Just what he needs,

And just what you wanted.

An overview of
the ORTHO VISION™ Analyzer
for ORTHO BioVue® Cassettes
 Jim Martin L. Quiambao, RMT
Laboratory Specialist

021435-140916
 Menu Assay

Ability to automate the full range of immunohematology testing.

• ABO/RH • Crossmatching
• Rh Phenotyping • Direct antiglobulin
• Antibody screen • Antigen testing
• Antibody identification
• Serial dilutions for
• Selected cell panel
titration studies

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 Must to know

Minimum 4-hour walk-away time under fully-loaded conditions and up to

24 hours of productivity

42 Patient samples 6 Sample racks

holding 7 tubes each

ORTHO BioVue®
140 Cassette supply
capacity
15 Minute daily maintenance
Day on-analyzer stability Day on-analyzer stability
3 for ORTHO 3% reagent
red blood cells for reverse 5 for ORTHO 0.8% reagent
red blood cells for antibody
grouping & antibody detection, 10mL vials*
detection, 3mL vials*

021435-140916 * See OAS Table 4

 Sample

  Antibody Screening Crossmatching Blood typing

40 ul of Patients 50 ul of PRBC
0.8% Plasma
40 ul Patient -
Plasma/Serum

10 ul of PRBC
3-5 % - 40 ul of Patient 40 ul of PRBC
Serum/Plasma

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 ORTHO BioVue® cassettes

Used in conjunction with Ortho Clinical Diagnostics’ trusted column

agglutination technology

+ Premium accuracy and standardized results offer the required

sensitivity and specificity

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Cassettes

Biovue Cassettes
Biovue cassettes utilizes Column Agglutination
Technology (CAT)
Foil Seal

Reaction Chamber
Reagent
Glass Beads
Foil seal
It act asserves as column
a filtration systemcover and prevents
that separates
Itcolumn
is where
It to the be
could sample and RBC reagent are dispensed.
agglutinateddry andAnti-sera,
up and Antihuman
protect it from
non-agglutinated Globulin
contamination.
RBCs.
or Diluent.
Cassette Type
 Column Agglutination Technology

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What’s inside:
The ORTHO VISION™ Analyzer
for ORTHO BioVue® Cassettes Top Down View

Pipettor arm
Gripper arm

Incubator Cassette punch set

Centrifuge 1
Imaging system
Cassette access area

Dual purpose
drawer Cassette waste Centrifuge 2
container
Patient sample and red cell
reagent load station

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 Monitoring Technology

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Unprecedented safety: Responsive safety checks and
Monitoring Technologies
balances gives you the ability to monitor every step in the
process.

+ Proprietary INTELLICHECK® Technology

+ E-Connectivity™ Technology
+ Advanced image verification
+ Virtual collaboration

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 Proprietary INTELLICHECK® Technology

Safety technology that verifies, documents, and resolves diagnostic

checks throughout sample processing.
•  Full traceability, operator notification, exception documentation

Custom
IntelliReports
whenever you
need them!

+ Confidence to detect analytical errors

+ Provides accurate and efficient process reporting
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 Proprietary INTELLICHECK® Technology

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 Proprietary INTELLICHECK® Technology

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 E-Connectivity™ Technology

24/7 remote data tracking

• Real-time, secure two-way interactive connection between the ORTHO
VISION™ Analyzer and Ortho Clinical Diagnostics Technical Support

+ Ensures instrument performance

+ Identifies pending issues and potential system improvements

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 Advanced image verification

Advanced image analysis that provides pre-qualification checks of the

front and back of every ORTHO BioVue® cassette & post process checks

+ Ensures confidence in the quality of every test result

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 Virtual collaboration

Lab staff can log on remotely from anywhere with a secure internet
connection for real-time interaction to review results

+ Ability to be connected when it matters most

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Unprecedented safety: Responsive safety checks and
Other Features
balances gives you the ability to monitor every step in the
process.

+ Continuous access
+ Increase Utilization
+ Reduced waste
+ ORTHO BioVue® cassettes
+ Intuitive interface

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 Continuous access

+ Allows for prioritization of STAT requests while handling full test volume

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 Increased Utilization

State of the art pipetting system and cassette punch set

+ Yields improved utilization of ORTHO BioVue® Cassette columns

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 Intuitive interface
User-friendly design
• Individual test progress tracker
• Tracks usage of cassettes, reagents, and more

+ Lets you deliver up-to-the-minute timing for in-progress tests

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 Holistic system status view
shows supply levels for all
consumables and samples
loaded onto the analyzer

Result summary screen

displays status of every test for
every sample that's been loaded on
to the analyzer – including
completed results and time
remaining for in process tests

Single result screen

displays high resolution front and
back cassette image results to aid
in result verification – available in
black and white and color image.
Image can also be magnified.
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 Results

  Antibody Screening Cross matching Blood typing

0.8% < 25 minutes <25 minutes -

3-5 %   < 20 minutes <10 minutes

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ORTHO Workstation
System Components

OWS Centrifuge

• Simple operation

• 10 cassette capacity

• Bi-phasic speed
o 2-minute centrifugation
o 3-minute centrifugation
System Components

OWS Incubator

• Temperature controlled

• 2 timers

• 20 cassette capacity

• (2 x 10 positions)
Column Agglutination Technology: Gel Vs. Beads

Gel CAT Glass Beads CAT

Centrifugation Time 10 minutes 5 minutes

Red Cell Suspension (RCS) 3-5% or 0.8% 3-5% or 0.8%

Concentration

RCS Preparation 0.8% RCS Preparation uses 3-5% or 0.8% Preparation

internal Diluent uses NSS or RCD
Blood Typing Turn Around More than 10 minutes Less than 10minutes
Time (TAT)

3-5% Crossmatching TAT More than 20 minutes (10 Less than 20 minutes (10
mins incubation+10 mins mins incubation+5 minutes
centrifugation) centrifugation)
0.8% Crossmatching TAT More than 25 minutes (15 Less than 25 minutes (15
mins incubation+10 mins mins incubation+5 mins
centrifugation) centrifugation)
Current Installation of Orthovision

30
Thank You
ORTHO VISION Systems
Two Instruments, one goal: science-driven safety and efficiency

ORTHO VISION™ is designed for ORTHO VISION™ Max is designed

small-to-mid size labs who need the for larger, higher-volume labs who are
benefits of automation (safety) but, in already automated and need greater
many instances, are testing manually due instrument capacity and throughput to
to space and cost constraints. drive lab efficiency.