Imipramin

Imipramin
(IUPAC) ime
	3-(10,11-dihidro-5H-dibenzo[b,f]azepin-5-il)-N,N-dimetilpropan-1-amin
Klinički podaci
Robne marke	Tofranil
AHFS/Drugs.com	Monografija
MedlinePlus	a682389
Identifikatori
CAS broj	50-49-7
ATC kod	N06AA02
PubChem	3696
DrugBank	DB00458
ChemSpider	3568
UNII	OGG85SX4E4
KEGG	D08070
ChEBI	CHEBI:47499
ChEMBL	CHEMBL11
Hemijski podaci
Formula	C19H24N2
Mol. masa	280,407 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 ; Key: BCGWQEUPMDMJNV-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	?
Metabolizam	Hepatički ; Glavni aktivni metabolit desipramin
Poluvreme eliminacije	11-25 sata
Izlučivanje	Renalno
Farmakoinformacioni podaci
Trudnoća	D(US)
Pravni status	℞ Prescription only
Način primene	Oralno

Imipramin (Antideprin, Deprimin, Deprinol, Depsol, Depsonil, Dinaprin, Evpramin, Imipramil, Irmin, Janimin, Melipramin, Surpliks, Tofranil, melipramin) je triciklični antidepresiv iz dibenzazepinske grupe. Imipramin se uglavnom koristi za tretmant kliničke depresije i enureze (nesposobnosti kontrole urinacije).^[6]

On je takođe izučavan za potencijalnu primenu u lečenju paničnog poremećaja.^[7]

Poređenje sa drugim antidepresivima

Potentnost (afinitet) imipramina i drugih antidepresiva na različitim trasporterima i receptorima je sumirana u donjoj tabli.^[8] Potentnost je izražena kao recipročna vrednosti konstante disocijacije pomnožene sa faktorom 10⁻⁷. Stoga što je veći broj, to je veća moć blokiranja

Lek	SERT	NET	DAT	α₁ blokada	D₂ blokada	H₁ blokada	muskarinska blokada	5HT₂ blokada
imipramin	70	2.7	0.012	1.5	0.05	9.1	1.1	1.2
desipramin	5.7	128	0.024	0.77	0.03	0.91	0.5	0.38
amitriptilin	23	2.9	0.023	3.7	0.1	91	5.6	3.4
klomipramin	360	2.7	0.045	2.6	0.53	3.2	2.7	3.7
paroksetin	800	2.5	0.2	0.025	0.003	0.03	0.93	0.005
citalopram	98	0.035	0.0038	0.053	0	0.21	0.045	0.34

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Delini-Stula A, Mikkelsen H, Angst J (October 1995). „Therapeutic efficacy of antidepressants in agitated anxious depression--a meta-analysis of moclobemide studies”. J Affect Disord 35 (1–2): 21–30. DOI:10.1016/0165-0327(95)00034-K. PMID 8557884.
↑ Lepola U, Arató M, Zhu Y, Austin C (June 2003). „Sertraline versus imipramine treatment of comorbid panic disorder and major depressive disorder”. J Clin Psychiatry 64 (6): 654–62. DOI:10.4088/JCP.v64n0606. PMID 12823079. ^{[mrtav link]}
↑ Richelson E (May 2001). „Pharmacology of antidepressants”. Mayo Clinic Proceedings. Mayo Clinic 76 (5): 511–27. DOI:10.4065/76.5.511. PMID 11357798.

Povezano

Triciklični antidepresiv

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid8557884-6] Delini-Stula A, Mikkelsen H, Angst J (October 1995). „Therapeutic efficacy of antidepressants in agitated anxious depression--a meta-analysis of moclobemide studies”. J Affect Disord 35 (1–2): 21–30. DOI:10.1016/0165-0327(95)00034-K. PMID 8557884.

[pmid12823079-7] Lepola U, Arató M, Zhu Y, Austin C (June 2003). „Sertraline versus imipramine treatment of comorbid panic disorder and major depressive disorder”. J Clin Psychiatry 64 (6): 654–62. DOI:10.4088/JCP.v64n0606. PMID 12823079. ^{[mrtav link]}

[pmid11357798-8] Richelson E (May 2001). „Pharmacology of antidepressants”. Mayo Clinic Proceedings. Mayo Clinic 76 (5): 511–27. DOI:10.4065/76.5.511. PMID 11357798.

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