Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins (Q28206918)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11719200%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

title

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins (English)

1 reference

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3 December 2019

0 references

1 reference

GOA release 2020-03-11

Presenilin 1

1 reference

Intercellular adhesion molecule 5, telencephalin

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Cary Esselens

2

1 reference

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3 December 2019

author name string

W G Annaert

1

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3 December 2019

V Baert

3

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3 December 2019

C Boeve

4

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3 December 2019

G Snellings

5

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3 December 2019

P Cupers

6

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3 December 2019

K Craessaerts

7

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3 December 2019

B De Strooper

8

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3 December 2019

language of work or name

English

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publication date

1 November 2001

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3 December 2019

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3 December 2019

volume

32

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3 December 2019

issue

4

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3 December 2019

page(s)

579-589

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Presenilins: molecular switches between proteolysis and signal transduction

3 December 2019

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Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

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The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

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7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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Where Notch and Wnt signaling meet. The presenilin hub

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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Transport-Dependent Proteolysis of SREBP

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Protein topology of presenilin 1

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The establishment of polarity by hippocampal neurons in culture

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins

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Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion molecules

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Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

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Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

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Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

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7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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7 January 2021

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

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7 January 2021

Subcellular localization of presenilins: association with a unique membrane pool in cultured cells

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7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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7 January 2021

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

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7 January 2021

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

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7 January 2021

Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule

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7 January 2021

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

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7 January 2021

Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction.

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7 January 2021

Evidence for a physical interaction between presenilin and Notch

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7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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7 January 2021

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

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7 January 2021

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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7 January 2021

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

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7 January 2021

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Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

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7 January 2021

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7 January 2021

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

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7 January 2021

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

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7 January 2021

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

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7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

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7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

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7 January 2021

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

1 reference

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7 January 2021

Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a / CD18

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7 January 2021

Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion

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7 January 2021

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

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7 January 2021

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

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7 January 2021

Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.

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7 January 2021

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

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7 January 2021

A Substrate-Based Difluoro Ketone Selectively Inhibits Alzheimer's γ-Secretase Activity

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7 January 2021

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

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7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease

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7 January 2021

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

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7 January 2021

Telencephalin: a neuronal area code molecule?

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7 January 2021

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7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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7 January 2021

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

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7 January 2021

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Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11719200%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017