Telomere-regulating genes and the telomere interactome in familial cancers. (Q34784471)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25244922%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

review article

1 reference

title

Telomere-regulating genes and the telomere interactome in familial cancers (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25244922%20AND%20SRC:MED&resulttype=core&format=json

Carla Daniela Robles-Espinoza

17 February 2020

author

series ordinal

1

1 reference

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17 February 2020

3

Nicholas K Hayward

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25244922%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

author name string

Martin del Castillo Velasco-Herrera

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25244922%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

David J Adams

series ordinal

4

1 reference

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17 February 2020

publication date

22 September 2014

1 reference

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Molecular Cancer Research

17 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25244922%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

volume

13

1 reference

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17 February 2020

issue

2

1 reference

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17 February 2020

page(s)

211-222

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25244922%20AND%20SRC:MED&resulttype=core&format=json

Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing

17 February 2020

cites work

1 reference

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POT1 loss-of-function variants predispose to familial melanoma

7 July 2018

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Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma

7 July 2018

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Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type

7 July 2018

1 reference

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Lymphocyte telomere length is long in BRCA1 and BRCA2 mutation carriers regardless of cancer-affected status

7 July 2018

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7 July 2018

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The association of telomere length with colorectal cancer differs by the age of cancer onset

7 July 2018

1 reference

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G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding

7 July 2018

1 reference

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A novel dyskerin (DKC1) mutation is associated with familial interstitial pneumonia

7 July 2018

1 reference

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Epidemiology of idiopathic pulmonary fibrosis

7 July 2018

1 reference

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Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy.

7 July 2018

1 reference

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7 July 2018

1 reference

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A common variant in the SIAH2 locus is associated with estrogen receptor-positive breast cancer in the Chinese Han population

7 July 2018

1 reference

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The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas

7 July 2018

1 reference

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Telomere-end processing: mechanisms and regulation

7 July 2018

1 reference

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Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation

7 July 2018

1 reference

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Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia

7 July 2018

1 reference

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DNA repair genes are selectively mutated in diffuse large B cell lymphomas

7 July 2018

1 reference

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Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

7 July 2018

1 reference

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Frequency of TERT promoter mutations in human cancers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Functional characterization of human CTC1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease Coats plus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

HMGA1: a master regulator of tumor progression in triple-negative breast cancer cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomere shortening in human diseases

7 July 2018

1 reference

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Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia

7 July 2018

1 reference

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Human RTEL1 deficiency causes Hoyeraal-Hreidarsson syndrome with short telomeres and genome instability

7 July 2018

1 reference

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Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Identification of seven loci affecting mean telomere length and their association with disease

7 July 2018

1 reference

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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

7 July 2018

1 reference

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Telomere length and risk of melanoma, squamous cell carcinoma, and basal cell carcinoma

7 July 2018

1 reference

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POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia

7 July 2018

1 reference

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Constitutional mutations in RTEL1 cause severe dyskeratosis congenita

7 July 2018

1 reference

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A two-step mechanism for TRF2-mediated chromosome-end protection

7 July 2018

1 reference

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Highly recurrent TERT promoter mutations in human melanoma

7 July 2018

1 reference

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TERT promoter mutations in familial and sporadic melanoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Finding the end: recruitment of telomerase to telomeres

7 July 2018

1 reference

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Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly.

7 July 2018

1 reference

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Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans

7 July 2018

1 reference

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Expression profile of HMBOX1, a novel transcription factor, in human cancers using highly specific monoclonal antibodies

7 July 2018

1 reference

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7 July 2018

The telomere syndromes

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A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese

7 July 2018

1 reference

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Biogenesis of telomerase ribonucleoproteins

7 July 2018

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Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma

7 July 2018

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RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity

7 July 2018

1 reference

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The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

7 July 2018

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Removal of shelterin reveals the telomere end-protection problem

7 July 2018

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Genetic skin diseases predisposing to basal cell carcinoma.

7 July 2018

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Mutations in CTC1, encoding the CTS telomere maintenance complex component 1, cause cerebroretinal microangiopathy with calcifications and cysts

7 July 2018

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Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers

7 July 2018

1 reference

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Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus

7 July 2018

1 reference

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TIN2 stability is regulated by the E3 ligase Siah2.

7 July 2018

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Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3

7 July 2018

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Mutations in BRIP1 confer high risk of ovarian cancer

7 July 2018

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Differences in Disease Severity but Similar Telomere Lengths in Genetic Subgroups of Patients with Telomerase and Shelterin Mutations

7 July 2018

1 reference

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A role for heterochromatin protein 1γ at human telomeres

7 July 2018

1 reference

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Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication

7 July 2018

1 reference

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TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres.

