Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in β Cell Function and Dysfunction (Q26777039)

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29 February 2020

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Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in β Cell Function and Dysfunction (English)

1 reference

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29 February 2020

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14 August 2020

insulin-secreting cells

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12 October 2019

27 January 2021

reactive oxygen species

1 reference

4 November 2019

1 reference

17 November 2019

nicotinamide adenine dinucleotide

1 reference

18 November 2019

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18 November 2019

respiratory chain complex I

1 reference

12 December 2019

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14 August 2020

0 references

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26568959%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

author name string

Xiaoting Luo

series ordinal

1

1 reference

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29 February 2020

Rongrong Li

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2

1 reference

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English

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publication date

19 October 2015

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29 February 2020

14 August 2020

27 January 2021

19 July 2022

Journal of Diabetes Research

23 references

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24 March 2019

5 August 2019

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14 August 2020

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2015

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29 February 2020

page(s)

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Creative Commons Attribution 3.0 Unported

29 February 2020

copyright license

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on focus list of Wikimedia project

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cites work

Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion

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The Cellular Fate of Glucose and Its Relevance in Type 2 Diabetes

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Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy

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13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

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Cellular and molecular mechanisms of metformin: an overview

7 April 2017

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The nuclear encoded subunits of complex I from bovine heart mitochondria

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NADH shuttle system regulates K(ATP) channel-dependent pathway and steps distal to cytosolic Ca(2+) concentration elevation in glucose-induced insulin secretion

7 April 2017

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Aldose reductase in glucose toxicity: a potential target for the prevention of diabetic complications

7 April 2017

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Berberine promotes glucose consumption independently of AMP-activated protein kinase activation

7 April 2017

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Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme

7 April 2017

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Malic enzyme is present in mouse islets and modulates insulin secretion

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Aldose reductase and the role of the polyol pathway in diabetic nephropathy

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Oxidative Stress and Diabetic Complications

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The pathobiology of diabetic complications: a unifying mechanism

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Metformin and respiratory chain complex I: the last piece of the puzzle?

28 September 2017

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Pathogenesis of chronic hyperglycemia: from reductive stress to oxidative stress

28 September 2017

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Glucose-stimulated insulin secretion: A newer perspective

28 September 2017

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Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion

28 September 2017

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Assessment of the metabolic pathways associated with glucose-stimulated biphasic insulin secretion

28 September 2017

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Metformin--mode of action and clinical implications for diabetes and cancer

28 September 2017

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Diabetes and beta cell function: from mechanisms to evaluation and clinical implications

28 September 2017

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Assembly factors for the membrane arm of human complex I.

28 September 2017

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Post-translational modifications near the quinone binding site of mammalian complex I.

28 September 2017

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Mitochondrial function and insulin secretion.

28 September 2017

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Metabolic signaling in fuel-induced insulin secretion

28 September 2017

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NAD⁺ metabolism: a therapeutic target for age-related metabolic disease

28 September 2017

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NAD and ADP-ribose metabolism in mitochondria

28 September 2017

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Influence of metabolism on epigenetics and disease

28 September 2017

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Vascular complications of diabetes: mechanisms of injury and protective factors

28 September 2017

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The NAD ratio redox paradox: why does too much reductive power cause oxidative stress?

28 September 2017

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Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome

28 September 2017

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Mitochondrial signal transduction in pancreatic β-cells.

28 September 2017

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Complex I deficiency: clinical features, biochemistry and molecular genetics

28 September 2017

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The molecular mechanisms of pancreatic β-cell glucotoxicity: recent findings and future research directions

28 September 2017

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Mitochondrial dysfunction in pancreatic β cells

28 September 2017

1 reference

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Aldose reductase, oxidative stress, and diabetic mellitus

28 September 2017

1 reference

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Hyperglycemia and endothelial dysfunction in atherosclerosis: lessons from type 1 diabetes.

28 September 2017

1 reference

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Over-nutrition, obesity and insulin resistance in the development of β-cell dysfunction

28 September 2017

1 reference

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Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells

28 September 2017

1 reference

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Fuel-Stimulated Insulin Secretion Depends upon Mitochondria Activation and the Integration of Mitochondrial and Cytosolic Substrate Cycles

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Reactive oxygen species are produced at low glucose and contribute to the activation of AMPK in insulin-secreting cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?

