Alternative splicing and evolution: diversification, exon definition and function (Q34618555)

3 August 2017

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title

Alternative splicing and evolution: diversification, exon definition and function (English)

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alternative mRNA splicing, via spliceosome

3 August 2017

main subject

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Hadas Keren

1

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3 August 2017

Galit Lev-Maor

series ordinal

2

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3 August 2017

Gil Ast

series ordinal

3

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3 August 2017

language of work or name

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8 April 2010

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3 August 2017

published in

Nature Reviews Genetics

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3 August 2017

volume

11

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3 August 2017

issue

5

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3 August 2017

page(s)

345-355

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A genomic view of alternative splicing

3 August 2017

cites work

1 reference

Alternative splicing and disease

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Splicing in disease: disruption of the splicing code and the decoding machinery

31 March 2020

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Listening to silence and understanding nonsense: exonic mutations that affect splicing

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Aberrant and alternative splicing in cancer

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Alternative isoform regulation in human tissue transcriptomes

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Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

31 March 2020

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Decrypting the genome's alternative messages

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31 March 2020

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RNA processing and its regulation: global insights into biological networks

31 March 2020

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Chromatin organization marks exon-intron structure

31 March 2020

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How did alternative splicing evolve?

31 March 2020

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SR proteins: a foot on the exon before the transition from intron to exon definition

31 March 2020

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Barriers to intron promiscuity in bacteria

31 March 2020

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Introns in protein-coding genes in Archaea

31 March 2020

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Gain and loss of an intron in a protein-coding gene in Archaea: the case of an archaeal RNA pseudouridine synthase gene.

31 March 2020

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Global analysis of exon creation versus loss and the role of alternative splicing in 17 vertebrate genomes

31 March 2020

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Comparative genomics and evolution of alternative splicing: the pessimists' science.

31 March 2020

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Alternative splicing: current perspectives

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The emergence of alternative 3' and 5' splice site exons from constitutive exons

31 March 2020

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The architecture of pre-mRNAs affects mechanisms of splice-site pairing.

31 March 2020

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Architectural limits on split genes

31 March 2020

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Patterns of intron gain and conservation in eukaryotic genes

31 March 2020

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Extensive, recent intron gains in Daphnia populations

31 March 2020

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Nonsense-mediated decay enables intron gain in Drosophila

31 March 2020

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Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome.

31 March 2020

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Large-scale comparative analysis of splicing signals and their corresponding splicing factors in eukaryotes

31 March 2020

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Systematic genome-wide annotation of spliceosomal proteins reveals differential gene family expansion

31 March 2020

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Large-scale comparison of intron positions among animal, plant, and fungal genes

31 March 2020

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Extremely intron-rich genes in the alveolate ancestors inferred with a flexible maximum-likelihood approach

31 March 2020

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New maximum likelihood estimators for eukaryotic intron evolution

31 March 2020

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Splicing in the eukaryotic ancestor: form, function and dysfunction

31 March 2020

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Remarkable interkingdom conservation of intron positions and massive, lineage-specific intron loss and gain in eukaryotic evolution

31 March 2020

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Rates of intron loss and gain: implications for early eukaryotic evolution

31 March 2020

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Three distinct modes of intron dynamics in the evolution of eukaryotes

31 March 2020

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Translational control of intron splicing in eukaryotes

31 March 2020

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Inter-kingdom conservation of mechanism of nonsense-mediated mRNA decay

31 March 2020

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Co-evolution of the branch site and SR proteins in eukaryotes

31 March 2020

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The pivotal roles of TIA proteins in 5' splice-site selection of alu exons and across evolution

31 March 2020

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Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing

31 March 2020

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The birth of an alternatively spliced exon: 3' splice-site selection in Alu exons

31 March 2020

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Low conservation of alternative splicing patterns in the human and mouse genomes.

31 March 2020

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Conservation of human alternative splice events in mouse

31 March 2020

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Evolution of alternative splicing: deletions, insertions and origin of functional parts of proteins from intron sequences

31 March 2020

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31 March 2020

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Origin of alternative splicing by tandem exon duplication

31 March 2020

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The multiplicity of domains in proteins

31 March 2020

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Directed evolution of proteins by exon shuffling

31 March 2020

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Protein domains correlate strongly with exons in multiple eukaryotic genomes--evidence of exon shuffling?

31 March 2020

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Tandem exon duplication tends to propagate rather than to create de novo alternative splicing.

31 March 2020

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Common exon duplication in animals and its role in alternative splicing

31 March 2020

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Alternative splicing of Alu exons--two arms are better than one

31 March 2020

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Intron phase correlations and the evolution of the intron/exon structure of genes

31 March 2020

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Genome evolution and the evolution of exon-shuffling--a review

31 March 2020

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Intron-dependent evolution: preferred types of exons and introns

31 March 2020

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Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity

31 March 2020

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Tandem repeats modify the structure of human genes hosted in segmental duplications

31 March 2020

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Structural organization of the 5' region of the thyroglobulin gene. Evidence for intron loss and "exonization" during evolution

31 March 2020

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Alu sequences in the coding regions of mRNA: a source of protein variability

31 March 2020

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Alu-containing exons are alternatively spliced

31 March 2020

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Transposable elements are found in a large number of human protein-coding genes

31 March 2020

1 reference

Short interspersed elements (SINEs) are a major source of canine genomic diversity

31 March 2020

1 reference

Origin and evolution of new exons in rodents

31 March 2020

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Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3

31 March 2020

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Evolution of the sugar receptors in insects

31 March 2020

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Alternative splicing of anciently exonized 5S rRNA regulates plant transcription factor TFIIIA.

