9 Nucleas and Ribosomes
9 Nucleas and Ribosomes
9 Nucleas and Ribosomes
Teacher's
Name
Noor Alsamarraie Grade
11 SAT
Subject Ap Biology Student's Name
10/25/2021
Ap Biology
Noor Alsamarraie
Nucleus and Ribosomes
The nucleus
The nucleus (plural, nuclei) houses the cell’s genetic material, or DNA, and is also
the site of synthesis for ribosomes, the cellular machines that assemble proteins.
Inside the nucleus, chromatin (DNA wrapped around proteins, described further
below) is stored in a gel-like substance called nucleoplasm.
Enclosing the nucleoplasm is the nuclear envelope, which is made up of two layers
of membrane: an outer membrane and an inner membrane. Each of these
membranes contains two layers of phospholipids, arranged with their tails pointing
inward (forming a phospholipid bilayer).
There’s a thin space between the two layers of the nuclear envelope, and this space
is directly connected to the interior of another membranous organelle,
the endoplasmic reticulum.
Nuclear pores, small channels that span the nuclear envelope, let substances enter
and exit the nucleus. Each pore is lined by a set of proteins, called the nuclear pore
complex, that control what molecules can go in or out.
How do you make a ribosome? Some chromosomes have sections of DNA that
encode ribosomal RNA, a type of structural RNA that combines with proteins to
make the ribosome. In the nucleolus, new ribosomal RNA combines with proteins to
form the subunits of the ribosome. The newly made subunits are transported out
through the nuclear pores to the cytoplasm, where they can do their job.
Some cell types have more than one nucleolus inside the nucleus. For instance, some
mouse cells have up to nucleoli. Prokaryotes, which do not have a nucleus, don't
Ribosomes
As mentioned above, ribosomes are the molecular machines responsible for protein
synthesis. A ribosome is made out of RNA and proteins, and each ribosome consists
of two separate RNA-protein complexes, known as the small and large subunits.
The large subunit sits on top of the small subunit, with an RNA template
sandwiched between the two. (A ribosome looks a little like a hamburger with a
In eukaryotes, ribosomes get their orders for protein synthesis from the nucleus,
where portions of DNA (genes) are transcribed to make messenger RNAs (mRNAs).
An mRNA travels to the ribosome, which uses the information it contains to build a
This process is called translation. Prokaryotes lack a nucleus, so their mRNAs are
Eukaryotic ribosomes may be either free, meaning that they are floating around in
the cytoplasm, or bound, meaning that they are attached to the endoplasmic
reticulum or the outside of the nuclear envelope. (In the first diagram in this
article, the red dots represent bound ribosomes; endoplasmic reticulum with bound
Because protein synthesis is an essential function of all cells, ribosomes are found
responsible for producing and secreting large amounts of digestive enzymes, so the
pancreatic cells that make these enzymes have an unusually high number of
ribosomes.