28 September 2017

1 reference

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Impaired mitochondrial respiratory functions and oxidative stress in streptozotocin-induced diabetic rats.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Evidence for two sites of superoxide production by mitochondrial NADH-ubiquinone oxidoreductase (complex I).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

The dicarboxylate carrier plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from rat pancreatic beta cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Glyceraldehyde-3-phosphate dehydrogenase in retinal microvasculature: implications for the development and progression of diabetic retinopathy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Mitochondria mediated cell death in diabetes

28 September 2017

1 reference

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Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.

28 September 2017

1 reference

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The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: a review

28 September 2017

1 reference

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The production of reactive oxygen species by complex I.

28 September 2017

1 reference

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Oxidative stress: the vulnerable beta-cell

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes

28 September 2017

1 reference

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Glucolipotoxicity: fuel excess and beta-cell dysfunction.

28 September 2017

1 reference

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NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences

28 September 2017

1 reference

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Bovine complex I is a complex of 45 different subunits.

28 September 2017

1 reference

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A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Islet beta cell failure in type 2 diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Anaplerotic roles of pyruvate carboxylase in mammalian tissues

28 September 2017

1 reference

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In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Increased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Glucose-sensing mechanisms in pancreatic beta-cells.

28 September 2017

1 reference

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Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

NADH augments blood flow in physiologically activated retina and visual cortex.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Glucose-stimulated signaling pathways in biphasic insulin secretion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

28 September 2017

1 reference

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Diabetic vascular dysfunction: links to glucose-induced reductive stress and VEGF.

28 September 2017

1 reference

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Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Mitochondrial function in normal and diabetic beta-cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Human complex I defects in neurodegenerative diseases

28 September 2017

1 reference

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Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Hyperglycemic pseudohypoxia and diabetic complications.

28 September 2017

1 reference

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Glucokinase as pancreatic beta cell glucose sensor and diabetes gene

28 September 2017

1 reference

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The pancreatic beta-cell glucose sensor.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Human mitochondrial complex I dysfunction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Architecture of mammalian respiratory complex I.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Efficacy of Evolvulus alsinoides (L.) L. on insulin and antioxidants activity in pancreas of streptozotocin induced diabetic rats

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Superoxide production by the mitochondrial respiratory chain

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

All hexokinase isoenzymes coexist in rat hepatocytes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Mitochondrial complex I deficiency in Parkinson's disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4629043

Reactive oxygen species regulate prosurvival ERK1/2 signaling and bFGF expression in gliosis within the retina.

31 May 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Hyperosmolarity drives hypertension and CKD--water and salt revisited.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Superoxide is produced by the reduced flavin in mitochondrial complex I: a single, unified mechanism that applies during both forward and reverse electron transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Mitochondrial complex I impairment in leukocytes from type 2 diabetic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Intra-mitochondrial poly(ADP-ribosyl)ation: potential role for alpha-ketoglutarate dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Protective effects of Pycnogenol on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Baicalin reduces mitochondrial damage in streptozotocin-induced diabetic Wistar rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Baicalin improves antioxidant status of streptozotocin-induced diabetic Wistar rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Antioxidant effects of a grape seed extract in a rat model of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Antioxidant protection of Malaysian tualang honey in pancreas of normal and streptozotocin-induced diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Prevention by metformin of alterations induced by chronic exposure to high glucose in human islet beta cells is associated with preserved ATP/ADP ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F512618

Protective effect of secoisolariciresinol diglucoside against streptozotocin-induced diabetes and its mechanism

21 January 2018

1 reference

12 December 2020

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1 reference

12 December 2020

Influence of glucose on pyruvate carboxylase expression in pancreatic islets

1 reference

12 December 2020

Role of mitochondria in metabolism-secretion coupling of insulin release in the pancreatic beta-cell

1 reference

12 December 2020

Dependence on NADH produced during glycolysis for beta-cell glucose signaling

1 reference

12 December 2020

Antioxidant activity and protection of pancreatic β-cells by embelin in streptozotocin-induced diabetes

1 reference

12 December 2020

Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion

1 reference

12 December 2020

Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo

1 reference

12 December 2020

Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress

1 reference

12 December 2020

Lack of Glyconeogenesis in Pancreatic Islets: Expression of Gluconeogenic Enzyme Genes in Islets

1 reference

12 December 2020

Identifiers

DOI

10.1155/2015/512618

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26568959%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26568959%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

26568959

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26568959%20AND%20SRC:MED&resulttype=core&format=json