31 March 2020

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Initial sequencing and analysis of the human genome

31 March 2020

1 reference

Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene

31 March 2020

1 reference

SERpredict: detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements

31 March 2020

1 reference

Diverse splicing patterns of exonized Alu elements in human tissues

31 March 2020

1 reference

Origin of primate orphan genes: a comparative genomics approach

31 March 2020

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The birth of new exons: mechanisms and evolutionary consequences

31 March 2020

1 reference

From "junk" to gene: curriculum vitae of a primate receptor isoform gene

31 March 2020

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Alu-SINE exonization: en route to protein-coding function

31 March 2020

1 reference

The origins and implications of Aluternative splicing

31 March 2020

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Alu exonization events reveal features required for precise recognition of exons by the splicing machinery

31 March 2020

1 reference

Minimal conditions for exonization of intronic sequences: 5' splice site formation in alu exons

31 March 2020

1 reference

Multifactorial interplay controls the splicing profile of Alu-derived exons

31 March 2020

1 reference

Exon creation and establishment in human genes

31 March 2020

1 reference

Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates

31 March 2020

1 reference

Lineage specific evolutionary events on SFTPB gene: Alu recombination-mediated deletion (ARMD), exonization, and alternative splicing events

31 March 2020

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Alternative splicing of conserved exons is frequently species-specific in human and mouse

31 March 2020

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The "alternative" choice of constitutive exons throughout evolution

31 March 2020

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Positive selection acting on splicing motifs reflects compensatory evolution

31 March 2020

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Intronic Alus influence alternative splicing

31 March 2020

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An Alu insertion in compound heterozygosity with a microduplication in GNPTAB gene underlies Mucolipidosis II

31 March 2020

1 reference

Exonization of Alu-generated splice variants in the survivin gene of human and non-human primates.

31 March 2020

1 reference

How prevalent is functional alternative splicing in the human genome?

31 March 2020

1 reference

Identification and analysis of alternative splicing events conserved in human and mouse

31 March 2020

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Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss

31 March 2020

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The importance of being divisible by three in alternative splicing

31 March 2020

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Widespread Evolutionary Conservation of Alternatively Spliced Exons in Caenorhabditis

31 March 2020

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Stochastic noise in splicing machinery

31 March 2020

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Alternative splicing and RNA selection pressure--evolutionary consequences for eukaryotic genomes

31 March 2020

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Fast rate of evolution in alternatively spliced coding regions of mammalian genes.

31 March 2020

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Splicing regulation: from a parts list of regulatory elements to an integrated splicing code

31 March 2020

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Differentiated evolutionary rates in alternative exons and the implications for splicing regulation

31 March 2020

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Sequence features responsible for intron retention in human

31 March 2020

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Nucleosome positioning as a determinant of exon recognition

31 March 2020

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Nucleosomes are well positioned in exons and carry characteristic histone modifications

31 March 2020

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Nucleosomal fluctuations govern the transcription dynamics of RNA polymerase II.

31 March 2020

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Differential chromatin marking of introns and expressed exons by H3K36me3.

31 March 2020

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Regulation of alternative splicing by histone modifications

31 March 2020

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Nucleosomes are preferentially positioned at exons in somatic and sperm cells

31 March 2020

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Chromatin polymorphism and the nucleosome superfamily: a genealogy.

31 March 2020

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Nucleosome conformational flexibility and implications for chromatin dynamics.

31 March 2020

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Nucleosome dynamics. Protein and DNA contributions in the chiral transition of the tetrasome, the histone (H3-H4)2 tetramer-DNA particle.

31 March 2020

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Alternative splicing in disease and therapy

31 March 2020

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Modulating the expression of disease genes with RNA-based therapy.

31 March 2020

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Mechanisms of alternative pre-messenger RNA splicing

31 March 2020

1 reference

Extensive Exon Reshuffling Over Evolutionary Time Coupled to Trans-Splicing in Drosophila

31 March 2020

1 reference

Molecular mechanisms of exon shuffling: illegitimate recombination

31 March 2020

1 reference

Current topics in genome evolution: molecular mechanisms of new gene formation

31 March 2020

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Exon shuffling and other ways of module exchange

31 March 2020

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Exon shuffling mimicked in cell culture

31 March 2020

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RNA editing by adenosine deaminases that act on RNA

31 March 2020

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Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome

31 March 2020

1 reference

RNA-editing-mediated exon evolution

31 March 2020

1 reference

Beyond DNA: RNA editing and steps toward Alu exonization in primates

31 March 2020

1 reference

RNA editing: a driving force for adaptive evolution?

31 March 2020

1 reference

Revealing the hidden relationship between nucleosomes and splicing

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20376054

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Transcriptome and genome conservation of alternative splicing events in humans and mice.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20376054

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG2776

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Dimensions Publication ID

3 August 2017

1009915786

0 references

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