Heart & Great Vessels: Structure, Function, Development

Biology 224
Human Anatomy and Physiology II

Week 2; Lecture 1; Monday
Dr. Stuart S. Sumida
Heart & Great Vessels:

Structure, Function,
Development
INTRODUCTION TO
BLOOD VESSELS
Blood vessels tubular structures, with particular named layers from
innermost to outermost:
INNERMOST
Tunica Intima (has three subcomponents):
Inner lining of simple epithelial cells attached to a basement
membrane.
Middle layer of fine connective tissue made up of collagen.
Internal elastic lamina outer elastic layer
Tunica Media smooth muscle, elastic fibers, other connictive tissue

components.
Tunica Adventitia (or Tunica Externa) mostly elastic and

collagenous fibers. (In large vessels this layer has dedicated nerves,
tiny blood vessles and lymphatics.
OUTERMOST
Tunica intima
Tunica media
Tunica externa
(adventicia)
Tunica intima
Tunica media
Tunica adventicia
The TUNICA MEDIA is relatively
much thinner in veins.
Veins usually have little or not smooth

muscle, expect in the largest of veins.
Veins have periodic valves to prevent

backflow.
Extremely thin
tunica media in a
vein.
ARTERIES to ARTERIOLES
Smallest definable arteries are arterioles.
They have relatively more smooth muscular tissue, less
elastic tissue.
Thus, they are more easily regulated by (autonomic)
nervous control.
Very smallest arterioles (terminal arterioles):
Have no internal elastic layer.
Tunica media densely supplied with sympathetic nerve
fibers.
VEINS TO VENULES
Some veins to have smooth muscle in them (the
very largest).
Have same layers as arteries, but tunica media is
much thinner.
Have relatively less elastic tissue.
Operate at low pressure.
Have periodic bicuspid-shaped valves to prevent
backflow.
Smallest (venules) receive capillary blood have
no tunica media.
Capillaries:
Blood to capillaries from arterioles.
Smallest and thinnest of vessels.
Usually constructed of only a single layer of

tunica intima.
Greatest loss of blood pressure is at capillaries.
Gas transfer takes place across wall.
Nutrient transfer takes place across walls.
Blood from capillaries to venules.

The first blood vessels of the
embryo form inside the
embryonic disc even before
somites appear. They form near
the edge of the yolksac (a
primitive condition inherited
from macrolecithal organisms
that stored yolk for food).
Angiogenetic cell clusters extend in an arc around the head end of
the ventral opening of the yolk sac. Initially, this means that the
angiogenetic cell clusters (and the blood vessel that forms from
them) have the pattern of a "horseshoe" if viewed from a dorsal or
ventral perspective.
An important point to understand is
that the coelom runs up and down
either side of the body.
At the head end, right underneath

the developing pharynx, the
coelom on the left communicates
with the coelom on the right.
Thus, the coelom cuts across the

midline here.
The brain grows at
an incredible rate. It
grows so fast that it
makes the head bend
around under the
embryo's body.
This is why the heart

winds up on the
VENTRAL SIDE of the
body.
The part of the heart ventral to the gut tube is a
single tube itself.
The tube exiting the heart at its cranial end is the

ventral aorta.
However, the heart cannot remain a simple tube

(like a fish), so it must be subdivided into a right
and left side.
A septum subdivides the heart into a left and right

side.
The tube exiting the heart at its cranial
end is the ventral aorta.
It also subdivides:
The right side connects with the lungs.
The left side supplies the body.
(More later)
Anatomy of
the Postnatal
Heart
Heart in
VENTRAL
view.
(You see
mostly
right
ventricle!)
Heart in
DORSAL
view.
(You see
mostly left
ventricle.)
HEART
The real
thing in
ventral
view.
Lungs have
been
removed.
Gross Anatomy of Heart
Right Atrium: Receives deoxygenated blood

from body.
Left Atrium: Receives oxygenated blood from

lungs.
Right Ventricle: Receives deoxygenated blood

from right atrium and sends it to lungs.
Left Ventricle: Receives oxygenated blood

from left atrium and sends it to body.
Walls of the ventricles:
Left wall is thicker!
Bicuspid
valve
Chordae
Tendonae
Trabeculae carnae Papillary muscles

Find:
1. Walls of the ventricles
2. Auricles
3. Inner walls of the atria
4. Fossa ovalis
5. Trabeculae carnae
6. Atrioventricular valve
(a) "Bicuspid valve"
(b) "Tricuspid valve"
7. Chordae tendonae
8. Papillary muscles
9. Aortic & pulmonary
valves
Blood Supply of the Heart Wall
1. Coronary arteries
(a) Left coronary artery
(b) Right coronary artery
(c) Interventricular branches
(d) Right marginal branch
2. Cardiac veins
Coronary arteries are the
FIRST branches of the
aorta!
1. Coronary arteries
(a) Left coronary artery
(b) Right coronary
artery
(c) Interventricular
branches
(d) Right marginal
branch
2. Cardiac veins
Heart in
VENTRAL
view.
(You see
mostly
right
ventricle!)
Heart in
DORSAL
view.
(You see
mostly left
ventricle.)
Characteristics of Cardiac Muscle
1. Cardiac muscle = intermediate

between skeletal & smooth muscle.
2. Cardiac muscle = uninucleate
3. Intercalated discs.
Function of the Heart & Control of Heartbeat
1. Contracts spontaneously; does not need nervous

stimulation to contract.
2. Motor nerves that supply the human heart = modulate
heart rate.
3. Sympathetic motor impulses speed up heart rate &
parasympathetic motor impulses slow it down.
SYMPATHETIC: UPPER THORACIC SEGMENTS (T3-T4) GO

