B.pharM Syllabus

Subject Syllabus
23990101-T - HUMAN ANATOMY AND PHYSIOLOGY I – THEORY
Course Bachelor of Pharmacy (B.Pharm.) Semester - 1

Type of Course Core Courses
Prerequisite
1. Students would have studied about the gross morphology, structure and functions of
cell, skeletal, muscular, cardiovascular system of the human body.
2. They would have understood the various homeostatic mechanisms and their imbalances.
3. Students would able to identify the different types of bones in human body.
Course Objective 4. Students would be able to identify the various tissues of different systems of human
body.
5. Students would learn about the various experimental techniques related to physiology.
6. They would have learnt various techniques like blood group determination, blood
pressure measurement, blood cells counting
Teaching Scheme (Contact Hours) Examination Scheme

Theory Marks Practical Marks
Total
Lecture Tutorial Lab Credit SEE CIA SEE CIA Marks
3 1 - 4 75 25 - - 100
SEE - Semester End Examination, CIA - Continuous Internal Assessment (It consists of Assignments/Seminars/Presentations/MCQ Tests, etc.)
Course Content T - Teaching Hours | W - Weightage

Sr. Topics T W
1 Introduction to human body 10 20
Definition and scope of anatomy and physiology, levels of structural organization and body systems, basic life processes,
homeostasis, basic anatomical terminology.
Cellular level of organization
Structure and functions of cell, transport across cell membrane, cell division, cell junctions. General principles of cell
communication, intracellular signaling pathway activation by extracellular signal molecule, Forms of intracellular signaling: a)
contact dependent b)Paracrine c) Synaptic d) endocrine
Tissue level of organization
Classification of tissues, structure, location and functions of epithelial, muscular and nervous and connective tissues.
2 Integumentary system 10 25
Structure and functions of skin.

Skeletal system:
Divisions of skeletal system, types of bone, salient features and functions of bones of axial and appendicular skeletal system
Organization of skeletal muscle, physiology of muscle contraction, neuromuscular junction.
Joints:
Structural and functional classification, types of joints movements and its articulation
3 Body fluids and blood: 10 25
Body fluids, composition and functions of blood, hemopoeisis, formation of hemoglobin, anemia, mechanisms of
coagulation, blood grouping, Rh factors, transfusion, its significance and disorders of blood, Reticulo endothelial system.
Lymphatic system:
Lymphatic organs and tissues, lymphatic vessels, lymph circulation and functions of lymphatic system
4 Peripheral nervous system: 8 17
1
Subject Syllabus
23990101-T - HUMAN ANATOMY AND PHYSIOLOGY I – THEORY

Sr. Topics T W
Classification of peripheral nervous system: Structure and functions of sympathetic and parasympathetic nervous system.
Origin and functions of spinal and cranial nerves.
Special senses: Structure and functions of eye, ear, nose and tongue and their disorders.
5 Cardiovascular system: 7 13
Heart – anatomy of heart, blood circulation, blood vessels, structure and functions of artery, vein and capillaries, elements of
conduction system of heart and heart beat, its regulation by autonomic nervous system, cardiac output, cardiac cycle.
Regulation of blood pressure, pulse, electrocardiogram and disorders of heart.
Total 45 100
Course Outcomes
At the end of this course, students will be able to:
CO1 Explain the gross morphology, structure and functions of various organs of the human body.
Describe the various homeostatic mechanisms and their imbalances and explain coordinated working pattern of different
CO2
organs of each system.
CO3 Clarify various tissues and organs of different systems of human body.
CO4 Describe various experiments related to special senses and nervous system.
Reference Books
1. Human Anatomy for Nursing & Allied Sciences (TextBook)
By Dr. M.K.Anand, Dr. Meena Verma | Arora Medical Publishers Pvt.Ltd | 1
2. Fattana, Human anatomy (TextBook)
By Saunder’s | C P Prism, Pub. Year 1991
3. Human Anatomy (TextBook)
By B.D. Chaurasia
4. Human Anatomy (TextBook)
By Snell
2
Subject Syllabus
23990102-T - PHARMACEUTICAL ANALYSIS I – THEORY

Prerequisite
1. Learning this subject content will develop the ideas with the fundamental of analytical
chemistry among the pupil.
2. It constructs the fundamental methodology to prepare different strength of solutions.
3. It facilitates the fellow pupil to predict the sources of mistakes and errors.
Course Objective 4. It helps to develop the fundamentals of volumetric analytical skills.
5. It peculates the basic knowledge in the principles of electrochemical analytical
techniques
The student interpretation skills will be improve by the course content in terms of
choice of analytical techniques to perform the estimation of different category drugs.

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Pharmaceutical analysis, Errors, Pharmacopoeia. 10 20
i) Different techniques of analysis ii) Methods of expressing concentration iii) Primary and secondary standards. iv)
Preparation and standardization of various molar and normal solutions-Oxalic acid, sodium hydroxide, hydrochloric acid,
sodium thiosulphate, sulphuric acid, potassium permanganate and ceric ammonium sulphate Sources of errors, types of
errors, methods of minimizing errors, accuracy, precision and significant figures Sources of impurities in medicinal agents,
limit tests..
2 Acid base titration, Non aqueous titration, 10 25
Theories of acid base indicators, classification of acid base titrations and theory involved in titrations of strong, weak, and
very weak acids and bases, neutralization curves Solvents, acidimetry and alkalimetry titration and estimation of Sodium
benzoate and Ephedrine HCl
3 Precipitation titrations, Complexometric titration, Gravimetry 10 25
Mohr’s method, Volhard’s, Modified Volhard’s, Fajans method, estimation of sodium chloride. Classification, metal ion
indicators, masking and demasking reagents, estimation of Magnesium sulphate, and calcium gluconate. Principle and steps
involved in gravimetric analysis. Purity of the precipitate: co-precipitation and post precipitation, Estimation of barium
sulphate. Basic Principles, methods and application of diazotisation titration.
4 Redox titrations 8 17
(a) Concepts of oxidation and reduction (b) Types of redox titrations (Principles and applications) Cerimetry, Iodimetry,
Iodometry, Bromatometry, Dichrometry, Titration with potassium iodate
5 Electrochemical methods of analysis, Potentiometry, Polarography - 7 13
3
Subject Syllabus
23990102-T - PHARMACEUTICAL ANALYSIS I – THEORY

Sr. Topics T W
Introduction, Conductivity cell, Conductometric titrations, applications. Electrochemical cell, construction and working of
reference (Standard hydrogen, silver chloride electrode and calomel electrode) and indicator electrodes (metal electrodes
and glass electrode), methods to determine end point of potentiometric titration and applications. Principle, Ilkovic
equation, construction and working of dropping mercury electrode and rotating platinum electrode, applications.
Total 45 100
Course Outcomes
Learning this subject content will develop the ideas with the fundamental of analytical chemistry. It constructs the
fundamental methodology to prepare different strength of solutions and to identify the sources of impurities and
CO1
errors.Learning this subject content will develop the ideas with the fundamental of analytical chemistry. It constructs the
fundamental methodology to prepare different strength of solutions and to identify the sources of impurities and errors.
To compute analytical results and understand the theories of acids-bases and about the solvents used in the volumetric
CO2
titration.
To develop the fundamentals ideas about the principle, methods, various indicators used and applications of Precipitation,
CO3
Complexometric and Gravimetry Titration.
To acquire knowledge about the principles, concepts of oxidation and reduction, various types of redox titration and its
CO4
applications.
To understand the basic knowledge about the principles, instrumentation and applications of electrochemical analytical
CO5
techniques like conductometry, potentiometry and polarography.
Reference Books
1. Text Book of Quantitative Inorganic analysis
By A.I. Vogel, | London longmans, green & co., ltd.,
2. Inorganic Pharmaceutical Chemistry
By P. Gundu Rao, | Vallabh Publications / Prakashan
3. Textbook of Pharmaceutical Chemistry
By Bentley and Driver's | London, Oxford University Press
4. Analytical chemistry principles
By John H. Kennedy | Saunders College Pub.,
5. Indian pharmacopoeia
By Indian Pharmacopoeia Committee | Delhi : Manager of Publications
4
Subject Syllabus
23990103-T - PHARMACEUTICS I –THEORY

Prerequisite
Upon completion of this program the student will have fundamental knowledge in
Course Objective
preparing conventional dosage forms

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Historical background and development of profession of pharmacy 10 20
Historical background and development of profession of pharmacy: History of profession of Pharmacy in India in relation to
pharmacy education, industry and organization, Pharmacy as a career, Pharmacopoeias: Introduction to IP, BP, USP and
Extra Pharmacopoeia.
Dosage forms: Introduction to dosage forms, classification and definitions
Prescription: Definition, Parts of prescription, handling of Prescription and Errors in prescription.
Posology: Definition, Factors affecting posology. Pediatric dose calculations based on age, body weight and body surface
area.
2 Pharmaceutical calculations 10 25
Pharmaceutical calculations: Weights and measures – Imperial & Metric system, Calculations involving percentage solutions,
alligation, proof spirit and isotonic solutions based on freezing point and molecular weight.
Powders: Definition, classification, advantages and disadvantages, Simple & compound powders – official preparations,
dusting powders, effervescent, efflorescent and hygroscopic powders, eutectic mixtures. Geometric dilutions.
Liquid dosage forms: Advantages and disadvantages of liquid dosage forms. Excipients used in formulation of liquid dosage
forms. Solubility enhancement techniques
3 Monophasic liquids 8 25
Monophasic liquids: Definitions and preparations of Gargles, Mouthwashes, Throat Paint, Eardrops, Nasal drops, Enemas,
Syrups, Elixirs, Liniments and Lotions.
Biphasic liquids:
Suspensions: Definition, advantages and disadvantages, classifications, Preparation of suspensions; Flocculated and
Deflocculated suspension & stability problems and methods to overcome.
Emulsions: Definition, classification, emulsifying agent, test for the identification of type of Emulsion, Methods of
preparation & stability problems and methods to overcome.
4 Suppositories 8 17
5
Subject Syllabus

Sr. Topics T W
Suppositories: Definition, types, advantages and disadvantages, types of bases, methods of preparations. Displacement
value & its calculations, evaluation of suppositories.
Pharmaceutical incompatibilities: Definition, classification, physical, chemical and therapeutic incompatibilities with
examples
5 Semisolid dosage 7 13
Semisolid dosage forms: Definitions, classification, mechanisms and factors influencing dermal penetration of drugs.
Preparation of ointments, pastes, creams and gels. Excipients used in semi solid dosage forms. Evaluation of semi solid
dosages forms
Total 43 100
Course Outcomes
CO1 To know the history of profession of pharmacy
CO2 To understand the basics of different dosage forms, pharmaceutical incompatibilities and pharmaceutical calculations
CO3 To understand the professional way of handling the prescription
CO4 To prepare various conventional dosage forms
Reference Books
1. Pharmaceutical Dosage Form and Drug Delivery System, (TextBook)
By H.C. Ansel et al., | Lippincott Williams and Walkins, New Delhi.
2. Dispensing for Pharmaceutical Students,
By Carter S.J., | Cooper and Gunn’s CBS publishers, New Delhi.
3. Pharmaceutics, The Science& Dosage Form Design,
By M.E. Aulton, | Churchill Livingstone, Edinburgh.
5. British pharmacopoeia
By Medicines and Healthcare products Regulatory Agency | TSO (The Stationery Office)
6. Theory and Practice of Industrial Pharmacy
By Lachmann | Lea& Febiger Publisher, The University of Michigan.
7. The Science and Practice of Pharmacy,
By Alfonso R. Gennaro Remington | Lippincott Williams, New Del
8. Cooper and Gunn’s. Tutorial Pharmacy,
By Carter S.J., | CBS Publications, New Delhi.
9. Bentley’s Text Book of Pharmaceutics,
By E.A. Rawlins, English Language Book Society, | Elsevier Health Sciences, USA
10. Pharmaceutical Pelletization Technology,
By Isaac Ghebre Sellassie: | Marcel Dekker, INC, New York
11. Pharmaceutical Emulsions and Suspensions,
By Francoise Nieloud and Gilberte Marti-Mestres | Marcel Dekker, INC, New York.
6
Subject Syllabus
7
Subject Syllabus
23990104-T - PHARMACEUTICAL INORGANIC CHEMISTRY –
THEORY

Prerequisite
1. Well acquainted with the principles of limit tests.
2. Familiar with different classes of inorganic pharmaceuticals and their analysis
3. Identification of different anions, cations and different inorganic pharmaceuticals.
Course Objective 4. Knowledge about the sources of impurities and methods to determine the impurities in
inorganic drugs and pharmaceuticals
5. understand the medicinal and pharmaceutical importance of inorganic compounds
6. To have been introduced to a variety of inorganic drug classes

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Impurities in pharmaceutical substances: 10 20
History of Pharmacopoeia, Sources and types of impurities, principle involved in the limit test for Chloride, Sulphate, Iron,
Arsenic, Lead and Heavy metals, modified limit test for Chloride and Sulphate
General methods of preparation, assay for the compounds superscripted with asterisk (*) properties and medicinal uses of
inorganic compounds belonging to the following classes
2 Acids, Bases and Buffers: 10 25
Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation, stability, buffered isotonic
solutions, measurements of tonicity, calculations and methods of adjusting isotonicity.
Major extra and intracellular electrolytes: Functions of major physiological ions, Electrolytes used in the replacement
therapy: Sodium chloride*, Potassium chloride, Calcium gluconate* and Oral Rehydration Salt (ORS), Physiological acid base
balance.
Dental products: Dentifrices, role of fluoride in the treatment of dental caries, Desensitizing agents, Calcium carbonate,
Sodium fluoride, and Zinc eugenol cement
3 Gastrointestinal agents Cathartics, 10 25
Acidifiers: Ammonium chloride* and Dil. HCl
Antacid: Ideal properties of antacids, combinations of antacids, Sodium Bicarbonate*, Aluminum hydroxide gel, Magnesium
hydroxide mixture
Cathartics: Magnesium sulphate, Sodium orthophosphate, Kaolin and Bentonite.
Antimicrobials: Mechanism, classification, Potassium permanganate, Boric acid, Hydrogen peroxide*, Chlorinated lime*,
Iodine and its preparations
4 Miscellaneous compounds: 8 17
8
Subject Syllabus
23990104-T - PHARMACEUTICAL INORGANIC CHEMISTRY –
THEORY

Sr. Topics T W
Expectorants: Potassium iodide, Ammonium chloride*. Emetics: Copper sulphate*, Sodium potassium tartarate
Haematinics: Ferrous sulphate*, Ferrous gluconate
Poison and Antidote: Sodium thiosulphate*, Activated charcoal, Sodium nitrite333
Astringents: Zinc Sulphate, Potash Alum
5 Radiopharmaceuticals: 7 13
Radio activity, Measurement of radioactivity, Properties of a, ß, γ radiations, Half-life, radio isotopes and study of
radio isotopes - Sodium iodide I131, Storage conditions, precautions & pharmaceutical application of radioactive substances.
Total 45 100
Course Outcomes
Students will be able to well acquainted with the sources of impurities, principles of limit tests and methods to determine
the impurities in pharmaceuticals
CO1
Students will be able to know about preparation, properties, assay and applications of buffers, dental products, major extra
CO2
cellular and intracellular electrolytes in Pharmacy.
CO3 Students will be able to know about preparation, properties, assay and applications of GIT agents.
Students will be able to know about preparation, properties, assay and applications of expectorants, emetics, antidotes and
CO4
antimicrobial agents.
CO5 Students will be able to know about the concepts, principles, handling, storage and application of radiopharmaceuticals.
Reference Books
1. Text Book of Quantitative Inorganic analysis
By A.I. Vogel, | London longmans, green & co., ltd.,
By P. Gundu Rao, | Vallabh Publications / Prakashan
By M.L Schroff, | National Book Centre, Calcutta 1968
4. Textbook of Pharmaceutical Chemistry
By Bentley and Driver's | London, Oxford University Press
By Anand & Chatwal | Himalaya Pub. House
9
Subject Syllabus
23990105-T - COMMUNICATION SKILLS – THEORY

Type of Course Skill Enhancement Courses
Prerequisite
This course will prepare the young pharmacy student to interact effectively with doctors, nurses,
dentists, physiotherapists and other health workers. At the end of this course the student will get the
Course Objective
soft skills set to work cohesively with the team as a team player and will add value to the pharmaceutical
business.

Total
2 - - 2 35 15 - - 50

Sr. Topics T W
1 Communication Skills, Barriers to communication, Perspectives in Communication 7 23
Communication Skills: Introduction, Definition, The Importance of Communication, The Communication Process – Source,
Message, Encoding, Channel, Decoding, Receiver, Feedback, Context
Barriers to communication: Physiological Barriers, Physical Barriers, Cultural Barriers, Language Barriers, Gender Barriers,
Interpersonal Barriers, Psychological Barriers, Emotional barriers
Perspectives in Communication: Introduction, Visual Perception,
Language, Other factors affecting our perspective - Past Experiences, Prejudices, Feelings, Environment
2 Elements of Communication, Communication Styles 7 24
Elements of Communication: Introduction, Face to Face Communication – Tone of Voice, Body Language (Non-verbal
communication), Verbal Communication, Physical Communication
Communication Styles: Introduction, The Communication Styles Matrix with example for each -Direct Communication Style,
Spirited Communication Style, Systematic Communication Style, Considerate
Communication Style
3 Basic Listening Skills, Effective Written Communication, Writing Effectively 7 23
Basic Listening Skills: Introduction, Self-Awareness, Active Listening, Becoming an Active Listener, Listening in Difficult
Situations
Effective Written Communication: Introduction, When and When Not to Use Written Communication - Complexity of the
Topic, Amount of Discussion Required, Shades of Meaning, Formal Communication
Writing Effectively: Subject Lines, Put the Main Point First, Know Your Audience, Organization of the Message
4 Interview Skills, Giving Presentations 5 17
Interview Skills: Purpose of an interview, Do‘s and Dont‘s of an interview

Giving Presentations: Dealing with Fears, Planning your Presentation, Structuring Your Presentation, Delivering Your
Presentation, Techniques of Delivery
5 Group Discussion 4 13
10
Subject Syllabus
23990105-T - COMMUNICATION SKILLS – THEORY

Sr. Topics T W
Group Discussion: Introduction, Communication skills in group discussion, Do’s and Dont’s of group discussion
Total 30 100
Course Outcomes
CO1 Understand the behavioral needs for a Pharmacist to function effectively in the areas of pharmaceutical operation
CO2 Communicate effectively (Verbal and Non Verbal)
CO3 Effectively manage the team as a team player
CO4 Develop interview skills
CO5 Develop Leadership qualities and essentials
Reference Books
1. Basic communication skills for Technology,
By Andreja. J. Ruther Ford,
2. Communication skills,
By Sanjay Kumar, Pushpalata,
3. Organizational Behaviour
By Stephen .P. Robbins
4. Brilliant- Communication skills
By Gill Hasson
5. The Ace of Soft Skills: Attitude, Communication and Etiquette for success,
By Gopala Swamy Ramesh
6. Developing your influencing skills,
By Deborah Dalley, Lois Burton, Margaret, Green hall,
7. Communication skills for professionals,
By Konar nira,
8. Personality development and soft skills,
By Barun K Mitra
9. Soft skill for everyone
By Butter Field
10. Soft skills and professional communication,
By Francis Peters SJ,
11. Effective communication,
By John Adair
12. Bringing out the best in people
By Aubrey Daniels,
11
Subject Syllabus
23990106-T - REMEDIAL BIOLOGY - THEORY

Type of Course Basic Science
Prerequisite
The main aim of this course is to make aware the students to understand and learn about :
1. Cell biology ( Basic Nature of Plant cell and Animal cell)
2. Classification System of both Plants & Animals
Course Objective
3. Various tissue system and organ system in plant and animals
4. Theory of evolution
5. Anatomy and Physiology of plants and animals

Total
2 - - 2 35 15 - - 50

Sr. Topics T W
1 Living world 7 20
•
Definition and characters of living organisms;
•
Diversity in the living world;
•
Binomial nomenclature ;
•
Five kingdoms of life and basis of classification. Salient features of Monera, Potista, Fungi, Animalia and Plantae,
Virus.
Morphology of Flowering plants:
• Morphology of different parts of flowering plants – Root, stem, inflorescence, flower, leaf, fruit, seed.
• General Anatomy of Root, stem, leaf of monocotyledons & Dicotylidones.
2 Body fluids and circulation; 7 25
• Composition of blood, blood groups, coagulation of blood;
• Composition and functions of lymph;
• Human circulatory system;
• Structure of human heart and blood vessels;
• Cardiac cycle, cardiac output and ECG
Digestion and Absorption:
• Human alimentary canal and digestive glands;

• Role of digestive enzymes;
• Digestion, absorption and assimilation of digested food.
Breathing and respiration:
• Human respiratory system;

• Mechanism of breathing and its regulation;
• Exchange of gases, transport of gases and regulation of respiration ;
• Respiratory volumes
3 Excretory products and their elimination: 7 25
12
Subject Syllabus

Sr. Topics T W
• Modes of excretion;
• Human excretory system- structure and function;
• Urine formation;
• Rennin angiotensin system
Neural control and coordination:
• Definition and classification of nervous system;

• Structure of a neuron;
• Generation and conduction of nerve impulse;
• Structure of brain and spinal cord;
• Functions of cerebrum, cerebellum, hypothalamus and medulla oblongata.
Chemical coordination and regulation:
• Endocrine glands and their secretions;

• Functions of hormones secreted by endocrine glands.
Human reproduction:
• Parts of female reproductive system;

• Parts of male reproductive system;
• Spermatogenesis and Oogenesis;
• Menstrual cycle
4 Plants and mineral nutrition: 5 17

• Essential mineral, macro and micronutrients;
• Nitrogen metabolism, Nitrogen cycle, biological nitrogen fixation.
Photosynthesis:
• Autotrophic nutrition, photosynthesis, Photosynthetic pigments,

• Factors affecting photosynthesis.
5 Plant respiration: 4 13
• Respiration, glycolysis, fermentation (anaerobic).
Plant growth and development:
• Phases and rate of plant growth, Condition of growth, Introduction to plant growth regulators.
Cell - The unit of life:
• Structure and functions of cell and cell organelles. Cell division.
Tissues:
• Definition, types of tissues, location and functions.
Total 30 100
Course Outcomes
CO1 To know the classification and salient features of five kingdoms of living organisms.
CO2 To understand the basic components of anatomy and physiology of plant.
CO3 To understand the basic components of anatomy and physiology of animal with special reference to human.
CO4 To understand the detail structure and function of cell and cell organelles.
13
Subject Syllabus
Reference Books
1. Text book of Biology (TextBook)
By S. B. Gokhale | Nirali Prakashan
2. A Text book of Biology
By Dr. Thulajappa and Dr. Seetaram | Expert Educational Publishers
14
Subject Syllabus
23990107-T - REMEDIAL MATHEMATICS – THEORY

Prerequisite
1. Apply mathematical concepts and principles to perform computations for
Pharmaceutical Sciences.
2. Create, use and analyze mathematical representations and mathematical relationships
Course Objective
3. Communicate mathematical knowledge and understanding to help in the field of
Clinical Pharmacy
4. Perform abstract mathematical reasoning

Total
2 - - 2 35 15 - - 50

Sr. Topics T W
1 Partial fraction 6 20
Introduction, Polynomial, Rational fractions, Proper and Improperfractions, Partial fraction , Resolving into Partial fraction,
Application ofPartial Fraction in Chemical Kinetics and Pharmacokinetics
Logarithms: Introduction, Definition, Theorems/Properties of logarithms, Common logarithms, Characteristic and Mantissa,
worked examples, application of logarithm to solve pharmaceutical problems.
Function: Real Valued function, Classification of real valued functions,
Limits and continuity : Introduction , Limit of a function, Definition of limit of a function.
2 Matrices and Determinant, 6 20
Introduction matrices, Types of matrices, Operation on matrices,Transpose of a matrix, Matrix Multiplication, Determinants,
Properties of determinants , Product of determinants, Minors and co-Factors, Adjoint or adjugate of a square matrix ,
Singular and non-singular matrices, Inverse of a matrix, Solution of system of linear of equations using matrix method,
Cramer’s rule, Characteristic equation and roots of a square matrix, Cayley–Hamilton theorem, Application of Matrices in
solving Pharmacokinetic equations.
3 Calculus 6 20
Differentiation : Introductions, Derivative of a function, Derivative of aconstant, Derivative of a product of a constant and a
function , Derivative of the sum or difference of two functions, Derivative of the product of two functions (product formula),
Derivative of the quotient of two functions(Quotient formula) – Without Proof, Derivative of xn w.r.tx, where n is any
rational number, Derivative of ex, Derivative of loge x , Derivative of ax, Derivative of trigonometric functionsfrom first
principles (without Proof), Successive Differentiation, Conditions for a function to be a maximum or a minimum at a point.
Application
4 Analytical Geometry 6 20
15
Subject Syllabus
23990107-T - REMEDIAL MATHEMATICS – THEORY

Sr. Topics T W
Introduction: Signs of the Coordinates, Distance formula,

Straight Line : Slope or gradient of a straight line, Conditions for parallelism and perpendicularity of two lines, Slope of a line
joining two points, Slope – intercept form of a straight line.
Integration: Introduction, Definition, Standard formulae, Rules of integration, Method of substitution, Method of Partial
fractions, Integration by parts, definite integrals, application
5 Differential Equations 6 20
Some basic definitions, Order and degree, Equations in separable form, Homogeneous equations, Linear Differential
equations, Exact equations, Application in solving Pharmacokinetic equations
Laplace Transform : Introduction, Definition, Properties of Laplace transform, Laplace Transforms of elementary functions,
Inverse Laplace transforms, Laplace transform of derivatives, Application to solve Linear differential equations, Application in
solving Chemical kinetics and Pharmacokinetics equations
Total 30 100
Course Outcomes
CO1 Apply mathematical concepts and principles to perform computations for Pharmaceutical Sciences.
CO2 Create, use and analyze mathematical representations and mathematical relationships
CO3 To gate idea about Calculus Differentiation and important application base on pharmacy practise and clinical Pharmacy.
CO4 To Know the Analytical Geometry and Integration with their application in pharmaceutical field.
CO5 To Know about Differential Equations and Laplace Transform with application in pharmacy.
Reference Books
1. Differential Calculus
By Shanthinarayan | S. Chand Publishing, Pub. Year 2005
2. Pharmaceutical Mathematics with application to Pharmacy
By Panchaksharappa Gowda D.H.
3. Integral Calculus
By Shanthinarayan
4. Higher Engineering Mathematics
By Dr. B. S. Grewal
16
Subject Syllabus
23990108-P - HUMAN ANATOMY AND PHYSIOLOGY – PRACTICAL

Prerequisite
. Students would have studied about the gross morphology, structure and functions of
cell, skeletal, muscular, cardiovascular system of the human body.
2. They would have understood the various homeostatic mechanisms and their imbalances.
3. Students would able to identify the different types of bones in human body.
Course Objective 4. Students would be able to identify the various tissues of different systems of human
body.
5. Students would learn about the various experimental techniques related to physiology.
6. They would have learnt various techniques like blood group determination, blood
pressure measurement, blood cells counting

Total
- - 4 2 - - 35 15 50
Reference Books
1. practical of human anatomy and physiology (TextBook)
By R.K Gohel | B.S Shah
2. Human Anatomy
By B.D. Chaurasia
3. Human neuro anatomy
By Carpenter MB Williams & Wilkins | Baltinore, Pub. Year 1983
17
Subject Syllabus
23990108-P - HUMAN ANATOMY AND PHYSIOLOGY – PRACTICAL
List of Practical
1. Study of compound microscope.
2. Microscopic study of epithelial and connective tissue

3. Microscopic study of muscular and nervous tissue
4. Identification of axial bones
5. Identification of appendicular bones
6. Introduction to hemocytometry.
7. Enumeration of white blood cell (WBC) count
8. Enumeration of total red blood corpuscles (RBC) count
9. Determination of bleeding time
10. Determination of clotting time
11. Estimation of hemoglobin content
12. Determination of blood group
13. Determination of erythrocyte sedimentation rate (ESR).
14. Determination of heart rate and pulse rate.
15. Recording of blood pressure.
18
Subject Syllabus
23990109-P - PHARMACEUTICAL ANALYSIS I – PRACTICAL

Prerequisite
. Learning this subject content will develop the ideas with the fundamental of analytical
chemistry among the pupil.
2. It constructs the fundamental methodology to prepare different strength of solutions.
3. It facilitates the fellow pupil to predict the sources of mistakes and errors.
Course Objective 4. It helps to develop the fundamentals of volumetric analytical skills.
5. It peculates the basic knowledge in the principles of electrochemical analytical
techniques
The student interpretation skills will be improve by the course content in terms of choice of
analytical techniques to perform the estimation of different category drugs.

Total
- - 4 2 - - 35 15 50
Reference Books
1. Practical Pharmaceutical Chemistry Vol I & II,
By A.H. Beckett & J. B. Stenlake's, | Stahlone Press of University of London
List of Practical
1. Limit test for Chlorides, Sulphates & Iron.
2. Preparation and standardization of Sodium hydroxide
3. Preparation and standardization of Sulphuric acid
4. Preparation and standardization of Sodium thiosulfate
5. Preparation and standardization of Ceric Ammonium Sulphate
6. Preparation and standardization of Potassium permanganate
7. Assay of Ammonium chloride by acid base titration
8. Assay of Ferrous sulphate by Cerimetry
9. Assay of Copper Sulphate by Iodometry
10. Assay of Calcium Gluconate by Complexometry
11. Assay of Hydrogen Peroxide by Permanganometry
12. Assay of Sodium Benzoate by non-aqueous titration
13. Conductometric titration of strong acid against strong base.
14. Conductometric titration of weak acid against strong base
15. Potentiometric titration of strong acid against strong base
19
Subject Syllabus
23990110-P - PHARMACEUTICS I – PRACTICAL

Prerequisite
Course Objective

Total
- - 4 2 - - 35 15 50
Reference Books
2. Handbook of Pharmaceutical Granulation Technology
By Dilip M. Parikh:
By Medicines and Healthcare products Regulatory Agency | TSO (The Stationery Office)
List of Practical
1. Syrups:
Syrups:
a) Syrup IP‘66
b) Compound syrup of Ferrous Phosphate BPC‘68
2. Elixirs:
Elixirs:
a) Piperazine citrate elixir
b) Paracetamol pediatric elixir
3. Linctus
Linctus
a) Terpin Hydrate Linctus IP‘66
b)Iodine Throat Paint (Mandles Paint)
4. Solutions
Solutions
a) Strong solution of ammonium acetate
b) Cresol with soap solution
c) Lugol‘s solution
5. Suspensions
Suspensions
a) Calamine lotion
b) Magnesium Hydroxide mixture
c) Aluminum Hydroxide gel
6. Emulsions
Emulsions
20
Subject Syllabus
23990110-P - PHARMACEUTICS I – PRACTICAL
a) Turpentine Liniment
b) Liquid paraffin emulsion
7. Powders
Powders
a) ORS powder (WHO)
b) Dusting powder
C) Divided powders
8. Granules
Granules Effervescent granules
9. Suppositories
Suppositories
a) Glycero gelatin suppository
b) Zinc Oxide suppository
10. Suppositories
a) Boric acid suppository
b) Coca butter suppository
11. Semisolids:
semisolids: Ointments:
a) Sulphur ointment
b) Non staining-iodine ointment with methyl salicylate
c) Carbopal gels
12. Jelly:
Jelly:
a) Carbopal gel
b) Sodium alginate lubricating jelly
13. Cream:
Cream:
a) Cold cream
b) Vanishing cream
14. Mouthwashes
Mouthwashes
a) Chlorhexidine mouthwash
b) Compound sodium chloride mouthwash
15. Gargles
Gargles
a) Iodine gargle
b) Phenol gargle
c) Potassium chlorate and phenol gargle
21
Subject Syllabus
23990111-P - PHARMACEUTICAL INORGANIC CHEMISTRY –
PRACTICAL

Prerequisite
1. Well acquainted with the principles of limit tests.
2. Familiar with different classes of inorganic pharmaceuticals and their analysis
3. Identification of different anions, cations and different inorganic pharmaceuticals.
Course Objective 4. Knowledge about the sources of impurities and methods to determine the impurities in
inorganic drugs and pharmaceuticals
5. understand the medicinal and pharmaceutical importance of inorganic compounds
6. To have been introduced to a variety of inorganic drug classes.

