Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase. (Q41447351)

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29 February 2020

title

Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase (English)

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29 February 2020

8

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29 February 2020

author name string

Shizuka Takagi-Niidome

1

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29 February 2020

Tomoki Sasaki

2

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29 February 2020

Satoko Osawa

3

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29 February 2020

Takeshi Sato

4

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29 February 2020

Kanan Morishima

5

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29 February 2020

Tetsuo Cai

6

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29 February 2020

Takeshi Iwatsubo

7

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language of work or name

English

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publication date

1 February 2015

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29 February 2020

published in

Journal of Neuroscience

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29 February 2020

volume

35

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29 February 2020

issue

6

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29 February 2020

page(s)

2646-2656

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C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin

29 February 2020

cites work

1 reference

12 December 2020

The PSIPRED protein structure prediction server

1 reference

12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

12 December 2020

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

1 reference

12 December 2020

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

1 reference

12 December 2020

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

1 reference

12 December 2020

The role of presenilin cofactors in the gamma-secretase complex

1 reference

12 December 2020

Designed Helical Peptides Inhibit an Intramembrane Protease

1 reference

12 December 2020

Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics

1 reference

12 December 2020

Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity

1 reference

12 December 2020

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

1 reference

12 December 2020

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

1 reference

12 December 2020

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

1 reference

12 December 2020

Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space

1 reference

12 December 2020

Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

1 reference

12 December 2020

Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex

1 reference

12 December 2020

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

1 reference

12 December 2020

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex

1 reference

12 December 2020

Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway

1 reference

12 December 2020

Structure of the membrane reconstituted transmembrane-juxtamembrane peptide EGFR(622-660) and its interaction with Ca2+/calmodulin

1 reference

12 December 2020

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

1 reference

12 December 2020

Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate

1 reference

12 December 2020

Control of inward rectifier K channel activity by lipid tethering of cytoplasmic domains

1 reference

12 December 2020

Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages

1 reference

12 December 2020

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

1 reference

12 December 2020

The Jpred 3 secondary structure prediction server

1 reference

12 December 2020

Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase

1 reference

12 December 2020

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

1 reference

12 December 2020

Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor?

1 reference

12 December 2020

Inhibition of gamma-secretase activity by helical beta-peptide foldamers.

1 reference

12 December 2020

gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment

1 reference

12 December 2020

An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production

1 reference

12 December 2020

Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

1 reference

12 December 2020

Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase

1 reference

12 December 2020

Alzheimer's disease: the challenge of the second century

1 reference

12 December 2020

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.

1 reference

12 December 2020

The crystal structure of GXGD membrane protease FlaK

1 reference

12 December 2020

Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane re

1 reference

12 December 2020

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1

1 reference

12 December 2020

Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain

1 reference

12 December 2020

Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein

1 reference

12 December 2020

Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology.

1 reference

12 December 2020

Structure of a presenilin family intramembrane aspartate protease

1 reference

12 December 2020

When detergent meets bilayer: birth and coming of age of lipid bicelles.

1 reference

12 December 2020

Structural biology of presenilins and signal peptide peptidases

1 reference

12 December 2020

Structure and mechanism of rhomboid protease

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12 December 2020

Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes

1 reference

12 December 2020

A structure-based model of substrate discrimination by a noncanonical PDZ tandem in the intramembrane-cleaving protease RseP

1 reference

12 December 2020

Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator

1 reference

12 December 2020

Three-dimensional structure of human γ-secretase

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12 December 2020

Protein topology of presenilin 1

1 reference

12 December 2020

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

12 December 2020

A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years.

1 reference

12 December 2020

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

12 December 2020

Substituted-cysteine accessibility method

1 reference

12 December 2020

Bicelles: a model membrane system for all seasons?

1 reference

12 December 2020

10.1523/JNEUROSCI.3164-14.2015

Identifiers

DOI

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29 February 2020

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29 February 2020

PubMed publication ID

25673856

1 reference