SB-742,457

SB-742,457
(IUPAC) ime
	3-fenilsulfonil-8-(piperazin-1-il)hinolin
Klinički podaci
Identifikatori
CAS broj	607742-69-8
ATC kod	nije dodeljen
PubChem	11256720
ChEMBL	CHEMBL1083390
Hemijski podaci
Formula	C19H19N3O2S
Mol. masa	353,44 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2 ; Key: JJZFWROHYSMCMU-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Nije kontrolisan
Način primene	Oralno

SB-742,457 je selektivni antagonist 5-HT₆ receptora sa uticajem na kogniciju, memoriju, i učenje.^[4]^[5]^[6]^[7] On je u razvoju za tretman Alchajmerove bolesti i preliminarno je pokazano da je efikasan u kliničkim ispitivanjima faze II.^[6]^[7]^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Upton N, Chuang TT, Hunter AJ, Virley DJ (July 2008). „5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease”. Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics 5 (3): 458–69. DOI:10.1016/j.nurt.2008.05.008. PMID 18625457.
↑ Idris N, Neill J, Grayson B, et al. (January 2010). „Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms”. Psychopharmacology 208 (1): 23–36. DOI:10.1007/s00213-009-1702-5. PMID 19851757.
↑ ^6,0 ^6,1 Maher-Edwards G, Zvartau-Hind M, Hunter AJ, et al. (December 2009). „Double-Blind, Controlled Phase II Study of a 5-HT6 Receptor Antagonist, SB-742457, in Alzheimer's Disease”. Current Alzheimer Research 7 (5): 374–85. PMID 20043816. Arhivirano iz originala na datum 2011-10-06. Pristupljeno 2014-04-05.
↑ ^7,0 ^7,1 Rossé G, Schaffhauser H (February 2010). „5-HT(6) Receptor Antagonists as Potential Therapeutics for Cognitive Impairment”. Current Topics in Medicinal Chemistry 10 (2): 207–21. DOI:10.2174/156802610790411036. PMID 20166958. Arhivirano iz originala na datum 2011-10-06. Pristupljeno 2014-04-05.
↑ „Search of: SB-742457 - List Results - ClinicalTrials.gov”.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid18625457-4] Upton N, Chuang TT, Hunter AJ, Virley DJ (July 2008). „5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease”. Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics 5 (3): 458–69. DOI:10.1016/j.nurt.2008.05.008. PMID 18625457.

[pmid19851757-5] Idris N, Neill J, Grayson B, et al. (January 2010). „Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms”. Psychopharmacology 208 (1): 23–36. DOI:10.1007/s00213-009-1702-5. PMID 19851757.

[pmid20043816-6] 6,0 ^6,1 Maher-Edwards G, Zvartau-Hind M, Hunter AJ, et al. (December 2009). „Double-Blind, Controlled Phase II Study of a 5-HT6 Receptor Antagonist, SB-742457, in Alzheimer's Disease”. Current Alzheimer Research 7 (5): 374–85. PMID 20043816. Arhivirano iz originala na datum 2011-10-06. Pristupljeno 2014-04-05.

[pmid20166958-7] 7,0 ^7,1 Rossé G, Schaffhauser H (February 2010). „5-HT(6) Receptor Antagonists as Potential Therapeutics for Cognitive Impairment”. Current Topics in Medicinal Chemistry 10 (2): 207–21. DOI:10.2174/156802610790411036. PMID 20166958. Arhivirano iz originala na datum 2011-10-06. Pristupljeno 2014-04-05.

[urlSearch_of:_SB-742457_-_List_Results_-_ClinicalTrials.gov-8] „Search of: SB-742457 - List Results - ClinicalTrials.gov”.

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