Total
- - 4 2 - - 35 15 50
Reference Books
2. Indian Pharmacopoeia.
List of Practical
1. To perform limit test for Chloride
2. To Perform limit test for Sulphate
3. To Perform limit test for Iron
4. To Perform limit test for Lead
5. To Perform limit test for Arsenic
6. To Perform limit test for Heavy Metals
7. Swelling power of Bentonite
8. Preparation of Boric Acid
9. Preparation of Potash Alum
10. Preparation of Ferrous sulphate
11. Neutralizing capacity of aluminum hydroxide gel
12. Identification test of Magnesium hydroxide
13. Identification test of Ferrous sulphate
14. Identification test of Sodium bicarbonate
15. Identification test of Calcium gluconate
16. Identification test of Copper sulphate
22
Subject Syllabus
23990112-P - COMMUNICATION SKILLS – PRACTICAL

Prerequisite
This course will prepare the young pharmacy student to interact effectively with doctors, nurses,
dentists, physiotherapists and other health workers. At the end of this course the student will get the
Course Objective
soft skills set to work cohesively with the team as a team player and will add value to the pharmaceutical
business.

Total
- - 2 1 - - 15 10 25
Reference Books
1. Personality development and soft skills, (TextBook)
By Barun K Mitra
2. Effective communication, (TextBook)
By John Adair
3. Developing your influencing skills, (TextBook)
By Deborah Dalley, Lois Burton, Margaret, Green hall,
4. Soft skills and professional communication, (TextBook)
By Francis Peters SJ,
23
Subject Syllabus
23990112-P - COMMUNICATION SKILLS – PRACTICAL
List of Practical
Basic communication covering the following topics which are to be conducted using words worth® English language lab
1.
software. Meeting People
2. Asking Questions,
3. Making Friends,
4. What did you do?
5. Do‘s and Dont‘s
6. Pronunciations covering the following topics
Pronunciation (Consonant Sounds),
Pronunciation and Nouns,
Pronunciation (Vowel Sounds)
7. Pronunciation (Consonant Sounds),
8. Pronunciation and Nouns
9. Pronunciation (Vowel Sounds)
10. Advanced Learning Advanced Learning Listening Comprehension / Direct and Indirect Speech
11. Figures of Speech
12. Effective Communication
13. Writing Skills,
14. Effective Writing
15. Interview Handling Skills,
16. E-Mail etiquette
17. Presentation Skills.
24
Subject Syllabus
23990113-P - REMEDIAL BIOLOGY – PRACTICAL

Prerequisite
The main aim of this course is to make aware the students to understand and learn about :
1. Cell biology ( Basic Nature of Plant cell and Animal cell)
2. Classification System of both Plants & Animals
Course Objective
3. Various tissue system and organ system in plant and animals
4. Theory of evolution
5. Anatomy and Physiology of plants and animals

Total
- - 2 1 - - 15 10 25
Reference Books
1. A manual for pharmaceutical biology practical. (TextBook)
By S.B. Gokhale and C. K. Kokate
2. Practical human anatomy and physiology. (TextBook)
By S.R.Kale and R.R.Kale
3. A Manual of pharmaceutical biology practical
By S.B.Gokhale, C.K.Kokate and S.P.Shriwastava
4. Biology practical manual according to National core curriculum
By Prof . M. J. H. Shafi | Biology forum of Karnataka
List of Practical
1. Solve and work with a professional context pertaining to ethics, social, cultural and regulations with regard to Pharmacy.
2. Study of cell and its inclusions

3. Study of Stem, Root, Leaf, seed, fruit, flower and their modifications
4. Detailed study of frog by using computer models
5. Microscopic study and identification of tissues pertinent to Stem, Root, Leaf, seed, fruit and flower
6. Identification of bones
7. Determination of blood group
8. Determination of blood pressure
9. Determination of tidal volume
25
Subject Syllabus
23990201-T - HUMAN ANATOMY AND PHYSIOLOGY II – THEORY

Prerequisite 23990101 - HUMAN ANATOMY AND PHYSIOLOGY I– THEORY
This subject is designed to impart fundamental knowledge on the structure and functions of the various
Course Objective systems of the human body. It also helps in understanding both homeostatic mechanisms. The subject
provides the basic knowledge required to understand the various disciplines of pharmacy.

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Nervous System & Central Nervous System 10 22
Organization of nervous system, neuron, neuroglia, classification and properties of nerve fibre electrophysiology, action
potential, nerve impulse, receptors, synapse, neurotransmitters. Meninges, ventricles of brain and cerebrospinal fluid.
structure and functions of brain (cerebrum, brain stem, cerebellum), spinal cord (gross structure, functions of afferent and
efferent nerve tracts,reflex activity)
2 Digestive System & Energetics 6 13
Anatomy of GI Tract with special reference to anatomy and functions of stomach, (Acid production in the stomach,
regulation of acid production through parasympathetic nervous system, pepsin role in protein digestion) small intestine and
large intestine, anatomy and functions of salivary glands, pancreas and liver, movements of GIT, digestion and absorption of
nutrients and disorders of GIT. Formation and role of ATP, Creatinine Phosphate and BMR.
3 Respiratory & Urinary System 10 22
Anatomy of respiratory system with special reference to anatomy of lungs, mechanism of respiration, regulation of
respiration Lung Volumes and capacities transport of respiratory gases, artificial respiration, and resuscitation
methods.Anatomy of urinary tract with special reference to anatomy of kidney and nephrons, functions of kidney and
urinary tract, physiology of urine formation, micturition reflex and role of kidneys in acid base balance, role of RAS in kidney
and disorders of kidney
4 Endocrine System 10 23
Classification of hormones, mechanism of hormone action, structure and functions of pituitary gland, thyroid gland,
parathyroid gland, adrenal gland, pancreas, pineal gland, thymus and their disorders.
5 Reproductive System & Introduction to Genetics 9 20
Anatomy of male and female reproductive system, Functions of male and female reproductive system, sex hormones,
physiology of menstruation, fertilization, spermatogenesis, oogenesis, pregnancy and parturition. Chromosomes, genes and
DNA, protein synthesis, genetic pattern of inheritance
Total 45 100
26
Subject Syllabus
23990201-T - HUMAN ANATOMY AND PHYSIOLOGY II – THEORY
Course Outcomes
CO1 To explain the gross morphology, structure and functions of various organs of the human body.
CO2 To identify the various tissues and organs of different systems of human body.
To perform the hematological tests like blood cell counts, haemoglobin estimation, bleeding/clotting time etc and also
CO3
record blood pressure, heart rate, pulse and respiratory volume.
Reference Books
1. Essentials of Medical Physiology
By K. Sembulingam and P. Sembulingam | Jaypee brothers medical publishers, New Delhi
2. Anatomy and Physiology in Health and Illness
By Kathleen J.W. Wilson | Churchill Livingstone, New York
3. Physiological basis of Medical Practice
By Best and Tailor | Williams & Wilkins Co, Riverview, MI USA
4. Text book of Medical Physiology (TextBook)
By Arthur C. Guyton and John E. Hall | Miamisburg, OH, U.S.A
5. Principles of Anatomy and Physiology
By Tortora Grabowski | Palmetto, GA, U.S.A
6. Textbook of Human Histology (TextBook)
By Inderbir singh | Jaypee brothers medical publishers, New Delhi
27
Subject Syllabus
23990202-T - PHARMACEUTICAL ORGANIC CHEMISTRY I –
THEORY

Prerequisite
. Students would have studied about the gross morphology, structure and functions of
nervous, respiratory, urinary and reproductive systems in the human body.
2. They would have studied in detailed about energy and metabolism.
3. Students would able to identify the various organs of different systems of human
body.
Course Objective 4. They would have performed and learnt about the experiments like neurological
reflex, body temperature measurement
5. They would have studied elaborate on interlinked mechanisms in the maintenance of
normal functioning of human body
6. They would have learnt and performed the experiments like Olfaction, gustation
reflex and eye sigh

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Classification, nomenclature and isomerism 7 13
Classification of Organic Compounds. Common and IUPAC systems of nomenclature of organic compounds (up to 10 Carbons
open chain and carbocyclic compounds) Structural isomerisms in organic compounds
2 Alkanes*, Alkenes* and Conjugated dienes* 10 23
SP3 hybridization in alkanes, Halogenation of alkanes, uses of paraffins. Stabilities of alkenes, SP2 hybridization in alkenes E1
and E2 reactions – kinetics, order of reactivity of alkyl halides, rearrangement of carbocations, Saytzeffs orientation and
evidences. E1 verses E2 reactions, Factors affecting E1 and E2 reactions. Ozonolysis, electrophilic addition reactions of
alkenes,
Markownikoff’s orientation, free radical addition reactions of alkenes,Anti Markownikoff’s orientation.Stability of conjugated
dienes, Diel-Alder, electrophilic addition, free radical addition reactions of conjugated dienes, allylic rearrangement
3 Alkyl halides* Alcohols* 10 23
SN1 and SN2 reactions - kinetics, order of reactivity of alkyl halides, stereochemistry and rearrangement of carbocations. SN1
versus SN2 reactions, Factors affecting SN1 and SN2 reactions Structure and uses of ethylchloride, Chloroform,
trichloroethylene, tetrachloroethylene, dichloromethane, tetrachloromethane and iodoform. Qualitative tests, Structure
and uses of Ethyl alcohol, Methyl alcohol, chlorobutanol, Cetosteryl alcohol, Benzyl alcohol, Glycerol, Propylene glyco
4 Carbonyl compounds* (Aldehydes and ketones) 10 24
Nucleophilic addition, Electromeric effect, aldol condensation, Crossed Aldol condensation, Cannizzaro reaction, Crossed
Cannizzaro reaction, Benzoin condensation, Perkin condensation, qualitative tests, Structure and uses of Formaldehyde,
Paraldehyde, Acetone, Chloral hydrate, Hexamine, Benzaldehyde, Vanilin, Cinnamaldehyde.
28
Subject Syllabus
23990202-T - PHARMACEUTICAL ORGANIC CHEMISTRY I –
THEORY

Sr. Topics T W
5 Carboxylic acids* Aliphatic amines* 8 17
Acidity of carboxylic acids, effect of substituents on acidity, inductive effect and qualitative tests for carboxylic acids ,amide
and ester Structure and Uses of Acetic acid, Lactic acid, Tartaric acid, Citric acid, Succinic acid. Oxalic acid, Salicylic acid,
Benzoic acid, Benzyl benzoate, Dimethyl phthalate, Methyl salicylate and Acetyl salicylic acid - Basicity, effect of substituent
on Basicity.
Qualitative test, Structure and uses of Ethanolamine, Ethylenediamine, Amphetamine
Total 45 100
Course Outcomes
CO1 Knowledge of the classification, nomenclature, structure and the type of isomerism of the organic compound.
Understanding of important physical properties, reactions (and underlying mechanisms) and methods of preparation of
CO2
various functional groups.
CO3 Account for reactivity/stability of compounds and intermediates forming in reactions.
CO4 Identify/confirm the identification of organic compound.
Reference Books
1. Textbook of Organic Chemistry
By B. S. Bahl &Arun Bahl | Sultan Chand & Sons
2. Organic Chemistry
By P. L. Soni | Sultan Chand & Sons
3. Organic Reaction Mechanism
By V.K. Ahluwalia and R.K. Parashar, | Narosa Publishing House, New Delhi.
4. Reaction Mechanism and Reagents in Organic Chemistry
By Chatwal | Himalaya Pub. House-New Delhi
29
Subject Syllabus
23990203-T - PHARMACEUTICAL ENGINEERING - THEORY

Prerequisite 23990103 - PHARMACEUTICS I –THEORY
This course is designed to impart a fundamental knowledge on the art and science of various
Course Objective
unit operations used in pharmaceutical industry.

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Flow of fluids, Size Reduction, Size Separation: 10 20
Flow of fluids: Types of manometers, Reynolds number and its significance, Bernoulli’s theorem and its applications, Energy
losses, Orifice meter, Venturimeter, Pitot tube and Rotometer. Size Reduction: Objectives, Mechanisms & Laws governing
size reduction, factors affecting size reduction, principles, construction, working, uses, merits and demerits of Hammer mill,
ball mill, fluid energy mill, Edge runner mill & end runner mill. Size Separation: Objectives, applications & mechanism of size
separation, official standards of powders, sieves, size separation Principles, construction, working, uses, merits and demerits
of Sieve shaker, cyclone separator, Air separator, Bag filter & elutriation tank.
2 Heat Transfer, Evaporation, Distillation 10 25
Heat Transfer: Objectives, applications & Heat transfer mechanisms. Fourier’s law, Heat transfer by conduction, convection &
radiation. Heat interchangers & heat exchangers. Evaporation: Objectives, applications and factors influencing evaporation,
differences between evaporation and other heat process. principles, construction, working, uses, merits and demerits of
Steam jacketed kettle, horizontal tube evaporator, climbing film evaporator, forced circulation evaporator, multiple effect
evaporator& Economy of multiple effect evaporator. Distillation: Basic Principles and methodology of simple distillation,
flash distillation, fractional distillation, distillation under reduced pressure, steam distillation & molecular distillation
3 Drying, Mixing 8 20
Drying: Objectives, applications & mechanism of drying process, measurements & applications of Equilibrium Moisture
content, rate of drying curve. principles, construction, working, uses, merits and demerits of Tray dryer, drum dryer spray
dryer, fluidized bed dryer, vacuum dryer, freeze dryer.
Mixing: Objectives, applications & factors affecting mixing, Difference between solid and liquid mixing, mechanism of solid
mixing, liquids mixing and semisolids mixing. Principles, Construction, Working, uses, Merits and Demerits of Double cone
blender, twin shell blender, ribbon blender, Sigma blade mixer, planetary mixers, Propellers, Turbines, Paddles & Silverson
Emulsifier.
4 Filtration, Centrifugation 8 20
Filtration: Objectives, applications, Theories & Factors influencing filtration, filter aids, filter Medias. Principle, Construction,
Working, Uses, Merits and demerits of plate & frame filter, filter leaf, rotary drum filter, Meta filter & Cartridge filter,
membrane filters and Seitz filter. Centrifugation: Objectives, principle & applications of Centrifugation, principles,
construction, working, uses, merits and demerits of Perforated basket centrifuge, Non-perforated basket centrifuge, semi
continuous centrifuge & super centrifuge.
30
Subject Syllabus
23990203-T - PHARMACEUTICAL ENGINEERING - THEORY

Sr. Topics T W
5 Materials of pharmaceutical plant construction 7 15
Materials of pharmaceutical plant construction, Corrosion and its prevention: Factors affecting during materials selected for
Pharmaceutical plant construction, Theories of corrosion, types of corrosion and there prevention. Ferrous and nonferrous
metals, inorganic and organic nonmetals, basic of material handling systems.
Total 43 100
Course Outcomes
CO1 To know various unit operations used in Pharmaceutical industries.
CO2 To understand the material handling techniques.
CO3 To perform various processes involved in pharmaceutical manufacturing process.
CO4 To carry out various test to prevent environmental pollution.
CO5 To appreciate and comprehend significance of plant lay out design for optimum use of resources.
CO6 To appreciate the various preventive methods used for corrosion control in Pharmaceutical industries.
Reference Books
1. Introduction to chemical engineering
By Walter L Badger & Julius Banchero
2. Solid phase extraction, Principles, techniques and applications
By Nigel J.K. Simpson Latest edition.
3. Pharmaceutical engineering principles and practice (TextBook)
By C.V.S Subrahmanyam et al., Latest edition
4. Remington practice of pharmacy-
By Martin, Latest edition.
5. Physical pharmaceutics (TextBook)
By C.V.S Subrahmanyam et al., Latest edition
6. Theory and Practice of Industrial Pharmacy
By Liberman H.A, Lachman C., | MarcelDekkar Inc.
7. Cooper and Gunn’s. Tutorial Pharmacy, (TextBook)
By Carter S.J., | CBS Publications, New Delhi.
8. Pharmaceutical engineering-I (TextBook)
By Dr.G.K.Jani
31
Subject Syllabus
23990204-T - COMPUTER APPLICATIONS IN PHARMACY –
THEORY

Prerequisite
On completion of this course, the students will be able to:
1. Apply the knowledge of mathematics and computing fundamentals to pharmaceutical
applications for any given requirement
2. Design and develop solutions to analyze pharmaceutical problems using computers.
Course Objective
3. Integrate and apply efficiently the contemporary IT tools to all Pharmaceutical related
activities.
4. Solve and work with a professional context pertaining to ethics, social, cultural and
regulations with regard to Pharmacy

Total
3 - - 3 50 25 - - 75

Sr. Topics T W
1 Number system: Concept of Information Systems and Software : 6 20
Binary number system, Decimal number system, Octal number system, Hexadecimal number systems, conversion decimal to
binary, binary to decimal, octal to binary etc, binary addition, binary subtraction – One’s complement ,Two’s complement
method, binary multiplication, binary division Information gathering, requirement and feasibility analysis, data flow
diagrams, process specifications, input/output design, process life cycle, planning and managing the project
2 Web technologies: 6 20
Introduction to HTML, XML,CSS and Programming languages, introduction to web servers and Server Products Introduction
to databases, MYSQL, MS ACCESS, Pharmacy Drug database
3 Application of computers in Pharmacy 6 20
Drug information storage and retrieval, Pharmacokinetics, Mathematical model in Drug design,Hospital and Clinical
Pharmacy, Electronic Prescribing and discharge (EP) systems, barcode medicine identification and automated dispensing of
drugs, mobile technology and adherence monitoring Diagnostic System, Lab-diagnostic System, Patient Monitoring System,
Pharma Information System
4 Bioinformatics: 6 20
Introduction, Objective of Bioinformatics, Bioinformatics Databases, Concept of Bioinformatics, Impact of Bioinformatics in

Vaccine Discovery
5 Computers as data analysis in Preclinical development: 6 20
Chromatographic dada analysis(CDS), Laboratory Information management System (LIMS) and Text Information
Management System(TIMS)
32
Subject Syllabus
THEORY
Total 30 100
33
Subject Syllabus
THEORY
Course Outcomes
Apply the knowledge of mathematics and computing fundamentals to pharmaceutical applications for any given
CO1
requirement
CO2 Design and develop solutions to analyze pharmaceutical problems using computers.
CO3 Integrate and apply efficiently the contemporary IT tools to all Pharmaceutical related activities.
CO4 Solve and work with a professional context pertaining to ethics, social, cultural and regulations with regard to Pharmacy.
Reference Books
1. Computer Application in Pharmacy
By William E.Fassett –Lea and Febiger | 600South Washington Square, USA, (215) 922-1330.
2. Computer Application in Pharmaceutical Research and Development
By Sean Ekins | Wiley-Interscience, A John Willey and Sons, INC., Publication, USA
3. Bioinformatics (Concept, Skills and Applications)
By S.C.Rastogi | CBS Publishers and Distributors, 4596/1- A, 11 Darya Gani,
4. Microsoft office Access - 2003, Application Development Using VBA, SQL Server, DAP and Infopath
By Cary N.Prague | Wiley Dreamtech India (P) Ltd., 4435/7, Ansari Road, Daryagani, New Delhi - 110002
34
Subject Syllabus
23990205-T - ENVIRONMENTAL SCIENCES – THEORY

Prerequisite
This program shall create an awareness about environmental problems, develop an attitude
Course Objective
towards of concern for the environment.

Total
3 - - 3 50 25 - - 75

Sr. Topics T W
1 The Multidisciplinary nature of environmental studies 10 34
Natural Resources,Renewable and non-renewable resources:Natural resources and associated problems,a) Forest resources;
b) Water resources; c) Mineral resources; d) Food resources;e) Energy resources;f) Land resources: Role of an individual in
conservation of natural resources
2 Ecosystems 10 33
Concept of an ecosystem.Structure and function of an ecosystem. Introduction, types, characteristic features, structure
and function of the ecosystems: Forest ecosystem; Grassland ecosystem; Desert ecosystem; Aquatic ecosystems (ponds,
streams, lakes, rivers, oceans, estuaries)
3 Environmental Pollution: 10 33
Air pollution; Water pollution; Soil pollution
Total 30 100
Course Outcomes
This program shall create an awareness about environmental problems, develop an attitude towards of concern for the
CO1
environment.
CO2 The multidisciplinary nature of environmental studies on natural resources
CO3 Introduction types , characteristic features, structure and function of the ecosystem
35
Subject Syllabus
23990205-T - ENVIRONMENTAL SCIENCES – THEORY
Reference Books
1. Environmental Science
By Y.K. Sing | New Age International Pvt, Publishers, Bangalore
2. Environmental Biology ,
By Agarwal, K.C. 2001 | Nidi Publ. Ltd. Bikaner.
3. Environmental Chemistry,
By De A.K., | Wiley Eastern Ltd
4. The Biodiversity of India
By Bharucha Erach, | Mapin Publishing Pvt. Ltd., Ahmedabad – 380 013, India
5. Marine Pollution
By Clark R.S., | Clanderson Press Oxford
36
Subject Syllabus
23990206-P - HUMAN ANATOMY AND PHYSIOLOGY II –
PRACTICAL

Prerequisite 23990108-P - HUMAN ANATOMY AND PHYSIOLOGY – PRACTICAL
1. Students would have studied about the gross morphology, structure and functions of
nervous, respiratory, urinary and reproductive systems in the human body.
2. They would have studied in detailed about energy and metabolism.
3. Students would able to identify the various organs of different systems of human
body.
Course Objective 4. They would have performed and learnt about the experiments like neurological
reflex, body temperature measurement
5. They would have studied elaborate on interlinked mechanisms in the maintenance of
normal functioning of human body
6. They would have learnt and performed the experiments like Olfaction, gustation
reflex and eye sight

Total
- - 4 2 - - 35 15 50
Reference Books
1. Clinical Trials and Human Research: A Practical Guide to Regulatory Compliance (TextBook)
By Fay A. Rozovsky and Rodney K. Adams
2. Physiological basis of Medical Practice
By Best and Tailor | Williams & Wilkins Co, Riverview, MI USA
3. Text book of Medical Physiology
By Arthur C. Guyton and John E. Hall | Miamisburg, OH, U.S.A
4. Human Physiology (Vol 1 and 2) by Dr. C.C. Chatterrje ,Academic Publishers Kolkata
5. Textbook of Practical Physiology by C.L. Ghai, Jaypee brothers medical publishers, New Delhi. (TextBook)
6. Textbook of Human Histology by Inderbir Singh, Jaypee brothers medical publishers, New Delhi. (TextBook)
7. Principles of Anatomy and Physiology by Tortora Grabowski. Palmetto, GA, U.S.A. (TextBook)
8. Text book of Medical Physiology- Arthur C, Guyton and John. E. Hall. Miamisburg, OH, U.S.A. (TextBook)
9. Physiological basis of Medical Practice-Best and Tailor. Williams & Wilkins Co, Riverview, MI USA (TextBook)
10. Anatomy and Physiology in Health and Illness by Kathleen J.W. Wilson, Churchill Livingstone, New York (TextBook)
List of Practical
37
Subject Syllabus
PRACTICAL
1. To study the integumentary and special senses using specimen, models, etc
38
Subject Syllabus
PRACTICAL
2. To study the nervous system using specimen, models, etc.
3. To study the endocrine system using specimen, models, etc
4. To demonstrate the general neurological examination

5. To demonstrate the function of olfactory nerve
6. To examine the different types of taste

7. To demonstrate the visual acuity
8. To demonstrate the reflex activity
9. Recording of body temperature
10. To demonstrate positive and negative feedback mechanism.
11. Determination of tidal volume and vital capacity.
Study of digestive, respiratory, cardiovascular systems, urinary and reproductive systems with the help of models, charts
12.
and specimens.
13. Recording of basal mass index
14. Study of family planning devices and pregnancy diagnosis test
15. Demonstration of total blood count by cell analyzer
16. Permanent slides of vital organs and gonads
39
Subject Syllabus
23990207-P - PHARMACEUTICAL ORGANIC CHEMISTRY I –
PRACTICAL

Prerequisite
1. Write the structure, name of the organic compound
2. Knowledge about the type of isomerism
3. Write the reaction, name the reaction and orientation of reactions
4. Account for reactivity/stability of compounds,
Course Objective
5. Identify/confirm the unknown organic compound
6. Knowledge about the naming reactions of carbonyl compounds
7. To perform common laboratory techniques including reflux, distillation,
recrystallization, vacuum filtration, etc.

Total
- - 4 2 - - 35 15 50
Reference Books
1. Practical Organic Chemistry
By Frederick George Mann, Bernard Charles Saunders | Longman
2. Vogel’s text book of Practical Organic Chemistry
By A.I. Vogel, A.R. Tatchell, B.S. Furnis, A.J. Hannaford, P.W.G. Smith | Pearson Education
3. Advanced Practical organic chemistry
By N. K. Vishnoi | Vikas Publishing House,
List of Practical
1. Preliminary test: Color, odour, aliphatic/aromatic compounds, saturation and unsaturation, etc
2. Detection of elements like Nitrogen, Sulphur and Halogen by Lassaigne’s test
3. Solubility test
Functional group test like Phenols, Amides/ Urea, Carbohydrates, Amines, Carboxylic acids, Aldehydes and Ketones,
4.
Alcohols, Esters, Aromatic and Halogenated Hydrocarbons, Nitro compounds and Anilides
5. Melting point/Boiling point of organic compounds
6. Identification of the unknown compound from the literature using melting point/ boiling point.
7. Preparation of the derivatives and confirmation of the unknown compound by melting point/ boiling point.
Minimum 5 unknown organic compounds to be analysed systematically. 2. Preparation of suitable solid derivatives from
8.
organic compounds 3. Construction of molecular models
40
Subject Syllabus
23990208-P - PHARMACEUTICAL ENGINEERING - PRACTICAL

Prerequisite 23990110 - PHARMACEUTICS I – PRACTICAL
Course Objective

Total
- - 4 2 - - 35 15 50
Reference Books
By Medicines and Healthcare products Regulatory Agency
3. Handbook of Pharmaceutical Granulation Technology (TextBook)
By Dilip M. Parikh:
41
Subject Syllabus
23990208-P - PHARMACEUTICAL ENGINEERING - PRACTICAL
List of Practical
1. Size reduction:
To verify the laws of size reduction using ball mill and determing kicks, rittingers, bonds coeffients, power requirement and
critical
2. Size analysis by sieving
To evaluate size distribution of tablet granulations – Construction of various size frequency curves including arithmetic and
logarithmic probability plots.
3. Demonstration of Instruments of various unit operations
Demonstration of colloid mill, planetary mixer, fluidized bed dryer, freeze dryer and such of the major equipment.
4. Determination of radiation constant
Determination of radiation constant of brass, iron, unpainted and painted glass
5. To determine the overall heat transfer coefficient by heat exchanger.
6. Steam distillation
To calculate the efficiency of steam distillation.
7. Determination of moisture content and loss on drying.
8. Determination of humidity of air
From wet and dry bulb temperatures –use of Dew point method.
9. Construction of drying curves
(for calcium carbonate and starch).
Description of Construction working and application of Pharmaceutical Machinery such as rotary tablet machine, fluidized
10.
bed coater, fluid energy mill, de humidifier.
11. To calculate the uniformity Index for given sample by using Double Cone Blender
12. Factors affecting rate of filtration
(surface area, viscosity, concentration, pressure)
13. Factors affecting Rate of Evaporation
(Surface area and viscosity)
14. To study the effect of time on the Rate of Crystallization.
15. To determine the particle size by size separation method.
42
Subject Syllabus
23990209-P - COMPUTER APPLICATIONS IN PHARMACY –
PRACTICAL

Prerequisite 23990209-P - COMPUTER APPLICATIONS IN PHARMACY – PRACTICAL
On completion of this course, the students will be able to:
1. Apply the knowledge of mathematics and computing fundamentals to pharmaceutical
applications for any given requirement
2. Design and develop solutions to analyze pharmaceutical problems using computers.
Course Objective
3. Integrate and apply efficiently the contemporary IT tools to all Pharmaceutical related
activities.
4. Solve and work with a professional context pertaining to ethics, social, cultural and
regulations with regard to Pharmacy.

Total
- - 2 1 - - 15 10 25
Course Outcomes
1. Apply the knowledge of mathematics and computing fundamentals to pharmaceutical applications for any given
CO1
requirement
CO2 Design and develop solutions to analyze pharmaceutical problems using computers.
CO3 Integrate and apply efficiently the contemporary IT tools to all Pharmaceutical related activities.
CO4 Solve and work with a professional context pertaining to ethics, social, cultural and regulations with regard to Pharmacy
Reference Books
1. Computer Application in Pharmacy
By William E.Fassett –Lea and Febiger | 600South Washington Square, USA, (215) 922-1330.
2. Computer Application in Pharmaceutical Research and Development
By Sean Ekins | Wiley-Interscience, A John Willey and Sons, INC., Publication, USA
3. Bioinformatics (Concept, Skills and Applications)
By S.C.Rastogi | CBS Publishers and Distributors, 4596/1- A, 11 Darya Gani,
4. Microsoft office Access - 2003, Application Development Using VBA, SQL Server, DAP and Infopath
By Cary N.Prague | Wiley Dreamtech India (P) Ltd., 4435/7, Ansari Road, Daryagani, New Delhi - 110002
43
Subject Syllabus
23990209-P - COMPUTER APPLICATIONS IN PHARMACY –
PRACTICAL
List of Practical
1. Design a questionnaire using a word processing package to gather information about a particular disease.
2. Create a HTML web page to show personal information.
3. Retrieve the information of a drug and its adverse effects using online tools
4. Creating mailing labels Using Label Wizard , generating label in MS WORD
5. Create a database in MS Access to store the patient information with the required fields Using access
6. Design a form in MS Access to view, add, delete and modify the patient record in the database
7. Generating report and printing the report from patient database
8. Creating invoice table using – MS Access
9. Drug information storage and retrieval using MS Access
10. Creating and working with queries in MS Access
11. Exporting Tables, Queries, Forms and Reports to web pages
12. Exporting Tables, Queries, Forms and Reports to XML pages
44
Subject Syllabus
23990301-T - PHARMACEUTICAL ORGANIC CHEMISTRY II –
THEORY

Prerequisite 23990202-T - PHARMACEUTICAL ORGANIC CHEMISTRY I – THEORY
1. Basic knowledge regarding general methods of preparation of organic compounds.
2. Understand the reactions of some organic compounds.
3. To understand Reactivity of organic compounds.
Course Objective
4. Special emphasis on mechanisms and orientation of chemical reactions.
5. To acquire knowledge in heterocyclic compounds
6. To acquire knowledge about the electrophilic and nucleophilic reactions.

