Fuel-Stimulated Insulin Secretion Depends upon Mitochondria Activation and the Integration of Mitochondrial and Cytosolic Substrate Cycles (Q39261010)

10 September 2017

Fuel-Stimulated Insulin Secretion Depends upon Mitochondria Activation and the Integration of Mitochondrial and Cytosolic Substrate Cycles (English)

1 reference

10 September 2017

1 reference

Gary W Cline

1

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10 September 2017

31 October 2011

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Diabetes & metabolism journal

10 September 2017

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10 September 2017

35

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10 September 2017

5

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10 September 2017

458-465

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Creative Commons Attribution-NonCommercial 3.0 Unported

10 September 2017

start time

1 January 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line

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Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter

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Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion

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Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.

10 September 2017

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Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function

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Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation

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Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets

10 September 2017

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Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell

10 September 2017

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10 September 2017

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Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion

10 September 2017

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A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion

10 September 2017

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10 September 2017

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13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

10 September 2017

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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

10 September 2017

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Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells

10 September 2017

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Molecular biology of adenosine triphosphate-sensitive potassium channels

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10 September 2017

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Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb’s cycle flux independent of ATP synthesis

10 September 2017

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13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells

10 September 2017

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Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

14 September 2017

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The mitochondrial malic enzymes. I. Submitochondrial localization and purification and properties of the NAD(P)+-dependent enzyme from adrenal cortex

14 September 2017

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Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues

14 September 2017

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Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion

25 September 2017

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Glucose-stimulated insulin secretion is not obligatorily linked to an increase in O2 consumption in betaHC9 cells

25 September 2017

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Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin

25 September 2017

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Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes

15 June 2018

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beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats

21 August 2018

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Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion

21 August 2018

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12 December 2020

Kinetics and regulation of hepatoma mitochondrial NAD(P) malic enzyme

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12 December 2020

Bicarbonate-carbon dioxide buffer system: a determinant of the mitochondrial pH gradient

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12 December 2020

The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion

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12 December 2020

10.4093/DMJ.2011.35.5.458

Identifiers

DOI

1 reference

release_xyvn7sqdbjg67knq7sadruedxm

10 September 2017

0 references

PMC publication ID

3221020

1 reference

PMC publication ID

3221020

10 September 2017

PubMed publication ID

22111036

1 reference

PMC publication ID

3221020