Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity (Q31909336)

4 July 2017

title

Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity (English)

1 reference

4 July 2017

2

Smyth MJ

1 reference

4 July 2017

Davis JE

1

1 reference

4 July 2017

Trapani JA

series ordinal

3

1 reference

4 July 2017

language of work or name

English

0 references

publication date

1 January 2001

1 reference

European Journal of Immunology

4 July 2017

published in

1 reference

4 July 2017

volume

31

1 reference

4 July 2017

issue

1

1 reference

4 July 2017

page(s)

39-47

1 reference

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

4 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Granule-mediated killing: pathways for granzyme B-initiated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Decreased tumor surveillance in perforin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Long-range disruption of gene expression by a selectable marker cassette

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Recruitment and activation of natural killer (NK) cells in vivo determined by the target cell phenotype. An adaptive component of NK cell-mediated responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Perforin dependence of natural killer cell-mediated tumor control in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Differential tumor surveillance by natural killer (NK) and NKT cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Perforin and serine esterase gene expression in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Xenospecific cytotoxic T lymphocytes use perforin- and Fas-mediated lytic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

Structure and biogenesis of lytic granules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200101%2931%3A1%3C39%3A%3AAID-IMMU39%3E3.0.CO%3B2-1

10.1002/1521-4141(200101)31:1<39::AID-IMMU39>3.0.CO;2-1

21 January 2018

Identifiers

DOI

1 reference

4 July 2017

1 reference