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Benzene and its derivatives 7 17
A. Analytical, synthetic and other evidences in the derivation of
structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule
B. Reactions of benzene-nitration, sulphonation, halogenation-reactivity, Friedelcrafts alkylation-reactivity, limitations,
Friedelcrafts acylation.
C. Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards
electrophilic substitution reaction D. Structure and uses of DDT, Saccharin, BHC and Chloramine
2 Phenols, Aromatic Amines, Aromatic Acids, 10 23
Phenols* - Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols,
resorcinol, naphthols
Aromatic Amines* - Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts
Aromatic Acids* –Acidity, effect of substituents on acidity and important reactions of benzoic acid.
3 Fats and Oils 10 23
a. Fatty acids – reactions.

b. Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.
c. Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value
–significance and principle involved in their determination.
4 Polynuclear hydrocarbons: 10 24
a. Synthesis, reactions
b. Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their
derivatives
5 Cyclo alkanes* 8 17
45
Subject Syllabus
23990301-T - PHARMACEUTICAL ORGANIC CHEMISTRY II –
THEORY

Sr. Topics T W
Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s
theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only
Total 45 104
Course Outcomes
CO1 Understand the introduction, orbital picture, resonance, reactions and effects of substituent’s of benzene.
Explain acidity, effect of substituents, reaction and qualitative test of phenols. Also elucidate basicity, effect of substituents,
CO2
reaction of aromatic amines.
CO3 Understand the theory and chemistry of fats and oils.
CO4 Knowledge of synthesis, reactions and structure and medicinal uses of some polynuclear hydrocarbons.
CO5 Understand the theory of cycloalkanes
Reference Books
1. Textbook of Organic Chemistry
By B. S. Bahl &Arun Bahl | Sultan Chand & Sons
46
Subject Syllabus
23990302-T - PHYSICAL PHARMACEUTICS I – THEORY

Upon successful completion of the course, students will be able to:
1. State the physicochemical properties of drug molecules, pH, and solubility
2. Explain the role of surfactants, interfacial phenomenon and thermodynamics
3. Describe the flow behavior of fluids and concept of complexation
Course Objective 4. Analyze the chemical stability tests of various drug Products
5. Understand the physical properties of solutions, buffers, isotonicity, disperse systems
and rheology.
6. Understand of physicochemical properties of drugs including solubility,
distribution, adsorption, and stability

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Solubility of drugs 10 24
Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation &
association, quantitative approach to the factors influencing solubility of drugs, diffusion principles in biological systems.
Solubility of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions.
Partially miscible liquids, Critical solution temperature and applications. Distribution law, its limitations and applications
2 States of Matter and properties of matter 10 23
States of Matter and properties of matter:State of matter, changes in the state of matter, latent heats, vapour pressure,
sublimation critical point, eutectic mixtures, gases, aerosols –inhalers, relative humidity, liquid complexes, liquid crystals,
glassy states, solid-crystalline, amorphous & polymorphism.
Physicochemical properties of drug molecules: Refractive index, optical rotation, dielectric constant, dipole moment,
dissociation constant, determinations and applications
3 Surface and interfacial phenomenon: 10 23
Surface and interfacial phenomenon: Liquid interface, surface & interfacial tensions, surface free energy, measurement of
surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB Scale,
solubilisation, detergency, adsorption at solid interface.
4 Complexation and protein binding: 8 17
Complexation and protein binding: Introduction, Classification of Complexation, Applications, methods of analysis, protein
binding, Complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability
constants.
5 pH, buffers and Isotonic solutions: 7 13
47
Subject Syllabus
23990302-T - PHYSICAL PHARMACEUTICS I – THEORY

Sr. Topics T W
pH, buffers and Isotonic solutions:Sorensen’s pH scale, pH determination (electrometric and calorimetric), applications of
buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions.
Total 45 100
Course Outcomes
CO1 State the physicochemical properties of drug molecules, pH, and solubility
CO2 Explain the role of surfactants, interfacial phenomenon and thermodynamics
CO3 Describe the flow behavior of fluids and concept of complexation
CO4 Analyze the chemical stability tests of various drug Products
CO5 Understand the physical properties of solutions, buffers, isotonicity, disperse systems and rheology.
CO6 Understand of physicochemical properties of drugs including solubility, distribution, adsorption, and stability.
Reference Books
1. Physical Pharmacy:
By Alfred N. Martin. Lea & Febiger, 1966
2. Experimental pharmaceutics Eugene
By L. Parrott and Witold Saski. Burges
3. Cooper and Gunn's Tutorial pharmacy
By Gunn Cooper S.J. Carter
4. Pharmaceutical Calculations
By Stocklosam J. | Lea & Febiger, Philadelphia
5. Pharmaceutical Dosage forms,
By Tablets Volume-1 to 3 Liberman H.A, Lachman C.,
6. Pharmaceutical Dosage forms. Disperse systems, volume 1, 2, 3.
By Liberman H.A, Lachman C, | Marcel Dekkar Inc.
7. Physical Pharmaceutics
By Ramasamy C and ManavalanR. | PharmaMed Press/BSP Books
48
Subject Syllabus
23990303-T - BIOCHEMISTRY - THEORY

Prerequisite 23990104 - PHARMACEUTICAL INORGANIC CHEMISTRY – THEORY
1. Students understand the importance of metabolism of substrates.
2. Will acquire chemistry and biological importance of biological macromolecules.
3. They acquire knowledge in qualitative and quantitative estimation of the biological macromolecules.
4. They know the interpretation of data emanating from a Clinical Test Lab.
Course Objective
5. Students would able to know how physiological conditions influence the structures and re-activities of
biomolecules.
6. They would able to understand the basic principles of protein and polysaccharide
structure.

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Biomolecules, Bioenergetics 8 20
Introduction, classification, chemical nature and biological role of carbohydrate, lipids, nucleic acids, amino acids and
proteins. Concept of free energy, endergonic and exergonic reaction, Relationship between free energy, enthalpy and
entropy; Redox potential. Energy rich compounds; classification; biological significances of ATP and cyclic AMP
2 Carbohydrate metabolism, Biological oxidation 10 25
Glycolysis – Pathway, energetics and significance Citric acid cycle- Pathway, energetics and significance HMP shunt and its
significance; Glucose-6-Phosphate dehydrogenase (G6PD) deficiency Glycogen metabolism Pathways and glycogen storage
diseases (GSD)
Gluconeogenesis- Pathway and its significance Hormonal regulation of blood glucose level and Diabetes mellitus Electron
transport chain (ETC) and its mechanism. Oxidative phosphorylation & its mechanism and substrate phosphorylation
Inhibitors ETC and oxidative phosphorylation/Uncouplers
3 Lipid metabolism, Amino acid metabolism, 10 25
β-Oxidation of saturated fatty acid (Palmitic acid) Formation and utilization of ketone bodies; ketoacidosis De novo
synthesis of fatty acids (Palmitic acid) Biological significance of cholesterol and conversion of cholesterol into bile acids,
steroid hormone and vitamin D Disorders of lipid metabolism: Hypercholesterolemia, atherosclerosis, fatty liver and obesity.
General reactions of amino acid metabolism: Transamination, deamination & decarboxylation, urea cycle and its
disorders Catabolism of phenylalanine and tyrosine and their metabolic disorders (Phenyketonuria, Albinism, alkeptonuria,
tyrosinemia) Synthesis and significance of biological substances; 5-HT, melatonin, dopamine, noradrenaline, adrenaline
Catabolism of heme; hyperbilirubinemia and jaundice
4 Nucleic acid metabolism and genetic information transfer 10 17
Biosynthesis of purine and pyrimidine nucleotides Catabolism of purine nucleotides and Hyperuricemia and Gout disease
Organization of mammalian genome Structure of DNA and RNA and their functions DNA replication (semi conservative
model)Transcription or RNA synthesis Genetic code, Translation or Protein synthesis and inhibitors
49
Subject Syllabus
23990303-T - BIOCHEMISTRY - THEORY

Sr. Topics T W
5 Enzymes 7 13
Introduction, properties, nomenclature and IUB classification of enzymes Enzyme kinetics (Michaelis plot, Line Weaver Burke
plot) Enzyme inhibitors with examples Regulation of enzymes: enzyme induction and repression, allosteric enzymes
regulationTherapeutic and diagnostic applications of enzymes and isoenzymes Coenzymes –Structure and biochemical
functions
Total 45 100
Course Outcomes
CO1 Understand classification, chemical nature, biological role and metabolism of biomolecules
CO2 Understand bioenergetics and biological oxidation pathway
CO3 Understand the genetic organization of mammalian genome and functions of DNA in the synthesis of RNAs and proteins.
CO4 Understand the catalytic role of enzymes and importance of enzyme in biochemical process.
Reference Books
1. Harper’s Biochemistry
By Robert K. Murry, Daryl K. Granner and Victor W. Rodwell. | Mcgraw-Hill Education / Medical;
2. Biochemistry
By Jeremy M Berg, John L Tymoczko, and Lubert Stryer. | WH Freeman
3. Biochemistry
By Dr. Satyanarayan
4. Textbook of Biochemistry
By Rama Rao | UBS Publishers Distributors Pvt. Limited,
5. Textbook of Biochemistry
By Deb | New Central Book Agency
50
Subject Syllabus
23990304-T - PATHOPHYSIOLOGY - THEORY

Prerequisite 23990101-T - HUMAN ANATOMY AND PHYSIOLOGY I – THEORY
Pathophysiology is the study of causes of diseases and reactions of the body to such
disease producing causes. This course is designed to impart a thorough knowledge of the relevant
aspects of pathology of various conditions with reference to its pharmacological applications and
understanding of basic pathophysiological mechanisms. Hence it will not only help to study the syllabus
of pathology, but also to get baseline knowledge required to practice medicine safely, confidently,
Course Objective
rationally and effectively.
Upon completion of the subject student shall be able to –
1. To describe the etiology and pathogenesis of the selected disease states;
2. To name the signs and symptoms of the diseases; and
3. To mention the complications of the diseases

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Basic principles of Cell injury and Adaptation 10 23
Basic principles of Cell injury and Adaptation- Introduction, definitions, Homeostasis, Components and Types of Feedback
systems, Causes of cellular injury, Pathogenesis (Cell
membrane damage, Mitochondrial damage, Ribosome damage, Nuclear damage), Morphology of cell injury – Adaptive
changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia),Cell swelling, Intra cellular accumulation, Calcification,
Enzyme leakage and Cell Death Acidosis & Alkalosis, Electrolyte imbalance
Basic mechanism involved in the process of inflammation and repair:
Introduction, Clinical signs of inflammation, Different types ofInflammation, Mechanism of Inflammation – Alteration in
vascular permeability and blood flow, migration of WBC’s, Mediators of inflammation, Basic principles of wound healing in
the skin, Pathophysiology of Atherosclerosis
2 Cardiovascular System: 10 25
Cardiovascular System:
Hypertension, congestive heart failure, ischemic heart disease (angina, myocardial infarction, atherosclerosis and
arteriosclerosis)
Respiratory system:
Asthma, Chronic obstructive airways diseases.
Renal system:
Acute and chronic renal failure
3 Haematological Diseases: 10 25
51
Subject Syllabus
23990304-T - PATHOPHYSIOLOGY - THEORY

Sr. Topics T W
Haematological Diseases:
Iron deficiency, megaloblastic anemia (Vit B12 and folic acid), sickle cell anemia, thalasemia, hereditary acquired anemia,
hemophilia
Endocrine system:
Diabetes, thyroid diseases, disorders of sex hormones
Nervous system:
Epilepsy, Parkinson’s disease, stroke, psychiatric disorders: depression, schizophrenia and Alzheimer’s disease.
Gastrointestinal system:
Peptic Ulcer
4 Inflammatorybowel diseases 8 17
Inflammatorybowel diseases: Jaundice, hepatitis (A, B, C, D, E, F) alcoholic liver disease.

Disease of bones and joints:
Rheumatoid arthritis, osteoporosis and gout
Principles of cancer:
classification, etiology and pathogenesis of cancer
Diseases of bones and joints
Rheumatoid Arthritis, Osteoporosis, Gout
Principles of Cancer:
Classification, etiology and pathogenesis of Cancer
5 Infectious diseases: 7 13
Infectious diseases:
Meningitis, Typhoid, Leprosy, Tuberculosis
Urinary tract infections
Sexually transmitted diseases: AIDS, Syphilis, Gonorrhea
Total 45 103
Course Outcomes
CO1 Describe the etiology and pathogenesis of the selected disease states
CO2 Describe the signs and symptoms of the diseases
CO3 Explain the complications of the diseases
Reference Books
1. Pathologic Basis of Disease; (TextBook)
By Vinay Kumar, Abul K. Abas, Jon C. Aster; | Robbins & Cotran South Asia edition; India; Elsevier; 2014
2. Pathologic basis of disease (TextBook)
By Cortran, Kumar, Robbins
3. Text book of Pathology (TextBook)
By Harsh Mohan;
52
Subject Syllabus
23990305-T - PHARMACOGNOSY AND PHYTOCHEMISTRY I -
THEORY

Prerequisite
The subject involves the fundamentals of Pharmacognosy like scope, classification of
Course Objective crude drugs, their identification and evaluation, phytochemicals present in them and their medicinal
properties.

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Introduction to Pharmacognosy 10 10
(a) Definition, history, scope and development of Pharmacognosy

(b) Sources of Drugs – Plants, Animals, Marine & Tissue culture
(c) Organized drugs, unorganized drugs (dried latex, dried juices, dried extracts, gums and mucilages, oleoresins and oleo-
gum -resins).
Classification of drugs:
Alphabetical, morphological, taxonomical, chemical, pharmacological,
chemo and sero taxonomical classification of drugs
Quality control of Drugs of Natural Origin:
Adulteration of drugs of natural origin. Evaluation by organoleptic,microscopic, physical, chemical and biological methods
and properties.
Quantitative microscopy of crude drugs including lycopodium spore
method, leafconstants, camera lucida and diagrams of microscopic objects
to scale with camera lucida.
2 Cultivation, Collection, Processing and storage of drugs of natural origin 10 10
Cultivation and Collection of drugs of natural origin

Factors influencing cultivation of medicinal plants.
Plant hormones and their applications.
Polyploidy, mutation and hybridization with reference to medicinal plants
Conservation of medicinal plants
3 Plant tissue culture 7 7

Historical development of plant tissue culture, types of cultures, Nutritional
requirements, growth and their maintenance.
Applications of plant tissue culture in pharmacognosy.
Edible vaccines
4 Pharmacognosy in various systems of medicine 10 10
53
Subject Syllabus
23990305-T - PHARMACOGNOSY AND PHYTOCHEMISTRY I -
THEORY

Sr. Topics T W
Role of Pharmacognosy in allopathy and traditional systems of medicine namely, Ayurveda, Unani, Siddha, Homeopathy and
Chinese systems of medicine.
Introduction to secondary metabolites: Definition, classification, properties and test for identification of Alkaloids,
Glycosides, Flavonoids, Tannins, Volatile oil and Resins
5 Study of biological source, chemical nature and uses of drugs of natural origin containing following drugs 8 8
Plant Products:
Fibers - Cotton, Jute, Hemp, Hallucinogens, Teratogens, Natural allergens Primary metabolites: General introduction,
detailed study with respect to chemistry, sources, preparation, evaluation, preservation, storage, therapeutic used and
commercial utility as Pharmaceutical Aids and/or Medicines for the following Primarymetabolites:
Carbohydrates: Acacia, Agar, Tragacanth, Honey
Proteins and Enzymes : Gelatin, casein, proteolytic enzymes (Papain, bromelain, serratiopeptidase, urokinase, streptokinase,
pepsin).
Lipids(Waxes, fats, fixed oils) : Castor oil, Chaulmoogra oil, Wool Fat, Bees Wax
Marine Drugs: Novel medicinal agents from marine sources
Total 45 45
Course Outcomes
CO1 Comprehend and explain Primary and secondary metabolites from source to their industrial applications.
CO2 Explain meaning & significance of Pharmacognostic parameters and pharmacognostic scheme of study of crude drugs.
Explain properties, methods of extraction, pharmaceutical and industrial applications of carbohydrates, lipids and proteins
CO3
and their derived products.
Explain properties, methods of extraction, and systematic pharmacognostic study of crude drugs from Glycosides and
CO4
Tannins.
Reference Books
1. “Trease and Evans’ Pharmacognosy”
By Trease, G.E. and Evans, | W.C. WB Saunders Co.
2. Text book of Pharmacognosy (TextBook)
By C.K. Kokate, Purohit, Gokhlae
3. Pharmacognosy and Phytochemistry (TextBook)
By Mohammad Ali
4. Pharmacognosy (TextBook)
By Tyler, V.E., Brady, L.R. and Robbers, J.E.
54
Subject Syllabus
23990306-P - PHARMACEUTICAL ORGANIC CHEMISTRY II –
PRACTICAL

Prerequisite 23990207-P - PHARMACEUTICAL ORGANIC CHEMISTRY I – PRACTICAL
1. Basic knowledge regarding general methods of preparation of organic compounds.
2. Understand the reactions of some organic compounds.
3. To understand Reactivity of organic compounds.
Course Objective
4. Special emphasis on mechanisms and orientation of chemical reactions.
5. To acquire knowledge in heterocyclic compounds
6. To acquire knowledge about the electrophilic and nucleophilic reactions.

Total
- - 4 2 - - 35 15 50
Reference Books
1. Advanced Practical organic chemistry
By N. K. Vishnoi | Vikas Publishing House,
2. Organic Reaction Mechanism
By V.K. Ahluwalia and R.K. Parashar, | Narosa Publishing House, New Delhi.
4. Reaction Mechanism and Reagents in Organic Chemistry
By Chatwal | Himalaya Pub. House-New Delhi
List of Practical
1. Experiments involving laboratory techniques : Recrystallization
2. Experiments involving laboratory techniques : Steam distillation
3. To determine Acid value of given oil sample
4. To determine Saponification value of given oil sample
5. To determine Iodine value of given oil sample
6. To Synthesize 2,4,6-Tribromo aniline/Para bromo acetanilide from Aniline/
7. To Synthesize Acetanilide by halogenation (Bromination)reaction
8. To Synthesize 5-Nitro salicylic acid/Meta di nitro benzene from Salicylic acid /Nitro benzene by nitration reaction.
9. To Synthesize Benzanilide/Phenyl benzoate/Acetanilide from Aniline/ Phenol/Aniline by acylation reaction
10. To Synthesize P-Iodo benzoic acid from P-amino benzoic acid
11. To Synthesize Benzoic acid/ Salicylic acid from alkyl benzoate/ alkyl salicylate by hydrolysis reaction
12. To Synthesize 1-Phenyl azo-2-napthol from Aniline by diazotization and coupling reactions.
13. To Synthesize Benzil from Benzoin by oxidation reaction
55
Subject Syllabus
PRACTICAL
14. To Synthesize Dibenzyl acetone from Benzaldehyde by Claison Schmidt reaction

15. To Synthesize Cinnammic acid from Benzaldehyde by Perkin reaction
56
Subject Syllabus
PRACTICAL
57
Subject Syllabus
23990307-P - PHYSICAL PHARMACEUTICS I – PRACTICAL

Prerequisite 23990110-P - PHARMACEUTICS I – PRACTICAL
Upon successful completion of the course, students will be able to:
1. State the physicochemical properties of drug molecules, pH, and solubility
2. Explain the role of surfactants, interfacial phenomenon and thermodynamics
3. Describe the flow behavior of fluids and concept of complexation
Course Objective 4. Analyze the chemical stability tests of various drug Products
5. Understand the physical properties of solutions, buffers, isotonicity, disperse systems
and rheology.
6. Understand of physicochemical properties of drugs including solubility, distribution,
adsorption, and stability.

Total
- - 4 2 - - 35 15 50
Reference Books
1. Laboratory Manual of Physical Pharmaceutics (TextBook)
By C. V. S. Subrahmanyam and J. Thimm a Setty | Vallabh Prakashan, Delhi
2. Physical Pharmaceutics (TextBook)
By C.V.S. Subramanyam | Vallabh Prakashan, Delhi
3. Test book of Physical Phramacy
By Gaurav Jain & Roop K. Khar | Elsevier India
58
Subject Syllabus
23990307-P - PHYSICAL PHARMACEUTICS I – PRACTICAL
List of Practical
1. Determination the solubility of drug at room temperature
Determination the solubility of drug at room temperature
2. Determination of pKa value by Half Neutralization/ Henderson Hasselbalch equation.
Determination of pKa value by Half Neutralization/ Henderson Hasselbalch equation.
3. Determination of Partition coefficient of benzoic acid in benzene and water
Determination of Partition coefficient of benzoic acid in benzene and water
4. Determination of Partition coefficient of Iodine in CCl4 and water
Determination of Partition coefficient of Iodine in CCl4 and water
5. Determination of % composition of NaCl in a solution using phenol-water system by CST metho
Determination of % composition of NaCl in a solution using phenol-water system by CST metho
6. Determination of surface tension of given liquids by drop count and drop weight method
Determination of surface tension of given liquids by drop count and drop weight method
7. Determination of HLB number of a surfactant by saponification method
Determination of HLB number of a surfactant by saponification method
8. Determination of Freundlich and Langmuir constants using activated charcoal
Determination of Freundlich and Langmuir constants using activated charcoal
9. Determination of Freundlich and Langmuir constants using activated char coal
Determination of Freundlich and Langmuir constants using activated char coal
10. Determination of critical micellar concentration of surfactants
Determination of critical micellar concentration of surfactants
11. rmination of stability constant and donor acceptor ratio of PABA?Caffeine complex by solubility method
rmination of stability constant and donor acceptor ratio of PABA?Caffeine complex by solubility method
59
Subject Syllabus
23990308-P - BIOCHEMISTRY – PRACTICAL

Prerequisite 23990111-P - PHARMACEUTICAL INORGANIC CHEMISTRY – PRACTICAL
1. Students understand the importance of metabolism of substrates.
2. Will acquire chemistry and biological importance of biological macromolecules.
3. They acquire knowledge in qualitative and quantitative estimation of the biological macromolecules.
Course Objective 4. They know the interpretation of data emanating from a Clinical Test Lab.
5. Students would able to know how physiological conditions influence the structures and re-activities of
biomolecules.
6. They would able to understand the basic principles of protein and polysaccharide structure.

Total
- - 4 2 - - 35 15 50
Reference Books
1. Practical Biochemistry for Medical students
By Rajagopal and Ramakrishna. | Orient Black Swan
2. Practical Biochemistry
By Harold Varley. | CBS Publisher
List of Practical
1. Qualitative analysis of carbohydrates (Glucose, Fructose, Lactose, Maltose, Sucrose and starch)
2. Identification tests for Proteins (albumin and Casein)
3. Quantitative analysis of reducing sugars (DNSA method) and Proteins (Biuret method)
4. Qualitative analysis of urine for abnormal constituents
5. Determination of blood creatinine
6. Determination of blood sugar
7. Determination of serum total cholesterol
8. Preparation of buffer solution and measurement of pH
9. Study of enzymatic hydrolysis of starch
10. Determination of Salivary amylase activity
11. Study the effect of Temperature on Salivary amylase activity.
12. Study the effect of substrate concentration on salivary amylase activity.
60
Subject Syllabus
23990309-P - PHARMACOGNOSY AND PHYTOCHEMISTRY I –
PRACTICAL

Prerequisite
The subject involves the fundamentals of Pharmacognosy like scope, classification of crude drugs, their
Course Objective
identification and evaluation, phytochemicals present in them and their medicinal properties.

Total
- - 4 2 - - 35 15 50
Reference Books
1. Practical Pharmacognosy
By Khandelwal K. R | Nirali Publication | 19th
61
Subject Syllabus
23990309-P - PHARMACOGNOSY AND PHYTOCHEMISTRY I –
PRACTICAL
List of Practical
1. Analysis of crude drugs by chemical tests: (i) Tragaccanth (ii) Acacia (iii)Agar iv)Gelatin (v) starch (vi) Honey (vii) Castor oil
2. Determination of stomatal number and index
3. Determination of vein islet number, vein islet termination and paliside ratio.
4. Determination of size of starch grains, calcium oxalate crystals by eye piece micrometer
5. Determination of Fiber length and width
6. Determination of number of starch grains by Lycopodium spore method
7. Determination of Ash value
8. Determination of Extractive values of crude drugs
9. Determination of moisture content of crude drugs
10. Determination of swelling index and foaming
62
Subject Syllabus
23990401-T - PHARMACEUTICAL ORGANIC CHEMISTRY III –
THEORY

Prerequisite 23990202-T - PHARMACEUTICAL ORGANIC CHEMISTRY I – THEORY
1. This subject imparts knowledge on stereo-chemical aspects of organic compounds and
organic reactions, important named reactions, chemistry of important hetero cyclic
Course Objective
compounds.
2. It also emphasizes on medicinal and other uses of organic compounds.

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Stereo isomerism 10 20
Optical isomerism –Optical activity, enantiomerism, diastereoisomerism, meso compounds

Elements of symmetry, chiral and achiral moleculesDL system of nomenclature of optical isomers, sequence rules, RS system
of nomenclature of optical isomersReactions of chiral moleculesRacemic modification and resolution of racemic mixture.
Asymmetric synthesis: partial and absolute
2 Geometrical isomerism 10 25
Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems) Methods of determination of configuration of
geometrical isomers. Conformational isomerism in Ethane, n-Butane and Cyclohexane.
Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity. Stereospecific and
stereoselective reactions
3 Heterocyclic compounds: 10 25
Nomenclature and classification Synthesis, reactions and medicinal uses of following compounds /derivatives Pyrrole, Furan,
and Thiophene Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene
4 Synthesis, reactions and medicinal uses of following compounds /derivatives 8 17
Pyrazole, Imidazole, Oxazole and Thiazole. Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine
Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives
5 Reactions of synthetic importance 7 13
Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction. Oppenauer-
oxidation and Dakin reaction. Beckmanns rearrangement and Schmidt rearrangement. Claisen-Schmidt condensation
Total 45 100
63
Subject Syllabus
23990401-T - PHARMACEUTICAL ORGANIC CHEMISTRY III –
THEORY
Course Outcomes
To build up fact on stereoisomerism. To yield insight of chirality and reactions of chiral molecules.
CO1
To gain dogma regarding the stereo chemical aspect of organic compounds & various stereo chemical reactions
To achieve expertise about geometric isomerism. To ponder comprehension in nomenclature method for determination of
CO2 geometric isomers. To gain dogma on stereoselective and stereospecific reactions. To extend knowledge about some
heterocyclic rings and their preparations.
To acquire the knowledge of various heterocyclic compounds. To procure the insight about structure, preparation and
CO3
reaction of various heterocyclic rings.
CO4 To understand the entire skeleton on mechanism of various name reactions.
Reference Books
1. Organic Chemistry Vol-1 & 2
By I.L. Finar | Pearson Publication
2. A Textbook of Organic chemistry
By Arun Bahl, B.S. Bahl | S. Chand Publication
3. Heterocyclic Chemistry
By Raj K. Bansal | New Age International Publishers
5. Heterocyclic Chemistry
By T.L. Gilchrist | Pearson Publication
64
Subject Syllabus
23990402-T - MEDICINAL CHEMISTRY I – THEORY

Prerequisite 23990301-T - PHARMACEUTICAL ORGANIC CHEMISTRY II – THEORY
1. This subject is designed to impart fundamental knowledge on the structure chemistry
and therapeutic value of drugs.
Course Objective 2. The subject emphasizes on structure activity relationships of drugs, importance of
physicochemical properties and metabolism of drugs.
3. The syllabus also emphasizes on chemical synthesis of important drugs under each class.

