 cases (69.2%) were focally positive for smooth muscle actin. In addition to fibroblasts, myofibroblastic differentiation was found in the 2 cases studied ultrastructurally. Conclusions. Immunohistochemistry was useful to confirm the presence of epithelium and to exclude other central fibrous tumors. COF also contains a variable number of mast cells, Langerhans cells, and myofibroblasts, and further studies are needed to better understand the participation of these cells in COF histogenesis. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112:349-358) Central odontogenic fibroma (COF) is a rare benign odontogenic tumor characterized by variable amounts of inactive-looking odontogenic epithelium embedded in a mature fibrous stroma. 1 Over the past 4 decades, several authors have pointed out the difficulties in determining if a fibrous proliferation of the jaws is of odontogenic origin, and it was recognized that many of the cases diagnosed as COF in earlier series and case reports were in fact nonneoplastic enlarged dental follicles or other types of mesenchymal proliferations. 2,3 Although some authors stated that the absence of odon
Indian Journal of Dental Research, 2013
Objectives: To report a case of central odontogenic fibroma (COF) with immunohistochemical study. :36 μμ] Clinical Presentation: We describe a case of epithelium-rich type of COF in the posterior region of the mandible of a 39-year-old woman. Immunohistochemical examination showed the odontogenic epithelium to be positive for high-molecular-weight cytokeratins, vimentin and CD99, and negative for CAM5.2. The stroma contained some myofibroblasts and many fibroblast-like cells positive for CD99.
Pediatric Dental Journal International Journal of Japanese Society of Pediatric Dentistry, 2010
Radiographically enlarged dental follicle is observed in many cases associated with delayed tooth eruption. Pericoronal radiolucencies are seen in neoplasms (odontogenic fibroma), developmental anomalies (regional odontodysplasia), hamartomatous lesions (odontogenic epithelial hamartoma), opercula of third molars, in follicles associated with unerupted third molars, regional odontodysplasia, in dental follicles around impacted teeth of enamel dysplasia with hypodontia syndrome and amelogenesis imperfecta cases with multiple impactions. Interestingly, operculum and the follicle of these lesions histopathologically are identical to odontogenic fibroma (WHO) type. However, the lack of universally accepted clinic-pathological features for such lesions may hinder their recognition. We report a case of regional odontodysplasia wherein (in which) the impacted canine is surrounded by radiolucency measuring about 1.5-2 cm, histopathologic examination of the excised opercula revealed features reminiscent of central odontogenic fibroma (WHO type) with an abundance of odontogenic epithelium and calcifications. The aim of this paper is to discuss various lesions exhibiting histopathological features similar to odontogenic fibroma, as awareness of the clinicopathological features of such lesions is very important to plan proper treatment. togenic fibroma), developmental anomalies (regional odontodysplasia) and hamartomatous lesions. Normal dental follicles associated with unerupted teeth are frequently misinterpreted histologically as central ossifying fibroma (COF). Central odontogenic fibroma is a rare benign tumour arising within the jaws. The relatively few reports in the literature suggest that odontogenic fibroma is rare and, in addition, its histogenesis and even its existence as an independent entity are disputed. Interestingly, the term odontogenic epithelial hamartoma was used in the past to describe lesions that were clinically and histopathologically identical to odontogenic fibroma and considered to represent a transitional stage between a developmental anomaly and a true odontogenic tumor 2). We review a case of an impacted canine surrounded by a pericoronal radiolucency, the excised
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