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    Dr. Yousif MCQs

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    M7md Allahham
    This document contains 36 multiple choice questions related to pharmacokinetics and drug metabolism. The questions cover topics such as routes of drug administration, factors affecting drug absorption, distribution, metabolism and excretion, pharmacokinetic parameters such as volume of distribution and half-life, and differences in drug metabolism between adults and neonates. The correct answer is provided for each multiple choice question.

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    © All Rights Reserved
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    Dr. Yousif MCQs

    Uploaded by

    M7md Allahham
    33 views11 pages
    This document contains 36 multiple choice questions related to pharmacokinetics and drug metabolism. The questions cover topics such as routes of drug administration, factors affecting drug absorption, distribution, metabolism and excretion, pharmacokinetic parameters such as volume of distribution and half-life, and differences in drug metabolism between adults and neonates. The correct answer is provided for each multiple choice question.

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    This document contains 36 multiple choice questions related to pharmacokinetics and drug metabolism. The questions cover topics such as routes of drug administration, factors affecting drug absorption, distribution, metabolism and excretion, pharmacokinetic parameters such as volume of distribution and half-life, and differences in drug metabolism between adults and neonates. The correct answer is provided for each multiple choice question.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    33 views11 pages

    Dr. Yousif MCQs

    Uploaded by

    M7md Allahham
    This document contains 36 multiple choice questions related to pharmacokinetics and drug metabolism. The questions cover topics such as routes of drug administration, factors affecting drug absorption, distribution, metabolism and excretion, pharmacokinetic parameters such as volume of distribution and half-life, and differences in drug metabolism between adults and neonates. The correct answer is provided for each multiple choice question.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 11

    Dr.

    Yousif Sahhory MCQs


    1_Which of the following drugs is administered by intranasal spray/application for
    systemic action:
    A. Phenylephrine
    B. Desmopressin
    C. Azelastine
    D. Beclomethasone dipropionate

    2_Alkalinization of urine hastens the excretion of:


    A. Weakly basic drugs
    B. Weakly acidic drugs
    C. Strong electrolytes
    D. Nonpolar drugs

    3_ Diffusion of drugs across cell membrane:


    A. Is dependent upon metabolic activity of the cell
    B. Is competitively inhibited by chemically related drugs
    C. Is affected by extent of ionization of drug molecules
    D. Exhibits saturation kinetics

    4_The most important factor which governs diffusion of drugs across capillaries
    other than those in the brain is:
    A. Blood flow through the capillary
    B. Lipid solubility of the drug
    C. pKa value of the drug
    D. pH of the medium
    5_Bioavailability of drug refers to:
    A. Percentage of administered dose that reaches systemic circulation in the unchanged
    form
    B. Ratio of oral to parenteral dose
    C. Ratio of orally administered drug to that excreted in the faeces
    D. Ratio of drug excreted unchanged in urine to that excreted as metabolites

    6_ The most important factor governing absorption of a drug from intact skin is:
    A. Molecular weight of the drug
    B. Site of application
    C. Lipid solubility of the drug
    D. Nature of the base used in the formulation

    7_If the total amount of a drug present in the body at a given moment is 2.0 g and
    its plasma concentration is 25 µg/ml, its volume of distribution is:
    A. 100 L
    B. 80 L
    C. 60 L
    D. 50 L

    8_The following attribute of a drug tends to reduce its volume of distribution:


    A. High lipid solubility
    B. Low ionisation at physiological pH values
    C. High plasma protein binding
    D. High tissue binding
    9_Marked redistribution is a feature of:
    A. Highly lipid soluble drugs
    B. Poorly lipid soluble drugs
    C. Depot preparations
    D. Highly plasma protein bound drugs

    10_The blood-brain barrier, which restricts entry of many drugs into brain, is
    constituted by:
    A. P-glycoprotein efflux carriers in brain capillary cells
    B. Tight junctions between endothelial cells of brain capillaries
    C. Enzymes present in brain capillary walls
    D. All of the above

    11.Weakly acidic drugs:


    A. Are bound primarily to α1 acid glycoprotein in plasma
    B. Are excreted faster in alkaline urine
    C. Are highly ionized in the gastric juice
    D. Do not cross blood-brain barrier

    12_High plasma protein binding:


    A. Increases volume of distribution of the drug
    B. Facilitates glomerular filtration of the drug
    C. Minimises drug interactions
    D. Generally makes the drug long acting
    13_Biotransformation of drugs is primarily directed to:
    A. Activate the drug
    B. Inactivate the drug
    C. Convert lipid soluble drugs into nonlipid soluble metabolites
    D. Convert nonlipid soluble drugs into lipid soluble metabolites

    14_A prodrug is:


    A. The prototype member of a class of drugs
    B. The oldest member of a class of drugs
    C. An inactive drug that is transformed in the body to an active metabolite
    D. A drug that is stored in body tissues and is then gradually released in the circulation

    15_Which of the following cytochrome P450 isoenzymes is involved in the


    metabolism of largest number of drugs in human beings and has been implicated in
    some dangerous drug interactions:
    A. CYP 3A4
    B. CYP 2C9
    C. CYP 2E1
    D. CYP 1A2