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Introduction to Medicinal Chemistry History and development of medicinal chemistry Physicochemical 10 20
properties in relation to biological action , Drug metabolism
Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding, Chelation, Bioisosterism, Optical and
Geometrical isomerism. Drug metabolism principles- Phase I and Phase II. Factors affecting drug metabolism including stereo
chemical aspects
2 Drugs acting on Autonomic Nervous System Adrenergic Neurotransmitters, Sympathomimetic agents, 10 25

Adrenergic Antagonists, Alpha adrenergic blockers, Beta adrenergic blockers,
Drugs acting on Autonomic Nervous System Adrenergic Neurotransmitters: Sympathomimetic agents: SAR of
Sympathomimetic agents, Adrenergic Antagonists:Alpha adrenergic blockers, Beta adrenergic blockers:
Biosynthesis and catabolism of catecholamine.
Adrenergic receptors (Alpha & Beta) and their distribution.
Sympathomimetic agents: SAR of Sympathomimetic agents
• Direct acting: Nor-epinephrine, Epinephrine, Phenylephrine*, Dopamine

• Methyldopa, Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol*,Bitolterol, Naphazoline, Oxymetazoline
and Xylometazoline.
• Indirect acting agents: Hydroxyamphetamine, Pseudoephedrine, Propylhexedrine.
• Agents with mixed mechanism: Ephedrine, Metaraminol.
Adrenergic Antagonists:
Alpha adrenergic blockers: Tolazoline*, Phentolamine Phenoxybenzamine, Prazosin, Dihydroergotamine,
Methysergide.
• Beta adrenergic blockers: SAR of beta blockers, Propranolol*,Metibranolol, Atenolol, Betazolol, Bisoprolol, Esmolol,
Metoprolol, Labetolol, Carvedilol.
3 Cholinergic neurotransmitters: Parasympathomimetic agents, Direct acting agents, Indirect acting/ 10 25
Cholinesterase inhibitors (Reversible & Irreversible):Cholinesterase reactivator:Cholinergic Blocking
agents:Solanaceous alkaloids and analogues, Synth
65
Subject Syllabus

Sr. Topics T W
Cholinergic neurotransmitters:
Biosynthesis and catabolism of acetylcholine. Cholinergic receptors (Muscarinic & Nicotinic) and their distribution.
Parasympathomimetic agents: SAR of Parasympathomimetic agents Direct acting agents: Acetylcholine, Carbachol*,
Bethanechol, Methacholine, Pilocarpine.
Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible):

Physostigmine, Neostigmine*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride,
Isofluorphate, Echothiophateiodide, Parathione, Malathion.
Cholinesterase reactivator: Pralidoxime chloride.
Cholinergic Blocking agents: SAR of cholinolytic agents Solanaceous alkaloids and analogues: Atropine sulphate,
Hyoscyamine sulphate, Scopolamine hydrobromide, Homatropine hydrobromide, Ipratropium bromide*.
Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide, Dicyclomine
hydrochloride*, Glycopyrrolate, Methantheline bromide, Propantheline bromide, Benztropine mesylate, Orphenadrine
citrate, Biperidine hydrochloride, Procyclidine hydrochloride*, Tridihexethyl chloride, Isopropamideiodide, Ethopropazine
hydrochloride.
4 Drugs acting on Central Nervous System, A. Sedatives and Hypnotics: Barbiturtes:Amides & imides:Alcohol & 8 17
their carbamate derivatives:B. Antipsychotics, Phenothiazeines:Ring Analogues of Phenothiazeines:Fluro
buterophenones:Benzamides:Beta amino keto
66
Subject Syllabus

Sr. Topics T W
Drugs acting on Central Nervous System

A. Sedatives and Hypnotics:
Benzodiazepines: SAR of Benzodiazepines, Chlordiazepoxide, Diazepam*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam,
Zolpidem
Barbiturtes: SAR of barbiturates, Barbital*, Phenobarbital, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital,

Secobarbital
Miscelleneous:
Amides & imides: Glutethmide.
Alcohol & their carbamate derivatives: Meprobomate, Ethchlorvynol.
Aldehyde & their derivatives: Triclofos sodium, Paraldehyde.
B. Antipsychotics
Phenothiazeines: SAR of Phenothiazeines - Promazine hydrochloride, Chlorpromazine hydrochloride*, Triflupromazine,
Thioridazine hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride.
Ring Analogues of Phenothiazeines: Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine.
Fluro buterophenones: Haloperidol, Droperidol, Risperidone.
Beta amino ketones: Molindone hydrochloride.
Benzamides: Sulpieride.
C. Anticonvulsants: SAR of Anticonvulsants, mechanism of anticonvulsant action
Barbiturates: Phenobarbitone, Methabarbital.
Hydantoins: Phenytoin*, Mephenytoin, Ethotoin
Oxazolidine diones: Trimethadione, Paramethadione
Succinimides: Phensuximide, Methsuximide, Ethosuximide*
Urea and monoacylureas: Phenacemide, Carbamazepine*
Benzodiazepines: Clonazepam
Miscellaneous: Primidone, Valproic acid , Gabapentin, Felbamate
5 Drugs acting on Central Nervous System General anesthetics: Inhalation anesthetics: Ultra short acting 7 13
barbitutrates:Dissociative anesthetics: Morphine and related drugs:Narcotic antagonists:Anti-inflammatory
agents:
67
Subject Syllabus

Sr. Topics T W
Drugs acting on Central Nervous System

General anesthetics:
Inhalation anesthetics: Halothane*, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane.
Ultra short acting barbitutrates: Methohexital sodium*, Thiamylal sodium, Thiopental sodium.
Dissociative anesthetics: Ketamine hydrochloride. *Narcotic and non-narcotic analgesics
Morphine and related drugs: SAR of Morphine analogues, Morphine sulphate, Codeine, Meperidine hydrochloride,
Anilerdine hydrochloride, Diphenoxylate hydrochloride, Loperamide hydrochloride, Fentanyl citrate*, Methadone
hydrochloride*, Propoxyphene hydrochloride, Pentazocine, Levorphanol tartarate.
Narcotic antagonists: Nalorphine hydrochloride, Levallorphan tartarate, Naloxone hydrochloride.
Anti-inflammatory agents: Sodium salicylate, Aspirin, Mefenamic acid*, Meclofenamate, Indomethacin, Sulindac, Tolmetin,
Zomepriac, Diclofenac, Ketorolac, Ibuprofen*, Naproxen, Piroxicam, Phenacetin, Acetaminophen, Antipyrine,
Phenylbutazone
Total 45 100
Course Outcomes
CO1 To understand the chemistry of drugs with respect to their pharmacological activity.
CO2 To understand the drug metabolic pathways, adverse effect and therapeutic value of drugs.
CO3 To know the Structural Activity Relationship (SAR) of different class of drugs
CO4 To impart fundamental knowledge on the structure chemistry and therapeutic value of drugs.
CO5 To impart fundamental knowledge on importance of physicochemical properties and metabolism of drugs
CO6 To emphasize on chemical synthesis of important drugs under each class
68
Subject Syllabus
Reference Books
1. Organic medicinal and Pharmaceutical Chemistry
By Wilson and Giswold Lippincott Williams and Wilkins; | 12th revised North American ed edition
2. Foye’s Principles of Medicinal Chemistry.
By David A. Williams | Lippincott Williams and Wilkins
3. Medicinal Chemistry, Vol I to IV
By Burger | Wiley Interscience; a John Wiley and Sons Inc., Publication
4. Introduction to principles of drug design
By Smith and Williams | CRC Press
5. Pharmaceutical Sciences
By Remington Lippincott | Williams and Wilkins
6. Extra pharmacopoeia
By Martindale | Pharmaceutical Press
7. Organic Chemistry- Vol 2
8. The Organic Chemistry of Drug Synthesis Vol 1-5
By Lednicer | Wiley-Interscience
69
Subject Syllabus
23990403-T - PHYSICAL PHARMACEUTICS II – THEORY

Prerequisite 19990112-T - PHARMACEUTICS - THEORY
Upon completion of the course the student shall be able to
1. Understand various physicochemical properties of drug molecules in the designing the
dosage forms
Course Objective 2. Know the principles of chemical kinetics & to use them for stability testing and
determination of expiry date of formulations
3. Demonstrate use of physicochemical properties in the formulation development and
evaluation of dosage forms

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Colloidal dispersions 7 7
Colloidal dispersions: Classification of dispersed systems & their general characteristics, size & shapes of colloidal particles,
classification of colloids & comparative account of their general properties. Optical, kinetic & electrical properties. Effect of
electrolytes, coacervation, peptization& protective action.
2 Rheology 10 10
Rheology: Newtonian systems, law of flow, kinematic viscosity, effect of temperature, non-Newtonian systems,
pseudoplastic, dilatant, plastic, thixotropy, thixotropy in formulation, determination of viscosity, capillary, falling Sphere,
rotational viscometers
Deformation of solids: Plastic and elastic deformation, Heckel equation, Stress, Strain, Elastic Modulus
3 Coarse dispersion 10 10
Coarse dispersion: Suspension, interfacial properties of suspended particles, settling in suspensions, formulation of
flocculated and deflocculated suspensions. Emulsions and theories of emulsification, microemulsion and multiple emulsions;
Stability of emulsions, preservation of emulsions, rheological properties of emulsions and emulsion formulation by HLB
method.
4 Micromeretics 10 10
Micromeretics: Particle size and distribution, mean particle size, number and weight distribution, particle number, methods
for determining particle size by different methods, counting and separation method, particle shape, specific surface,
methods for determining surface area, permeability, adsorption, derived properties of powders, porosity, packing
arrangement, densities, bulkiness & flow properties.
70
Subject Syllabus
5 Drug stability 10 10
71
Subject Syllabus

Sr. Topics T W
Drug stability: Reaction kinetics: zero, pseudo-zero, first & second order, units of basic rate constants, determination of
reaction order. Physical and chemical factors influencing the chemical degradation of pharmaceutical product: temperature,
solvent, ionic strength, dielectric constant, specific & general acid base catalysis, Simple numerical problems. Stabilization of
medicinal agents against common reactions like hydrolysis & oxidation. Accelerated stability testing in expiration dating of
pharmaceutical dosage forms. Photolytic degradation and its prevention
Total 47 47
Course Outcomes
CO1 Relate various physicochemical properties of drug and excipient molecules in designing the dosage forms.
Distinguish the principles of chemical kinetics & to use them for stability testing and determination of expiry date of
CO2
formulations
CO3 Demonstrate use of physicochemical properties in evaluation of dosage forms.
CO4 Understand physicochemical properties of drug molecules in formulation research and development.
Reference Books
1. Physical Pharmcy (TextBook)
By Alfred Martin | Peepee Publishers
2. Tutorial Pharmacy
By Cooper and Gunn’s | CBS Publishers and Distributors
3. Pharmaceutical Calculations
By Stocklosam J. | Lea & Febiger, Philadelphia
4. Pharmaceutical Dosage forms. Disperse systems, volume 1, 2, 3. (TextBook)
By Liberman H.A, Lachman C, | Marcel Dekkar Inc.
5. Physical Pharmaceutics (TextBook)
By Ramasamy C and ManavalanR. | PharmaMed Press/BSP Books
72
Subject Syllabus
23990404-T - PHARMACOLOGY I – THEORY

Prerequisite 23990101 - HUMAN ANATOMY AND PHYSIOLOGY I– THEORY
1. Understand the pharmacological actions of different categories of drugs
2. Explain the mechanism of drug action at organ system/sub cellular/ macromolecular
levels
Course Objective
3. Apply the basic pharmacological knowledge in the prevention and treatment of various
diseases.
4. Observe the effect of drugs on animals by simulated experiments
5. Appreciate correlation of pharmacology with other bio medical sciences

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 General Pharmacology 8 8
a. Introduction to Pharmacology- Definition, historical landmarks and scope of pharmacology, nature and source of drugs,
essential drugs concept and routes of drug administration, Agonists, antagonists( competitive and non competitive), spare
receptors, addiction, tolerance, dependence, tachyphylaxis, idiosyncrasy, allergy.
b. Pharmacokinetics- Membrane transport, absorption, distribution, metabolism and excretion of drugs .Enzyme induction,
enzyme inhibition, kinetics of elimination.
2 General Pharmacology 12 12
a. Pharmacodynamics- Principles and mechanisms of drug action. Receptor theories and classification of receptors,
regulation of receptors. drug receptors interactions signal transduction mechanisms, G-protein –coupled receptors, ion
channel receptor, transmembrane enzyme linked receptors, transmembrane JAK-STAT binding receptor and receptors that
regulate transcription factors, dose response relationship, therapeutic index, combined effects of drugs and factors
modifying drug action. b.Adverse drug reactions. c. Drug interactions (pharmacokinetic and
pharmacodynamic)
d. Drug discovery and clinical evaluation of new drugs -Drug discovery phase,preclinical evaluation phase, clinical trial
phase, phases of clinical trials and pharmacovigilance.
3 Pharmacology of drugs acting on peripheral nervous system 10 10
73
Subject Syllabus
a. Organization and function of ANS.

b.Neurohumoral transmission,co-transmission and classification of
neurotransmitters.
c. Parasympathomimetics, Parasympatholytics, Sympathomimetics,
sympatholytics.
d. Neuromuscular blocking agents and skeletal muscle relaxants
(peripheral). e. Local anesthetic agents.
f. Drugs used in myasthenia gravis and glaucoma
4 Pharmacology of drugs acting on central nervous system 8 8
74
Subject Syllabus

Sr. Topics T W
a. Neurohumoral transmission in the C.N.S.special emphasis on
importance of various neurotransmitters like with GABA, Glutamate,
Glycine, serotonin, dopamine.
b. General anesthetics and pre-anesthetics.
c. Sedatives, hypnotics and centrally acting muscle relaxants.
d. Anti-epileptics e. Alcohols and disulfiram
5 Pharmacology of drugs acting on central nervous system 7 7
a. Psychopharmacological agents: Antipsychotics, antidepressants, anti?anxiety agents, anti-manics and hallucinogens.
b. Drugs used in Parkinsons disease and Alzheimer’s disease.
c. CNS stimulants and nootropics.
d. Opioid analgesics and antagonists
e. Drug addiction, drug abuse, tolerance and dependence
Total 45 45
Course Outcomes
CO1 To study the gather knowledge of Understand the pharmacological actions of different categories of drugs.
The main purpose of the understand Explain the mechanism of drug action at organ system/sub cellular/ macromolecular
CO2
levels.
CO3 To acquire the knowledge of the basic pharmacological knowledge in the prevention and treatment of various diseases.
CO4 To study Observe the effect of drugs on animals by simulated experiments.
CO5 To Appreciate correlation of pharmacology with other bio medical sciences.
Reference Books
1. Pharmacology & Pharmacotherapeutics (TextBook)
By RS Satoskar, SD Bhandakar & Nirmala N Rege
2. Essential of Medical Pharmacology (TextBook)
By KD Tripathi
3. Basic and clinical Pharmacology (TextBook)
By Bertram G Katzung
75
Subject Syllabus
23990405-T - PHARMACEUTICAL JURISPRUDENCE – THEORY

Prerequisite 19990216-T - PHARMACY LAW AND ETHICS
This course is designed to impart basic knowledge on important legislations related to the
Course Objective
profession of pharmacy in India

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Drugs and Cosmetics Act, 1940 and its rules 1945: 10 20
Objectives, Definitions, Legal definitions of schedules to the Act and Rules Import of drugs – Classes of drugs and cosmetics
prohibited from import, Import under license or permit. Offences and penalties. Manufacture of drugs – Prohibition of
manufacture and sale of certain drugs, Conditions for grant of license and conditions of license for manufacture of drugs,
Manufacture of drugs for test, examination and analysis, manufacture of new drug, loan license and repacking license
2 Drugs and Cosmetics Act, 1940 and its rules 1945. 10 25

Detailed study of Schedule G, H, M, N, P,T,U, V, X, Y, Part XII B, Sch F & DMR (OA)
Sale of Drugs – Wholesale, Retail sale and Restricted license. Offences and penalties
Labeling & Packing of drugs- General labeling requirements and specimen labels for drugs and cosmetics, List of permitted
colors.
Offences and penalties.
Administration of the Act and Rules – Drugs Technical Advisory Board, Central drugs Laboratory, Drugs Consultative
Committee, Government drug analysts,Licensing authorities, controlling authorities, Drugs Inspectors
3 Pharmacy Act –1948: Medicinal and Toilet Preparation Act –1955: Narcotic Drugs and Psychotropic Substances 10 25
Act-1985 and Rules:
Objectives, Definitions, Pharmacy Council of India; its constitution and functions, Education Regulations, State and Joint
state pharmacy councils; constitution and functions, Registrationof Pharmacists, Offences and Penalties
Objectives, Definitions,Licensing, Manufacture In bond and Outside bond, Export of
alcoholicpreparations, Manufacture of Ayurvedic, Homeopathic, Patent &Proprietary Preparations. Offences and Penalties.
Objectives, Definitions, Authorities and Officers, Constitution and Functions of narcotic & Psychotropic Consultative
Committee, National Fund for Controlling the Drug Abuse, Prohibition, Control and Regulation, opium poppy cultivation and
production of poppy straw, manufacture, sale and export of opium, Offences and Penalties
4 Study of Salient Features of Drugs and Magic Remedies Act and itsrules: Prevention of Cruelty to animals Act- 8 17
1960: National Pharmaceutical Pricing Authority:
76
Subject Syllabus

Sr. Topics T W
Objectives, Definitions, Prohibition of certain advertisements, Classes of Exempted advertisements, Offences and Penalties
Objectives, Definitions,Institutional Animal Ethics Committee, CPCSEA guidelines for Breeding and Stocking of Animals,
Performance of Experiments,Transfer and acquisition of animals for experiment, Records, Power to suspend or revoke
registration, Offences and Penalties
Drugs Price ControlOrder

(DPCO)- 2013. Objectives, Definitions, Sale prices of bulk drugs,Retail price of formulations, Retail price and ceiling price of
scheduledformulations, National List of EssentialMedicines (NLEM)
5 Pharmaceutical Legislations Code of Pharmaceutical Ethics 7 13

A brief review, Introduction, Study of drugs enquiry committee, Health survey and development committee, Hathi
committee and Mudaliar committee
• Definition, Pharmacist in relation to his job, trade, medical profession and his profession, Pharmacist ’s oath
• Medical Termination of Pregnancy Act
• Right to Information Act
• Introduction to Intellectual Property Rights (IPR)
Total 45 100
Course Outcomes
To generalize the Pharmaceutical legislations related to import and manufacturing manufacturing of drug with reference to
CO1
Drug and cosmetic act 1940.
To gather knowledge of Pharmaceutical legislations related to selling, labelling and packaging of drug with reference to Drug
CO2
and cosmetic act 1940 including the detail of regulatory authorities
CO3 To acquire the knowledge of Indian Pharmaceutical acts including Pharmacy council of India constitution.
To generalize regulations related to licensing procedure for manufacturing of medicinal and toilet preparations and narcotic
CO4
and psychotropic substances.
To attribute about regulations related to magic remedies, prevention of cruelty to animals, and price control of bulk drug and
CO5
their formulations.
To categorize code of ethics of the pharmaceutical practice, Intellectual property rights and Medical termination of
CO6
pregnancy.
77
Subject Syllabus
Reference Books
1. Forensic Pharmacy (TextBook)
By B. Suresh 123 | Birla Publication Pvt. Ltd
2. A text book of Forensic Pharmacy
By N.K. Jain | Vallabh Prakashan
3. Hand book of drug law
By M.L. Mehra
4. Text book of Forensic Pharmacy
By B.M. | Mithal Paperback Publication
5. Drugs and Cosmetics Act/Rules
Govt. of India publications
6. Medicinal and Toilet preparations act 1955
Govt. of India publication
7. Narcotic drugs and psychotropic substances act (TextBook)
8. Drugs and Magic Remedies act
9. Bare Acts of the said laws published
Government. Reference books
78
Subject Syllabus
23990406-P - MEDICINAL CHEMISTRY I – PRACTICAL

Prerequisite 23990202 - PHARMACEUTICAL ORGANIC CHEMISTRY I – THEORY
1. This subject is designed to impart fundamental knowledge on the structure chemistry
and therapeutic value of drugs.
Course Objective 2. The subject emphasizes on structure activity relationships of drugs, importance of
physicochemical properties and metabolism of drugs.
3. The syllabus also emphasizes on chemical synthesis of important drugs under each class.

Total
- - 4 2 - - 35 15 50
Reference Books
1. Text book of practical organic chemistry
By Vogels | Pearson Publication
2. Extra pharmacopoeia
By Martindale | Pharmaceutical Press
3. Organic Chemistry- Vol 2
4. The Organic Chemistry of Drug Synthesis Vol 1-5
By Daniel Lednicer, Lester A. Mitscher | Wiley-Interscience
List of Practical
1. Preparationofdrugs/intermediates
1. 1,3-pyrazole 2. 1,3-oxazole 3. Benzimidazole 4. Benztriazole 5. 2,3- diphenyl quinoxaline 6. Benzocaine 7. Phenytoin 8.
Phenothiazine 9. Barbiturate
2. Assayofdrugs
1. Chlorpromazine 2. Phenobarbitone 3. Atropine 4. Ibuprofen 5. Aspirin 6. Furosemide
3. Determination of Partition coefficient for any two drugs
79
Subject Syllabus
23990407-P - PHYSICAL PHARMACEUTICS II – PRACTICAL

Prerequisite 23990407-P - PHYSICAL PHARMACEUTICS II – PRACTICAL
1. Understand various physicochemical properties of drug molecules in the designing the
dosage forms
Course Objective 2. Know the principles of chemical kinetics & to use them for stability testing nad
determination of expiry date of formulations
3. Demonstrate use of physicochemical properties in the formulation development and
evaluation of dosage forms

Total
- - 4 2 - - 35 15 50
Reference Books
1. Experimental Pharmaceutics by Eugene, Parrott.
By Eugene L. Parrott, Wotold saski | Burgess International Group Inc.
List of Practical
1. Determination of particle size, particle size distribution using sieving method
2. Determination of particle size, particle size distribution using Microscopic method
3. Determination of bulk density, true density and porosity
4. Determine the angle of repose and influence of lubricant on angle of repose
5. Determination of viscosity of liquid using Ostwald’s viscometer
6. Determination sedimentation volume with effect of different suspending agent
7. Determination sedimentation volume with effect of different concentration of single suspending agent
8. Determination of viscosity of semisolid by using Brookfield viscometer
9. Determination of reaction rate constant first order.
10. Determination of reaction rate constant second order
11. Accelerated stability studies
80
Subject Syllabus
23990408-P - PHARMACOLOGY I – PRACTICAL

Prerequisite 23990206-P - HUMAN ANATOMY AND PHYSIOLOGY II – PRACTICAL
1. Understand the pharmacological actions of different categories of drugs
2. Explain the mechanism of drug action at organ system/sub cellular/ macromolecular levels
Course Objective
3. Apply the basic pharmacological knowledge in the prevention and treatment of various diseases.
4. Observe the effect of drugs on animals by simulated experiments
5. Appreciate correlation of pharmacology with other bio medical sciences

Total
- - 4 2 - - 35 15 50
Reference Books
1. Fundamentals of experimental Pharmacology (TextBook)
By M.N.Ghosh
2. Hand book of Experimental Pharmacology (TextBook)
By S.K.Kulakarni
List of Practical
1. Introduction to experimental pharmacology
2. Commonly used instruments in experimental pharmacology.
3. Study of common laboratory animals
4. Maintenance of laboratory animals as per CPCSEA guide
Common laboratory techniques. Blood withdrawal, serum and plasma separation, anesthetics and euthanasia used for
5.
animal studies.
6. Study of different routes of drugs administration in mice/rats
7. Study of effect of hepatic microsomal enzyme inducers on the phenobarbitone sleeping time in mice.
8. Effect of drugs on ciliary motility of frog oesophagus
9. Effect of drugs on rabbit eye
10. Effects of skeletal muscle relaxants using rota-rod apparatus
11. Effect of drugs on locomotor activity using actophotometer.
12. Anticonvulsant effect of drugs by MES and PTZ method
81
13. Study of stereotype and anti-catatonic activity of drugs on rats/mice.
14. Study of anxiolytic activity of drugs using rats/mice
15. Study of local anesthetics by different methods
Note: All laboratory techniques and animal experiments are demonstrated by simulated experiments by softwares and
videos.
82
Subject Syllabus
23990501-T - MEDICINAL CHEMISTRY II – THEORY

Prerequisite 23990501-T - MEDICINAL CHEMISTRY II – THEORY
1. Helps in correlating between pharmacology of a disease and its mitigation or cure.
2. To write the chemical synthesis of some drugs.
3. To know the structural activity relationship of different class of drugs.
Course Objective
4. Knowledge about the mechanism pathways of different class of medicinal compounds.
5. To acquire knowledge about the chemotherapy for cancer.
6. To understand the chemistry of drugs with respect to their pharmacological activity.

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Antihistaminic agents, H1–antagonists, H2-antagonists,Gastric Proton pump inhibitors,Anti-neoplastic agents, 10 23
Alkylating agents, Antimetabolites, Antibiotics, Plant products, Miscellaneous
Histamine, receptors and their distribution in the human body, Diphenhydramine hydrochloride*, Dimenhydrinate,
Doxylamines cuccinate, Clemastine fumarate, Diphenylphyraline hydrochloride, Tripelenamine hydrochloride, Chlorcyclizine
hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride*,
Phenidamine tartarate, Promethazine hydrochloride*, Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine
maleate, Astemizole, Loratadine, Cetirizine, Levocetrazine Cromolyn sodium Cimetidine*, Famotidine, Ranitidine.
Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole Meclorethamine*, Cyclophosphamide, Melphalan, Chlorambucil,
Busulfan, Thiotepa Mercaptopurine*, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate*, Azathioprine
Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin Etoposide, Vinblastin sulphate, Vincristin sulphate Cisplatin, Mitotane.
2 Anti-anginal, Vasodilators, Calcium channel blockers, Diuretics, Carbonic anhydrase inhibitors, Thiazides, Loop 10 24
diuretics, Potassium sparing Diuretics, Osmotic Diuretics, Anti-hypertensive Agents,
Amyl nitrite, Nitroglycerin*, Pentaerythritol tetranitrate, Isosorbide dinitrite*, Dipyridamole. Verapamil, Bepridil
hydrochloride, Diltiazem hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine. Acetazolamide*,
Methazolamide, Dichlorphenamide. Chlorthiazide*, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide, Furosemide*,
Bumetanide, Ethacrynic acid. Spironolactone, Triamterene, Amiloride. Mannitol Timolol, Captopril, Lisinopril, Enalapril,
Benazepril hydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride,* Clonidine hydrochloride, Guanethidine
monosulphate, Guanabenz acetate, Sodium nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride.
3 Anti-arrhythmic Drugs, Anti-hyperlipidemic agents, Coagulant & Anticoagulants, Drugs used in Congestive 10 23
Heart Failure
Quinidine sulphate, Procainamide hydrochloride, Disopyramide phosphate*, Phenytoin sodium, Lidocaine hydrochloride,
Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone, Sotalol. Clofibrate, Lovastatin,
Cholesteramine and Cholestipol Menadione, Acetomenadione, Warfarin*, Anisindione, clopidogrel Digoxin, Digitoxin,
Nesiritide, Bosentan, Tezosentan
83
Subject Syllabus
4 Drugs acting on Endocrine system, Sex hormones, Drugs for erectile dysfunction, Oral contraceptives, 8 17
Corticosteroids, Thyroid and antithyroid drugs,
Nomenclature, Stereochemistry and metabolism of steroids Testosterone, Nandralone, Progestrones, Oestriol, Oestradiol,
Oestrione, Diethyl stilbestrol. Sildenafil, Tadalafil. Mifepristone, Norgestril, Levonorgestrol Cortisone, Hydrocortisone,
Prednisolone, Betamethasone, Dexamethasone L-Thyroxine, L-Thyronine, Propylthiouracil, Methimazole.
5 Antidiabetic agents, Sulfonyl ureas, Biguanides, Thiazolidinediones, Glucosidase inhibitors, Local Anesthetics, 7 13
Benzoic Acid derivatives, Amino Benzoic acid derivatives, Lidocaine/Anilide derivatives, Miscellaneous,
84
Subject Syllabus

Sr. Topics T W
Insulin and its preparations Tolbutamide*, Chlorpropamide, Glipizide, Glimepiride. Metformin. Pioglitazone, Rosiglitazone.
Meglitinides: Repaglinide, Nateglinide. Acrabose, Voglibose. SAR of Local anesthetics Cocaine, Hexylcaine, Meprylcaine,
Cyclomethycaine, Piperocaine. Benzocaine*, Butamben, Procaine*, Butacaine, Propoxycaine, Tetracaine, Benoxinate.
Lignocaine, Mepivacaine, Prilocaine, Etidocaine. Phenacaine, Diperodon, Dibucaine.
Total 45 100
Course Outcomes
To understand the drugs including classification, nomenclature, SAR, mechanism of action, Synthesis and
CO1
adverse effects of Antihistaminic drugs.
To understand drugs including classification, nomenclature, structure activity relationship (SAR), mechanism of
CO2
action, adverse effects, therapeutic uses Anti-anginal, Diuretics.
To understand the drugs including classification, nomenclature SAR, mechanism of action of Anti-arrhythmic drugs,
CO3
anti-hyperlipidemic agents & drugs used in congestive heart failure.
To understand the drugs including classification, nomenclature, SAR, mechanism of action, adverse effects of
CO4 drugs acting on Endocrine system, Sex hormones, Drugs for erectile dysfunction, Oral contraceptives
and Corticosteroids.
To understand the drugs including classification, nomenclature, SAR, mechanism of action, Synthesis and
CO5
adverse effects of Antidiabetic agents and Local Anesthetics agents.
Reference Books
1. Burger’s Medicinal Chemistry, Vol I to IV.
By Donald J. Abraham, David P. Rotella | Wiley-Blackwell
2. Foye’s Principles of Medicinal Chemistry.
By David A. Williams | Lippincott Williams and Wilkins
4. Introduction to principles of drug design
By H. John Smith, Hywel Williams | CRC Press
5. Martindale’s extra pharmacopoeia.
By William Martindale, Wynn Westcott | Pharmaceutical Press
6. Organic Chemistry Volume- II
By I.L. Finar | ( 3rd.ed.) Longmans Green & Co. 1964
7. Remington’s Pharmaceutical Sciences
By Arthur Osol And John E. Hoover | Mack. Publishing Co
8. The Organic Chemistry of Drug Synthesis, Vol. 1-5.
By Daniel Lednicer, Lester A. Mitscher | Wiley-Blackwell
10. Wilson and Giswold’s Organic medicinal and Pharmaceutical Chemistry
By John M Beale, John Block | Lippincott Williams and Wilkin
85
Subject Syllabus
23990502-T - PHARMACOLOGY II – THEORY

Prerequisite 23990404-T - PHARMACOLOGY I – THEORY
1. Students would have understood the mechanism of drug action and its relevance in
the treatment of different diseases
2. They would be trained with isolation of different organs/tissues from the laboratory
animals by simulated experiments
3. They would have observed the various receptor actions using isolated tissue
Course Objective
preparation
4. Students would appreciate the correlation of pharmacology with related medical
sciences
5. They would have understood the cell communication mechanism
6. They would appreciate the newer targets of several disease conditions for treatment.

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Pharmacology of drugs acting on cardio vascular system 10 23
a) Introduction to hemodynamic and electrophysiology of heart. b.
Drugs used in congestive heart failure
b) Anti-hypertensive drugs.
c) Anti-anginal drugs.
d) Anti-arrhythmic drugs.
e) Anti-hyperlipidemic drugs.
2 Pharmacology of drugs acting on cardio vascular system 10 23
1.Pharmacology of drugs acting on cardio vascular system
a) Drug used in the therapy of shock.
b) Hematinics, coagulants and anticoagulants.
c) Fibrinolytics and anti-platelet drugs
d) Plasma volume expanders
2. Pharmacology of drugs acting on urinary system
a) Diuretics
b) Anti-diuretics
3 Autocoids and related drugs 10 24
86
Subject Syllabus
Autocoids and related drugs

a) Introduction to autacoids and classification
b) Histamine, 5-HT and their antagonists.
c) Prostaglandins, Thromboxanes and Leukotrienes.
d) Angiotensin, Bradykinin and Substance P.
e) Non-steroidal anti-inflammatory agents
f) Anti-gout drugs
g) Antirheumatic drugs
4 Pharmacology of drugs acting on endocrine system 8 17
87
Subject Syllabus

Sr. Topics T W
Pharmacology of drugs acting on endocrine system
a) Basic concepts in endocrine pharmacology.
b) Anterior Pituitary hormones- analogues and their inhibitors.
c) Thyroid hormones- analogues and their inhibitors.
d) Hormones regulating plasma calcium level- Parathormone,
Calcitonin and Vitamin-D.
e) Insulin, Oral Hypogl ycemic agents and glucagon.
f) ACTH and corticosteroids.
5 Pharmacology of drugs acting on endocrine system 7 13
Pharmacology of drugs acting on endocrine system
a) Androgens and Anabolic steroids.
b) Estrogens, progesterone and oral contraceptives.
c) Drugs acting on the uterus.
6. Bioassay
a) Principles and applications of bioassay.
b) Types of bioassay
c) Bioassay of insulin, oxytocin, vasopressin, ACTH, d tubocurarine,
digitalis, histamine and 5-HT
Total 45 100
Course Outcomes
CO1 To understand the pharmacological actions of different categories of drugs
CO2 To study in detailed about mechanism of drug action at organ system/sub cellular/ macromolecular levels
CO3 To understand the application of basic pharmacological knowledge in the prevention and treatment of various diseases.
CO4 To observed the effect of drugs on animals by simulated experiments
Reference Books
1. Essential of Medical Pharmacology (TextBook)
By KD Tripathi
2. Pharmacology & Pharmacotherapeutics (TextBook)
By RS Satoskar, SD Bhandakar & Nirmala N Rege
3. Goodman’s & Gilman’s the pharmacological basis of therapeutics (TextBook)
88
Subject Syllabus
23990503-T - PHARMACOGNOSY AND PHYTOCHEMISTRY II –
THEORY

Prerequisite 23990305-T - PHARMACOGNOSY AND PHYTOCHEMISTRY I - THEORY
1. This course is one of the most advanced introductionsin Herbal Medicines that is
offered. Will learn and get experience about
2. Herbs, and their Science.
3. Classification of Medicinal Plants, Phytochemistry, Carbohydrates, Lipids, Terpenes,
Polyphenols, Alkaloids,
4. Pharmacology, Toxicity, Formulations and Preparations of Herbal Medicines.
Course Objective
5. How herbs influence our physiology and can be helpful against several disorders.
6. Relationsbetween Phyto-therapy and the Elderly, Phytotherapy and Children,
Understanding Herbal Action, and Understanding the MateriaMedica.
7. The recognition of medicinal plants, identification of adulteration and Contamination.
Ethnobotany&Ethnopharmacology in drug discovery process.
8. DNA Finger printing.

