Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology. (Q44967903)

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21 February 2020

title

Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology (English)

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21 February 2020

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9

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21 February 2020

author name string

Solenne Ousson

1

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21 February 2020

Arman Saric

2

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21 February 2020

Aurelie Baguet

3

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21 February 2020

Christophe Losberger

4

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21 February 2020

Stephane Genoud

5

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21 February 2020

Francis Vilbois

6

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21 February 2020

Bruno Permanne

7

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21 February 2020

Ishrut Hussain

8

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language of work or name

English

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publication date

18 January 2013

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Journal of Neurochemistry

21 February 2020

published in

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volume

125

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21 February 2020

issue

4

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page(s)

610-619

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Activation and intrinsic γ-secretase activity of presenilin 1

21 February 2020

cites work

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Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.

21 January 2018

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Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

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First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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Membrane inserted APP fragments containing the beta A4 sequence of Alzheimer's disease do not aggregate

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Novel γ-Secretase Enzyme Modulators Directly Target Presenilin Protein

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

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Substrate-targeting gamma-secretase modulators

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Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane re

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

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The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain

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Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

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GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

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Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor.

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Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1

21 January 2018

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Beta-amyloid precursor protein mutants respond to gamma-secretase modulators

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Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

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Dissociation between the Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations

21 January 2018

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Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages

21 January 2018

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Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein

21 January 2018

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A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

21 January 2018

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gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment

21 January 2018

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The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

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Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment.

21 January 2018

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Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

21 January 2018

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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JNC.12129

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21 February 2020

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