9 Nucleas and Ribosomes

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2021/2022 Worksheet # 9 1st Semester

International Section High School

Teacher's
Name
Noor Alsamarraie Grade
11 SAT
Subject Ap Biology Student's Name

Topic Nucleus and Ribosomes Date

Nucleus and Ribosomes


Noor Alsamarraie

10/25/2021
Ap Biology
Noor Alsamarraie
Nucleus and Ribosomes

The nucleus

The nucleus (plural, nuclei) houses the cell’s genetic material, or DNA, and is also
the site of synthesis for ribosomes, the cellular machines that assemble proteins.

Inside the nucleus, chromatin (DNA wrapped around proteins, described further
below) is stored in a gel-like substance called nucleoplasm.

Enclosing the nucleoplasm is the nuclear envelope, which is made up of two layers
of membrane: an outer membrane and an inner membrane. Each of these
membranes contains two layers of phospholipids, arranged with their tails pointing
inward (forming a phospholipid bilayer).

There’s a thin space between the two layers of the nuclear envelope, and this space
is directly connected to the interior of another membranous organelle,
the endoplasmic reticulum.

Nuclear pores, small channels that span the nuclear envelope, let substances enter
and exit the nucleus. Each pore is lined by a set of proteins, called the nuclear pore
complex, that control what molecules can go in or out.

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Nucleus and Ribosomes

How do you make a ribosome? Some chromosomes have sections of DNA that

encode ribosomal RNA, a type of structural RNA that combines with proteins to

make the ribosome. In the nucleolus, new ribosomal RNA combines with proteins to

form the subunits of the ribosome. The newly made subunits are transported out

through the nuclear pores to the cytoplasm, where they can do their job.

Some cell types have more than one nucleolus inside the nucleus. For instance, some

mouse cells have up to nucleoli. Prokaryotes, which do not have a nucleus, don't

have nucleoli and build their ribosomes in the cytosol.

Ribosomes

As mentioned above, ribosomes are the molecular machines responsible for protein

synthesis. A ribosome is made out of RNA and proteins, and each ribosome consists

of two separate RNA-protein complexes, known as the small and large subunits.

The large subunit sits on top of the small subunit, with an RNA template

sandwiched between the two. (A ribosome looks a little like a hamburger with a

puffy bun on top, an RNA “patty” threading through it.)

In eukaryotes, ribosomes get their orders for protein synthesis from the nucleus,

where portions of DNA (genes) are transcribed to make messenger RNAs (mRNAs).

An mRNA travels to the ribosome, which uses the information it contains to build a

protein with a specific amino acid sequence.

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Nucleus and Ribosomes

This process is called translation. Prokaryotes lack a nucleus, so their mRNAs are

transcribed in the cytoplasm and can be translated by ribosomes immediately.

Eukaryotic ribosomes may be either free, meaning that they are floating around in

the cytoplasm, or bound, meaning that they are attached to the endoplasmic

reticulum or the outside of the nuclear envelope. (In the first diagram in this

article, the red dots represent bound ribosomes; endoplasmic reticulum with bound

ribosomes is known as rough endoplasmic reticulum.)

Because protein synthesis is an essential function of all cells, ribosomes are found

in practically every cell type of multicellular organisms, as well as in prokaryotes

such as bacteria. However, eukaryotic cells that specialize in producing proteins

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Nucleus and Ribosomes

have particularly large numbers of ribosomes. For example, the pancreas is

responsible for producing and secreting large amounts of digestive enzymes, so the

pancreatic cells that make these enzymes have an unusually high number of

ribosomes.

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