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Metabolic pathways in higher plants and their determination 7 15
1. Brief study of basic metabolic pathways and formation of different secondary metabolites through these pathways-
Shikimic acid pathway, Acetate pathways and Amino acid pathway.
2. Study of utilization of radioactive isotopes in the investigation of Biogenetic studies.
2 General introduction, composition, chemistry & chemical classes, bio-sources, therapeutic uses and commercial 14 31
applications of following secondary metabolites
Alkaloids: Vinca,Rauwolfia,Belladonna,Opium, Phenyl propanoids and Flavonoids: Lignans,Tea,Ruta Steroids,Cardiac
Glycosides & Triterpenoids: Liquorice,Dioscorea,Digitalis Volatileoils: Mentha,Clove,Cinnamon,Fennel,Coriander, Tannins:
Catechu,Pterocarpus Resins: Benzoin,Guggul,Ginger,Asafoetida,Myrrh,Colophony Glycosides: Senna,Aloes,BitterAlmond
Iridoids, Other terpenoids & Naphtha quinones: Gentian,Artemisia,taxus,carotenoids
3 Isolation, Identification and Analysis of Phytoconstituents 6 14
1. Terpenoids: Menthol,Citral,Artemisin
2. Glycosides:Glycyrhetinicacid&Rutin
3. Alkaloids:Atropine, Quinine, Reserpine, Caffeine
4. Resins:Podophyllotoxin,Curcumin
4 Industrial production, estimation and utilization of the following phytoconstituents 10 24
Forskolin, Sennoside, Artemisinin, Diosgenin, Digoxin, Atropine, Podophyllotoxin, Caffeine, Taxol, Vincristine and Vinblastine
89
Subject Syllabus
THEORY
5 Basics of Phytochemistry 8 18
Modern methods of extraction, application of latest techniques like Spectroscopy, chromatography and electrophoresis in
the isolation, purification and identification of crude drugs.
Total 45 102
90
Subject Syllabus
THEORY
Course Outcomes
CO1 To understand various secondary metabolites and metabolic pathways.
CO2 To understand and carryout isolation and purification of phytoconstituents.
CO3 To understand the industrial production of crude drugs.
CO4 To understand the basics of Phytochemicals.
Reference Books
1. Trease and Evans Pharmacognosy,
By W. C. Evans | 16th Edition, W.B. Sounders & Co., London, 2009
2. Pharmacognosy and Phytochemistry,
By Mohammad Ali. | CBS Publishers & Distribution, New Delhi.
3. Rangari, V.D., Text book of Pharmacognosy and Phytochemistry
By Vol. I , Carrier Pub., 200
4. Herbal drug industry
By R.D. Choudhary
5. Essentials of Pharmacognosy
By Dr.SH.Ansari
6. Herbal Cosmetics
By H.Pande | Asia Pacific Business press, Inc, New Delhi
7. Plant cell Biotechnology,
By R Endress, | Springer-Verlag, Berlin, 1994.
8. Textbook of Industrial Pharmacognosy
By A.N. Kalia, | CBS Publishers, New Delhi, 2005
9. Pharmacognosy & Pharmacobiotechnology
By by James E. Robbers, Marilyn Speedie, Varo E. Tyler | Lippincott Williams and Wilkins
10. Remington’s Pharmaceutical Sciences
By Arthur Osol And John E. Hoover | Mack. Publishing Co
11. Text Book of Biotechnology
By Vyas S. P and Dixit V. K. | CBS
12. Text Book of Biotechnology
By R.C. Dubey. | S. Chand Publishing
91
Subject Syllabus
23990504-T - PHARMACEUTICAL MICROBIOLOGY – THEORY

Prerequisite 23990504-T - PHARMACEUTICAL MICROBIOLOGY – THEORY
1. Students will be able to acquire, articulate, retain and apply specialized language and
knowledge relevant to microbiology.
2. Students will acquire and demonstrate competency in laboratory safety and in routine
and specialized microbiological laboratory skills applicable to microbiological research
or clinical methods, including accurately reporting observations and analysis.
3. Students will communicate scientific concepts, experimental results and analytical
Course Objective
arguments clearly and concisely, both verbally and in writing.
4. Students will demonstrate isolation of and identification of microbes.
5. Students can able to design microbiology laboratory considering all the aspects of
safety
6. Students will acquire knowledge about validating the microbiological equipment and
reporting the observations

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Introduction, history of microbiology 10 24
Introduction, history of microbiology, its branches, scope and its importance. Introduction to Prokaryotes and Eukaryotes
Study of ultra-structure and morphological classification of bacteria, nutritional requirements, raw materials used for culture
media and physical parameters for growth, growth curve, isolation and preservation methods for pure cultures, cultivation
of anaerobes, quantitative measurement of bacterial growth (total & viable count). Study of different types of phase
constrast microscopy, dark field microscopy and electron microscopy.
2 Identification of bacteria using staining techniques 10 23
Identification of bacteria using staining techniques (simple, Gram’s &Acid fast staining) and biochemical tests (IMViC). Study
of principle, procedure, merits, demerits and applications of physical, chemical gaseous, radiation and mechanical method of
sterilization. Evaluation of the efficiency of sterilization methods. Equipments employed in large scale sterilization. Sterility
indicators
3 Study of morphology 10 23
Study of morphology, classification, reproduction/replication and cultivation of Fungi and Viruses. Classification and mode of
action of disinfectants Factors influencing disinfection, antiseptics and their evaluation. For bacteriostatic and bactericidal
actions Evaluation of bactericidal & Bacteriostatic. Sterility testing of products (solids, liquids, ophthalmic and other sterile
products) according to IP, BP and USP.
4 Designing of aseptic area, laminar flow equipment 8 17
92
Subject Syllabus
Designing of aseptic area, laminar flow equipments; study of different sources of contamination in an aseptic area and
methods of prevention, clean area classification. Principles and methods of different microbiological assay. Methods for
standardization of antibiotics, vitamins and amino acids. Assessment of a new antibiotic.
5 Types of spoilage, factors affecting the microbial spoilage of pharmaceutical products, 7 13
93
Subject Syllabus

Sr. Topics T W
Types of spoilage, factors affecting the microbial spoilage of pharmaceutical products, sources and types of microbial
contaminants, assessment of microbial contamination and spoilage. Preservation of pharmaceutical products using
antimicrobial agents, evaluation of microbial stability of formulations. Growth of animal cells in culture, general procedure
for cell culture, Primary, established and transformed cell cultures. Application of cell cultures in pharmaceutical industry and
research.
Total 45 100
Course Outcomes
To identify and theories the knowledge of various microorganisms with its nutritional requirements, preparation and
CO1
preservation for pure culture, cultivation and quantitative measurement of it using various microscopy
To detect various microorganisms using staining technique and carry out the knowledge of it for various sterilization
CO2
methods in pharmaceutical processing and industries
To explain and specify the Microbial spoilage , animal cell culture technology and using it for stability of various
CO3
pharmaceutical products
CO4 To integrate the sterilization methods, equipments and its validation
CO5 To extrapolate Fungi, Viruses and disinfectants, and organise sterility testing of pharmaceutical products.
CO6 To plan of Aseptic area and Interpret the different test of microbiological assays
Reference Books
1. Burrows Textbook of Microbiology (TextBook)
By Bob A freeman | W.B. Saunders | 21, Pub. Year 1979
2. A Text Book of Medical Microbiology (TextBook)
By Anathanarayana & Panikar
3. Anathanarayana & Panikar Medical Microbioloty (TextBook)
4. A Text Book of Microbiology

By P. Chakraborthy
94
Subject Syllabus
23990505-T - PHARMACEUTICAL BIOTECHNOLOGY - THEORY

Prerequisite 23990103-T - PHARMACEUTICS I –THEORY
1. Students will understand the various techniques used in modern biotechnology.
2. Students can design research strategy with step-by-step instructions to address a research
problem
3. Students can able to provide examples of current applications of biotechnology and
advances in the different areas like medical, microbial, environmental, bioremediation,
Course Objective agricultural, plant, animal, andForensic
4. Students can explain the concept and application of monoclonal antibody Technology
5. Students can demonstrate and Provide examples on how to use microbes and
mammalian cells for the production of pharmaceutical products
6. Students can able to explain the general principles of generating transgenic plants,
animals and microbes

Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Introduction to Biotechnology 10 23
1. Brief introduction to Biotechnology with reference to Pharmaceutical Science
2. Enzyme Biotechnology- Methods of enzyme immobilization and applicatio
3. Biosensors- Working and applications of biosensors in Pharmaceutical Industrie
4. Brief introduction to Protein Engineering.
5. Use of microbes in industry. Production of Enzymes- General consideration - Amylase, Catalase, Peroxidase, Lipase,
Protease, Penicillinase.
6. Basic principles of genetic engineering.
2 Recombinant DNA technology 10 23
95
Subject Syllabus
1. Study of cloning vectors, restriction endonucleases and DNA ligase.

2. Recombinant DNA technology. Application of genetic engineering in medicine.
3. Application of r DNA technology and genetic engineering in the production of:
i) Interferon
ii) Vaccines- hepatitis- B
iii) Hormones-Insulin.
4. Brief introduction to PCR
3 . 10 23
96
Subject Syllabus

Sr. Topics T W
Types of immunity- humoral immunity, cellular immunity
1. Structure of Immunoglobulins
2. Structure and Function of MHC
3. Hypersensitivity reactions, Immune stimulation and Immune suppressi
4. General method of the preparation of bacterial vaccines, toxoids, viral vaccine, antitoxins, serum-immune blood
derivatives and other products relative to immunity.
5. Storage conditions and stability of official vaccines
6. Hybridoma technology- Production, Purification and Applications
Blood products and Plasma Substituties.
4 . 8 17
1. Immuno blotting techniques- ELISA, Western blotting, Southern blotting.
2. Genetic organization of Eukaryotes and Prokaryotes
3. Microbial genetics including transformation, transduction, conjugation, plasmids and tra
4. Introduction to Microbial biotransformation and applications
5. Mutation: Types of mutation/mutants.
5 . 7 13
1. Fermentation methods and general requirements, study of media, equipments, sterilization methods, aeration
process, stirring.
2. Large scale production fermenter design and its various c
3. Study of the production of - penicillins, citric acid, Vitamin B12, Glutamic acid, Griseofulvin,
4. Blood Products: Collection, Processing and Storage of whole human blood, dried human plasma, plasma Substituties.
Total 45 99
Course Outcomes
CO1 Understand basic Introduction of scope, Potential and achievements in biotechnology.
CO2 Understand the New concepts of Biotechnology, Genetic engineering techniques and recombinant DNA technology.
CO3 Study the examples of biotechnology derived products and transgenic animals, cryopreservation and germplasm storage.
CO4 Understand and Study steps involved in monoclonal antibody production, enzyme technology and fermentation technology.
97
Subject Syllabus
Reference Books
1. Molecular Biotechnology: Principles and Applications of Recombinant DNA
By B.R. Glick and J.J. Pasternak: | ASM Press Washington D.C.
2. Kuby Immunology
By Richard A. Goldsby, Thomas J. Kindt, Barbara A. Osborne, Janis Immunology Kuby | W H Freeman & Co
3. Monoclonal Antibodies.
By J.W. Goding | Academic Press
4. Molecular Biology and Biotechnology
By J.M. Walker and E.B. Gingold: | Royal Society of Chemistry.
5. Immobilized Enzymes (TextBook)
By Zaborsky | CRC Press, Degraland, Ohio.
6. Molecular Biotechnology (TextBook)
By S.B. Primrose | Blackwell Scientific Publication. | 2nd Edition
7. Principles of fermentation technology, (TextBook)
By Stanbury F., P., Whitakar A., and Hall J., S., | Aditya books Ltd., New Delhi | 2nd edition
98
Subject Syllabus
23990506-P - PHARMACOLOGY II – PRACTICAL

Prerequisite 23990408 - PHARMACOLOGY I – PRACTICAL
1. Students would have understood the mechanism of drug action and its relevance in
the treatment of different diseases
2. They would be trained with isolation of different organs/tissues from the laboratory
animals by simulated experiments
3. They would have observed the various receptor actions using isolated tissue
Course Objective
preparation
4. Students would appreciate the correlation of pharmacology with related medical
sciences
5. They would have understood the cell communication mechanism
6. They would appreciate the newer targets of several disease conditions for treatment.

Total
- - 4 2 - - 35 15 50
Reference Books
By S.K.Kulakarni
By M.N.Ghosh
List of Practical
1. Introduction to in-vitro pharmacology and physiological salt solutions
2. Effect of drugs on isolated frog heart.
3. Effect of drugs on blood pressure and heart rate of dog.
4. Study of diuretic activity of drugs using rats/mice.
5. DRC of acetylcholine using frog rectus abdominis muscle
6. Effect of physostigmine and atropine on DRC of acetylcholine using frog
7. Bioassay of histamine using guinea pig ileum by matching method
8. Bioassay of oxytocin using rat uterine horn by interpolation method.
99
Subject Syllabus
9. Bioassay of serotonin using rat fundus strip by three point bioassay.

10. Bioassay of acetylcholine using rat ileum/colon by four point bioassay
11. Determination of PA2 value of prazosin using rat anococcygeus muscle (by Schilds plot method).
12. Determination of PD2 value using guinea pig ileum
13. Effect of spasmogens and spasmolytics using rabbit jejunum
14. Anti-inflammatory activity of drugs using carrageenan induced pawedema model.
15. Analgesic activity of drug using central and peripheral methods
10
0
Subject Syllabus
10
1
Subject Syllabus
23990507-P - PHARMACOGNOSY AND PHYTOCHEMISTRY II –
PRACTICAL

Prerequisite 23990309-P - PHARMACOGNOSY AND PHYTOCHEMISTRY I – PRACTICAL
1. This course is one of the most advanced introductionsin Herbal Medicines that is
offered. Will learn and get experience about
2. Herbs, and their Science.
3. Classification of Medicinal Plants, Phytochemistry, Carbohydrates, Lipids, Terpenes,
Polyphenols, Alkaloids,
4. Pharmacology, Toxicity, Formulations and Preparations of Herbal Medicines.
Course Objective
5. How herbs influence our physiology and can be helpful against several disorders.
6. Relationsbetween Phyto-therapy and the Elderly, Phytotherapy and Children,
Understanding Herbal Action, and Understanding the MateriaMedica.
7. The recognition of medicinal plants, identification of adulteration and Contamination.
Ethnobotany&Ethnopharmacology in drug discovery process.
8. DNA Finger printing.

Total
- - 4 2 - - 35 15 50
Reference Books
1. The formulation and preparation of cosmetic, fragrances and flavours
By Louis Appell | Micelle Press
2. Essentials of Pharmacognosy
By Dr.SH.Ansari
102
Subject Syllabus
23990507-P - PHARMACOGNOSY AND PHYTOCHEMISTRY II –
PRACTICAL
List of Practical
Morphology,histologyandpowdercharacteristics&extraction&detectionof:
1.
Cinchona,Cinnamon,Senna,Clove,Ephedra,FennelandCoriander
Exercise involving isolation & detection of active principles a) Caffeine - from tea dust. b) Diosgenin from Dioscorea c)
2.
Atropine from Belladonna d. Sennosides from Senna
3. Separation of sugars by Paper chromatography
4. TLC of herbal extract
5. Distillation of volatile oils and detection of phytoconstitutents by TLC
6. Analysis of crude drugs by chemical tests: i. Asafoetida ii. Benzoin iii. Colophony iv. Aloes v. Myrrh
103
Subject Syllabus
23990508-P - PHARMACEUTICAL MICROBIOLOGY - PRACTICAL

Prerequisite 23990110-P - PHARMACEUTICS I – PRACTICAL
1. Students will be able to acquire, articulate, retain and apply specialized language and
knowledge relevant to microbiology.
2. Students will acquire and demonstrate competency in laboratory safety and in routine
and specialized microbiological laboratory skills applicable to microbiological research
or clinical methods, including accurately reporting observations and analysis.
Course Objective 3. Students will communicate scientific concepts, experimental results and analytical
arguments clearly and concisely, both verbally and in writing.
4. Students will demonstrate isolation of and identification of microbes.
5. Students can able to design microbiology laboratory considering all the aspects of safety
Students will acquire knowledge about validating the microbiological equipment and
reporting the observations

Total
- - 4 2 - - 35 15 50
Reference Books
1. Pharmaceutical Microbiology (TextBook)
By Malcolm Harris, Balliere Tindall and Cox
2. Guide to microbiological control in pharmaceuticals and medical devices
By Denyer, S. P. and Baird, R. M. | CRC Press, Boca Raton (2008). | 2nd edition
3. Pharmaceutical Microbiology
By W.B. Hugo and A.D. Russel: | Blackwell Scientific publications, Oxford London.
104
Subject Syllabus
23990508-P - PHARMACEUTICAL MICROBIOLOGY - PRACTICAL
List of Practical
1. Introduction and study of different equipment's
Introduction and study of different equipments and processing
Introduction and study of different equipments and processing, e.g., B.O.D. incubator, laminar flow, aseptic hood, autoclave,
hot air sterilizer, deep freezer, refrigerator, microscopes used in experimental microbiology
2. Sterilization of glassware, preparation and sterilization of media.

Sterilization of glassware, preparation and sterilization of media.
Sterilization of glassware, preparation and sterilization of media.
3. Sub culturing of bacteria and fungus. Nutrient stabs and slants preparations
Sub culturing of bacteria and fungus. Nutrient stabs and slants preparations
4. Stainingmethods-Simple,Gramsstainingandacidfaststaining
Staining methods- Simple, Grams staining and acid fast staining (Demonstration with practical).
5. Isolation of pure culture of micro-organisms by multiple streak plate technique and other techniques
Isolation of pure culture of micro-organisms by multiple streak plate technique and other techniques.
6. Microbiological assay of antibiotics by cup plate method and other methods
Microbiological assay of antibiotics by cup plate method and other methods
7. Motility determination by Hanging drop method.
Motility determination by Hanging drop method
8. Sterility testing of pharmaceuticals.
Sterility testing of pharmaceuticals.
9. Bacteriological analysis of water

Bacteriological analysis of water
10. Biochemical test
Biochemical test
105
SubjectSyllabus
23990601-T-MEDICINALCHEMISTRYIII–THEORY
Course BachelorofPharmacy(B.Pharm.) Semester-6

TypeofCourse CoreCourses
Prerequisite 23990501-T-MEDICINALCHEMISTRYII–THEORY
1. Theywouldabletodevelopanunderstandingofthephysico-chemicalpropertiesofdrugs.
2. Studentsabletounderstandhowcurrentdrugsweredevelopedbyusingpharmacophoremodeling and
docking technique.
3. Theyacquireknowledgeinthechemotherapyforcancerandmicrobialdiseasesanddifferentanti-viral
CourseObjective agents.
4. Theyacquireknowledgeaboutthemechanismpathwaysofdifferentclassofmedicinalcompounds.
5. Theyhavebeenintroducedtoavarietyofdrugclassesandsomepharmacological
properties.
6. Theyacquireknowledgeonthrustareasfirfurtherresearch
TeachingScheme(ContactHours) ExaminationScheme
TheoryMarks PracticalMarks
Total
3 1 - 4 75 25 - - 100
SEE-SemesterEndExamination,CIA-ContinuousInternalAssessment(ItconsistsofAssignments/Seminars/Presentations/MCQTests,etc.)
CourseContent T-TeachingHours| W- Weightage

Sr. Topics T W
1 Antibiotics,β-Lactamantibiotics:Aminoglycosides:Tetracyclines: 10 23
Historicalbackground,Nomenclature,Stereochemistry,Structureactivityrelationship,Chemicaldegradationclassification and
important products of the following classes.Penicillin, Cepholosporins, β- Lactamase inhibitors, Monobactams
Streptomycin, Neomycin, Kanamycin, Tetracycline, Oxytetracycline, Chlortetracycline, Minocycline, Doxycycline
2 Antibiotics,Macrolide,Miscellaneous,Antimalarial,Quinolines,Biguanidesanddihydrotriazine 10 24
Historicalbackground,Nomenclature,Stereochemistry,Structureactivityrelationship,Chemicaldegradationclassification and
important products of the following classes.Erythromycin Clarithromycin, Azithromycin. Chloramphenicol*, Clindamycin.
Prodrugs: Basic concepts and application of prodrugs design. Etiology of malaria. Quinolines: SAR, Quinine sulphate,
Chloroquine*, Amodiaquine, Primaquine phosphate, Pamaquine*, Quinacrine hydrochloride, Mefloquine.
Biguanidesanddihydrotriazines:Cycloguanilpamoate,Proguanil.Miscellaneous:Pyrimethamine,Artesunete,Artemether,
Atovoquone.
3 Anti-tubercularAgents,Urinarytractanti-infectiveagents,Quinolones,Antiviralagents, 10 23
Synthetic antitubercular agents: Isoniozid*, Ethionamide, Ethambutol, Pyrazinamide, Para amino salicylic acid.*
Antitubercularantibiotics:Rifampicin,Rifabutin,Cycloserine,Streptomycine,Capreomycinsulphate.Urinarytractanti- infective
agents. Quinolones: SAR of quinolones, Nalidixic Acid,Norfloxacin, Enoxacin, Ciprofloxacin*, Ofloxacin,
Lomefloxacin,Sparfloxacin,Gatifloxacin,Moxifloxacin.Miscellaneous:Furazolidine,Nitrofurantoin*,Methanamine.Antiviral
agents: Amantadine hydrochloride, Rimantadine hydrochloride, Idoxuridine trifluoride, Acyclovir*, Gancyclovir, Zidovudine,
Didanosine, Zalcitabine, Lamivudine, Loviride, Delavirding, Ribavirin, Saquinavir,Indinavir, Ritonavir.
4 Antifungalagents,Antifungalantibiotics,Anthelmintic,SulphonamidesandSulfones, 8 17
106
SubjectSyllabus
23990601-T-MEDICINALCHEMISTRYIII–THEORY

Sr. Topics T W
Antifungal agents: Antifungal antibiotics: Amphotericin-B, Nystatin, Natamycin, Griseofulvin. Synthetic Antifungal agents:
Clotrimazole,Econazole,Butoconazole,OxiconazoleTioconozole,Miconazole*,Ketoconazole,Terconazole,Itraconazole,
Fluconazole, Naftifine hydrochloride, Tolnaftate*.
Anti-protozoal Agents: Metronidazole*, Tinidazole, Ornidazole, Diloxanide, Iodoquinol, Pentamidine Isethionate,
Atovaquone, Eflornithine. Anthelmintics: Diethylcarbamazine citrate*, Thiabendazole, Mebendazole*, Albendazole,
Niclosamide,Oxamniquine,Praziquantal,Ivermectin.SulphonamidesandSulfonesHistoricaldevelopment,chemistry,
classificationandSARofSulfonamides:Sulphamethizole,Sulfisoxazole,Sulphamethizine,Sulfacetamide*,Sulphapyridine,
Sulfamethoxaole*, Sulphadiazine, Mefenide acetate, Sulfasalazine. Folate reductase inhibitors: Trimethoprim*,
Cotrimoxazole. Sulfones: Dapsone*
5 IntroductiontoDrugDesign,CombinatorialChemistry 7 13
Introduction to Drug Design, Various approaches used in drug design. Physicochemical parameters used in quantitative
structure activity relationship (QSAR) such as partition coefficient, Hammet’s electronic parameter, Tafts steric parameter
andHanschanalysis.Pharmacophoremodelinganddockingtechniques.CombinatorialChemistry:Conceptandapplications of
combinatorial chemistry: solid phase and solution phase synthesis
Total 45 100
CourseOutcomes
Attheendofthiscourse,studentswillbeableto:
ToExtrapolatehistoryanddevelopmentandentireskeletonaboutAntifungalagents,Antiprotozoalagents,Anthelmintics,
CO1
Sulphonamides and sulphones and Antimalarial agents.
CO2 TorecallinadetailedaboutIntroductiontodrugdesignandcombinatorialchemistry.
CO3 Togetdetaileddogmaaboutantitubercularagents,UrinarytractantiinfectiveagentsandAntiviralagents.
CO4 Togettriviaonβ-lactamantibiotics,aminoglycosides,tetracyclines,macrolideandmiscellaneousantibiotics.
ReferenceBooks
1. WilsonandGiswold’sOrganicmedicinalandPharmaceuticalChemistry
ByJohnMBeale,JohnBlock|LippincottWilliamsandWilkin
2. Foye’sPrinciplesofMedicinalChemistry.
ByDavidA.Williams|LippincottWilliamsandWilkins
3. Burger’sMedicinalChemistry,VolIto IV.
ByDonaldJ.Abraham,DavidP.Rotella|Wiley-Blackwell
4. Introductiontoprinciplesofdrugdesign
ByH.JohnSmith,HywelWilliams|CRCPress
5. Remington’sPharmaceuticalSciences
ByArthurOsolAndJohnE.Hoover|Mack.PublishingCo
6. Martindale’sextrapharmacopoeia.
ByWilliamMartindale,WynnWestcott|PharmaceuticalPress
7. OrganicChemistryVolume-II
ByI.L.Finar|(3rd.ed.)LongmansGreen&Co.1964
107
SubjectSyllabus
23990602-T-PHARMACOLOGYIII–THEORY

Prerequisite 23990602-T-PHARMACOLOGYIII–THEORY
1. Studentswouldhavestudiedelaboratelyonmechanismofdrugactionanditsrelevanceinthe
treatment of different infectious diseases
2. Theycomprehendedtheprinciplesoftoxicologyandtreatmentofvariouspoisonings
CourseObjective 3. Theycameacrossthemethodsoftoxicitystudies
4. Theystudiedaboutsymptomsofseveralpoisonings
5. Theystudiedabouttreatmentofseveralpoisonings
6. Studentsunderstoodthetoxicityprofileofeachdrugs
Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 PharmacologyofdrugsactingonRespiratorysystem 10 23
1. Anti-asthmaticdrugs
2. Drugsusedinthemanagementof COPD
3. Expectorantsandantitussivesd.Nasaldecongestants
4. Respiratorystimulants
PharmacologyofdrugsactingontheGastrointestinalTract
1. Antiulcerage
2. Drugsforconstipationanddiarrhoea.
3. Appetitestimulantsandsuppressa
4. Digestantsandcarminative
5. Emeticsandanti-emetics.
2 Chemotherapy 10 23
1. Generalprinciplesofchemotherapy.
2. Sulfonamidesandcotrimoxazole.
Antibiotics-Penicillins,cephalosporins,chloramphenicol,macrolides,quinolonesandfluoroquinolins,tetracyclineand aminogl
ycosides
3 Chemotherapy 10 24
1. Antitubercularagents
2. Antileproticagents
3. Antifungalagents
4. Antiviraldrugs
5. Anthelmintics
6. Antimalarialdrugs
7. Antiamoebicagent
4 Chemotherapy 8 17
108
SubjectSyllabus
23990602-T-PHARMACOLOGYIII–THEORY

Sr. Topics T W
1. Urinarytractinfectionsandsexuallytransmitteddisease
2. Chemotherapyofmalignancy.
Immunopharmacology
1. Immunostimulants
2. Immunosuppressant
Proteindrugs,monoclonalantibodies,targetdrugstoantigen,biosimilars
5 Principlesoftoxicology 7 13
1. Definitionandbasicknowledgeofacute,subacuteandchronictoxicity.
2. Definitionandbasicknowledgeofgenotoxicity,carcinogenicity,teratogenicityandmutagenicity
3. Generalprinciplesoftreatmentofpoisoning
4. Clinicalsymptomsandmanagementofbarbiturates,morphine,organophosphosphoruscompoundandlead,mercury and
arsenic poisoning.
Chronopharmacology
1. Definitionofrhythmandcycle
Biologicalclockandtheirsignificanceleadingtochronotherapy.
Total 45 100
SuggestedDistributionOfTheoryMarksUsingBloom'sTaxonomy
Level Remembrance Understanding Application Analyze Evaluate Create
Weightage 16 18 14 16 16 16
NOTE:Thisspecificationtableshallbetreatedasageneralguidelineforthestudentsandtheteachers.Theactualdistributionofmarksintheque stionpapermayvary slightly from
above table.
CourseOutcomes
CO1 TostudythegatherknowledgeofUnderstandthepharmacologicalactionsofdifferentcategoriesofdrugs.
ThemainpurposeistounderstandExplainthemechanismofdrugactionatorgansystem/subcellular/macromolecular levels.
CO2
CO3 Toacquiretheknowledgeofthebasicpharmacologicalknowledgeinthepreventionandtreatmentofvariousdiseases.
CO4 TostudyObservetheeffectofdrugsonanimalsbysimulatedexperiments.
CO5 ToAppreciatecorrelationofpharmacologywithotherbiomedicalsciences.
ReferenceBooks
1. EssentialofMedicalPharmacology(TextBook)
ByKD Tripathi
2. Goodman’s&Gilman’sthepharmacologicalbasisoftherapeutics(TextBook)
3. Pharmacology&Pharmacotherapeutics(TextBook)
ByRSSatoskar,SDBhandakar&NirmalaNRege
4. BasicandclinicalPharmacology(TextBook)
ByBertramGKatzung
109
SubjectSyllabus
23990603-T-HERBALDRUGTECHNOLOGY–THEORY

Prerequisite 23990305-T-PHARMACOGNOSYANDPHYTOCHEMISTRYI-THEORY
1. Theaimofthedegreecourseistoprovidegraduateswithagoodknowledge
ofthebasicandappliedknow-howandprofessionalskillsinHerbaldrugScienceand
Technology and the necessary training for admission to the postgraduate courses in
this field.
2. They will acquire operative know-how and be able to carry out technical and
management tasks and professional activities in the areas of transformation of
medicinalherbs,managementofthequalityoftheprocesses,marketingofmedicinal
CourseObjective
plants and derivatives for use in herbal, food and cosmetic products, Guaranteeing
conformity with the national and EU laws in force.
3. Attheendofthecourse,thegraduatewillhaveacquiredthefollowingknowledgeandskills: The
recognition, collection and preservation of medicinal plants.
Analysesanddosageofactiveingredients. The
biological effects of medicinal plants.
Thetoxicologicalaspectsofactiveingredientsandfinishedproducts.
Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 Herbsasrawmaterials,BiodynamicAgriculture,IndianSystemsofMedicine 11 15
Herbsasrawmaterials
Definition of herb, herbal medicine, herbal medicinal product, herbal drug preparation, Source of Herbs, Selection,
identificationandauthenticationofherbalmaterials,Processingofherbalrawmaterial,Goodagriculturalpracticesin cultivation of
medicinal plants including Organic farming.
PestandPestmanagementinmedicinalplants:Biopesticides/Bioinsecticides.
IndianSystemsofMedicine
a. BasicprinciplesinvolvedinAyurveda,Siddha,UnaniandHomeopathy
b. PreparationandstandardizationofAyurvedicformulationsvizAristasandAsawas,Ghutika,Churna,LehyaandBhasma.
2 Nutraceuticals,Herbal-DrugandHerb-FoodInteractions 7 31
Nutraceuticals
General aspects, Market, growth, scope and types of products available in the market. Health benefits and role of
NutraceuticalsinailmentslikeDiabetes,CVSdiseases,Cancer,IrritablebowelsyndromeandvariousGastrointestinal diseases.
Study of following herbs as health food: Alfaalfa, Chicory, Ginger,
Fenugreek,Garlic,Honey,Amla,Ginseng,Ashwagandha,Spirulina.
Herbal-DrugandHerb-FoodInteractions:Generalintroductiontointeractionandclassification.Studyoffollowingdrugsand their
possible side effects and interactions: Hypercium, kava-kava, Ginkobiloba, Ginseng, Garlic, Pepper & Ephedra.
3 HerbalCosmetics,Herbalexcipients,Herbalformulations 10 14
110
SubjectSyllabus
23990603-T-HERBALDRUGTECHNOLOGY–THEORY

