Clarithromycin Drug Study

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NAME OF ACTION MECHANISM INDICATION ADVERSE EFFECT CONTRAINDICATION NURSING

DRUG OF ACTION RESPONSIBILITIES


Generic Name: Antibiotic; Binds to Treatment of Antibiotic- Hypersensitivity to  Observe the 12
Clarithromycin Macrolide ribosomal susceptible associated colitis, clarithromycin, other rights of nursing
receptor sites infections due to other macrolide antibiotics. administration.
Brand Name: of susceptible C. pneumoniae, superinfections History of QT  Assess the
Biaxin organisms, H. influenzae, H. (abdominal prolongation or patient before
inhibiting parainfluenzae, H. cramps, severe ventricular administering
Dosage: 500 protein pylori, M. watery diarrhea, arrhythmias, including the drug.
mg -1 tab synthesis of catarrhalis, M. fever) may result torsades de pointes.  Evaluate for
bacterial cell avium, M. from altered History of cholestatic therapeutic
Route: PO wall. pneumoniae, S. bacterial balance jaundice or hepatic response (relief
aureus, S. in GI tract. Rarely, impairment with prior of GI symptoms).
Frequency: BID pneumoniae, S. hepatotoxicity, use of clarithromycin.
(8 AM, 6 PM) pyogenes, and Concomitant use with
including bacterial thrombocytopenia. colchicine (in patients
exacerbation of with renal/hepatic
bronchitis, otitis impairment), statins,
media, acute pimozide, ergotamine,
maxillary sinusitis, dihydroergotamine.
Mycobacterium Hepatic/ renal
avium complex impairment, elderly
(MAC), with severe renal
pharyngitis, impairment,
tonsillitis, H. myasthenia gravis,
pylori duodenal coronary artery
ulcer, community- disease. Patients at
acquired risk of prolonged
pneumonia, skin cardiac repolarization.
and soft tissue Avoid use with
infections. uncorrected
Prevention of electrolytes (e.g.,
MAC disease. hypokalemia,
hypomagnesemia),
clinically significant
bradycardia, class IA
or III antiarrhythmics

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