Scribd Logo
Upload

Welcome to Scribd!

  • 3 views

    Bio Printing

    Uploaded by

    jasminewuu2305

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd

    Bio Printing

    Uploaded by

    jasminewuu2305
    3 views7 pages

    Copyright

    © © All Rights Reserved

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    3 views7 pages

    Bio Printing

    Uploaded by

    jasminewuu2305

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 7

    Bioprinting

    Jasmine Wu
    3D Bioprinting
    3D bioprinting is a technology that uses bioinks combined with living cells to print 3D structures which resemble
    natural tissue. Currently, this technology is utilized in a wide variety of areas, such as tissue engineering and drug
    development.

    3D Bioprinters 3D Bioprinting Bioinks


    • Similar to 3D printers • Base material for bioprinting tissue-, organ-, or bonelike
    • Designed to print solid materials and handle sensitive structures with bioprinters
    material • Composed of the cells that are being used immersed in
    • Can be inkjet based, laser assisted, or extrusion based biopolymer gel or synthetic biomaterial
    • Cells could come from patients themselves and
    grown into more cells (cloning)
    • Can be cell-laden, scaffold-free or cell-free
    How it works
    • A digital file is used as a blueprint for
    printing (STL file from CAD software)
    • Uses bioinks to print structures made of
    living cells layer by layer
    • Cells naturally bond together to form living
    tissue
    • Imitates behaviour and structure of natural
    tissues
    • Enables researchers to study functions of the
    human body in vitro
    • More biologically relevant than in vitro
    studies performed in 2D
    Applications
    • Applied to various fields of study:
    • Tissue engineering and regenerative medicine
    • Transplantation and clinics
    • 3D printed skin, bone grafts, implants, 3D
    printed organs
    • Functioning bladders, grown using bioprinted
    tissue from patients’ own cells have already
    been transplanted into human body
    successfully!
    • Drug screening and high throughput assays
    • Bioprinted tissue can help determine a drug
    candidates efficacy sooner, saving money and
    time
    • Cancer research
    • Bioprinted cancer models
    Bioprinting: the Brain
    • Production of 3D bioprinted human brain tissue
    • Allowed for the creation of functioning neural networks
    • Developed a bioink using fibrin gel
    • Employed an extrusion-based bioprinting technique to deposit the gel in layers
    • Simulates brain structures like human cortex laminations.
    • Each 50mm thick layer were horizontally arranged to create thin, functional, multi-
    layered 3D-printed brain tissues with established cell compositions
    • The printed neuronal progenitors developed into neurons within weeks
    • Formed functional neural networks inside and across tissue layers
    • Underwent maturation and maintained tissue structure
    • Preserved consistent structure and enabled neural progenitor proliferation and formation
    of neural networks
    • Demonstrated the ability of 3D bioprinting to generate functioning brain tissues for
    simulating network activity in normal and pathological settings
    • Potential to print the full human brain, likewise many other organs
    Limitations and
    challenges
    • Expensive
    • Ethical concerns
    • Equal access to treatment, clinical
    safety complications, and the
    enhancement of human body
    • Selection of optimal biomaterials is critical,
    most materials so far are not the most
    biologically appropriate
    • The creation of vascular networks is the
    greatest challenge
    • Maintaining cell environment becomes
    difficult
    The Future
    • Used to face the crucial demands for repair
    and replacement of human organs and
    tissues
    • Organ donors become unnecessary,
    personalized human organs can be printed
    from their own cells or stem cells
    • Immunosuppression medicine will be
    unneeded after transplantation as organ
    is made of own cells
    • Increasing the convenience and efficacy of
    drug delivery

    You might also like