Sr. Topics T W
HerbalCosmetics
Sourcesanddescriptionofrawmaterialsofherbaloriginusedvia,fixedoils,waxes,gumscolours,perfumes,protective agents,
bleachingagents, antioxidants in products such as skin care, hair care and oral hygiene products.
Herbalexcipients: HerbalExcipients–Significanceofsubstancesofnaturaloriginasexcipients–
colorants,sweeteners,binders,diluents, viscosity builders, disintegrants, flavors & perfumes.
Herbalformulations:
Conventionalherbalformulationslikesyrups,mixturesandtabletsandNoveldosageformslikephytosomes.
4 EvaluationofDrugs,PatentingandRegulatoryrequirementsofnaturalproducts,RegulatoryIssues 10 24
EvaluationofDrugsWHO&ICHguidelinesfortheassessmentof herbal
drugs Stability testing of herbal drugs.
PatentingandRegulatoryrequirementsofnaturalproducts:
a. Definitionoftheterms:Patent,IPR,Farmersright,Breeder’sright,BioprospectingandBiopiracy
b. PatentingaspectsofTraditionalKnowledgeandNaturalProducts.CasestudyofCurcuma&Neem.
RegulatoryIssues -RegulationsinIndia(ASUDTAB,ASUDCC),RegulationofmanufactureofASUdrugs-ScheduleZofDrug &
Cosmetics Act for ASU drugs.
5 GeneralIntroductiontoHerbalIndustry,ScheduleT –GoodManufacturingPracticeofIndiansystemsof medicine 7 18
GeneralIntroductiontoHerbalIndustry
Herbaldrugsindustry:Presentscopeandfutureprospects.Abriefaccountofplantbasedindustriesandinstitutionsinvolved in work
on medicinal and aromatic plants in India.
ScheduleT–GoodManufacturingPracticeofIndiansystemsof medicine ComponentsofGMP(Schedule–
T)anditsobjectives,Infrastructuralrequirements,workingspace,storagearea,machinery and equipments, standard operating
procedures, health and hygiene, documentation and records.
Total 45 102
CourseOutcomes
Tounderstandrawmaterialassourceofherbaldrugsfromcultivationtoherbaldrugproductandtraditionalsystemsof medicines
CO1
CO2 Knowtheherbalcosmetics,naturalsweetenersandnutraceuticalsandformulationsofeach.
CO3 ToknowtheWHOandICHguidelinesforevaluationofherbaldrugs
CO4 Toappreciatepatentingofherbaldrugs, GMP
ReferenceBooks
1. HerbalCosmetics
ByH.Pande|AsiaPacificBusinesspress,Inc,NewDelhi
2. Herbaldrugindustry
ByR.D.Choudhary
111
SubjectSyllabus
23990604-T-BIOPHARMACEUTICSANDPHARMACOKINETICS–
THEORY

Prerequisite 23990103-T-PHARMACEUTICSI–THEORY
1. Tounderstandthebasicconceptsinbiopharmaceuticsandpharmacokineticsandtheirsignificance.
2. Touseofplasmadrugconcentration-timedatatocalculatethepharmacokineticparametersto
describe the kinetics of drug absorption, distribution, metabolism, excretion, elimination.
CourseObjective
3. Tounderstandtheconceptsofbioavailabilityandbioequivalenceofdrugproductsandtheir
significance.
4. Tounderstandvariouspharmacokineticparameters,theirsignificance&applications.
Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 IntroductiontoBiopharmaceutics 10 23
Absorption;
MechanismsofdrugabsorptionthroughGIT,factorsinfluencingdrugabsorptionthoughGIT,absorptionofdrugfromNon per oral
extra-vascular routes,
Distribution
Tissuepermeabilityofdrugs,bindingofdrugs,apparent,volumeofdrugdistribution,plasmaandtissueproteinbindingof drugs,
factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs
2 Elimination: 10 23
Drugmetabolismandbasicunderstandingmetabolicpathwaysrenalexcretionofdrugs,factorsaffectingrenalexcretionof drugs,
renal clearance, Non renal routes of drug excretion of drugs
BioavailabilityandBioequivalence:
DefinitionandObjectivesofbioavailability,absoluteandrelativebioavailability,measurementofbioavailability,in-vitrodrug
dissolution models, in-vitro-in-vivo correlations, bioequivalence studies, methods to enhance the dissolution rates and
bioavailability of poorly soluble drugs.
3 Pharmacokinetics: 10 23
DefinitionandintroductiontoPharmacokinetics,Compartmentmodels,Noncompartmentmodels,physiologicalmodels, One
compartment open model.
a) IntravenousInjection(Bolus)
b) Intravenousinfusionand
c) Extravascularadministrations.
Pharmacokineticsparameters-KE,t1/2,Vd,AUC,Ka,CltandCLRdefinitionsmethodsofeliminations,understandingoftheir
significance and application
4 Multicompartmentmodels: 8 17
Twocompartmentopenmodel.IVbolusKineticsofmultipledosing,steadystatedruglevels,calculationofloadingand mainetnance
doses and their significance in clinical settins.
112
SubjectSyllabus
23990604-T-BIOPHARMACEUTICSANDPHARMACOKINETICS–
THEORY

Sr. Topics T W
5 NonlinearPharmacokinetics: 7 13
a) Introduction
b) FactorscausingNon-linearity.
c) Michaelis-mentonmethodofestimatingparameters.
Explanation with example of drugs
Total 45 99
CourseOutcomes
CO1 UnderstandtheconceptofADMEofdruginhuman body
Determinethevariouspharmacokineticparametersfromeitherplasmaconcentrationorurinaryexcretiondatafor drug
CO2
CO3 ToacquiretheknowledgeofIndianPharmaceuticalactsincludingPharmacycouncilofIndiaconstitution
CO4 ApplythevariousregulationsrelatedtodevelopingBA-BEstudyprotocolforthenewdrugmolecule
ReferenceBooks
1. “IntroductiontotheprinciplesofDrugDesign
BySmithHJ,WilliamsH,eds,|WrightBoston
2. AtextbookofForensicPharmacy(TextBook)
ByN.K.Jain|VallabhPrakashan
3. AnatomyandPhysiology
BySmoutandMcdowell
4. Bentley’sTextBookofPharmaceutics,
ByE.A.Rawlins,EnglishLanguageBookSociety,|ElsevierHealthSciences, USA
5. EncyclopediaofBioprocessTechnology.
ByFlickinger,M.C.andDrew,S.W.|Wiley-Interscience,NewJersey.(1999).
113
SubjectSyllabus
23990605-T-INDUSTRIALPHARMACY–THEORY

Prerequisite 23990103-PHARMACEUTICSI –THEORY
1. Aftersuccessfulcompletionofthecoursestudentwillbeabletounderstandthevarious drug
delivery system and its mechanisms.
2. Studentswilllearnadvanceddrugdeliverysystemearlystage.
3. Developingapreparationofthedrugwhichisbothstableandacceptabletothepatient.
4. Theyknowverywellaboutorallyadministereddrugs,injectables,aerosolandsemisolid
CourseObjective
preparations with standard protocols.
5. Formulateddrugsarestoredinasuitablecontainerclosuresystemforextendedperiods of
time.
6. Alsotheyknowthestabilitystudyanditsstandardevaluationprocedureforbetter
storage condition
Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 PreformulationStudies 7 13
PreformulationStudies:Introductiontopreformulation,goalsandobjectives,studyofphysicochemicalcharacteristicsof drug
substances.
1. Physicalproperties:Physicalform(crystal&amorphous),particlesize,shape,flowproperties,solubilityprofile(pKa, pH,
partition coefficient), polymorphism
2. ChemicalProperties:Hydrolysis,oxidation,reduction,racemisation,polymerization
BCS classification of drugs & its significant
Applicationofpreformulationconsiderationsinthedevelopmentofsolid,liquidoralandparenteraldosageformsandits impact on
stability of dosage forms.
2 Tablets 10 23
Tablets:
1. Introduction,idealcharacteristicsoftablets,classificationoftableExcipients,Formulationoftablets,granulation
methods, compression and processing problems. Equipments and tablet tooling.
2. Tabletcoating:Typesofcoating,coatingmaterials,formulationofcoatingcomposition,methodsofcoating,
equipment employed and defects in coating.
3. Qualitycontroltests:Inprocessandfinishedproducttests
Liquidorals:Formulationandmanufacturingconsiderationofsyrupsandelixirssuspensionsandemulsions;Fillingand packaging;
evaluation of liquid orals official in pharmacopoeia
3 Capsules 8 17
114
SubjectSyllabus

Sr. Topics T W
Capsules: a) Hard gelatin capsules: Introduction, Production of hard gelatin capsule shells. size of capsules, Filling,
finishingandspecialtechniquesofformulationofhardgelatincapsules,manufacturingdefects.Inprocessandfinalproduct quality
control tests for capsules. b) Soft gelatin capsules: Nature of shell and capsule content, size of capsules,
importanceofbaseadsorptionandminim/gramfactors,production,inprocessandfinalproductqualitycontroltests. Packing,
storage and stability testing of soft gelatin capsules and their applications. Pellets: Introduction, formulation requirements,
pelletization process, equipments for manufacture of pellets
4 ParenteralProducts 10 24
ParenteralProducts:
a) Definition,types,advantagesandlimitations.Preformulationfactorsandessentialrequirements,vehicles,additives,
importance of isotoniciy
b) Production procedure, production facilities and controls, aseptic processing
c) Formulation of injections, sterile powders, large volume parenterals and lyophilized products.
d) Containersandclosuresselection,fillingandsealingofampoules,vialsandinfusionfluids.Qualitycontroltestsof
parenteral products.
OphthalmicPreparations:Introduction,formulationconsiderations;formulationofeyedrops,eyeointmentsandeye lotions;
methods of preparation; labeling, containers; evaluation of ophthalmic preparations
5 Cosmetics 10 23
Cosmetics:Formulationandpreparationofthefollowingcosmeticpreparations:lipsticks,shampoos,coldcreamand vanishing
cream, tooth pastes, hair dyes and sunscreens.
PharmaceuticalAerosols:Definition,propellants,containers,valves,typesofaerosolsystems;formulationand
manufactureofaerosols;Evaluationofaerosols;Quality control and stability studies.
Packaging Materials Science: Materials used for packaging of pharmaceutical products, factors influencing choice of
containers,legalandofficialrequirementsforcontainers,stabilityaspectsofpackagingmaterials,qualitycontroltests.
Total 45 100
CourseOutcomes
CO1 Abletoperformpreformulationstudiesoftabletsandcapsule
CO2 Understandtheknowledgetoformulate,evaluateandlabeloftabletsandcapsules
CO3 Preparelabelstosuitregulatoryrequirements.
CO4 Abletoconductthesurveyandreportitsfinding.
115
SubjectSyllabus
ReferenceBooks
1. PharmaceuticalDosageforms,TabletsVolume-1to3(TextBook)
ByLibermanH.A,LachmanC.,|MarcelDekkarInc.
2. PharmaceuticalDosageforms,Parenteralmedication,Volume-1&2(TextBook)
3. PharmaceuticalDosageforms.Dispersesystems,volume1(TextBook)
ByLibermanH.A,LachmanC,|MarcelDekkar Inc.
4. ModernPharmaceutics
ByGilbertS.Banker&C.T.Rhodes| 3rdEdition
5. Remington:TheScienceandPracticeofPharmacy,
PharmaceuticalScience(RPS)|20thedition
6. TheoryandPracticeofIndustrialPharmacy(TextBook)
7. Pharmaceutics-Thescienceofdosageformdesign
ByM.E.Aulton,|Churchilllivingstone,Latestedition
8. IntroductiontoPharmaceuticalDosageForms
ByH.C.Ansel,|Lea&Febiger,Philadelphia|5thedition,Pub.Year2005
9. Drugstability-Principlesandpractice
ByCartensen&C.J.Rhodes,|MarcelDekkerSeries,|3rdEdition
116
SubjectSyllabus
23990606-P-MEDICINALCHEMISTRYIII–PRACTICAL

Prerequisite 23990406-P-MEDICINALCHEMISTRYI–PRACTICAL
1. Theywouldabletodevelopanunderstandingofthephysico-chemicalpropertiesofdrugs.
2. Studentsabletounderstandhowcurrentdrugsweredevelopedbyusingpharmacophoremodeling and
docking technique.
3. Theyacquireknowledgeinthechemotherapyforcancerandmicrobialdiseasesanddifferentanti-viral
CourseObjective agents.
4. Theyacquireknowledgeaboutthemechanismpathwaysofdifferentclassofmedicinalcompounds.
5. Theyhavebeenintroducedtoavarietyofdrugclassesandsomepharmacological
properties.
6. Theyacquireknowledgeonthrustareasfirfurtherresearch.
Total
- - 4 2 - - 35 15 50
ReferenceBooks
1. TheOrganicChemistryofDrugSynthesis,Vol.1-5.(TextBook)
ByDanielLednicer,LesterA.Mitscher|Wiley-Blackwell
2. Indianpharmacopoeia
ByIndianPharmacopoeiaCommittee|Delhi:ManagerofPublications
3. Vogel’stextbookofPracticalOrganicChemistry
ByA.I.Vogel,A.R.Tatchell,B.S.Furnis,A.J.Hannaford,P.W.G.Smith|PearsonEducation
ListofPractical
1. IPreparationofdrugsandintermediates
1. Sulphanilamide 2. 7-Hydroxy, 4-methyl coumarin 3. Chlorobutanol 4. Triphenyl imidazole 5. Tolbutamide 6. Hexamine
2. Assayofdrugs
1.Isonicotinicacidhydrazide2.Chloroquine3.Metronidazole4.Dapsone5.Chlorpheniraminemaleate6.Benzylpenicillin
3. IIIPreparationofmedicinallyimportantcompoundsorintermediatesbyMicrowaveirradiationtechnique
4. IVDrawingstructuresandreactionsusingchemdraw®
VDeterminationofphysicochemicalpropertiessuchaslogP,clogP,MR,Molecularweight,Hydrogenbonddonorsand acceptors
5.
for class of drugs course content using drug design software Drug likeliness screening (Lipinskies RO5)
117
SubjectSyllabus
23990607-P-PHARMACOLOGYIII–PRACTICAL

Prerequisite 23990408-PHARMACOLOGYI–PRACTICAL
1. Studentswouldhavestudiedelaboratelyonmechanismofdrugactionandits
relevance in the treatment of different infectious diseases
2. Theycomprehendedtheprinciplesoftoxicologyandtreatmentofvarious
poisonings
CourseObjective
3. Theycameacrossthemethodsoftoxicitystudies
4. Theystudiedaboutsymptomsofseveralpoisonings
5. Theystudiedabouttreatmentofseveralpoisonings
6. Studentsunderstoodthetoxicityprofileofeachdrugs
Total
- - 4 2 - - 35 15 50
ReferenceBooks
1. EssentialofMedicalPharmacology
ByKD Tripathi
2. BasicandclinicalPharmacology(TextBook)
ByBertramGKatzung
3. ClinicalPharmacology(TextBook)
ByD.R.Laurence,PNBennet,MJBrown
118
SubjectSyllabus
23990607-P-PHARMACOLOGYIII–PRACTICAL
ListofPractical
1. Dosecalculationinpharmacologicalexperiments
2. Antiallergicactivitybymastcellstabilizationassay
3. Studyofanti-ulceractivityofadrugusingpylorusligand(SHAY)ratmodelandNSAIDSinducedulcermodel.
4. Studyofeffectofdrugsongastrointestinalmotility
5. Effectofagonistandantagonistsonguineapigileum
6. Estimationofserumbiochemicalparametersbyusingsemi-autoanalyser
7. EffectofsalinepurgativeonfrogintestineInsulinhypoglycemiceffectinrabbit
8. Insulinhypoglycemiceffectinrabbit
9. Testforpyrogens(rabbitmethod)
10. Determinationofacuteoraltoxicity(LD50)ofadrugfromagiven data
11. Determinationofacuteskinirritation/corrosionofatestsubstance
12. Determinationofacuteeyeirritation/corrosionofatestsubstance
13. Calculationofpharmacokineticparametersfromagivendata
14. Biostatisticsmethodsinexperimentalpharmacology(student’sttest,ANOVA)
15. Biostatisticsmethodsinexperimentalpharmacology(Chisquaretest,WilcoxonSignedRanktest)
119
SubjectSyllabus
23990608-P-HERBALDRUGTECHNOLOGY–PRACTICAL

Prerequisite 23990309-P-PHARMACOGNOSYANDPHYTOCHEMISTRYI–PRACTICAL
1. Theaimofthedegreecourseistoprovidegraduateswithagoodknowledge
ofthebasicandappliedknow-howandprofessionalskillsinHerbaldrugScienceand
Technology and the necessary training for admission to the postgraduate courses in
this field.
2. They will acquire operative know-how and be able to carry out technical and
management tasks and professional activities in the areas of transformation of
medicinalherbs,managementofthequalityoftheprocesses,marketingofmedicinal
CourseObjective
plants and derivatives for use in herbal, food and cosmetic products, Guaranteeing
conformity with the national and EU laws in force.
3. Attheendofthecourse,thegraduatewillhaveacquiredthefollowingknowledgeandskills: The
recognition, collection and preservation of medicinal plants.
Analysesanddosageofactiveingredients. The
biological effects of medicinal plants.
Thetoxicologicalaspectsofactiveingredientsandfinishedproducts.
Total
- - 4 2 - - 35 15 50
ReferenceBooks
1. TextbookofPharmacognosy
ByC.K.Kokate,Purohit,Gokhlae|37thEdition(2007),NiraliPrakashan,NewDelhi.
2. PracticalPharmacognosy
ByKhandelwalK.R|NiraliPublication| 19th
ListofPractical
1. Toperformpreliminaryphytochemicalscreeningofcrudedrugs.
2. DeterminationofthealcoholcontentofAsavaandArista.
3. Evaluationofexcipientsofnaturalorigin.
Incorporationofpreparedandstandardizedextractincosmeticformulationslikecreams,lotionsandshampoosandtheir
4.
evaluation.
Incorporationofpreparedandstandardizedextractinformulationslikesyrups,mixturesandtabletsandtheirevaluation as per
5.
Pharmacopoeial requirements.
6. MonographanalysisofherbaldrugsfromrecentPharmacopoeias.
7. DeterminationofAldehydecontent.
8. DeterminationofPhenolcontent.
9. Determinationoftotalalkaloids.
120
SubjectSyllabus
23990609-P-INDUSTRIALPHARMACY–PRACTICAL

Prerequisite 23990307-PHYSICALPHARMACEUTICSI–PRACTICAL
1. Aftersuccessfulcompletionofthecoursestudentwillbeabletounderstandthevarious drug
delivery system and its mechanisms.
2. Studentswilllearnadvanceddrugdeliverysystemearlystage.
3. Developingapreparationofthedrugwhichisbothstableandacceptabletothepatient.
4. Theyknowverywellaboutorallyadministereddrugs,injectables,aerosolandsemisolid
CourseObjective
preparations with standard protocols.
5. Formulateddrugsarestoredinasuitablecontainerclosuresystemforextendedperiods of
time.
6. Alsotheyknowthestabilitystudyanditsstandardevaluationprocedureforbetter
storage conditions
Total
- - 4 2 - - 35 15 50
ReferenceBooks
1. PharmaceuticalDosageforms,TabletsVolume-1to3
2. PharmaceuticalDosageforms,Parenteralmedication,Volume-1&2
3. PharmaceuticalDosageforms.Dispersesystems,volume1
ByLibermanH.A,LachmanC,|MarcelDekkar Inc.
4. ModernPharmaceutics
ByGilbertS.Banker&C.T.Rhodes| 3rdEdition
5. Remington:TheScienceandPracticeofPharmacy,
PharmaceuticalScience(RPS)|20thedition
6. TheoryandPracticeofIndustrialPharmacy
7. Pharmaceutics-Thescienceofdosageformdesign
ByM.E.Aulton,|Churchilllivingstone,Latestedition
8. IntroductiontoPharmaceuticalDosageForms(TextBook)
ByH.C.Ansel,|Lea&Febiger,Philadelphia|5thedition,Pub.Year2005
9. Drugstability-Principlesandpractice(TextBook)
ByCartensen&C.J.Rhodes,|MarcelDekkerSeries,|3rdEdition
121
SubjectSyllabus
23990609-P-INDUSTRIALPHARMACY–PRACTICAL
ListofPractical
1. Preformulationstudiesonparacetamol/asparin/oranyotherdrug
2. PreparationandevaluationofParacetamoltablets
3. PreparationandevaluationofAspirintablets
4. Coatingoftablets-filmcoatingoftables/granules
5. PreparationandevaluationofTetracyclinecapsules
6. PreparationofCalciumGluconateinjection
7. PreparationofAscorbicAcidinjection
8. Qualitycontroltestof(asperIP)marketedtabletsandcapsules
9. PreparationofEyedrops/andEyeointments
10. PreparationofCreams(cold/vanishingcream)
11. EvaluationofGlasscontainers(asper IP)
122
SubjectSyllabus
23990701-T-INSTRUMENTALMETHODSOFANALYSIS–THEORY

Prerequisite 23990701-T-INSTRUMENTALMETHODSOFANALYSIS–THEORY
Thestudentwilllearnto
1. Thebasictheoreticalknowledgeoftheinstrumentationtechniquesavailable.
2. Theoreticallyunderstandtheaspectsofseparationformulticomponents.
3. Practicalskillsfortheanalysisofdrugsandexcipientsusingvariousinstrumentation
CourseObjective techniques.
4. Theyabletomakeaccurateanalysisandreporttheresultsindefinedformats.
5. Theylearndocumentationandexpresstheobservationswithclarity.
6. Theyunderstandtheprofessionalandsafetyresponsibilitiesforworkingintheanalysis
laboratory.
Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 UVVisiblespectroscopy&Fluorimetry 10 23
Electronictransitions,chromophores,auxochromes,spectralshifts,solventeffectonabsorptionspectra,BeerandLambert’s law,
Derivation and deviations. Instrumentation - Sources of radiation, wavelength selectors, sample cells, detectors- Photo tube,
Photomultiplier tube, Photo voltaic cell, Silicon Photodiode. Applications - Spectrophotometric titrations, Single component
and multi component analysis .Theory, Concepts of singlet, doublet and triplet electronic states, internal and external
conversions, factors affecting fluorescence,quenching, instrumentation and applications
2 Spectroscopy 10 24
Introduction, fundamental modes of vibrations in poly atomic molecules, sample handling, factors affecting vibrations
Instrumentation-Sourcesofradiation,wavelengthselectors,detectors-Golaycell,Bolometer,Thermocouple,Thermister,
Pyroelectric detector and applications -Principle, interferences, instrumentation and applications. Principle, interferences,
instrumentation and applications .Principle, instrumentation and applications
3 Introductiontochromatography 10 23
Methodology,advantages,disadvantagesandapplications.Introduction,Principle,Methodology,Rfvalues,advantages,
disadvantages and applications. Introduction, methodology, development techniques, advantages, disadvantages and
applications,Introduction,factorsaffectingelectrophoreticmobility,Techniquesofpaper,gel,capillaryelectrophoresis,
applications
4 GC&HPLC 8 17
Introduction,theory,instrumentation,derivatization,temperatureprogramming,advantages,disadvantagesand applications
Introduction, theory,instrumentation, advantages and application.
5 Chromatography 7 13
123
SubjectSyllabus
23990701-T-INSTRUMENTALMETHODSOFANALYSIS–THEORY

Sr. Topics T W
Introduction, classification, ion exchange resins, properties, mechanism of ion exchange process, factors affecting ion
exchange,methodologyandapplicationsIntroduction,theory,instrumentationandapplicationsIntroduction,theory,
instrumentation and applications
Total 45 100
CourseOutcomes
CO1 Tointerpretfundamentals,Instrumentation,Working&useofUVandFlourimetry.
Togeneralizefundamentals,Instrumentation,Working&useofdifferentchromatographictechniques,andatomic absorption
CO2
spectroscopy, Nepheloturbidometry and IR and Flame Photometry.
Toextrapolatebasicprinciple,Instrumentation,Working&factoraffectingseparation&applicationsofdifferenttypesof
CO3
Electrophoresis and TLC, Paper, Column and Gas chromatography.
Torecallandtransformbasicprinciple,InstrumentationandApplicationofHPLC,Ionexchange,GelandAffinity chromatography.
CO4
ReferenceBooks
1. InstrumentalMethodsofChemicalAnalysis
ByB.KSharma|KrishnaPrakashan Media
2. Organicspectroscopy
ByY.RSharma|SChand
3. TextbookofPharmaceuticalAnalysis(TextBook)
ByKennethA.Connors|WileyIndiaPvt.Limited,2007
4. TextBookofQuantitativeInorganicanalysis(TextBook)
ByA.I.Vogel,|Londonlongmans,green&co.,ltd.,
5. PracticalPharmaceuticalChemistryVolI&II,
ByA.H.Beckett&J.B.Stenlake's,|StahlonePressofUniversityofLondon
6. OrganicChemistryVolume-I&II
ByI.L.Finar|(3rd.ed.)LongmansGreen&Co.1964
7. Organicspectroscopy
ByWilliamKemp|PalgraveMacmillan, USA
8. QuantitativeAnalysisofDrugs
ByVonD.C.GarrettinZusammenarbeitmitL.Brealy,C.A.Johnson,K.L.SmithundG.Sykes.| 3.Ausgabe,925Seiten. Chapman & Hall
Ltd., London 1964
9. QuantitativeAnalysisofDrugsinPharmaceuticalFormulations
ByP.D.Sethi|CBSPublishers&Distributors
10. SpectrophotometricidentificationofOrganicCompounds
BybyRobertM.Silverstein,FrancisX.Webster|Wiley;Sixthedition
124
SubjectSyllabus
23990702-T-INDUSTRIALPHARMACYII–THEORY

Prerequisite 23990702-T-INDUSTRIALPHARMACYII–THEORY
1. Theyknowthevariouspharmaceuticaldosageformsandtheirmanufacturing
techniques.
2. Studentswouldabletoknowvariousconsiderationsindevelopmentofpharmaceutical
CourseObjective
dosage forms
3. Theyabletoformulatesolid,liquidandsemisoliddosageformsandevaluatethemfor their
quality.
Total
3 1 - 4 75 - - - 100

Sr. Topics T W
1 Pilotplantscaleuptechniques 10 23
Generalconsiderations-includingsignificanceofpersonnelrequirements,spacerequirements,rawmaterials,Pilotplantscale
upconsiderationsforsolids,liquidorals,semisolidsandrelevantdocumentation,SUPACguidelines,Introductiontoplatform
technology
2 Technologydevelopmentandtransfer: 10 23
WHOguidelinesforTechnologyTransfer(TT):Terminology,Technologytransferprotocol,Qualityriskmanagement,Transfer from R
& D to production (Process, packaging and cleaning), Granularit y of TT Process (API, excipients, finished products, packaging
materials) Documentation, Premises and equipments, qualification and validation, quality control, analytical method
transfer, Approved regulatory bodies and agencies, Commercialization - practical aspects and problems (case
studies),TTagenciesinIndia-APCTD,NRDC,TIFAC,BCIL,TBSE/SIDBI;TTrelateddocumentation-confidentiality agreement,
licensing, MoUs, legal issues
3 Regulatoryaffairs 10 23
Introduction, Historical overview of Regulatory Affairs, Regulatory authorities, Role of Regulatory affairs department,
ResponsibilityofRegulatoryAffairsProfessionals.DrugDevelopmentTeams,Non-ClinicalDrugDevelopment,Pharmacology, Drug
Metabolism and Toxicology, General considerations of Investigational New Drug (IND) Application, Investigator’s Brochure
(IB) and New Drug Application (NDA), Clinical research / BE studies, Clinical Research Protocols, Biostatistics in
Pharmaceutical Product Development, Data Presentation for FDA Submissions, Management of Clinical Studies
4 Qualitymanagementsystems: 8 17
Qualitymanagement&Certifications:ConceptofQuality,TotalQualityManagement,QualitybyDesign(QbD),SixSigma concept,
Out of Specifications (OOS), Change control, Introduction to ISO 9000 series of quality systems standards, ISO 14000, NABL,
GLP
5 IndianRegulatoryRequirements 7 13
125
SubjectSyllabus
23990702-T-INDUSTRIALPHARMACYII–THEORY

Sr. Topics T W
CentralDrugStandardControlOrganization(CDSCO)andStateLicensingAuthority:Organization,Responsibilities, Certificate of
Pharmaceutical Product (COPP), Regulatory requirements and approval procedures for New Drugs
Total 45 99
CourseOutcomes
CO1 Knowtheprocessofpilotplantandscaleupofpharmaceuticaldosageforms.
CO2 Understandtheprocessoftechnologytransferfromlabscaletocommercialbatch.
KnowdifferentLawsandActsthatregulatepharmaceuticalindustry.
CO3
CO4 Understandtheapprovalprocessandregulatoryrequirementsfordrug products.
ReferenceBooks
1. IndustrialPharmacy-II(TextBook)
ByBy:KosikaSandeep(Author)|Publisher:NotionPress
2. “IntroductiontotheprinciplesofDrugDesign
BySmithHJ,WilliamsH,eds,|WrightBoston
ByLachmann|Lea&FebigerPublisher,TheUniversityofMichigan.
By Lachmann
126
SubjectSyllabus
23990703-T-PHARMACYPRACTICE–THEORY

Prerequisite 23990703-T-PHARMACYPRACTICE–THEORY
1. Studentswilldemonstrateknowledgeofandabilitytouseprinciplesoftherapeutics,
quality improvement, communication, economics, health behavior, social and
administrative aspects, health policy and legal issues in the practice of pharmacy.
2. Studentswilluseknowledgeofdrugdistributionmethodsinhospitalandapplyitinthe
practice of pharmacy.
3. Studentswilleffectivelyapplyprinciplesofdrugstoremanagementandinventory
CourseObjective
control to medication use.
4. Studentswillprovidepatient-centeredcaretodiversepatientsusingthebestavailable
evidence and monitor drug therapy of patient through medication chart review, obtain
medication history interview and counsel the patients, identify drug related problems.
5. Studentswillengageininnovativeactivitiesbymakinguseoftheknowledgeofclinical trials
Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 hospitalanditsorganizationsb)Hospitalpharmacyanditsorganizationc)Adversedrugreactiond)Community 10 23
Pharmacy
Definition, Classification of hospital- Primary, Secondary andTertiary hospitals, Classification based on clinical and non-
clinicalbasis,OrganizationStructureofaHospital,andMedicalstaffsinvolvedinthehospitalandtheirfunctions.Definition, functions
of hospital pharmacy, Organization structure, Location, Layout and staff requirements, and Responsibilities and functions of
hospital pharmacists.Classifications- Excessive pharmacological effects, secondarypharmacological effects,
idiosyncrasy, allergic drug reactions, genetically determined toxicity, toxicity following sudden withdrawalof drugs, Drug
interaction-beneficialinteractions,adverseinteractions,andpharmacokineticdruginteractions,Methodsfordetectingdrug
interactions, spontaneous case reports and record linkage studies, and Adverse drug reaction reporting and
management.Organization and structure of retail and wholesale drug store, t ypes and design, Legal requirements for
establishment and maintenance of a drug store, Dispensing of proprietary products, maintenance of records of retail and
wholesale drug store.
2 Drugdistributionsysteminahospitalb)Hospitalformularyc)Therapeuticdrugmonitoringd)Medication adherencee) 10 24
Patient medication history interview
Dispensing of drugs to inpatients, types of drug distribution systems, charging policy and labelling, Dispensing of drugs to
ambulatory patients, and Dispensing of controlled drugs.Definition, contents of hospital formulary, Differentiation of
hospitalformularyandDruglist,preparationandrevision,andadditionanddeletionofdrugfromhospitalformulary.Need
for Therapeutic Drug Monitoring, Factors to be considered during the Therapeutic Drug Monitoring, and Indian scenario for
Therapeutic Drug Monitoring.Causes of medication non-adherence, pharmacist role in the medication adherence, and
monitoringofpatientmedicationadherence.Needforthepatientmedicationhistoryinterview,medicationinterviewforms.
Financial, materials, staff, and infrastructure requirements.
127
SubjectSyllabus
3 Pharmacyandtherapeuticcommitteeb)Druginformationservicesc)Patientcounselinge)Prescribed medication 10 23
order and communication skillsd) Education and training program in the hospital
128
SubjectSyllabus

