HIV-1 Nef: a multifaceted modulator of T cell receptor signaling (Q34316824)

1 August 2017

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title

HIV-1 Nef: a multifaceted modulator of T cell receptor signaling (English)

1 reference

1 August 2017

Oliver T Fackler

2

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Libin Abraham

series ordinal

1

object named as

Libin Abraham

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1 August 2017

publication date

10 December 2012

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Cell Communication and Signaling

1 August 2017

published in

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1 August 2017

volume

10

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1 August 2017

issue

1

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1 August 2017

page(s)

39

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Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond

1 August 2017

cites work

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6 July 2018

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6 July 2018

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6 July 2018

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SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

6 July 2018

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Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease

6 July 2018

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Mechanisms of HIV-1 Nef Function and Intracellular Signaling

6 July 2018

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Understanding the structure and function of the immunological synapse

6 July 2018

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The LAT story: a tale of cooperativity, coordination, and choreography

6 July 2018

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Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins

6 July 2018

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Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse

6 July 2018

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The immunological synapse: a dynamic platform for local signaling

6 July 2018

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Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling

6 July 2018

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Implications of Nef: host cell interactions in viral persistence and progression to AIDS.

6 July 2018

1 reference

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Multiple microclusters: diverse compartments within the immune synapse

6 July 2018

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The immunological synapse, TCR microclusters, and T cell activation

6 July 2018

1 reference

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HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells

6 July 2018

1 reference

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The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.

6 July 2018

1 reference

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Inhibition of T-cell receptor-induced actin remodeling and relocalization of Lck are evolutionarily conserved activities of lentiviral Nef proteins

6 July 2018

1 reference

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HIV-1 Nef interferes with host cell motility by deregulation of Cofilin

6 July 2018

1 reference

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Ras/MAPK signaling from endomembranes

6 July 2018

1 reference

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Dynamic regulation of T-cell costimulation through TCR-CD28 microclusters

6 July 2018

1 reference

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T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

6 July 2018

1 reference

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Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo

6 July 2018

1 reference

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6 July 2018

1 reference

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Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B.

6 July 2018

1 reference

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Tailoring T-cell receptor signals by proximal negative feedback mechanisms

6 July 2018

1 reference

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Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells

6 July 2018

1 reference

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HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling

6 July 2018

1 reference

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Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting

6 July 2018

1 reference

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Regulation of HIV-1 latency by T-cell activation.

6 July 2018

1 reference

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Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist

6 July 2018

1 reference

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Inhibition of T-cell receptor signal transduction and viral expression by the linker for activation of T cells-interacting p12(I) protein of human T-cell leukemia/lymphoma virus type 1.

6 July 2018

1 reference

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Modulation of the immunological synapse: a key to HIV-1 pathogenesis?

6 July 2018

1 reference

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New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cells

6 July 2018

1 reference

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Regulation of T-cell activation by the cytoskeleton

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Persistence of cooperatively stabilized signaling clusters drives T-cell activation

6 July 2018

1 reference

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Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

T cell homeostasis in steady state and lymphopenic conditions

6 July 2018

1 reference

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

6 July 2018

1 reference

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Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells

6 July 2018

1 reference

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How T lymphocytes switch between life and death

6 July 2018

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Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1

6 July 2018

1 reference

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Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways

6 July 2018

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The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity

6 July 2018

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Endogenous factors enhance HIV infection of tissue naive CD4 T cells by stimulating high molecular mass APOBEC3G complex formation

6 July 2018

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Compartmentalized Ras/MAPK signaling

6 July 2018

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SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond

6 July 2018

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Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1.

6 July 2018

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Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

6 July 2018

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Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells

6 July 2018

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The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation

6 July 2018

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Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

6 July 2018

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Visualizing Ras signalling in real-time

6 July 2018

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Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein

6 July 2018

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Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.

6 July 2018

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HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane

6 July 2018

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The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes

6 July 2018

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6 July 2018

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Cooperative interactions of simian immunodeficiency virus Nef, AP-2, and CD3-zeta mediate the selective induction of T-cell receptor-CD3 endocytosis

6 July 2018

1 reference

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The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation

6 July 2018

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

6 July 2018

1 reference

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HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells

6 July 2018

1 reference

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Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

6 July 2018

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CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo

6 July 2018

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High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT.

6 July 2018

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Structure--function relationships in HIV-1 Nef.

6 July 2018

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Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators

6 July 2018

1 reference

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Cell signaling by receptor tyrosine kinases

6 July 2018

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T cell activation and the cytoskeleton

6 July 2018

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Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway

6 July 2018

1 reference

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H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

6 July 2018

1 reference

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The Nef protein of HIV-1 associates with rafts and primes T cells for activation

6 July 2018

1 reference

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Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

6 July 2018

1 reference

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The immunological synapse: a molecular machine controlling T cell activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

HIV-1 Nef increases T cell activation in a stimulus-dependent manner

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo.

6 July 2018

1 reference

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Induction of fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj14.

6 July 2018

1 reference

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Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells

6 July 2018

1 reference

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Three-dimensional segregation of supramolecular activation clusters in T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus

6 July 2018

1 reference

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Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia

6 July 2018

1 reference

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Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

6 July 2018

1 reference

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The role of HIV1 Nef in T-cell activation: Nef impairs induction of Th1 cytokines and interacts with the Src family tyrosine kinase Lck.

6 July 2018

1 reference

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Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

6 July 2018

1 reference

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Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function

6 July 2018

1 reference

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Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

6 July 2018

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The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeys

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 antigen.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

HIV-1 replication is controlled at the level of T cell activation and proviral integration

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

6 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

HIV Nef increases T cell ERK MAP kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

HIV-1 Nef limits communication between linker of activated T cells and SLP-76 to reduce formation of SLP-76-signaling microclusters following TCR stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534016

The HIV-1 Nef protein has a dual role in T cell receptor signaling in infected CD4+ T lymphocytes

28 October 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1478-811X-10-39

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23227982

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23227982

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1478-811X-10-39

1 reference

Dimensions Publication ID

1 August 2017

0 references

1 reference

1 August 2017

1 reference