7 July 2018

1 reference

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Genetic polymorphisms of DNA double strand break gene Ku70 and gastric cancer in Taiwan

7 July 2018

1 reference

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A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer

7 July 2018

1 reference

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Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase

7 July 2018

1 reference

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Hallmarks of Cancer: The Next Generation

7 July 2018

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Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

7 July 2018

1 reference

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Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita

7 July 2018

1 reference

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Telomeres in cancer and ageing

7 July 2018

1 reference

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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

7 July 2018

1 reference

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WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies

7 July 2018

1 reference

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The MRN complex in double-strand break repair and telomere maintenance

7 July 2018

1 reference

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Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression

7 July 2018

1 reference

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Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

7 July 2018

1 reference

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Alternative lengthening of telomeres: models, mechanisms and implications

7 July 2018

1 reference

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Telomeres: protecting chromosomes against genome instability

7 July 2018

1 reference

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High-mobility group box 1 and cancer

7 July 2018

1 reference

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Yeast telomerase subunit Est1p has guanine quadruplex-promoting activity that is required for telomere elongation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Conservation of telomere protein complexes: shuffling through evolution

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomere dysfunction in human diseases: the long and short of it!

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomerase modulates Wnt signalling by association with target gene chromatin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Cancer in dyskeratosis congenita

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Purification of proteins associated with specific genomic Loci

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

The telosome/shelterin complex and its functions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Structure of the Tribolium castaneum telomerase catalytic subunit TERT

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

7 July 2018

The telomerase database

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomere protection by mammalian Pot1 requires interaction with Tpp1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Protein composition of catalytically active human telomerase from immortal cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

The POT1-TPP1 telomere complex is a telomerase processivity factor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

RNase MRP RNA and human genetic diseases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Inside the mammalian telomere interactome: regulation and regulatory activities of telomeres

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Short telomeres, even in the presence of telomerase, limit tissue renewal capacity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

The effect of TERC haploinsufficiency on the inheritance of telomere length

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Consequences of mutations in the non-coding RMRP RNA in cartilage-hair hypoplasia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Shelterin: the protein complex that shapes and safeguards human telomeres

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomeres and human disease: ageing, cancer and beyond

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

The human Rap1 protein complex and modulation of telomere length

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

The c-Rel transcription factor and B-cell proliferation: a deal with the devil

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Targeted deletion reveals an essential function for the telomere length regulator Trf1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomerase in the human organism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Switching and signaling at the telomere

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomerase and human tumorigenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

X-linked dyskeratosis congenita is predominantly caused by missense mutations in the DKC1 gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

TRF2 Protects Human Telomeres from End-to-End Fusions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Extension of life-span by introduction of telomerase into normal human cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Normal human chromosomes have long G-rich telomeric overhangs at one end

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

A survey of telomerase activity in human cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

TRF1 is a dimer and bends telomeric DNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomerase activity in human germline and embryonic tissues and cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Excess of rare cancers in Werner syndrome (adult progeria)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Functional reintroduction of human telomeres into mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Progressive telomere shortening in aplastic anemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomerase gene mutations are associated with cirrhosis formation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Telomere shortening and chromosomal instability in myelodysplastic syndromes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Breast cancer survival is associated with telomere length in peripheral blood cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Association of the heterozygous germline I171V mutation of the NBS1 gene with childhood acute lymphoblastic leukemia.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Genetic variation in telomeric repeat binding factors 1 and 2 in aplastic anemia.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

TNFalpha induces rapid activation and nuclear translocation of telomerase in human lymphocytes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Generation of Telomeric G Strand Overhangs Involves Both G and C Strand Cleavage

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4278843

Longer relative telomere length in blood from women with sporadic and familial breast cancer compared with healthy controls

9 December 2018

1 reference

12 December 2020

Dyskeratosis congenita: Advances in the understanding of the telomerase defect and the role of stem cell transplantation

1 reference

12 December 2020

Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation

1 reference

12 December 2020

Severe telomere shortening in patients with paroxysmal nocturnal hemoglobinuria affects both GPI- and GPI+ hematopoiesis

1 reference

12 December 2020

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

1 reference

12 December 2020

Tankyrase promotes telomere elongation in human cells

1 reference

12 December 2020

Accelerated telomere shortening and telomerase activation in Fanconi's anaemia

1 reference

12 December 2020

10.1158/1541-7786.MCR-14-0305

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25244922%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25244922%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PubMed publication ID

25244922

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25244922%20AND%20SRC:MED&resulttype=core&format=json