Sr. Topics T W
Organization,functions,Policiesofthepharmacyandtherapeuticcommitteeinincludingdrugsintoformulary,inpatientand
outpatient prescription, automatic stop order, and emergency drug list preparation. Drug and Poison information centre,
Sources of drug information, Computerised services, and storage and retrieval of information.Definition of patient
counseling; steps involved in patient counseling, and Special cases that require the pharmacist Role of pharmacist in the
educationandtrainingprogram,Internalandexternaltrainingprogram,Servicestothenursinghomes/clinics,Codeofethics for
community pharmacy, and Role of pharmacist in the interdepartmental communication and community health education.
Prescribed medication order-interpretation and legal requirements,and Communication skills- communication with
prescribers and patients.
4 Budgetpreparationandimplementationb)ClinicalPharmacyc)Overthecounter(OTC)sales 8 17
Budget preparation and implementation Introduction to Clinical Pharmacy, Concept of clinical pharmacy, functions and
responsibilities of clinical pharmacist, Drug therapy monitoring - medication chart review, clinical review, pharmacist
intervention,Wardroundparticipation,MedicationhistoryandPharmaceuticalcare.Dosingpatternanddrugtherapybased on
Pharmacokinetic & disease pattern.Introduction and sale of over the counter, and Rational use of common over the counter
medications
5 Drugstoremanagementandinventorycontrolb)Investigationaluseofdrugsc)InterpretationofClinical Laboratory 7 13
Tests
Organization of drug store, types of materials stocked and storage conditions, Purchase and inventory control: principles,
purchase procedure, purchase order, procurement and stocking, Economic order quantity, Reorder quantity level, and
MethodsusedfortheanalysisofthedrugexpenditureDescription,principlesinvolved,classification,control,identification, role of
hospital pharmacist, advisory committee. Blood chemistry, hematology, and urinalysis
Total 45 100
SuggestedDistributionOfTheoryMarksUsingBloom'sTaxonomy
Level Remembrance Understanding Application Analyze Evaluate Create
Weightage 20 21 21 20 20 12
NOTE:Thisspecificationtableshallbetreatedasageneralguidelineforthestudentsandtheteachers.Theactualdistributionofmarksintheque stionpapermayvary slightly from
above table.
CourseOutcomes
Studentswilldemonstrateknowledgeofandabilitytouseprinciplesoftherapeutics,qualityimprovement,communication,
CO1
economics, health behavior, social and administrative aspects, health policy and legal issues in the practice of pharmacy.
CO2 Studentswilluseknowledgeofdrugdistributionmethodsinhospitalandapplyitinthepracticeofpharmacy.
CO3 Studentswilleffectivelyapplyprinciplesofdrugstoremanagementandinventorycontroltomedicationuse.
Studentswillprovidepatient-centeredcaretodiversepatientsusingthebestavailableevidenceandmonitordrugtherapyof patient
CO4 through medication chart review, obtain medication history interview and counsel the patients, identify drug related
problems.
CO5 Studentswillengageininnovativeactivitiesbymakinguseoftheknowledgeofclinicaltrials
129
SubjectSyllabus
ReferenceBooks
1. ATextbookofclinicalpharmacypractice-essentialconceptsandskills(TextBook)
ByParthasarathiG,KarinNyforyHansen,MilapCNhata| 1st,Pub.Year2004
2. Hospitalpharmacy(TextBook)
ByWilliamE.Hassan.|5thed.Philadelphia:Lea&Febiger; 1986.
3. textbookofhospitalpharmacy(TextBook)
BymerchantS.HandDr.J.SQuardy| 4th,Pub.Year2001
130
SubjectSyllabus
23990704-T-NOVELDRUGDELIVERYSYSTEM–THEORY

Prerequisite 23990605-T-INDUSTRIALPHARMACY–THEORY
1. Theneed,concept,designandevaluationofvariouscustomized,sustainedandcontrolled
CourseObjective release dosage forms.
2. Theyabletoformulateandevaluatevariousnoveldrugdeliverysystems
Total
3 1 - 4 75 - - - 100

Sr. Topics T W
1 Controlleddrugdeliverysystems 10 23
Introduction,terminology/definitionsandrationale,advantages,disadvantages,selectionofdrugcandidates.Approachesto
design controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and
biological properties of drugs relevant to controlled release formulation. Introduction, classification, properties, advantages
and application of polymers in formulation of controlled release drug delivery systems.
2 Microencapsulation 10 23
Definition,advantagesanddisadvantages,microspheres/microcapsules,microparticles,methodsofmicroencapsulation,
applications.Introduction,Principlesofbioadhesion/mucoadhesion,concepts,advantagesanddisadvantages,transmucosal
permeability and formulation considerations of buccal delivery systems.Introduction, advantages and disadvantages,concept
of implants and osmotic pump
3 TransdermalDrugDeliverySystems 10 24
Introduction, Permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS,
formulationapproaches.Introduction,advantages,disadvantages,approachesforGRDDS –Floating,highdensitysystems,
inflatableandgastroadhesivesystemsandtheirapplications.IntroductiontoNasalandPulmonaryroutesofdrugdelivery,
Formulation ofInhalers (dry powder and metered dose), nasal sprays, nebulizers
4 GasTargeteddrugDelivery 8 17
Conceptsandapproachesadvantagesanddisadvantages,introductiontoliposomes,niosomes,nanoparticles,monoclonal
antibodies and their applications
5 OcularDrugDeliverySystems 7 13
Introduction, intra ocularbarriersandmethods to overcome –Preliminary study, ocular formulations and

ocuserts.Introduction,advantagesanddisadvantages,developmentofintrauterinedevices(IUDs)andapplications
Total 45 100
131
SubjectSyllabus
23990704-T-NOVELDRUGDELIVERYSYSTEM–THEORY
CourseOutcomes
CO1 StudyofModifiedDrugReleaseSystems,PolymersandNoveldrugdeliverysystems
CO2 Studyofformulationandprocessingoftherapeuticaerosols
CO3 Studyofmicroencapsulation&itsapplications
CO4 Studyoftechniquesofoptimization
ReferenceBooks
1. NovelDrugDeliverySystems
ByYW.Chien|MarcelDekker| 2nd edition
2. Controlleddrugdelivery:fundamentalsandapplications
ByRobinson,JosephR.,Lee,VincentH.L.,|NewYork:Dekker|29,Pub.Year1987
3. EncyclopediaofControlledDelivery
ByEdithMathiowitz|WileyIntersciencePublication,JohnWileyandSons,Inc,NewYork.Chichester/Weinheim
4. AdvancesinControlledandNovelDrugDelivery(TextBook)
ByNKJain|CBSPublishersandDistributorsPvt.Ltd.|1stEdition,Pub.Year2023
5. ControlledDrugDelivery-conceptsandadvances,(TextBook)
ByS.P.VyasandR.K.Khar,|VallabhPrakashan|1stedition,Pub.Year2002
132
SubjectSyllabus
23990705-T-QUALITYASSURANCE–THEORY

Prerequisite 23990705-T-QUALITYASSURANCE–THEORY
Uponcompletionofthecoursethestudentshallbeableto
1. understandthecGMPaspectsinapharmaceuticalindustry
CourseObjective 2. appreciatetheimportanceofdocumentation
3. understandthescopeofqualitycertificationsapplicabletopharmaceuticalindustries
4. UnderstandtheresponsibilitiesofQA&QCdepartments.
Total
3 1 - 4 75 25 - - 100

Sr. Topics T W
1 QualityAssuranceandQualityManagementconcepts 10 23
Quality Assurance and Quality Management concepts: Definition and concept of Quality control, Quality assurance and
GMP.TotalQualityManagement(TQM):Definition,elements,philosophiesICHGuidelines:purpose,participants,processof
harmonization, Brief overview of QSEM, with special emphasis on Q-series guidelines, ICH stability testing guidelinesQuality
by design (QbD): Definition, overview, elements of QbD program, tools.ISO 9000 & ISO14000: Overview, Benefits,
Elements, steps for registration.NABL accreditation : Principles and procedures
2 Organizationandpersonnel 10 23
Organization and personnel: Personnel responsibilities, training, hygiene and personal records.Premises: Design,
constructionandplantlayout,maintenance,sanitation,environmentalcontrol,utilitiesandmaintenanceofsterileareas, control
of contamination.Equipments and raw materials: Equipment selection, purchase specifications, maintenance, purchase
specifications and maintenance of stores for raw materials.
3 QualityControl 10 24
Quality Control: Quality control test for containers, rubber closures and secondary packing materials.Good Laboratory
Practices: General Provisions, Organization and Personnel, Facilities, Equipment, Testing Facilities Operation, Test and
ControlArticles,ProtocolforConductofaNonclinicalLaboratoryStudy,RecordsandReports,DisqualificationofTesting Facilities
4 Complaints 8 17
Complaints: Complaints and evaluation of complaints, Handling of return good, recalling and waste disposal.Document
maintenanceinpharmaceuticalindustry:BatchFormulaRecord,MasterFormulaRecord,SOP,Qualityaudit,QualityReview and
Quality documentation, Reports and documents, distribution records
5 CalibrationandValidation 7 13
133
SubjectSyllabus
23990705-T-QUALITYASSURANCE–THEORY

Sr. Topics T W
Calibration and Validation: Introduction, definition and general principles of calibration, qualification and validation,
importanceandscopeofvalidation,typesofvalidation,validationmasterplan.CalibrationofpHmeter,QualificationofUV- Visible
spectrophotometer, General principles of Analytical method Validation.Warehousing: Good warehousing practice, materials
management
Total 45 100
CourseOutcomes
CO1 ToacquireandintegrettheresponsibilitiesofQA&QCdepartmentsincludingTQM,ICHguidelines,ISOandQbD.
CO2 ToextrapolateknowledgeaboutcGMPaspectsinapharmaceuticalindustry
CO3 TotransformknowledgeaboutGLPinapharmaceuticalindustry.
Toidentifyandinterpretknowledgeaboutimportanceofdocumentationandtorecognizethescopeofqualitycertifications
CO4
applicable to pharmaceutical industries
ReferenceBooks
1. HowtoPracticeGMP’s
ByPPSharma.
2. ISO9000andTotalQualityManagement
BySadhankGGhosh
3. GoodlaboratoryPractices
ByMarcelDeckkerSeries
4. AguidetoTotalQualityManagement
ByKaushikMaitraandSedanKGhosh
134
SubjectSyllabus
23990706-P-INSTRUMENTALMETHODSOFANALYSIS–
PRACTICAL

Prerequisite 23990706-P-INSTRUMENTALMETHODSOFANALYSIS–PRACTICAL
Thestudentwilllearnto
1. Thebasictheoreticalknowledgeoftheinstrumentationtechniquesavailable.
2. Theoreticallyunderstandtheaspectsofseparationformulticomponents.
3. Practicalskillsfortheanalysisofdrugsandexcipientsusingvariousinstrumentation
CourseObjective techniques.
4. Theyabletomakeaccurateanalysisandreporttheresultsindefinedformats.
5. Theylearndocumentationandexpresstheobservationswithclarity.
6. Theyunderstandtheprofessionalandsafetyresponsibilitiesforworkingintheanalysis
laboratory.
Total
- - 4 2 - - 35 15 50
ReferenceBooks
1. PracticalPharmaceuticalChemistryVolI&II,
ByA.H.Beckett&J.B.Stenlake's,|StahlonePressofUniversityofLondon
2. QuantitativeAnalysisofDrugsinPharmaceuticalFormulations
ByP.D.Sethi|CBSPublishers&Distributors
ListofPractical
1. Determinationofabsorptionmaximaandeffectofsolventsonabsorptionmaximaoforganiccompounds
2. Estimationofdextrosebycolorimetry
3. Estimationofsulfanilamidebycolorimetry
4. SimultaneousestimationofibuprofenandparacetamolbyUVspectroscopy
5. AssayofparacetamolbyUV-Spectrophotometry
6. Estimationofquininesulfatebyfluorimetry
7. Studyofquenchingoffluorescence
8. Determinationofsodiumbyflamephotometry
9. Determinationofpotassiumbyflamephotometry
10. Determinationofchloridesandsulphatesbynepheloturbidometry
11. Separationofaminoacidsbypaperchromatography
12. Separationofsugarsbythinlayerchromatography
135
SubjectSyllabus
23990706-P-INSTRUMENTALMETHODSOFANALYSIS–
13. Separationofplantpigmentsbycolumnchromatography
14. DemonstrationexperimentonHPLC
15. DemonstrationexperimentonGasChromatography
136
SubjectSyllabus
23990707-P-PRACTICESCHOOL

Prerequisite 23990707-P-PRACTICESCHOOL
CourseObjective -
Total
- - 12 6 - - 125 25 150
ListofPractical
1. Guidelines
IntheVIIsemester,everycandidateshallundergopracticeschoolforaperiodof150hoursduringthesemester.The student shall opt
any one of the following activity for practice school:
• Hospitaltraining(Hospitalhavingminimum10bedfacilities)
• TraininginDrugstore/CHC/PHC
• TraininginaR&Dorganization/CRO/Manufacturingorganization/QA&QCLaboratory/Publictestinglaboratory/ Drug
regulatory body
• SuccessfullypassMOOCScourseequivalentto6creditsthroughSWAYAMPlatform
• Detailedliteraturereviewonanytechnicaltopic(Atleast50referencesshouldbeincludedinthereporttobe
submitted)
At the end of the practice school, every student shall submit a printed report (in triplicate) on the practice school he/she
attended(about25pages).AlongwiththeexamsofsemesterVII,thereportsubmittedbythestudent,knowledgeandskills acquired
by the student through practice school shall be evaluated by the subject experts at college level and grade point shall be
awarded.
• Certificate of training should be incorporated in the report.
137
Subject Syllabus
23990801 - BIOSTATISTICS AND RESEARCH METHODOLOGY -
THEORY

Prerequisite
1. Know the operation of M.S. Excel, SPSS, R and MINITAB®, DoE (Design of Experiment)
Course Objective
2. Know the various statistical techniques to solve statistical problems
3. Appreciate statistical techniques in solving the problems

Total
3 1 0 4 80 20 - - 100

Sr. Topics T W
1 Introduction: 10 23
Statistics, Biostatistics, Frequency distribution

Measures of central tendency: Mean, Median, Mode- Pharmaceutical examples
Measures of dispersion: Dispersion, Range, standard deviation, Pharmaceutical Problems
Correlation: Definition, Karl Pearson’s coefficient of correlation, Multiple correlation - Pharmaceuticals examples
2 Regression: 10 23
Curve fitting by the method of least squares, fitting the lines y= a + bx and x = a + by, Multiple regression, standard error of
regression– Pharmaceutical Examples
Probability: Definition of probability, Binomial distribution, Normal distribution Poisson’s distribution, properties – problems
Sample, Population, large sample, small sample, Null hypothesis, alternative hypothesis, sampling, essence of sampling,
types of sampling, Error-I type, Error-II type, Standard error of mean (SEM) - Pharmaceutical examples
Parametric test: t-test(Sample, Pooled or Unpaired and Paired) , ANOVA, (One way and Two way), Least Significance
difference
3 Non Parametric tests: 10 24

Wilcoxon Rank Sum Test, Mann-Whitney U test, Kruskal-Wallis test, Friedman Test
Introduction to Research: Need for research, Need for design of Experiments,Experiential Design Technique, plagiarism
Graphs: Histogram, Pie Chart, Cubic Graph, response surface plot, Counter Plot graph.
Designing the methodology: Sample size determination and Power of a study, Report writing and presentation of data,
Protocol, Cohorts studies, Observational studies, Experimental studies, Designing clinical trial, various phases
4 Blocking and confounding system for Two-level factorials 8 17
Regression modeling: Hypothesis testing in Simple and Multiple regression models

Introduction to Practical components of Industrial and Clinical Trials Problems: Statistical Analysis Using Excel, SPSS,
MINITAB®, DESIGN OF EXPERIMENTS, R - Online Statistical Software’s to Industrial and Clinical trial approach
5 Design and Analysis of experiments: 7 13
138
Subject Syllabus
23990801 - BIOSTATISTICS AND RESEARCH METHODOLOGY -
THEORY

Sr. Topics T W
Factorial Design: Definition, 22, 23design. Advantage of factorial design.

Response Surface methodology: Central composite design, Historical design, Optimization Techniques.
Total 45 100
Course Outcomes
To provide students with a strong foundation in understanding and applying statistical methods to analyze biological and
CO1
health-related data, as well as developing skills in research design and methodology.
To Know the various statistical techniques to solve statistical problems in pharmaceuticals research and drug devlopment
CO2
technology
CO3 To understand about parametric and non parametric test with their application and research modeling in pharmacy.
CO4 To gather information about various advance software of Industrial and Clinical Trials.
CO5 To design different factorial model and Response Surface methodology in pharmaceutical research and education.
Reference Books
1. Pharmaceutical statistics- Practical and clinical applications,
By Sanford Bolton | publisher Marcel Dekker Inc. NewYork
2. Fundamental of Statistics
By S.C.Gupta | Himalaya Publishing House
3. BIOSTATISTICS AND RESEARCH METHODOLOGY (TextBook)
By Dr. Ashok A. Hajare | Nirali Prakashan, Pub. Year 2022
139
Subject Syllabus
23990802 - SOCIAL AND PREVENTIVE PHARMACY - THEORY

Prerequisite
1. Acquire high consciousness/realization of current issues related to health and pharmaceutical
Course Objective problems within the country and worldwide
2. Have a critical way of thinking based on current healthcare development
3. Evaluate alternative ways of solving problems related to health and pharmaceutical issues

Total
3 1 0 4 80 20 - - 100

Sr. Topics T W
1 Concept of health and disease, Social and health education, Sociology and health: 10 23
• Definition, concepts and evaluation of public health. Understanding the concept of prevention and control of disease,
social causes of diseases and social problems of the sick.
• Food in relation to nutrition and health, Balanced diet, Nutritional deficiencies, Vitamin deficiencies, Malnutrition and
its prevention.
• Socio cultural factors related to health and disease, Impact of urbanization on health and disease, Poverty and health.
• Personal hygiene and health care; avoidable habits.
2 Preventive medicine: 10 23
• General principles of prevention and control of diseases such as cholera, SARS, Ebola virus, influenza, acute
respiratory infections, malaria, Chicken guinea, dengue, lymphatic filariasis, pneumonia, hypertension,
diabetesmellitus, cancer, drug addiction-drug substance abuse.
3 National health programs, its objectives, functioning and outcome of the following: 10 24
• HIV AND AIDS control programme, TB, Integrated disease surveillance program (IDSP), National leprosy control
programme, National mental health program, National programme for prevention and control of deafness, Universal
immunization programme, National programme for control of blindness, Pulse polio programme
4 National health programme: 8 17
• National health intervention programme for mother and child, National family welfare programme, National tobacco
control programme, National Malaria Prevention Program, National programme for the health care for the elderly,
Social health programme; role of WHO in Indian national program.
5 Community services in rural, urban and school health: 7 13
• Functions of PHC, Improvement in rural sanitation, national urban health mission, Health promotion and education in
school.
Total 45 100
140
Subject Syllabus
23990802 - SOCIAL AND PREVENTIVE PHARMACY - THEORY
Course Outcomes
CO1 To understand the concept of health, disease and to know about Sociology, Health education, Hygiene and health.
CO2 To gather knownledge about the various diseases with its preventive medicine.
CO3 To develop ideas about the National Health Programme including its objectives and Functions.
To introduce about various National health intervention programme for mother and child including the role of WHO in Indian
CO4
national program.
CO5 To know about the Community service, Functions of PHC, Health promotion and Education in school.
Reference Books
1. Short Textbook of Preventive and Social Medicine
By Prabhakara GN | 2nd Edition, 2010, ISBN: 9789380704104, JAYPEE Publications
2. Textbook of Preventive and Social Medicine
By (Mahajan and Gupta), Edited by Roy Rabindra Nath, Saha Indranil | 4th Edition, 2013, ISBN: 9789350901878, JAYPEE
Publications
3. Review of Preventive and Social Medicine (Including Biostatistics),
By Jain Vivek | 6th Edition, 2014, ISBN: 9789351522331, JAYPEE Publications
4. Essentials of Community Medicine—A Practical Approach (TextBook)
By Hiremath Lalita D, Hiremath Dhananjaya A , | 2nd Edition, 2012, ISBN: 9789350250440, JAYPEE Publications
5. Park Textbook of Preventive and Social Medicine,
By K Park, | 21st Edition, 2011, ISBN-14: 9788190128285, BANARSIDAS BHANOT PUBLISHERS
6. Community Pharmacy Practice,
By Ramesh Adepu | BSP publishers, Hyderabad
141
Subject Syllabus
23990803 - PHARMA MARKETING MANAGEMENT - THEORY

Type of Course Core Elective Courses
Prerequisite 23990405 - PHARMACEUTICAL JURISPRUDENCE-THEORY
The pharmaceutical industry not only needs highly qualified researchers, chemists and, technical people,
but also requires skilled managers who can take the industry forward by managing and taking the
Course Objective complex decisions which are imperative for the growth of the industry.
The Knowledge and Know how of marketing management groom the people for taking a challenging role
in Sales and Product management.

Total
3 1 0 4 80 20 - - 100

Sr. Topics T W
1 Marketing: 10 23
Definition, general concepts and scope of marketing; Distinction between marketing & selling; Marketing environment;
Industry and competitive analysis; Analyzing consumer buying behavior; industrial buying behavior.
Pharmaceutical market: Quantitative and qualitative aspects; size and composition of the market; demographic descriptions
and socio-psychological characteristics of the consumer; market segmentation& targeting. Consumer profile; Motivation and
prescribing habits of the physician; patients' choice of physician and retail pharmacist. Analyzing the Market; Role of market
research.
2 Product decision: 10 23
Classification, product line and product mix decisions, product life cycle, product portfolio analysis; product positioning; New
product decisions;Product branding, packaging and labeling decisions, Product management in pharmaceutical industry.
3 Promotion: 10 24
Methods, determinants of promotional mix, promotional budget; An overview of personal selling, advertising, direct mail,
journals, sampling, retailing, medical exhibition, public relations, online promotional techniques for OTC Products.
4 Pharmaceutical marketing channels: 8 17
Designing channel, channel members, selecting the appropriate channel, conflict in channels, physical distribution
management : Strategic importance, tasks in physical distribution management.
Professional sales representative (PSR): Duties of PSR, purpose of detailing, selection and training, supervising, norms for
customer calls, motivating, evaluating, compensation and future prospects of the PSR.
5 Pricing 7 13
142
Subject Syllabus
23990803 - PHARMA MARKETING MANAGEMENT - THEORY

Sr. Topics T W
Meaning, importance, objectives, determinants of price; pricing methods and strategies, issues in price management in
pharmaceutical industry. An overview of DPCO (Drug Price Control Order) and NPPA (National Pharmaceutical Pricing
Authority).
Emerging concepts in marketing: Vertical & Horizontal Marketing; Rural Marketing; Consumerism; Industrial Marketing;
Global Marketing.
Total 45 100
Course Outcomes
CO1 To understand the fundamental concepts of Pharmaceutical marketing.
CO2 To understand the different aspects of consumers in the pharmaceutical market.
CO3 Discussion about the concepts of the product management in Pharmaceutical Industry.
CO4 Discussion on various components of promotion of pharmaceutical products.
CO5 To study about different pharmaceutical marketing channels.
CO6 Discussion on the roles and responsibilities of pricing authorities in India.
Reference Books
1. 2. Marketing Management – ASouth Asian Perspective
By Philip Kotler, Kevin Lane Keller, Abraham Koshy & MithileshwarJha | Pearson
2. Marketing Strategy- Planning and Implementation
By Walker, Boyd and Larreche | Tata MC GrawHill, New Delhi.
3. Marketing Management
By Arun Kumar and N Menakshi: | Vikas Publishing, India
4. Marketing
By Dhruv Grewal and Michael Levy | Tata MC Graw Hill
By Rajan Saxena | Tata MC Graw-Hill (India Edition)
By Ramaswamy, U.S & Nanakamari | Global Perspective, IndianContext,Macmilan India, New Delhi
7. Service Marketing (TextBook)
By Shanker, Ravi | Excell Books, New Delhi
8. Pharmaceutical Marketing in India
By Subba Rao Changanti | (GIFT – Excel series) Excel Publications.
143
Subject Syllabus
23990804 - PHARMACEUTICAL REGULATORY SCIENCE - THEORY

Prerequisite 23990705 - QUALITY ASSURANCE - THEORY
This course is designed to impart the fundamental knowledge on the regulatory requirements for
approval of new drugs, and drug products in regulated markets of India & other countries like US, EU,
Course Objective
Japan, Australia, UK etc. It prepares the students to learn in detail on the regulatory requirements,
documentation requirements, and registration procedures for marketing the drug product

Total
3 1 0 4 80 20 - - 100

Sr. Topics T W
1 New Drug Discovery and development 10 13
Stages of drug discovery, Drug development process, pre-clinical studies, nonclinical activities, clinical studies, Innovator and
generics, Concept of generics, Generic drug product development.
2 Regulatory Approval Process 10 23
Approval processes and timelines involved in Investigational New Drug (IND), New Drug Application (NDA), Abbreviated New
Drug Application (ANDA). Changes to an approved NDA / ANDA.
Regulatory authorities and agencies:
Overview of regulatory authorities of India, United States, European Union, Australia, Japan, Canada (Organization structure
and types of applications)
3 Registration of Indian drug product in overseas market 10 24
Procedure for export of pharmaceutical products, Technical documentation, Drug Master Files (DMF), Common Technical
Document (CTD), electronic Common Technical Document (eCTD), ASEAN Common Technical Document (ACTD)research.
4 Clinical trials 8 17
Developing clinical trial protocols, Institutional Review Board / Independent Ethics committee - formation and working
procedures, Informed consent process and procedures, GCP obligations of Investigators, sponsors & Monitors, Managing and
Monitoring clinical trials, Pharmacovigilance – safety monitoring in clinical trials.
5 Regulatory Concepts 7 13
Basic terminology, guidance, guidelines, regulations, Laws and Acts, Orange book, Federal Register, Code of Federal
Regulatory, Purple book.
Total 45 90
144
Subject Syllabus
23990804 - PHARMACEUTICAL REGULATORY SCIENCE - THEORY
Course Outcomes
To understand the stages of drug discovery process and importance development of generic drugs.
CO1
To understand the regulatory approval process for Investigational new drug, regulatory process, organizational structure and
CO2
functions of regulatory authority of India, United States, European Union, Australia, Japan, Canada.
To understand the procedure for the export of pharmaceutical products from India, different types of drug master file,
CO3 Common technical document, and basic requirements of ACTD research.
To understand the basic ethical principles and ethical issues in clinical trials, the role of sponsors and investigators in clinical
CO4
trials.
To understand the Regulatory Concepts Basic terminology, guidance, guidelines, regulations, Laws and Acts, Orange book,
CO5
Federal Register, Code of Federal Regulatory, Purple book.
Reference Books
1. Drug Regulatory Affairs
By by Sachin Itkar, Dr. N.S. Vyawahare | Nirali Prakashan
2. The Pharmaceutical Regulatory Process
By Second Edition Edited by Ira R. Berry and Robert P. Martin, | Drugs and the Pharmaceutical Sciences,Vol. 185. Informa
Health care Publishers.
3. New Drug Approval Process: Accelerating Global Registrations
By Richard A Guarino | MD, 5th edition, Drugs and the Pharmaceutical Sciences,Vol.190.
4. Guidebook for drug regulatory submissions
By SandyWeinberg | John Wiley & Sons. Inc.
5. FDA Regulatory Affairs: a guide for prescription drugs, medical devices, and biologics
By edited by Douglas J. Pisano, David Mantus.
6. Generic Drug Product Development, Solid Oral Dosage forms,
By Leon Shargel and Isader Kaufer | Marcel Dekker series, Vol.143
7. Clinical Trials and Human Research: A Practical Guide to Regulatory Compliance
By Fay A. Rozovsky and Rodney K. Adams
8. Principles and Practices of Clinical Research,
By Second Edition Edited by John I. Gallin and Frederick P. Ognibene
9. Drugs: From Discovery to Approval
By Second Edition By Rick Ng
145
Subject Syllabus
23990805 - PHARMACOVIGILANCE - THEORY

This paper will provide an opportunity for the student to learn about development of pharmacovigilance
as a science, basic terminologies used in pharmacovigilance, global scenario of Pharmacovigilance, train
Course Objective students on establishing pharmacovigilance programme in an organization,
various methods that can be used to generate safety data and signal detection. This paper also develops
the skills of classifying drugs, diseases and adverse drug reactions.

