Scribd Logo
Upload

Welcome to Scribd!

  • 538 views

    Itopride

    Uploaded by

    LesValenzuela
    Itopride is a prokinetic drug used to treat functional dyspepsia and other gastrointestinal conditions by increasing gastrointestinal motility. Unlike similar drugs, it does not act by inhibiting dopamine. Itopride is approved for use in many countries but not the United States or United Kingdom. Studies show itopride significantly improves symptoms of functional dyspepsia and motility disorders. Common side effects include abdominal pain and diarrhea.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    Itopride

    Uploaded by

    LesValenzuela
    538 views2 pages
    Itopride is a prokinetic drug used to treat functional dyspepsia and other gastrointestinal conditions by increasing gastrointestinal motility. Unlike similar drugs, it does not act by inhibiting dopamine. Itopride is approved for use in many countries but not the United States or United Kingdom. Studies show itopride significantly improves symptoms of functional dyspepsia and motility disorders. Common side effects include abdominal pain and diarrhea.

    Original Description:

    Itopride

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Itopride is a prokinetic drug used to treat functional dyspepsia and other gastrointestinal conditions by increasing gastrointestinal motility. Unlike similar drugs, it does not act by inhibiting dopamine. Itopride is approved for use in many countries but not the United States or United Kingdom. Studies show itopride significantly improves symptoms of functional dyspepsia and motility disorders. Common side effects include abdominal pain and diarrhea.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    538 views2 pages

    Itopride

    Uploaded by

    LesValenzuela
    Itopride is a prokinetic drug used to treat functional dyspepsia and other gastrointestinal conditions by increasing gastrointestinal motility. Unlike similar drugs, it does not act by inhibiting dopamine. Itopride is approved for use in many countries but not the United States or United Kingdom. Studies show itopride significantly improves symptoms of functional dyspepsia and motility disorders. Common side effects include abdominal pain and diarrhea.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    Itopride

    Itopride (INN, trade name Ganaton) is a prokinetic benzamide derivative


    unlike metoclopramide or domperidone. These drugs inhibit dopamine and have
    a gastrokinetic effect.
    [1]
    Itopride is indicated for the treatment of
    functional dyspepsia and other gastrointestinal conditions.
    Itopride is not currently approved by the U.S. Food and Drug Administration (FDA)
    for use in the United States, nor is it yet approved in the United Kingdom. This may
    explain the apparent lack of patient information available in English compared to
    other similar classes of medication.
    Clinical use
    A blister package of Ganaton (Itopride) 50 mg tablets intended for distribution in the Slovak Republic.
    Typically, itopride is indicated in the treatment of GI symptoms caused by reduced GI
    motility:
    dyspepsia of a non-ulcer/dysmotility type (gastric "fullness", discomfort, and
    possible pain)
    Delayed gastric emptying
    anorexia
    heartburn
    regurgitation
    bloating
    nausea and vomiting
    other possible gastric, prolactin, or dopamine related conditions
    Itopride is typically taken three times a day. The dose is usually taken on an empty
    stomach about an hour before meals. However, the dosage and details of
    administration may vary depending on the patients age, symptoms, and other factors.
    Itopride was shown to significantly improve symptoms in patients with functional
    dyspepsia and motility disorders in placebo-controlled trials.
    These studies concluded that the reduction in the severity of symptoms of functional
    dyspepsia after 8 weeks of treatment with itopride indicated that itopride was
    significantly superior to placebo and that itopride yielded a greater rate of response
    than placebo in significantly reducing pain and fullness.
    Contraindications and precautions
    Itopride is a relatively new drug and it is not currently approved for normal prescribed
    use nor OTC use in either the US nor the UK. However, this does not necessarily
    indicate that itopride is not effective or safe.
    Patients taking itopride should report any side-effects to their treating physician.
    Itopride is contraindicated in hypersensitivity to itopride or benzamides; lactation,
    GI hemorrhage, obstruction or perforation. Itopride may not be indicated for those
    suffering from Parkinson's disease or other conditions involving dopamine regulation
    issues. Itopride should be used with special caution in the young and the elderly. Little
    information is available at this time regarding the safe use of itopride during
    pregnancy.
    Adverse drug reactions
    The most common side-effects of itopride include mild to moderate abdominal pain
    and diarrhoea. Some other side effects that may occur include: rash, giddiness,
    exhaustion, back or chest pain, increased salivation, constipation, headache, sleeping
    disorders, dizziness, galactorrhea, and gynecomastia.
    Other side effects may also be present.
    Leukopenia, a reduction in the normal level of white blood cells, can be a potentially
    life-threatening reaction to itopride.
    Central nervous system adverse effects do not tend to occur due to poor penetration
    across the blood brain barrier, although a slight raising of prolactin levels may
    occur. Raising of prolactin levels is more common with high dose regimes of itopride.
    Mechanism of action
    Itopride increases acetylcholine concentrations by inhibiting dopamine D2
    receptors and acetylcholinesterase. Higher acetylcholine increases GI peristalsis,
    increases the lower esophageal sphincter pressure, stimulates gastric motility,
    accelerates gastric emptying, and improves gastro-duodenal coordination.

    You might also like