Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes. (Q36112824)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22640559%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes (English)

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2 February 2020

0 references

2

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2 February 2020

Tomonori Nochi

5

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2 February 2020

author name string

Wei Zou

1

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2 February 2020

Richard L Watkins

3

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2 February 2020

John F Krisko

4

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2 February 2020

John L Foster

6

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2 February 2020

J Victor Garcia

7

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publication date

28 May 2012

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2 February 2020

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2 February 2020

volume

9

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2 February 2020

page(s)

44

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Vpu augments the initial burst phase of HIV-1 propagation and downregulates BST2 and CD4 in humanized mice

2 February 2020

cites work

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One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates

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2 October 2017

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Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo

2 October 2017

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2 October 2017

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Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism

2 October 2017

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Crystal Structure of NFAT Bound to the HIV-1 LTR Tandem κB Enhancer Element

2 October 2017

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HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein

2 October 2017

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Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice

2 October 2017

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Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses

2 October 2017

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2 October 2017

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Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef.

2 October 2017

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Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1

2 October 2017

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Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice

2 October 2017

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Entire genome of a strain of human immunodeficiency virus type 1 with a deletion of nef that was recovered 20 years after primary infection: large pool of proviruses with deletions of env.

2 October 2017

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CXCR4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immature infected thymocytes that resembles thymocyte negative selection

2 October 2017

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Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis

2 October 2017

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CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo

2 October 2017

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Separation of human immunodeficiency virus type 1 replication from nef-mediated pathogenesis in the human thymus

2 October 2017

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Lentivirus Nef specifically activates Pak2.

2 October 2017

1 reference

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Characterization of three nef-defective human immunodeficiency virus type 1 strains associated with long-term nonprogression. Australian Long-Term Nonprogressor Study Group

2 October 2017

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Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo.

2 October 2017

1 reference

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Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

2 October 2017

1 reference

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Regions of human immunodeficiency virus type 1 nef required for function in vivo

2 October 2017

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Grossly defective nef gene sequences in a human immunodeficiency virus type 1-seropositive long-term nonprogressor

2 October 2017

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Human immunodeficiency virus type 1 long terminal repeat variants from 42 patients representing all stages of infection display a wide range of sequence polymorphism and transcription activity.

2 October 2017

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Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice

2 October 2017

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The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

2 October 2017

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Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity

2 October 2017

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Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene

2 October 2017

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

2 October 2017

1 reference

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Identification of cis-acting repressive sequences within the negative regulatory element of human immunodeficiency virus type 1

2 October 2017

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Chicken ovalbumin upstream promoter transcription factor binds to a negative regulatory region in the human immunodeficiency virus type 1 long terminal repeat.

2 October 2017

1 reference

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

2 October 2017

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Activation of the human immunodeficiency virus type 2 enhancer is dependent on purine box and kappa B regulatory elements

2 October 2017

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Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized mice

2 October 2017

1 reference

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TFII-I regulates induction of chromosomally integrated human immunodeficiency virus type 1 long terminal repeat in cooperation with USF.

2 July 2018

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Construction and in vitro properties of HIV-1 mutants with deletions in "nonessential" genes

2 July 2018

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Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI.

2 July 2018

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Disease progression due to dual infection in an HLA-B57-positive asymptomatic long-term nonprogressor infected with a nef-defective HIV-1 strain

2 July 2018

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Clinical outcomes of elite controllers, viremic controllers, and long-term nonprogressors in the US Department of Defense HIV natural history study

23 September 2018

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Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1.

23 September 2018

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HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation

23 September 2018

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T-cell repopulation and thymic volume in HIV-1-infected adult patients after highly active antiretroviral therapy

23 September 2018

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Evidence for increased T cell turnover and decreased thymic output in HIV infection

23 September 2018

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Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort

23 September 2018

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23 September 2018

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Changes in thymic function with age and during the treatment of HIV infection

23 September 2018

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Crossref

https://api.crossref.org/works/10.1186%2F1742-4690-9-44

Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

21 January 2018

1 reference

12 December 2020

Declining CD4 T-cell counts in a person infected with nef-deleted HIV-1

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12 December 2020

Identification of attenuated variants of HIV-1 circulating recombinant form 01_AE that are associated with slow disease progression due to gross genetic alterations in the nef/long terminal repeat sequences

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12 December 2020

Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation

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12 December 2020

Slow disease progression and robust therapy-mediated CD4+ T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection

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12 December 2020

Identifiers

DOI

10.1186/1742-4690-9-44

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22640559%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22640559%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

22640559

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22640559%20AND%20SRC:MED&resulttype=core&format=json