Total
3 1 - 4 80 20 - - 100

Sr. Topics T W
1 Introduction to Pharmacovigilance: 10 23
• History and development of Pharmacovigilance
• Importance of safety monitoring of Medicine
• WHO international drug monitoring programme
• Pharmacovigilance Program of India(PvPI)
Introduction to adverse drug reactions:
• Definitions and classification of ADRs
• Detection and reporting
• Methods in Causality assessment
• Severity and seriousness assessment
• Predictability and preventability assessment
• Management of adverse drug reactions
Basic terminologies used in pharmacovigilance:
• Terminologies of adverse medication related events
• Regulatory terminologies
2 Drug and disease classification: 10 23
• Anatomical, therapeutic and chemical classification of drugs
• International classification of diseases
• Daily defined doses
• International Non proprietary Names for drugs
Drug dictionaries and coding in pharmacovigilance:
• WHO adverse reaction terminologies
• MedDRA and Standardised MedDRA queries
Information resources in pharmacovigilance:
• WHO drug dictionary
• Eudravigilance medicinal product dictionary Basic drug information resources
Establishing pharmacovigilance programme:
• Specialised resources for ADRs Establishing in a hospital
• Establishment & operation of drug safety department in industry
• Contract Research Organisations (CROs)
• Establishing a national programme
146
3 Vaccine safety surveillance: 10 24
147
Subject Syllabus

Sr. Topics T W
• Vaccine Pharmacovigilance
• Vaccination failure
• Adverse events following immunization
Pharmacovigilance methods:
• Passive surveillance ʹSpontaneous reports and case series
• Stimulated reporting
• Active surveillance ʹSentinel sites, drug event monitoring and registries
• Comparative observational studies ʹCross sectional study, case control study and cohort study
• Targeted clinical investigations
Communication in Pharmacovigilance:
• Effective communication in Pharmacovigilance
• Communication in Drug Safety Crisis management
• Communicating with Regulatory Agencies, Business Partners, Healthcare facilities & Media
4 Safety data generation ICH Guidelines for Pharmacovigilance 8 17
• Pre clinical phase
• Clinical phase
• Post approval phase (PMS)
ICH Guidelines for Pharmacovigilance:
• Organization and objectives of ICH
• Expedited reporting
• Individual case safety reports
• Periodic safety update reports
• Post approval expedited reporting
• Pharmacovigilance planning
• Good clinical practice in pharmacovigilance studies
5 Pharmacogenomics of adverse drug reactions: 7 13
• Genetics related ADR with example focusing PK parameters.
Drug safety evaluation in special population:
• Paediatrics
• Pregnancy and lactation
• Geriatrics
CIOMS:
• CIOMS Working Groups
• CIOMS Form
CDSCO (India) and Pharmacovigilance:
• D&C Act and Schedule Y
• Differences in Indian and global pharmacovigilance requirements
Total 45 100
148
Subject Syllabus
Course Outcomes
To develop the fundamental ideas about Pharmacovigilance and its development, basic terminologies and about the adverse
CO1
drug reactions.
To clarify about the drug and its classification, dictionaries, coding, Information Resourses and establishing
CO2
pharmacovigilance programme
CO3 To acquire knowledge about Vaccine safety surveilllance, its methods and communication in pharmacovigilance.
CO4 To acquire knowledge on Safety data generation and ICH Guidelines for pharmacovigilance.
CO5 To understand about the Pharmacogenomics of adverse drug reactions, Drug safety, CIOMS, CDSCO.
Reference Books
1. Textbook of Pharmacovigilance
By S K Gupta, | Jaypee Brothers Medical Publishers
2. Practical Drug Safety from A to Z
By Barton Cobert, Pierre Biron, Jones | Bartlett Publishers
3. Mann's Pharmacovigilance
By Elizabeth B. Andrews, Nicholas | Wiley Publisher
4. Stephens' Detection of New Adverse Drug Reactions
By John Talbot, Patrick Walle | WileyPublishers
5. An Introduction to Pharmacovigilance
By Patrick Waller | WileyPublisher
6. Cobert's Manual of Drug Safety and Pharmacovigilance
By Barton Cobert | Jones & BartlettPublishers.
7. Textbook of Pharmacoepidemiolog
By Brian L. Strom, Stephen E Kimmel, SeanHennessy | WileyPublishers
8. A Textbook of Clinical Pharmacy Practice -Essential Concepts and Skills
By G. Parthasarathi, Karin NyfortHansen,Milap C. Nahata | NA
9. National Formulary of India
10. Text Book of Medicine

By Yashpal Munjal
11. Text book of Pharmacovigilance: concept and practice
By GP Mohanta and PK Manna
149
Subject Syllabus
23990806 - QUALITY CONTROL AND STANDARDIZATION OF
HERBALS - THEORY

Prerequisite 23990603-T - HERBAL DRUG TECHNOLOGY – THEORY
In this subject the student learns about the various methods and guidelines for evaluation and
Course Objective standardization of herbs and herbal drugs. The subject also provides an opportunity for the student to
learn cGMP, GAP and GLP in traditional system of medicines..

Total
3 1 - 4 80 20 - - 100

Sr. Topics T W
1 Basic tests for drugs: 10 23
Pharmaceutical substances, Medicinal plants materials and dosage forms, WHO guidelines for quality control of herbal drugs.
Evaluation of commercial crude drugs intended for use.
2 Quality assurance in herbal drug industry: 10 23
cGMP, GAP, GMP and GLP in traditional system of medicine. WHO Guidelines on current good manufacturing Practices
(cGMP) for Herbal Medicines WHO Guidelines on GACP for Medicinal Plants.
3 EU and ICH guidelines: 10 24
Guidelines for quality control of herbal drugs. Research Guidelines for Evaluating the Safety and Efficacy of Herbal
Medicines.
4 Stability testing of herbal medicines: 8 17
Application of various chromatographic techniques in standardization of herbal products. Preparation of documents for
new drug application and export registration GMP requirements and Drugs & Cosmetics Act provisions.
5 Regulatory requirements for herbal medicines: 7 13
WHO guidelines on safety monitoring of herbal medicines in pharmacovigilance systems Comparison of various Herbal
Pharmacopoeias. Role of chemical and biological markers in standardization of herbal products.
Total 45 100
150
Subject Syllabus
23990806 - QUALITY CONTROL AND STANDARDIZATION OF
HERBALS - THEORY
Course Outcomes
CO1 Describe guidelines for quality control and evalution of safety and efficacy of herbal medicines.
CO2 Explain guidelines for cGMP, GMP, GAP and GLP for quality assurance in herbal drug industry.
CO3 Know the regulatory approval process and their registration in national and international markets.
CO4 Explain WHO guidelines on safety monitoring of herbal medicine in pharmacovigilance systems.
Reference Books
1. Pharmacognosy
By Trease and Evans
2. Pharmacognosy Kokate,
By Purohit and Gokhale
4. Herbal Drug Technology
By Aggrawal, S.S. | Universities Press, 2002
5. EMEA. Guidelines on Quality of Herbal Medicinal Products/Traditional Medicinal Products (TextBook)
6. Quality Control of Herbal Drugs: An Approach to Evaluation of Botanicals

By Mukherjee, P.W | Business Horizons Publishers, New Delhi, India, 2002.
7. Application of quality control principles to herbal drugs
By Shinde M.V., Dhalwal K., Potdar K., Mahadik K. | International Journal of Phytomedicine 1(2009)
8. WHO. Quality Control Methods for Medicinal Plant Materials,World Health Organization, Geneva, 1998. WHO. Guidelines
for the Appropriate Use of Herbal Medicines
WHO Regional Publications, Western Pacific Series No 3, WHO Regional office for the
9. Quality Specifications, 3rd edn.
By World Health Organization Geneva, 1981 | WHO. The International Pharmacopeia, Vol. 2:
10. WHO. Quality Control Methods for Medicinal Plant Materials.
By World Health Organization Geneva, 1999
11. WHO. WHO Global Atlas of Traditional, Complementary and Alternative Medicine
By World Health Organization, Geneva, 2005 | 2 vol. set. Vol. 1 contains text and Vol. 2, maps
12. WHO. Guidelines on Good Agricultural and Collection Practices (GACP) for Medicinal Plants.
By World Health Organization, Geneva, 2004.
151
Subject Syllabus
23990807 - COMPUTER AIDED DRUG DESIGN - THEORY

Prerequisite 23990404 - PHARMACOLOGY I-THEORY
Upon completion of the course, the student shall be able to understand
Design and discovery of lead molecules
The role of drug design in drug discovery process
Course Objective
The concept of QSAR and docking
Various strategies to develop new drug like molecules.
The design of new drug molecules using molecular modeling software

Total
3 1 0 4 80 20 - - 100

Sr. Topics T W
1 Introduction to Drug Discovery and Development 10 23
Stages of drug discovery and development Lead discovery and Analog Based Drug Design Rational approaches to lead
discovery based on traditional medicine, Random screening, Non-random screening, serendipitous drug discovery, lead
discovery based on drug metabolism, lead discovery based on clinical observation. Analog Based Drug Design:Bioisosterism,
Classification, Bioisosteric replacement. Any three case studies.
2 Quantitative Structure Activity Relationship (QSAR) SAR versus QSAR, 10 23
History and development of QSAR, Types of physicochemical parameters, experimental and theoretical approaches for the
determination of physicochemical parameters such as Partition coefficient, Hammet’s substituent constant and Tafts steric
constant. Hansch analysis, Free Wilson analysis, 3D QSAR approaches like COMFA and COMSIA.
3 Molecular Modeling and virtual screening Techniques 10 24
Drug likeness screening, Concept of pharmacophore mapping and pharmacophore based Screening, Molecular docking: Rigid
docking, flexible docking, manual docking, Docking based screening. De novo drug design
4 Informatics & Methods in drug design 8 17
Introduction to Bioinformatics, chemoinformatics. ADME databases, chemical, biochemical and pharmaceutical databases
5 Molecular Modeling 7 13
Introduction to molecular mechanics and quantum mechanics. Energy Minimization methods and Conformational Analysis,
global conformational minima determination
Total 45 100
152
Subject Syllabus
23990807 - COMPUTER AIDED DRUG DESIGN - THEORY
Course Outcomes
To understand the various stages of Drug Discovery and Development, various rational approaches to lead discovery, design
CO1
the analogue synthesis using lead molecule.
To understand the Quantitative Structure Activity Relationship (QSAR) SAR versus QSAR, and experimental and theoretical
CO2
approaches for the determination of physicochemical parameters.
To understand the Molecular and virtual screening techniques with the various docking and De novo drug design.
CO3
To understand about Informatics & Methods in drug design

CO4
To understand the molecular modelling and different methods and to explain the various Energy Minimization Methods.
CO5
Reference Books
1. “Drug Action at the Molecular Level”
By Robert GCK, ed | University Prak Press Baltimore
2. Quantitative Drug Design
By Martin YC | Dekker, New Yor
3. Wilson & Gisvolds’s Text Book of Organic Medicinal & Pharmaceutical Chemistry”
By Delgado JN, Remers WA eds | Lippincott, New York
4. “Principles of Medicinal chemistry ‘
By Lea & Febiger. Foye WO
5. “Essentials of Medicinal Chemistry”
By Koro lkovas A, Burckhalter JH e | Wiley Interscienc
6. “The Basis of Medicinal Chemistry,
By Burger’s Medicinal Chemistry” Wolf ME, | ed JohnWiley& Sons, New York
7. An Introduction to Medicinal Chemistry
By Patrick Graham, L. | Oxford University Press
8. Introduction to the principles of Drug Design
By Smith HJ, Williams H, eds, | Wright Boston
9. The organic Chemistry of Drug Design and Drug Action”
By Silverman R.B | Academic Press New York
153
Subject Syllabus
23990808 - CELL AND MOLECULAR BIOLOGY - THEORY

Prerequisite 23990201 - HUMAN ANATOMY AND PHYSIOLOGY II – THEORY
cell biology is the branch of biology that studies cells their physiological properties, their structure, the
organelles they contain, interactions with their environment, their life cycle, division, death and cell
Course Objective function. This is done both on microscopic and molecular level. Cell biology research encompasses both
the great diversity of single-celled organisms like bacteria and protozoa, as well as the many specialized
cells in multi-cellular organisms such as humans, plants, and sponges.

Total
3 1 0 4 80 20 - - 100

Sr. Topics T W
1 a) Cell and Molecular Biology: Definitions theory and basics and Applications. 10 23
b) Cell and Molecular Biology: History and Summation.
c) Properties of cells and cell membrane.
d) Prokaryotic versus Eukaryotic
e) Cellular Reproduction
f) Chemical Foundations – an Introduction and Reactions (Types)
2 a) DNA and the Flow of Molecular Information 10 23
b) DNA Functioning
c) DNA and RNA
d) Types of RNA
e) Transcription and Translation
3 a) Proteins: Defined and Amino Acids 10 24
b) Protein Structure 173
c) Regularities in Protein Pathways
d) Cellular Processes
e) Positive Control and significance of Protein Synthesis.
4 a) Science of Genetics 8 17
b) Transgenics and Genomic Analysis
c) Cell Cycle analysis
d) Mitosis and Meiosis
e) Cellular Activities and Checkpoints
5 a) Cell Signals: Introduction 7 13
b) Receptors for Cell Signals
c) Signaling Pathways: Overview
d) Misregulation of Signaling Pathways
e) Protein-Kinases: Functioning
154
Total 45 100
155
Subject Syllabus
23990808 - CELL AND MOLECULAR BIOLOGY - THEORY
Course Outcomes
CO1 To understand concept of molecular cell biology and its application.
CO2 To gather knowledge about molecular composition of genetic material.
CO3 To discuss the biomolecular composition of protein and aminoacid with their structote and application.
CO4 To study the science of genetics and cell cycle of biological organism.
CO5 To know the pathway of cell signaling, Protein-Kinases and Functioning.
Reference Books
1. Essentials of Biochemistry by U. Satyanarayana
By W.B. Hugo and A.D. Russel: | Blackwell Scientific publications, Oxford London.
3. Industrial Microbiology
By Prescott and Dunn 4th edition | , CBS Publishers & Distributors, Delhi
4. Microbiology Industrial Microbiology Tata McGraw Hill edn
By Tata McGraw Hill edn
6. Rose: Industrial Microbiology
7. Fundamentals of Microbiology
By Alcomo, I.E. | VI Edition, Jones and Bartlett Publishers. Sudbury. Massachusetts., Pub. Year 2001
8. Tutorial Pharmacy
By Cooper and Gunn’s | CBS Publishers and Distributors
9. Microbial Technology
By Pepple
10. Fundamentals of Microbiology (TextBook)
By Edward Cartwright
By N.K.Jain
12. Bergeys manual of systematic bacteriology
By Williams and Wilkins- A Waverly company
13. Molecular Biotechnology: Principles and Applications of RecombinantDNA
By B.R. Glick and J.J. Pasternak:
14. Kuby Immunology
By Richard A. Goldsby, Thomas J. Kindt, Barbara A. Osborne, Janis Immunology Kuby | W H Freeman & Co
156
Subject Syllabus
23990809 - COSMETIC SCIENCE - THEORY

1. To know and explain about cosmetics, and related sciences, cosmeceuticals (cosmetics with skin, hair
and oral care benefits) and personal care and hygiene products.
Course Objective
2. To demonstrate practical skills in the area of biology, formulation science and analytical techniques
required to scientifically design and develop various cosmetic products.
3. To describe about basic cosmetic problems associated with skin, hair and oral care etc.

Total
3 1 - 4 80 20 - - 100

Sr. Topics T W
1 Classification of cosmetic and cosmeceutical products 10 23
Definition of cosmetics as per Indian and EU regulations, Evolution of cosmeceuticals from cosmetics, cosmetics as quasi and
OTC drugs.
Cosmetic Excipients: Surfactants, rheologymodifiers, humectants, emollients, preservatives.
Classification and application Skin: Basic structure and function of skin.
Hair: Basic structure of hair. Hair growth cycle.
Oral Cavity: Common problem associated with teeth and gums.
2 Principles of formulation and building blocks of skin care products: 10 23
Face wash, Moisturizing cream, Cold Cream, Vanishing cream and their advantages and disadvantages. Application of these
products in formulation of cosmecuticals. Antiperspants & deodorants- Actives & mechanism of action.
Principles of formulation and building blocks of Hair care products: Conditioning shampoo, Hair conditioner,anti-dandruff
shampoo. Hair oils. Chemistry and formulation of Para-phylene diamine based hair dye.
Principles of formulation and building blocks of oral care products: Toothpaste for bleeding gums, sensitive teeth. Teeth
whitening, Mouthwash.
3 Sun protection, Classification of Sunscreens and SPF. 10 24
157
Role of herbs in cosmetics: Skin Care: Aloe and turmeric Hair care: Henna and amla.
Oral care: Neem and clove Analytical cosmetics: BIS specification and analytical methods for shampoo, skincream and
toothpaste.
4 Principles of Cosmetic Evaluation 8 17
158
Subject Syllabus
23990809 - COSMETIC SCIENCE - THEORY

Sr. Topics T W
Principles of sebumeter, corneometer. Measurement of TEWL, Skin Color, Hair tensile strength, Hair combing properties
Soaps and syndet bars. Evolution and skin benfits
5 Oily and dry skin, causes leading to dry skin, skin moisturisation 7 13
Basic understanding of the terms Comedogenic, dermatitis.
Cosmetic problems associated with Hair and scalp: Dandruff, Hair fall causes Cosmetic.
Problems associated with skin: blemishes, wrinkles, acne, prickly heat and body odor. Antiperspirants and Deodorants-
Actives and mechanism of actio.
Total 45 100
Course Outcomes
Understand the roles and interactions of ingredients, predicting compatibility and stability, ensuring informed ingredient
CO1
selection for safe and effective products.
Design cosmetic products, balancing ingredient ratios, overcoming challenges, and creating prototypes with desired sensory
CO2
attributes and performance outcomes.
Navigate regulations, assess ingredient risks, and conduct stability tests to develop compliant and safe cosmetic
CO3
formulations.
Explore innovative trends like sustainable formulations, nanotechnology, and digital integration, adapting them to create
CO4
forward-thinking cosmetic products.
Master consumer perception assessment, interpret data, and refine formulations to align with user preferences, ensuring
CO5
products meet both scientific and consumer demands.
Reference Books
1. Harry’s Cosmeticology
By Wilkinson, Moore | Seventh Edition, George Godwin
2. Cosmetics – Formulations, Manufacturing and Quality Contro
By P.P. Sharma | 4thEdition, Vandana Publications Pvt. Ltd., Delhi
3. Drugs and Cosmetics Act/Rules
4. Poucher’s Perfumes, Cosmetics and Soaps
5. Handbook of Cosmetic Science and Technology 3rd Edition
6. Pulok K.Mukherjee. Quality Control Herbal Drugs Business Horizons
159
7. “Trease and Evans’ Pharmacognosy”
By Trease, G.E. and Evans, | W.C. WB Saunders Co.
160
Subject Syllabus
23990810 - EXPERIMENTAL PHARMACOLOGY - THEORY

Prerequisite 23990404 - PHARMACOLOGY I-THEORY
This subject is designed to impart the basic knowledge of preclinical studies in experimental animals
Course Objective
including design, conduct and interpretations of results.

Total
3 1 - 4 80 20 - - 100

Sr. Topics T W
1 Laboratory Animals: 8 20
Study of CPCSEA and OECD guidelines for maintenance, breeding and conduct of experiments on laboratory animals,
Common lab animals: Description and applications of different species and strains of animals. Popular transgenic and mutant
animals. Techniques for collection of blood and common routes of drug administration in laboratory animals, Techniques of
blood collection and euthanasia.
2 Introduction to preclinical studies 5 20
Dose selection, calculation and conversions, preparation of drug solution/suspensions, grouping of animals and importance
of sham negative and positive control groups. Rationale for selection of animal species and sex for the study.
3 Preclinical screening models 12 24
Preclinical screening models for drugs acting on CNS :- analgesic, antipyretic, anti-inflammatory, general anesthetics,
sedative and hypnotics, antipsychotic, antidepressant, antiepileptic, nootropics, anti-Parkinsonism drugs, anti-Alzheimer
drug.
Preclinical screening models for drugs acting on eye and local aesthetics.
4 Preclinical screening models for drugs acting on ANS: 5 15

sympathomimetics, sympatholytics, parasympathomimetics, parasympatholytics, skeletal muscle relaxants.
5 Preclinical screening models for drugs acting on CVS:- 10 10
antihypertensives, diuretics, antiarrhythmic, antidyslepidemic, antiaggregatory, coagulants, and anticoagulants.
Preclinical screening models for antiulcer, antidiabetic, anticancer and
antiasthmatic activities
6 Research methodology and Bio-statistics 5 11
161
Selection of research topic, review of literature, research hypothesis and study design Pre-clinical data analysis and
interpretation using Students‘t’ test and One-way ANOVA. Graphical representation of data.
Total 45 100
162
Subject Syllabus
23990810 - EXPERIMENTAL PHARMACOLOGY - THEORY
Course Outcomes
CO1 Appreciate the applications of various commonly used laboratory animals.
CO2 Appreciate and demonstrate the various screening methods used in preclinical research
CO3 Appreciate and demonstrate the importance of biostatistics and research methodology
CO4 Understanding Design and execute a research hypothesis independently
Reference Books
By M.N.Ghosh
By S.K.Kulakarni
3. CPCSEA guidelines for laboratory animal facility
4. Drug discovery and Evaluation

By Vogel H.G
5. Drug Screening Methods
By Suresh Kumar Gupta and S. K. Gupta
6. Introduction to biostatistics and research methods
By PSS Sundar Rao and J Richard
163
Subject Syllabus
23990811 - ADVANCED INSTRUMENTATION TECHNIQUES -
THEORY

Prerequisite 23990705 - QUALITY ASSURANCE - THEORY
1. Understand the advanced instruments used and its application in drug analysis
Course Objective 2. Understand the chromatographic separation and analysis of drugs
3. Understand the calibration of various analytical instruments
4. Know analysis of drugs using various analytical instruments

Total
3 1 0 4 80 20 - - 100

Sr. Topics T W
1 Nuclear Magnetic Resonance spectroscopy, Mass Spectrometry 10 20
Principles of H-NMR and C-NMR, chemical shift, factors affecting chemical shift, coupling constant, Spin - spin coupling,
relaxation, instrumentation and applications- Principles, Fragmentation, Ionization techniques – Electron impact, chemical
ionization, MALDI, FAB, Analyzers-Time of flight and Quadrupole, instrumentation, applications
2 Thermal Methods of Analysis X-Ray Diffraction Methods: 10 25
Principles, instrumentation and applications of ThermogravimetricAnalysis (TGA), Differential Thermal Analysis (DTA),
Differential Scanning Calorimetry (DSC) : Origin of X-rays, basic aspects of crystals, Xray Crystallography, rotating crystal
technique, single crystal diffraction,powder diffraction, structural elucidation and applications.
3 Calibration and validation, Calibration of following Instruments 10 25
Calibration and validation, Calibration of following Instruments as per ICH and USFDA guidelines Electronic balance, UV-
Visible spectrophotometer, IR spectrophotometer, Fluorimeter, Flame Photometer, HPLC and GC
4 Radio immune assay, Extraction techniques: 8 15
Radio immune assay, Extraction techniques: Importance, various components, Principle, different methods, Limitation and
Applications of Radio immuno assay General principle and procedure involved in the solid phase extraction and liquid-liquid
extraction
5 Hyphenated techniques 7 15
164
Hyphenated techniques-LC-MS/MS, GC-MS/MS, HPTLC-MS.
Total 45 100
165
Subject Syllabus
23990811 - ADVANCED INSTRUMENTATION TECHNIQUES -
THEORY
Course Outcomes
CO1 To interpret fundamentals, Instrumentation, Working & use of NMR and Mass Spectrometry.
CO2 To extrapolate fundamentals of calibration and validation of various analytical instruments as per ICH and USFDA guidelines.
CO3 To generalize fundamentals, Instrumentation, Working & use of Thermal Method of Analysis and X-ray diffraction Methods.
CO4 To recall and transform basic knowledge of Radio Immune assay, Extraction techniques and hyphenated techniques.
Reference Books
1. Instrumental Methods of Chemical Analysis
By B.K Sharma | Krishna Prakashan Media
2. Organic spectroscopy
By Y.R Sharma | S Chand
3. Text book of Pharmaceutical Analysis
By Kenneth A. Connors | Wiley India Pvt. Limited, 2007
4. Vogel’s Text book of Quantitative Chemical Analysis
By A.I. Vogel,
6. Organic Chemistry Vol-1 & 2
7. Organic spectroscopy
By William Kemp | Palgrave Macmillan, USA
8. Quantitative Analysis of Drugs
By Von D. C. Garrett in Zusammenarbeit mit L. Brealy, C. A. Johnson, K. L. Smith und G. Sykes.
9. Quantitative Analysis of Drugs in Pharmaceutical Formulations
By P. D. Sethi
10. Spectrophotometric identification of Organic Compounds
By by Robert M. Silverstein, Francis X. Webster
166
Subject Syllabus
23990812 - DIETARY SUPPLEMENTS AND NUTRACEUTICALS -
THEORY

This module aims to provide an understanding of the concepts behind the theoretical applications of
dietary supplements. By the end of the course, students should be able to:
1. Understand the need of supplements by the different group of people to maintain healthy life.
Course Objective 2. Understand the outcome of deficiencies in dietary supplements.
3. Appreciate the components in dietary supplements and the application.
4. Appreciate the regulatory and commercial aspects of dietary supplements including health
claims.

Total
3 1 0 4 80 20 - - 100

Sr. Topics T W
1 a. Definitions of Functional foods 7 20
a. Definitions of Functional foods, Nutraceuticals and Dietary supplements. Classification of Nutraceuticals, Health problems
and diseases that can be prevented or cured by Nutraceuticals i.e. weight control, diabetes, cancer, heart disease, stress,
osteoarthritis, hypertension etc.
b. Public health nutrition, maternal and child nutrition, nutrition and ageing, nutrition education in community.
c. Source, Name of marker compounds and their chemical nature, Medicinal uses and health benefits of following used as
nutraceuticals/functional foods: Spirulina, Soyabean, Ginseng, Garlic, Broccoli, Gingko, Flaxseeds.
2 Phytochemicals as nutraceuticals: 15 25
Occurrence and characteristic features(chemical nature medicinal benefits) of following

a) Carotenoids- α and β-Carotene, Lycopene, Xanthophylls, leutin
b) Sulfides: Diallyl sulfides, Allyl trisulfide.
c) Polyphenolics: Reservetrol
d) Flavonoids- Rutin , Naringin, Quercitin, Anthocyanidins, catechins, Flavones
e) Prebiotics / Probiotics.: Fructo oligosaccharides, Lacto bacillum
f) Phyto estrogens : Isoflavones, daidzein, Geebustin, lignans
g) Tocopherols
h) Proteins, vitamins, minerals, cereal, vegetables and beverages as functional foods: oats, wheat bran, rice bran, sea foods,
coffee, tea and the like.
3 Introduction to free radicals: 7 25
167
Introduction to free radicals:
a) Free radicals, reactive oxygen species, production of free radicals in cells, damaging reactions of free radicals on lipids,
proteins, Carbohydrates, nucleic acids.
b) Dietary fibres and complex carbohydrates as functional food ingredients.
4 a) Free radicals in Diabetes mellitus, Inflammation, Ischemic reperfusion injury, 10 15
168
Subject Syllabus
THEORY

Sr. Topics T W
a) Free radicals in Diabetes mellitus, Inflammation, Ischemic reperfusion injury, Cancer, Atherosclerosis, Free radicals in brain
metabolism and pathology, kidney damage, muscle damage. Free radicals involvement in other disorders. Free radicals
theory of ageing.
b) Antioxidants: Endogenous antioxidants – enzymatic and non-enzymatic antioxidant defence, Superoxide dismutase,
catalase, Glutathione peroxidase Glutathione Vitamin C, Vitamin E, α- Lipoic acid, melatonin Synthetic antioxidants:
Butylated hydroxyl Toluene, Butylated hydroxyl Anisole.
c) Functional foods for chronic disease prevention
5 Regulatory Aspects; 6 15
a) Effect of processing, storage and interactions of various environmental factors on the potential of nutraceuticals.
b) Regulatory Aspects; FSSAI, FDA, FPO, MPO, AGMARK. HACCP and GMPs on Food Safety. Adulteration of foods.
c) Pharmacopoeia Specifications for dietary supplements and nutraceuticals.
Total 45 100
Course Outcomes
CO1 Knowledge about supplements by the different group of people to maintain or Improve healthy life.
CO2 Understand the outcome of deficiencies in dietary supplements.
CO3 Appreciate the components in dietary supplements and the application
CO4 Obliged the regulatory and commercial aspects of dietary supplements including health claims.
Reference Books
1. Role of dietary fibers and nutraceuticals in preventing diseases
By K.T Agusti and P.Faiza
2. Dietetics
By Sri Lakshmi
3. Advanced Nutritional Therapies
By Cooper. K.A., (1996)
4. The Food Pharmacy
By Jean Carper, Simon & Schuster
5. Prescription for Nutritional Healing
By James F.Balch and Phyllis A.Balch
6. 2000 Functional Foods and Dietary Supplements: Safety, Good Manufacturing Practice (GMPs) and Shelf Life Testing in
Essentials of Functional Foods
169
7. Functional Foods. 1994
8. 2000 Functional foods
9. Handbook of Nutraceuticals and Functional Foods
10. Modern Nutrition in Health and Disease.
170
Subject Syllabus
THEORY
171
Subject Syllabus
23990813 - PROJECT WORK

Prerequisite
Course Objective -

Total
0 0 12 6 - - 100 50 150

Sr. Topics T W
1 Guidelines: 0 0
All the students shall undertake a project under the supervision of a teacher and submit a report. The area of the project
shall directly relate any one of the elective subject opted by the student in semester VIII or Minor research project at R & D
organization/ CRO/ Manufacturing organization/QA & QC Laboratory/ Public testing laboratory/ Drug regulatory
body/Hospital/ Community Pharmacy/ Help Centre or at Institute.
1. The project shall be carried out in group not exceeding 5 in number.
2. The project report shall be submitted in triplicate (typed & bound copy not less than 25 pages).
3. The students can perform the activities for project work after completion of Semester VI onwards (during the vacation/
official Holidays) but the credit of project work will be transferred in Semester VIII.
Those who are doing Project work during this period must complete the prescribed days or hours for Project work as per the
guidelines. Institute should maintain documentation regarding project Work for each student with requisite evidence
Total 0 0
List of Practical
172

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Subject Syllabus

23990101-T - HUMAN ANATOMY AND PHYSIOLOGY I – THEORY

Course Bachelor of Pharmacy (B.Pharm.) Semester - 1

Teaching Scheme (Contact Hours) Examination Scheme

Course Content T - Teaching Hours | W - Weightage

Structure and functions of skin.

3 Body fluids and blood: 10 25

4 Peripheral nervous system: 8 17

Course Content T - Teaching Hours | W - Weightage

Course Bachelor of Pharmacy (B.Pharm.) Semester - 1

Teaching Scheme (Contact Hours) Examination Scheme

Course Content T - Teaching Hours | W - Weightage

2 Acid base titration, Non aqueous titration, 10 25

3 Precipitation titrations, Complexometric titration, Gravimetry 10 25

5 Electrochemical methods of analysis, Potentiometry, Polarography - 7 13

Course Content T - Teaching Hours | W - Weightage

Course Bachelor of Pharmacy (B.Pharm.) Semester - 1

Teaching Scheme (Contact Hours) Examination Scheme

Course Content T - Teaching Hours | W - Weightage

Course Content T - Teaching Hours | W - Weightage

Course Bachelor of Pharmacy (B.Pharm.) Semester - 1

Teaching Scheme (Contact Hours) Examination Scheme

Course Content T - Teaching Hours | W - Weightage

2 Acids, Bases and Buffers: 10 25

3 Gastrointestinal agents Cathartics, 10 25

Acidifiers: Ammonium chloride* and Dil. HCl

Cathartics: Magnesium sulphate, Sodium orthophosphate, Kaolin and Bentonite.

Course Content T - Teaching Hours | W - Weightage

Poison and Antidote: Sodium thiosulphate*, Activated charcoal, Sodium nitrite333

Astringents: Zinc Sulphate, Potash Alum

Course Bachelor of Pharmacy (B.Pharm.) Semester - 1

Teaching Scheme (Contact Hours) Examination Scheme

Course Content T - Teaching Hours | W - Weightage

2 Elements of Communication, Communication Styles 7 24

3 Basic Listening Skills, Effective Written Communication, Writing Effectively 7 23

4 Interview Skills, Giving Presentations 5 17

Interview Skills: Purpose of an interview, Do‘s and Dont‘s of an interview

Course Content T - Teaching Hours | W - Weightage

Course Bachelor of Pharmacy (B.Pharm.) Semester - 1

Teaching Scheme (Contact Hours) Examination Scheme

Course Content T - Teaching Hours | W - Weightage

Digestion and Absorption:

• Human alimentary canal and digestive glands;

Breathing and respiration:

• Human respiratory system;

Course Content T - Teaching Hours | W - Weightage

Neural control and coordination:

• Definition and classification of nervous system;

Chemical coordination and regulation:

• Endocrine glands and their secretions;

• Parts of female reproductive system;

4 Plants and mineral nutrition: 5 17

• Autotrophic nutrition, photosynthesis, Photosynthetic pigments,

Course Bachelor of Pharmacy (B.Pharm.) Semester - 1

Teaching Scheme (Contact Hours) Examination Scheme

Course Content T - Teaching Hours | W - Weightage

2 Matrices and Determinant, 6 20

Course Content T - Teaching Hours | W - Weightage

Introduction: Signs of the Coordinates, Distance formula,

Course Bachelor of Pharmacy (B.Pharm.) Semester - 1

2 Alkanes, Alkenes and Conjugated dienes* 10 23