Granzyme B: pro-apoptotic, antiviral and antitumor functions (Q34263689)

1 August 2017

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title

Granzyme B: pro-apoptotic, antiviral and antitumor functions (English)

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1 August 2017

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1

Joseph A Trapani

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1 August 2017

Vivien R Sutton

2

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1 August 2017

language of work or name

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1 October 2003

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Current Opinion in Immunology

1 August 2017

published in

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1 August 2017

volume

15

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1 August 2017

issue

5

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1 August 2017

page(s)

533-543

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Cytotoxic T lymphocytes: all roads lead to death

1 August 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Functional significance of the perforin/granzyme cell death pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

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https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

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https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Adenovirus L4-100K assembly protein is a granzyme B substrate that potently inhibits granzyme B-mediated cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis

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https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

A triple-mutated allele of granzyme B incapable of inducing apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Endocytosing the death sentence

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https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor

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https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Lymphocyte-mediated cytotoxicity.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

The mannose 6-phosphate/insulin-like growth factor II receptor is a nanomolar affinity receptor for glycosylated human leukemia inhibitory factor.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Interactions of recombinant and platelet transforming growth factor-beta 1 precursor with the insulin-like growth factor II/mannose 6-phosphate receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

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https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis

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https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Definition and redesign of the extended substrate specificity of granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1

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https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis

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https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Pro-apoptotic BH3-only Bcl-2 family members in vertebrate model organisms suitable for genetic experimentation

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https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway

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https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Suppression of lymphoma and epithelial malignancies effected by interferon gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzymes are essential for natural killer cell-mediated and perf-facilitated tumor control

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Cutting Edge: Granzyme B Proteolysis of a Neuronal Glutamate Receptor Generates an Autoantigen and Is Modulated by Glycosylation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzyme B/Perforin-Mediated Apoptosis of Jurkat Cells Results in Cleavage of Poly(ADP-ribose) Polymerase to the 89-kDa Apoptotic Fragment and Less Abundant 64-kDa Fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Pro-caspase-3 is a major physiologic target of caspase-8.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Catalytic properties of the caspases

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

Caspases - controlling intracellular signals by protease zymogen activation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900107-9

7 January 2021

10.1016/S0952-7915(03)00107-9

Identifiers

DOI

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1 August 2017

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