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STEM CELL TECHNOLOGIES

Written by
Godson Ifezurunachi Zoe
Department of Biological sciences
Programme microbiology
Reg number: 2020/20737MCB

www.ccu.edu.ng
Outline
• STEM CELL TECHNOLOGIES
STEM CELL TECHNOLOGIES
Stem cells are cells with the potential to develop
into many different types of cells in the body.
They serve as a repair system for the body.

Stem cell technologies involve the use of stem


cells, which are undifferentiated cells with the
ability to differentiate into specialized cell types.
TYPES OF STEM CELLS
• Embryonic Stem Cells (ESCs): Derived from
embryos, these cells have the potential to
differentiate into any cell type in the body.
• Adult or Somatic Stem Cells: Found in various
tissues, these cells can differentiate into specific
cell types related to the tissue they originate
from.
• Induced Pluripotent Stem Cells (iPSCs):
Created by reprogramming adult cells to behave
like embryonic stem cells, iPSCs can potentially
generate any cell type.
APPLICATIONS 0F STEM
CELL TECHNOLOGIES
• Regenerative Medicine:
• Tissue Repair: Stem cells can replace or repair damaged
tissues, making them crucial for treating injuries or
degenerative diseases.

• Drug Discovery and Development:


• In vitro Testing: Stem cells are used to test the safety and
efficacy of new drugs before clinical trials, providing a more
accurate representation of human cellular responses.

• Disease Modeling:
• iPSCs: Valuable for creating disease-specific cell lines,
allowing researchers to study genetic diseases and test
potential therapies.
CRISPR-Cas9 Technology
Gene Editing:
CRISPR-Cas9 enables precise modifications to
the stem cell genome, correcting genetic defects
or introducing desired changes.
Applications:
Used in research, therapy development, and
understanding gene function.
Organoids and 3D
Cultures
• Organoids: These are three-dimensional
structures derived from stem cells that mimic the
architecture and function of organs, providing a
more accurate representation for research and
drug testing.
• 3D Cultures: Stem cells can be grown in three-
dimensional cultures, allowing better simulation
of the in vivo environment
Applications:
Used for studying organ development, disease
mechanisms, and drug testing.
Clinical Trials
• Therapeutic Applications:
Neurodegenerative Diseases: Trials are exploring the use
of stem cells to treat conditions like Parkinson's and
Alzheimer's.
Cardiovascular Disorders: Stem cell therapies aim to
repair damaged heart tissue after events like heart attacks.
• Challenges:
Immune Rejection: Strategies are being developed to
overcome immune responses against transplanted stem
cells.
Tumor Formation: Monitoring and controlling the
potential for stem cells to form tumors are crucial
considerations.
BIOENGINEERING AND
TISSUE ENGINEERING
• Bioprinting:
Stem cells are being used in combination with
3D bioprinting technologies to create functional
tissues and organs.
• Synthetic Biology:
Advances in synthetic biology enable the
creation of artificial stem cells and the
manipulation of cellular functions for specific
purposes.
Ethical Considerations
• Embryonic Stem Cells:
Ethical concerns revolve around the destruction
of embryos, sparking debates on the moral status
of the embryo.
• iPSCs and Gene Editing:
The creation and use of iPSCs and gene editing
technologies require careful ethical
considerations to avoid misuse or unintended
consequences
Conclusion
Stem cell technologies have a lot of potential in
medicine and research. They come in different
types and can be used to treat diseases, test
drugs, and understand illnesses. Technologies
like gene editing and 3D cultures make these
advancements more precise and realistic.
Coal City University is an Innovative and Globally focused
university that offers students Quality you can count on!

www.ccu.edu.ng

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