    16_ The most commonly occurring conjugation reaction for drugs and their
    metabolites is:
    A. Glucuronidation
    B. Acetylation
    C. Methylation
    D. Glutathione conjugation
    17_The following drug metabolizing reaction is entirely nonmicrosomal:
    A. Glucuronide conjugation
    B. Acetylation
    C. Oxidation
    D. Reduction

    18_ Which of the following types of drug metabolizing enzymes are inducible:
    A. Microsomal enzymes
    B. Nonmicrosomal enzymes
    C. Both microsomal and nonmicrosomal enzymes
    D. Mitochondrial enzymes

    19_Select the drug that undergoes extensive first-pass metabolism in the liver:
    A. Phenobarbitone
    B. Propranolol
    C. Phenylbutazone
    D. Theophylline

    20_ Drugs which undergo high degree of first-pass metabolism in liver:


    A. Have low oral bioavailability
    B. Are excreted primarily in bile
    C. Are contraindicated in liver disease
    D. Exhibit zero order kinetics of elimination
    21_ Glomerular filtration of a drug is affected by its:
    A. Lipid solubility
    B. Plasma protein binding
    C. Degree of ionization
    D. Rate of tubular secretion

    22_ The plasma half life of penicillin-G is longer in the newborn because their:
    A. Plasma protein level is low
    B. Drug metabolizing enzymes are immature
    C. Glomerular filtration rate is low
    D. Tubular transport mechanisms are not well developed

    23_ If a drug is eliminated by first order kinetics:


    A. A constant amount of the drug will be eliminated per unit time
    B. Its clearance value will remain constant
    C. Its elimination half life will increase with dose
    D. It will be completely eliminated from the body in 2 × half life period

    24_ If the clearance of a drug remains constant, doubling the dose rate will increase
    the steady-state plasma drug concentration by a factor of:
    A. × 3
    B. × 2
    C. × 1.5
    D. × 1.3
    25_ When the same dose of a drug is repeated at half life intervals, the steady-state
    (plateau) plasma drug concentration is reached after:
    A. 2–3 half lives
    B. 4–5 half lives
    C. 6–7 half lives
    D. 8–10 half lives

    26_ The loading dose of a drug is governed by its:


    A. Renal clearance
    B. Plasma half life
    C. Volume of distribution
    D. Elimination rate constant

    27_Interindividual variations in equieffective doses of a drug are most marked if it


    is disposed by:
    A. Glomerular filtration
    B. Tubular secretion
    C. Both glomerular filtration and tubular secretion
    D. Hepatic metabolism

    28_ The pharmacokinetics of drugs in the neonate differs from that in adults,
    because their:
    A. Intestinal transit is fast
    B. Drug metabolizing enzymes are overactive
    C. Tubular transport mechanisms are not well developed
    D. Glomerular filtration rate is high
    29_ Drug metabolism can be induced by the following factors except:
    A. Cigarette smoking
    B. Acute alcohol ingestion
    C. Exposure to insecticides
    D. Consumption charcoal broiled meat

    30_ Drug administered through the following route is most likely to be subjected to
    first-pass metabolism:
    A. Oral
    B. Sublingual
    C. Subcutaneous
    D. Rectal

    31_A small amount of the volume of distribution is common for lipophylic


    substances easy penetrating through barriers and widely distributing in plasma,
    interstitial and cell fluids:
    a) True
    b) False

    32_Pick out the right statement:


    a) Microsomal oxidation always results in inactivation of a compound
    b) Microsomal oxidation results in a decrease of compound toxicity
    c) Microsomal oxidation results in an increase of ionization and water solubility of a drug
    d) Microsomal oxidation results in an increase of lipid solubility of a drug thus its
    excretion from the organism is facilitated
    33_Conjugation is:
    a) Process of drug reduction by special enzymes
    b) Process of drug oxidation by special oxidases
    c) Coupling of a drug with an endogenous substrate
    d) Solubilization in lipids

    34_In case of liver disorders accompanied by a decline in microsomal enzyme


    activity the duration of action of some drugs is:
    a) Decreased
    b) Enlarged
    c) Remained unchanged
    d) Changed insignificantly

    35_The most rapid eliminated drugs are those with high glomerular filtration rate
    and actively secreted but aren’t passively reabsorbed:
    a) True
    b) False

    36_45 year old male , 70 kg. Has ischemic stroke and take clopidegrel. She was
    hospitalized again after 6 months due to recurrent ischemic stroke. Which of the
    following is likely reason she did not respond to clopidogrel therapy? She is a:
    A) Poor CYP2D6 metabolizer
    B)Fast CYP1A2 metabolizer
    C)Poor CYP2E1 metabolizer
    D)Fast CYP3A4 metabolizer
    E)Poor CYP2C19 metabolizer
    1_B

    2_B

    3_C

    4_A

    5_A

    6_C

    7_B

    8_C

    9_A

    10_D

    11_B

    12_D

    13_C

    14_C

    15_A

    16_A

    17_B

    18_A

    19_B

    20_A

    21_B

    22_D

    23_B

    24_B

    25_B

    26_C

    27_D

    28_C

    29_B

    30_A

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