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    GAP Syllabus 2018A Vertical

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    Nithya R
    This document outlines a course on genomics and proteomics. The course aims to provide basic knowledge of genomes and proteomes, introduce tools for genomic analysis, and describe genomic and proteomic techniques. The course is divided into 5 units that cover: 1) genome organization of bacteria, archaea, and eukaryotes; 2) mapping techniques like radiation hybrid mapping; 3) functional genomics including gene finding and transcriptomics; 4) proteomics techniques like 2D gel electrophoresis and mass spectrometry; and 5) protein profiling and bioinformatics tools for proteomics data analysis. The course objectives are mapped to program outcomes and articulation matrix is provided.

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    GAP Syllabus 2018A Vertical

    Uploaded by

    Nithya R
    8 views3 pages
    This document outlines a course on genomics and proteomics. The course aims to provide basic knowledge of genomes and proteomes, introduce tools for genomic analysis, and describe genomic and proteomic techniques. The course is divided into 5 units that cover: 1) genome organization of bacteria, archaea, and eukaryotes; 2) mapping techniques like radiation hybrid mapping; 3) functional genomics including gene finding and transcriptomics; 4) proteomics techniques like 2D gel electrophoresis and mass spectrometry; and 5) protein profiling and bioinformatics tools for proteomics data analysis. The course objectives are mapped to program outcomes and articulation matrix is provided.

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    GAP Syllabus 2018A vertical

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    This document outlines a course on genomics and proteomics. The course aims to provide basic knowledge of genomes and proteomes, introduce tools for genomic analysis, and describe genomic and proteomic techniques. The course is divided into 5 units that cover: 1) genome organization of bacteria, archaea, and eukaryotes; 2) mapping techniques like radiation hybrid mapping; 3) functional genomics including gene finding and transcriptomics; 4) proteomics techniques like 2D gel electrophoresis and mass spectrometry; and 5) protein profiling and bioinformatics tools for proteomics data analysis. The course objectives are mapped to program outcomes and articulation matrix is provided.

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    © All Rights Reserved
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    Download as docx, pdf, or txt
    8 views3 pages

    GAP Syllabus 2018A Vertical

    Uploaded by

    Nithya R
    This document outlines a course on genomics and proteomics. The course aims to provide basic knowledge of genomes and proteomes, introduce tools for genomic analysis, and describe genomic and proteomic techniques. The course is divided into 5 units that cover: 1) genome organization of bacteria, archaea, and eukaryotes; 2) mapping techniques like radiation hybrid mapping; 3) functional genomics including gene finding and transcriptomics; 4) proteomics techniques like 2D gel electrophoresis and mass spectrometry; and 5) protein profiling and bioinformatics tools for proteomics data analysis. The course objectives are mapped to program outcomes and articulation matrix is provided.

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    © All Rights Reserved
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    Download as docx, pdf, or txt
    of 3

    BRANCH INDUSTRIAL BIOTECHNOLOGY

    COURSE
    GENOMICS AND PROTEOMICS SEMESTER
    CODE
    22BPE$13

    PREREQUISITES CATEGORY L T P C

    PE 3 0 0 3

    Course 1. Provide basic knowledge of genomes and proteomes.


    Objectives 2. Introduce relevant tools for the analysis of genomes.
    3. Describe methodologies of genomic and proteomic techniques.
    OVERVIEW OF GENOMES OF BACTERIA,
    UNIT – I 9 periods
    ARCHAEA AND EUKARYOTA
    Genome organization of prokaryotes and eukaryotes, Gene structure of Bacteria, Archaea
    and Eukaryotes, Minimal cell Genome, Human genome project, Introduction to functional
    and comparative genomics.
    UNIT – II MAPPING TECHNIQUES 9 periods
    Cytogenetic mapping, Radiation hybrid mapping, Fish-STS mapping, SNP mapping, Optical
    mapping. Linking and jumping of clones, Gap closure, Pooling strategies, Electronic PCR,
    Automation in Genome sequencing-Next Generation Sequencing.
    UNIT – III FUNCTIONAL GENOMICS 9 periods
    Gene finding, Annotation of genome – experimental and computational approach. ORF
    and functional prediction, Transcriptomics (RNA sequencing) & analysis of transcriptomic
    data, high-throughput analysis of gene expression, DNA microarrays and expression
    profiling
    UNIT – IV PROTEOMICS TECHNIQUES 9 periods
    Protein level estimation-Edman protein microsequencing, Protein cleavage, 2D gel
    electrophoresis, metabolic labelling. Detection of proteins on SDS gels. Mass spectrometry
    principles of MALDI-TOF, Fourier Transform Ion Cyclotron Resonance Mass
    Spectrometer, Orbitrap Mass Analyzer, Tandem MS, Peptide mass fingerprinting.
    UNIT – V PROTEIN PROFILING 9 periods
    Large-scale protein profiling using proteomics, Protein-protein interactions, Functional
    Proteomics Protein microarrays, proteome database. Bioinformatics-based tools for
    analysis of proteomics data.
    Contact Periods: 45
    Lecture: 45 Periods Tutorial: 0 Periods Practical: 0 Periods Total: 45 Periods
    Full Time B.E. 2022 Regulations 1/2

    TEXT BOOKS:

    1 Arthur Lesk., “Introduction to Genomics”, 3rd Edition, Oxford University Press, 2017.

    2 Richard Twyman, Ph.D Cfe, George A, Principles of Proteomics”, 2nd Edition, Garland
    Science, 2013.
    3 Nawin C. Mishra, Günter Blobel, “Introduction to Proteomics: Principles and Applications”,
    1st Edition, Wiley, 2010.

    REFERENCES

    1 Conard, Edward. “Genomics”. Apple Academics, 2010

    2 Liebler, ‘Introduction to Proteomics’, Humana Press, 2002


    3 T.A Brown, ‘Introduction to Genetic: A molecular Approach’, Garland Science, Taylor and
    Francis, 2012
    4 R.M.Twyman, S.B. Primrose, ‘Principle of Genome Analysis and Genomics’, Wiley Blackwell
    Publications, 2007.

    COURSE OUTCOMES: Bloom’s


    Taxonomy
    On completion of the course, the students will be able to: Mapped
    CO1 Understand the basic structure and organization of genomes of K2
    Prokaryotes
    CO2 Understand the basic structure and organization of genomes of Eukaryotes K2
    CO3 Have insight on basic organization of proteomes. K2
    CO4 Analyze proteomes and genomes using the relevant tools. K3
    CO5 Get familiarize with the principles of the methodologies of genomic K3
    and proteomic

    a) Course Articulation Matrix


    PO PO PO PO PO PO PO PSO
    COs/POs PO1
    2
    PO3 PO4
    5
    PO6
    7
    PO8
    9 10 11 12 1
    PSO2
    CO1 L L - - - - - - - - - - H L
    CO2 L L - - - - - - - - - - H L
    CO3 L L L - - - - - - - - - H L
    CO4 L L - - - - - - - - - - H L
    CO5 L L - - - - - - - - - - H L
    22BPE$13 L L L - - - - - - - - - H L
    L – Low, M – Moderate, H – High

    Prepared by Checked by Head of the Department


    Full Time B.E. 2022 Regulations 2/2

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