Ajmalicin

Ajmalicin
(IUPAC) ime
	metil estar (19α)-16,17-didehidro- 19-metiloksajohimban- 16-karboksilne kiseline
Klinički podaci
Identifikatori
CAS broj	483-04-5
ATC kod	nije dodeljen
PubChem	251561
ChemSpider	390541
ChEMBL	CHEMBL123325
Hemijski podaci
Formula	C21H24N2O3
Mol. masa	352,43 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1 ; Key: GRTOGORTSDXSFK-XJTZBENFSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Oralno

Ajmalicin (δ-johimbin, raubazin) je antihipertenziv koji se koristi kao tretman za visoki krvni pritisak.^[5] On je bio u prodaji pod raznim imenima, neka od kojih su: Card-Lamuran, Circolene, Cristanyl, Duxil, Duxor, Hydroxysarpon, Iskedyl, Isosarpan, Isquebral, Lamuran, Melanex, Saltucin Co, Salvalion, i Sarpan.^[5] On je isto tako alkaloid koji je prirodno javlja u raznim biljkama kao što su Rauwolfia spp., Catharanthus roseus, i Mitragyna speciosa.^[5]^[6]^[7]

Ajmalicin je strukturno srodan sa johimbinom, rauvolscinom, i drugim johimbanskim derivatima. Poput korinantina, on deluje kao antagonist α₁-adrenergičkog receptora. On je znatno manje aktivan na α₂-adrenergičkim receptorima, iz čega proizilazi njegovo hipotenzivno dejstvo.^[5]^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ ^5,0 ^5,1 ^5,2 ^5,3 Wink, Michael; Roberts, M. W. (1998). Alkaloids: biochemistry, ecology, and medicinal applications. New York: Plenum Press. ISBN 0-306-45465-3.
↑ Kurz WG, Chatson KB, Constabel F, et al. (May 1981). „Alkaloid Production in Catharanthus roseus Cell Cultures VIII1”. Planta Medica 42 (5): 22–31. DOI:10.1055/s-2007-971541. PMID 17401876.
↑ León F, Habib E, Adkins JE, Furr EB, McCurdy CR, Cutler SJ (July 2009). „Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A”. Natural Product Communications 4 (7): 907–10. PMID 19731590.
↑ Roquebert J, Demichel P (October 1984). „Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine”. European Journal of Pharmacology 106 (1): 203–5. DOI:10.1016/0014-2999(84)90698-8. PMID 6099269.

Povezano

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[isbn0-306-45465-3-5] 5,0 ^5,1 ^5,2 ^5,3 Wink, Michael; Roberts, M. W. (1998). Alkaloids: biochemistry, ecology, and medicinal applications. New York: Plenum Press. ISBN 0-306-45465-3.

[pmid17401876-6] Kurz WG, Chatson KB, Constabel F, et al. (May 1981). „Alkaloid Production in Catharanthus roseus Cell Cultures VIII1”. Planta Medica 42 (5): 22–31. DOI:10.1055/s-2007-971541. PMID 17401876.

[pmid19731590-7] León F, Habib E, Adkins JE, Furr EB, McCurdy CR, Cutler SJ (July 2009). „Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A”. Natural Product Communications 4 (7): 907–10. PMID 19731590.

[pmid6099269-8] Roquebert J, Demichel P (October 1984). „Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine”. European Journal of Pharmacology 106 (1): 203–5. DOI:10.1016/0014-2999(84)90698-8. PMID 6099269.

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