UP TO THE NECK, AND COME BACK DOWN TO THE HEART.
Why would it do this?!?
PARASYMPATHETIC: VAGUS NERVE (X)

Intrinsic regulation of heart beat
System made up of cells called Purkinje fibers
(insulated from surrounding cells of heart.
Sinoatrial node is PACEMAKER OF HEART, and
beginning of process. Geenrates periodic impulses
that initiate contraction of right atrium.
Signal then runs to Atrioventricular node. Message is
passed along a track of Purkinje fibers called the...
Atrioventricular bundle. Atrioventricular bundle then
splits into right and left limbs/branches that pass to
individual inner ventricular walls on right and left.
Intrinsic regulation
of heart beat
1 1. Sinoatrial node is
PACEMAKER OF
HEART, and
beginning of process.
Geenrates periodic
impulses that initiate
contraction of right
atrium.
2. Signal then runs to
Atrioventricular
node. Message is
passed along a track
of Purkinje fibers
2 3 A-V bundle called the...
path shown 3. Atrioventricular
bundle.
with blue Atrioventricular
arrows bundle then splits
into right and left
limbs/branches that
pass to individual
M A X IM U M H EA R TR ATE
C A LC U LATIO N
(Suggested) MAXIMUM HEARTRATE can be calculated by the formula:
208 - (0.7)(your age) = normal

maximum heartrate.
H EA R TR ATE
Resting heartrate average is variable depending on ages, sex,

weight, etc.
MAXIMUM HEARTRATE used to be calculated by the formula:
220 - your age = normal maximum heartrate.
(This is now known to be oversimplified and incorrect.)
The Great Vessels of the
thorax are a logical extension
of the heart
Embryonic Origin of Great

Vessels: They are derivatives
of the aortic arches.
STOP here and review the
aortic arches!
Draw them
diagrammatically
This is in
your lab
manual!
Aortic Arch Summary:
Arch I: Mostly disappears

( a small part becomes a
bit of the maxillary
artery).
Arch II: DISAPPEARS

Arch III: CAROTID

ARCH becomes part of
carotid arteries.
Arch IV: AORTIC ARCH

-- Right side disappears.
Left side becomes ARCH
OF AORTA.
Arch V: DISAPPEARS
Arch VI: PULMONARY

ARCH Becomes
pulmonary artery to lungs.
Great Veins of the Thorax
1. Venous blood dumps in the right atrium of the heart.

(a) Blood from the cranial region enters via superior
vena cava
(b) Body blood enters via inferior vena cava
2. Inferior vena cava - passes through the diaphragm

after receiving blood from the abdominal gut.
3. Superior vena cave & its 3 tributaries:

(a) Azygous vein
(b) Right brachiocephalic vein
(c) Left brachiocephalic vein
Superior
Vena Cava
Hemiazygous
Vein
Azygous
Vein
Great Veins of the Thorax
1. Venous blood dumps in the right atrium of the heart.

(a) Blood from the cranial region enters via superior
vena cava
(b) Body blood enters via inferior vena cava
2. Inferior vena cava - passes through the diaphragm

after receiving blood from the abdominal gut.
3. Superior vena cave & its 3 tributaries:

(a) Azygous vein
(b) Right brachiocephalic vein
(c) Left brachiocephalic vein

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Biology 224

Human Anatomy and Physiology II

Heart & Great Vessels:

Tunica Media smooth muscle, elastic fibers, other connictive tissue

Tunica Adventitia (or Tunica Externa) mostly elastic and

Veins usually have little or not smooth

Veins have periodic valves to prevent

Smallest and thinnest of vessels.

Usually constructed of only a single layer of

Greatest loss of blood pressure is at capillaries.

Gas transfer takes place across wall.

Nutrient transfer takes place across walls.

Blood from capillaries to venules.

At the head end, right underneath

Thus, the coelom cuts across the

This is why the heart

The tube exiting the heart at its cranial end is the

However, the heart cannot remain a simple tube

A septum subdivides the heart into a left and right

The right side connects with the lungs.

The left side supplies the body.

Right Atrium: Receives deoxygenated blood

Left Atrium: Receives oxygenated blood from

Right Ventricle: Receives deoxygenated blood

Left Ventricle: Receives oxygenated blood

Trabeculae carnae Papillary muscles

1. Cardiac muscle = intermediate

2. Cardiac muscle = uninucleate

1. Contracts spontaneously; does not need nervous

SYMPATHETIC: UPPER THORACIC SEGMENTS (T3-T4) GO

PARASYMPATHETIC: VAGUS NERVE (X)

208 - (0.7)(your age) = normal

Resting heartrate average is variable depending on ages, sex,

Embryonic Origin of Great

Arch I: Mostly disappears

Arch II: DISAPPEARS

Arch III: CAROTID

Arch IV: AORTIC ARCH

Arch VI: PULMONARY

1. Venous blood dumps in the right atrium of the heart.

2. Inferior vena cava - passes through the diaphragm

3. Superior vena cave & its 3 tributaries:

1. Venous blood dumps in the right atrium of the heart.

2. Inferior vena cava - passes through the diaphragm

3. Superior vena cave & its 3 tributaries:

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