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Cell Division

Meiosis
Cell Division – Mitosis (Review)
– Division of a somatic cell that results in 2 genetically
identical daughter cells
• Cells must divide for growth, repair of tissues, and
asexual reproduction
• Cell division begins in Interphase when the
chromosomes duplicate
Chromosomes
Parent cell duplicate 2 new daughter
cells identical to
parent cell

• Daughter cells are genetically identical to parent cell –


same kind and number of chromosomes
• Mitosis occurs in somatic or body cells
Ex: liver, heart, skin, stomach
• Every organism has its own unique number of
chromosomes. Humans have 46.
This is called its diploid number or the total number of
chromosomes in a somatic cell.
Diploid means “2 sets” and is written as “2N”.
• Body cells of adult organisms have 2 sets of
homologous (matching) chromosomes – 1 set from
female parent and 1 set from male parent
Cell Division –Meiosis
– the process in which the number of chromosomes in the
original cell is reduced by HALF through the separation of
homologous chromosomes
• Meiosis occurs in sex organs only
• Males (XY) – sex organs are the testes in humans
• Females (XX) – sex organs are the ovaries in humans
• Meiosis also occurs in the sex organs of other
animals, plants, fungi, etc…
Meiosis
Division 2

Division 1
Chromosomes
duplicate Daughter cells
have half as
many
chromosomes
Parent
as parent cell
cell
Meiosis produces sex cells –
cells with ½ the number of
chromosomes as the original
cell
• Males – meiosis produces
4 sperm
• Females – meiosis
produces 1 (viable) egg
The other 3 cells are
called polar bodies – they
give up their cytoplasm to
nourish the 1 good egg.
• Egg and sperm (sex cells)
are also called gametes
• Gametes have ½ the number of chromosomes as
somatic (body) cells. We call this the haploid number.
Haploid means “1 set” and is written as “N”.
If human diploid number is 46, what is its haploid
number? 23
Diploid # of a dog – 78 Haploid # of a dog – 39
Diploid # of a fly – 8 Haploid # of a fly – 4
Interphase I
• Similar to mitosis interphase.

• Chromosomes replicate (S phase).

• Each duplicated chromosome consist of two identical


sister chromatids attached at their centromeres.

• Centriole pairs also replicate.


Interphase I
• Nucleus and nucleolus visible.

chromatin nuclear
membrane

cell membrane

nucleolus
Homologous Chromosomes
• Pair of chromosomes (maternal and paternal) that are similar in
shape and size.
• Homologous pairs (tetrads) carry genes controlling the same
inherited traits.
• Each locus (position of a gene) is in the same position on
homologues.
• Humans have 23 pairs of homologous chromosomes.

a. 22 pairs of autosomes
b. 01 pair of sex chromosomes
Meiosis I (four phases)
• Cell division that reduces the chromosome number
by one-half.

• four phases:
a. prophase I
b. metaphase I
c. anaphase I
d. telophase I
Prophase I
• Longest and most complex phase (90%).
• Chromosomes condense.
• Synapsis occurs: homologous chromosomes come
together to form a tetrad.
• Tetrad is two chromosomes or four chromatids
(sister and nonsister chromatids).
Prophase I - Synapsis
Homologous chromosomes

sister chromatids sister chromatids


Tetrad
Karyotype
• A method of organizing the chromosomes of a cell in
relation to number, size, and type.
Homologous Chromosomes

eye color eye color


locus locus

hair color hair color


locus locus

Paternal Maternal
Sex Chromosomes
The Sex Chromosomes code for the sex of the offspring.
** If the offspring has two “X” chromosomes it will be a female.
** If the offspring has one “X” chromosome and one “Y” chromosome it will be a male.

In Humans the
“Sex
Chromosomes”
are the 23rd set

XX chromosome - female XY chromosome - male


Crossing Over - variation
nonsister chromatids Tetrad

chiasmata: site variation


of crossing over
Prophase I

spindle fiber
centrioles

aster
fibers
Metaphase I
• Shortest phase
• Tetrads align on the metaphase plate.
• INDEPENDENT ASSORTMENT OCCURS:
1. Orientation of homologous pair to poles is random.
2. Variation
3. Formula: 2n
Example: 2n = 4
then n = 2
thus 22 = 4 combinations
Metaphase I

OR

metaphase plate metaphase plate


Question:
• In terms of Independent Assortment -how
many different combinations of sperm could
a human male produce?
Answer
• Formula: 2n
• Human chromosomes: 2n = 46
n = 23

• 223 = ~8 million combinations


Anaphase I
• Homologous chromosomes separate and move
towards the poles.

• Sister chromatids remain attached at their


centromeres.
Anaphase I
Telophase I

• Each pole now has haploid set of chromosomes.

• Cytokinesis occurs and two haploid daughter cells


are formed.
Telophase I
Meiosis II
• No interphase II
(or very short - no more DNA replication)

• Remember: Meiosis II is similar to mitosis


Prophase II
• same as prophase in mitosis
Metaphase II
• same as metaphase in mitosis

metaphase plate metaphase plate


Anaphase II
• same as anaphase in mitosis
• sister chromatids separate
Telophase II

• Same as telophase in mitosis.


• Nuclei form.
• Cytokinesis occurs.
• Remember: four haploid daughter cells
produced.

gametes = sperm or egg


Telophase II
• When does meiosis occur in humans?
1. Males beginning at puberty
2. Females before birth – all eggs are produced before
birth and at puberty eggs mature
Chromosome Number
• Remember, chromosome number is unique to each
kind of organism and all cells (except sex cells) in an
organism have the same kind and number of
chromosomes.
Ex: All humans have 46 chromosomes and all cells in
the human body (except sperm and egg) have 46
chromosomes.
• This is why the chromosome number in sex cells must
be reduced in half by meiosis
Ex: Humans have 46 chromosomes in their somatic
cells, but 23 chromosomes in their sex cells
(egg and sperm)
WRONG!!!
Zygote develops into
embryo and finally adult
organism by mitosis
23
Fertilized egg –
zygote

46

23

Fertilization – process by which an egg and sperm unite


Zygote – fertilized egg
Embryo – organism in early stage of development
• Without meiosis …………

46 Fertilized egg –
zygote

92

46
Unique events in Meiosis
• Homologous (matching) chromosomes pair up before 1st
cell division
Homologous chromosomes:
-look alike
-code for same traits
-receive one from each parent
• During 1st division, homologous chromosomes exchange
genes during process called “crossing over”

• These homologous chromosomes separate during 2nd


division of meiosis – so chromosomes in gametes are
different from each other due to crossing over
• Crossing over increases genetic variation and is the
reason why siblings look different
No crossing over
– daughter cells
are identical to
parent cells

Crossing over
occurs –causes
genetic variation
(Daughter cells
are NOT identical
to parent cell)
Variation
• Important to population as the raw material for
natural selection.

• Question:
What are the three sexual sources of
genetic variation?
Answer:
1. crossing over (prophase I)

2. independent assortment (metaphase I)


3. random fertilization

Remember: variation is good!


Question:

• A cell containing 20 chromosomes (diploid) at


the beginning of meiosis would, at its completion,
produce cells containing how many
chromosomes?
Answer:
• 10 chromosomes (haploid)
Comparing Mitosis and Meiosis

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